Potent lung tumor promotion by inhaled MWCNT

References

• Barbarino, M., and A. Giordano. 2021. “Assessment of the Carcinogenicity of Carbon Nanotubes in the Respiratory System.” Cancers 13 (6): 1318. https://doi.org/10.3390/cancers13061318
   PubMed Web of Science ®Google Scholar
• Barra, V., and D. Fachinetti. 2018. “The Dark Side of Centromeres: Types, Causes and Consequences of Structural Abnormalities Implicating Centromeric DNA.” Nature Communications 9 (1): 4340. https://doi.org/10.1038/s41467-018-06545-y
   PubMedGoogle Scholar
• Barrett, J. C. 1993. “Mechanisms of Multistep Carcinogenesis and Carcinogen Risk Assessment.” Environmental Health Perspectives 100: 9–20. https://doi.org/10.1289/ehp.931009
   PubMed Web of Science ®Google Scholar
• Barthel, Hélène, Christian Darne, Laurent Gaté, Athanase Visvikis, and Carole Seidel. 2021. “Continuous Long-Term Exposure to Low Concentrations of MWCNTS Induces an Epithelial-Mesenchymal Transition in BEAS-2B Cells.” Nanomaterials (Basel, Switzerland) 11 (7): 1742. https://doi.org/10.3390/nano11071742
   PubMedGoogle Scholar
• Bauer, A. K., and L. D. Dwyer-Nield. 2021. “Two-Stage 3-Methylcholanthrene and Butylated Hydroxytoluene-Induced Lung Carcinogenesis in Mice.” Methods in Cell Biology 163: 153–173. https://doi.org/10.1016/bs.mcb.2020.07.003
   Google Scholar
• Beeharry, N., J. B. Rattner, J. P. Caviston, and T. Yen. 2013. “Centromere Fragmentation is a Common Mitotic Defect of S and G2 Checkpoint Override.” Cell Cycle (Georgetown, Tex.) 12 (10): 1588–1597. https://doi.org/10.4161/cc.24740
   PubMed Web of Science ®Google Scholar
• Bloomberg. 2020. “Carbon Nanotubes Market Size Is Projected to Reach USD 5.8 Billion by 2027 - Valuates Reports.” https://www.Bloomberg.Com/press-releases/2020-09-16/carbon-nanotubes-market-size-is-projected-to-reach-usd-5-8-billion-by-2027-valuates-reports.
   Google Scholar
• Chahine, N. O., N. M. Collette, C. B. Thomas, D. C. Genetos, and G. G. Loots. 2014. “Nanocomposite Scaffold for Chondrocyte Growth and Cartilage Tissue Engineering: Effects of Carbon Nanotube Surface Functionalization.” Tissue Engineering. Part A