Investigation of HUVEC response to exposure to PAMAM dendrimers – changes in cell elasticity and vesicles release

References

• Albertazzi, L., L. Gherardini, M. Brondi, S. S. Sato, A. Bifone, T. Pizzorusso, G. M. Ratto, and G. Bardi. 2013. “In Vivo Distribution and Toxicity of PAMAM Dendrimers in the Central Nervous System Depend on Their Surface Chemistry.” Molecular Pharmaceutics 10 (1): 249–260. doi:10.1021/mp300391v.
   PubMed Web of Science ®Google Scholar
• Berényi, S., J. Mihály, A. Wacha, O. Tőke, and A. Bóta. 2014. “A Mechanistic View of Lipid Membrane Disrupting Effect of PAMAM Dendrimers.” Colloids and Surfaces B, Biointerfaces 118: 164–171. doi:10.1016/j.colsurfb.2014.03.048.
   PubMed Web of Science ®Google Scholar
• Białkowska, K., K. Miłowska, S. Michlewska, P. Sokołowska, P. Komorowski, T. Lozano-Cruz, R. Gomez-Ramirez, F. J. de la Mata, and M. Bryszewska. 2021. “Interaction of Cationic Carbosilane Dendrimers and Their siRNA Complexes with MCF- 7 Cells.” International Journal of Molecular Sciences 22 (13): 7097. doi:10.3390/ijms22137097.
   PubMed Web of Science ®Google Scholar
• Carl, P., and H. Schillers. 2008. “Elasticity Measurement of Living Cells with an Atomic Force Microscope: Data Acquisition and Processing.” Pflugers Archiv: European Journal of Physiology 457 (2): 551–559. doi:10.1007/s00424-008-0524-3.
   PubMed Web of Science ®Google Scholar
• Cosgun, Z. C., B. Fels, and K. Kusche-Vihrog. 2020. “Nanomechanics of the Endothelial Glycocalyx from Structure to Function.” The American Journal of Pathology 190 (4): 732–741. doi:10.1016/j.ajpath.2019.07.021.
   PubMed Web of Science ®Google Scholar
• Darling, E. M., M. Topel, S. Zauscher, T. P. Vail, and F. Guilak. 2008. “Viscoelastic Properties of Human Mesenchymally‐Derived Stem Cells and Primary Osteoblasts, Chondrocytes, and Adipocytes.” Journal of Biomechanics 41 (2): 454–464. doi:10.1016/j.jbiomech.2007.06.019.
   PubMed Web of Science ®Google Scholar
• Fletcher, D. A., and M. R. Dyche. 2010. “Cell Mechanics and the Cytoskeleton.” Nature 463 (7280): 485–492. doi:10.1038/nature08908.
   PubMed Web of Science ®Google Scholar
• Giergiel, M., K. Ewa Malek-Zietek, J. Konior, and M. Targosz-Korecka. 2021. “Endothelial Glycocalyx Detection and Characterization by Means of Atomic Force Spectroscopy: Comparison of Various Data Analysis Approaches.” Micron (Oxford, England: 1993) 151: 103153. doi:10.1016/j.micron.2021.103153..
   PubMed Web of Science ®Google Scholar
• Grady, M. E., R. J. Composto, and D. M. Eckmann. 2016. “Cytoskeletal Perturbing Drugs and Their Effect on Cell Elasticity, Mechanics of Biological Systems and Materials.” Mechanics of Biological Systems and Materials 6: 169–177. doi:10.1007/978-3-319-41351-8_24.
   Google Scholar
• Harris, A. R., and G. T. Charras. 2011. “Experimental Validation of Atomic Force Microscopy‐Based Cell Elasticity Measurements.” Nanotechnology 22 (34): 345102. doi:10.1088/0957-4484/22/34/345102.
   PubMed Web of Science ®Google Scholar
• He, X., Z. Qu, F. Xu, M. Lin, J. Wang, X. Shi, and T. Lu. 2014. “Molecular Analysis of Interactions between Dendrimers and Asymmetric Membranes at Different Transport Stages.” Soft Matter 10 (1): 139–148. doi:10.1039/C3SM51990B.
   PubMed Web of Science ®Google Scholar
• Hong, S., A. U. Bielinska, A. Mecke, B. Keszler, J. L. Beals, X. Shi, L. Balogh, B. G. Orr, J. R. Baker, and M. M. Banaszak Holl. 2004. “Interaction of Poly(Amidoamine) Dendrimers with Supported Lipid Bilayers and Cells: Hole Formation and the Relation to Transport.” Bioconjugate Chemistry 15 (4): 774–782. doi:10.1021/bc049962b.
   PubMed Web of Science ®Google Scholar
• Hong, S., P. R. Leroueil, E. K. Janus, J. L. Peters, M. M. Kober, M. T. Islam, B. G. Orr, J. R. Baker, and M. M. Banaszak Holl. 2006. “Interaction of Polycationic Polymers with Supported Lipid Bilayers and Cells: Nanoscale Hole Formation and Enhanced Membrane Permeability.” Bioconjugate Chemistry 17 (3): 728–734. doi:10.1021/bc060077y.
   PubMed Web of Science ®Google Scholar
• Janaszewska, A., J. Lazniewska, P. Trzepinski, M. Marcinkowska, and B. Klajnert-Maculewicz. 2019. “Cytotoxicity of Dendrimers.” Biomolecules 9 (8): 330 doi:10.3390/biom9080330.
   PubMed Web of Science ®Google Scholar
• Jevprasesphant, R., J. Penny, R. Jalal, D. Attwood, N. B. McKeown, and A. D’Emanuele. 2003. “The Influence of Surface Modification on the Cytotoxicity of PAMAM Dendrimers.” International Journal of Pharmaceutics 252 (1–2): 263–266. doi:10.1016/S0378-5173(02)00623-3.
   PubMed Web of Science ®Google Scholar
• Kabedev, A., and V. Lobaskin. 2018. “Structure and Elasticity of Bush and Brush-like Models of the Endothelial Glycocalyx.” Scientific Reports 8 (1): 1–13. doi:10.1038/s41598-017-18577-3.
   PubMedGoogle Scholar
• Kelly, C. V., P. R. Leroueil, B. G. Orr, M. M. B. Holl, and I. Andricioaei. 2008. “Poly(Amidoamine) Dendrimers on Lipid Bilayers II: Effects of Bilayer Phase and Dendrimer Termination.” The Journal of Physical Chemistry B 112 (31): 9346–9353. doi:10.1021/jp8013783.
   PubMed Web of Science ®Google Scholar
• Keszthelyi, T., G. Hollo, G. Nyitrai, J. Kardos, and L. Heja. 2015. “Bilayer Charge Reversal and Modification of Lipid Organization by Dendrimers as Observed by Sum-Frequency Vibrational Spectroscopy.” Langmuir: The ACS Journal of Surfaces and Colloids 31 (28): 7815–7825. doi:10.1021/acs.langmuir.5b00734.
   PubMed Web of Science ®Google Scholar
• Khanal, D., F. Zhang, Y. Song, H. Hau, A. Gautam, S. Yamaguchi, J. Uertz, et al. 2019. “Biological Impact of Nanodiamond Particles – Label Free, High-Re Methods for Nanotoxicity Assessment.” Nanotoxicology 13 (9): 1210–1226. doi:10.1080/17435390.2019.1650970.
   PubMed Web of Science ®Google Scholar
• Klajnert, B, and M. Bryszewska. 2007. Dendrimers in Medicines. Medicine & Health Sciences. 1st ed. New York, NY: Nova Science Publisher Inc.
   Google Scholar
• Kolodziejczyk, A. M., G. D. Brzezinka, K. Khurana, M. Targosz-Korecka, and M. Szymonski. 2013. “Nanomechanical Sensing of the Endothelial Cell Response to anti-Inflammatory Action of 1-Methylnicotinamide Chloride.” International Journal of Nanomedicine 8: 2757–2767. doi:10.2147/IJN.S46936.
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk, A. M., A. Jakubowska, M. Kucinska, T. Wasiak, P. Komorowski, K. Makowski, and B. Walkowiak. 2018. “Sensing of Silver Nanoparticles on/in Endothelial Cells Using Atomic Force Spectroscopy.” Journal of Molecular Recognition 31 (9): e2723–9. doi:10.1002/jmr.2723.
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk, A. M., M. Kucinska, A. Jakubowska, P. Sokolowska, M. Rosowski, B. Tkacz-Szczesna, P. Komorowski, K. Makowski, and B. Walkowiak. 2020. “Endothelial Cell Aging Detection by Means of Atomic Force Spectroscopy.” Journal of Molecular Recognition 33 (12): 1–10. doi:10.1002/jmr.2853.
   Web of Science ®Google Scholar
• Kolodziejczyk, A. M., P. Sokolowska, A. Zimon, M. Grala, M. Rosowski, M. Siatkowska, P. Komorowski, and B. Walkowiak. 2021. “Dysfunction of Endothelial Cells Exposed to Nanomaterials Assessed by Atomic Force Spectroscopy.” Micron 145: 103062. doi:10.1016/j.micron.2021.103062.
   PubMed Web of Science ®Google Scholar
• Kolodziejczyk, A. M., M. Targosz-Korecka, and M. Szymonski. 2017. “Nanomechanical Testing of Drug Activities at the Cellular Level: Case Study for Endothelium-Targeted Drugs.” Pharmacological Reports 69 (6): 1165–1172. doi:10.1016/j.pharep.2017.06.007.
   PubMed Web of Science ®Google Scholar
• Kusche-Vihrog, K., K. Sobczak, N. Bangel, M. Wilhelmi, V. Nechyporuk-Zloy, A. Schwab, H. Schillers, and H. Oberleithner. 2008. “Aldosterone and Amiloride Alter ENaC Abundance in Vascular Endothelium.” Pflugers Archiv: European Journal of Physiology 455 (5): 849–857. doi:10.1007/s00424-007-0341-0.
   PubMed Web of Science ®Google Scholar
• Lee, C. C., J. A. Mackay, J. M. J. Frechet, and F. C. Szoka. 2005. “Designing Dendrimers for Biological Applications.” Nature Biotechnology 23 (12): 1517–1526. doi:10.1038/nbt1171.
   PubMed Web of Science ®Google Scholar
• Lee, H., and R. G. Larson. 2006. “Molecular Dynamics Simulations of PAMAM Dendrimer-Induced Pore Formation in DPPC Bilayers with a Coarse-Grained Model.” The Journal of Physical Chemistry B 110 (37): 18204–18211. doi:10.1021/jp0630830.
   PubMed Web of Science ®Google Scholar
• Li, Y., X. Zeng, S. Wang, Y. Sun, Z. Wang, J. Fan, P. Song, and D. Ju. 2015. “Inhibition of Autophagy Protects against PAMAM Dendrimers-Induced Hepatotoxicity.” Nanotoxicology 9 (3): 344. doi:10.3109/17435390.2014.930533.
   PubMed Web of Science ®Google Scholar
• Lombardo, D., P. Calandra, E. Bellocco, G. Lagana, D. Barreca, S. Magazu, U. Wanderlingh, and M. A. Kiselev. 2016. “Effect of Anionic and Cationic Polyamidoamine (PAMAM) Dendrimers on a Model Lipid Membrane.” Biochimica et Biophysica Acta 1858 (11): 2769–2777. doi:10.1016/j.bbamem.2016.08.001.
   PubMed Web of Science ®Google Scholar
• Lüchtefeld, I., A. Bartolozzi, J. Mejía Morales, O. Dobre, M. Basso, T. Zambelli, and M. Vassalli. 2020. “Elasticity Spectra as a Tool to Investigate Actin Cortex Mechanics.” Journal of Nanobiotechnology 18 (1): 11. doi:10.1186/s12951-020-00706-2.
   PubMed Web of Science ®Google Scholar
• Malik, N., R. Wiwattanapatapee, R. Klopsch, K. Lorenz, H. Frey, J. W. Weener, E. W. Meijer, W. Paulus, and R. Duncan. 2000. “Dendrimers: Relationship between Structure and Biocompatibility in Vitro, and Preliminary Studies on the Biodistribution of 125I-Labelled Polyamidoamine Dendrimers in Vivo.” Journal of Controlled Release 68 (2): 133–148. doi:10.1016/S0168-3659(99)00246-1.
   Web of Science ®Google Scholar
• Martin, H., H. Kinns, N. Mitchell, Y. Astier, R. Madathil, and S. Howorka. 2007. “Nanoscale Protein Pores Modified with PAMAM Dendrimers.” Journal of the American Chemical Society 129 (31): 9640–9649. doi:10.1021/ja0689029.
   PubMed Web of Science ®Google Scholar
• Mecke, A., I. J. Majoros, A. K. Patri, J. R. Baker, M. M. Banaszak Holl, and B. G. Orr. 2005. “Lipid Bilayer Disruption by Polycationic Polymers: The Roles of Size and Chemical Functional Group.” Langmuir: The ACS Journal of Surfaces and Colloids 21 (23): 10348–10354. doi:10.1021/la050629l.
   PubMed Web of Science ®Google Scholar
• Mukherjee, S. P., and H. J. Byrne. 2013. “Polyamidoamine Dendrimer Nanoparticle Cytotoxicity, Oxidative Stress, Caspase Activation and Inflammatory Response: Experimental Observation and Numerical Simulation.” Nanomedicine: Nanotechnology, Biology, and Medicine 9 (2): 202–211. doi:10.1016/j.nano.2012.05.002.
   PubMed Web of Science ®Google Scholar
• Mukherjee, S. P., M. Davoren, and H. J. Byrne. 2010. “In Vitro Mammalian Cytotoxicological Study of PAMAM Dendrimers-towards Quantitative Structure Activity Relationships.” Toxicology in Vitro: An International Journal Published in Association with BIBRA 24 (1): 169–177. doi:10.1016/j.tiv.2009.09.014.
   PubMed Web of Science ®Google Scholar
• Oberleithner, H., C. Riethmuller, T. Ludwig, M. Hausberg, and H. Schillers. 2006. “Aldosterone Remodels Human Endothelium.” Acta Physiologica (Oxford, England) 187 (1–2): 305–312. doi:10.1111/j.1748-1716.2006.01574.x.
   PubMed Web of Science ®Google Scholar
• Patel, M., S. De Paoli, O. K. Elhelu, S. Farooq, and J. Simak. 2019. “Cell Membrane Disintegration and Extracellular Vesicle Release in a Model of Different Size and Charge PAMAM Dendrimers Effects on Cultured Endothelial Cells.” Nanotoxicology 13 (5): 664–681. doi:10.1080/17435390.2019.1570373.
   PubMed Web of Science ®Google Scholar
• Rico, F., P. Roca-Cusachs, N. Gavara, R. Farré, M. Rotger, and D. Navajas. 2005. “Probing Mechanical Properties of Living Cells by Atomic Force Microscopy with Blunted Pyramidal Cantilever Tips.” Physical Review E 72 (2): 1–10. doi:10.1103/PhysRevE.72.021914.
   Web of Science ®Google Scholar
• Siatkowska, M., P. Sokołowska, K. Białkowska, A. Zimon, M. Grala, M. Rosowski, K. Kądzioła-Długołęcka, et al. 2021. “Impact of Micron-Sized Diamond Particles on Barrier Cells of the Human Small Intestine.” Diamond and Related Materials 114: 108307–108309. doi:10.1016/j.diamond.2021.108307.
   Web of Science ®Google Scholar
• Simak, J. 2016. “The Effects of Engineered Nanomaterials on Cultured Endothelial Cells.” In Handbook of Immunological Properties of Engineered Nanomaterials, edited by Marina A Dobrovolskaia and Scott E McNeil, 105–162. 2nd ed. Singapore: World Scientific. doi:10.1142/9789813140455_0005.
   Google Scholar
• Stetefeld, J., S. A. McKenna, and T. R. Patel. 2016. “Dynamic Light Scattering: A Practical Guide and Applications in Biomedical Sciences.” Biophysical Reviews 8 (4): 409–427. doi:10.1007/s12551-016-0218-6.
   PubMedGoogle Scholar
• Szczygiel, A. M., G. Brzezinka, M. Targosz‐Korecka, S. Chlopicki, and M. Szymonski. 2012. “Elasticity Changes anti‐Correlate with NO Production for Human Endothelial Cells Stimulated with TNF.” Pflugers Archiv: European Journal of Physiology 463 (3): 487–496. doi:10.1007/s00424-011-1051-1.
   PubMed Web of Science ®Google Scholar
• Szymonski, M., M. Targosz-Korecka, and K. E. Malek-Zietek. 2015. “Nano-Mechanical Model of Endothelial Dysfunction for AFM-Based Diagnostics at the Cellular Level.” Pharmacological Reports 67 (4): 728–735. doi:10.1016/j.pharep.2015.05.003.
   PubMed Web of Science ®Google Scholar
• Targosz-Korecka, M., M. Jaglarz, K. E. Malek-Zietek, A. Gregorius, A. Zakrzewska, B. Sitek, Z. Rajfur, S. Chlopicki, and M. Szymonski. 2017. “AFM-Based Detection of Glycocalyx Degradation and Endothelial Stiffening in the db/db Mouse Model of Diabetes.” Scienftific Reports 7: 1–13. doi:10.1038/s41598-017-16179-7.
   PubMed Web of Science ®Google Scholar
• Tomalia, D. A. 2005. “Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building Blocks for Nanoscale Synthetic Polymer Chemistry.” Progress in Polymer Science 30 (3–4): 294–324. doi:10.1016/j.progpolymsci.2005.01.007.
   Web of Science ®Google Scholar
• Vargas-Pinto, R., H. Gong, A. Vahabikashi, and M. Johnson. 2013. “The Effect of the Endothelial Cell Cortex on Atomic Force Microscopy Measurements.” Biophysical Journal 105 (2): 300–309. doi:10.1016/j.bpj.2013.05.034.
   PubMed Web of Science ®Google Scholar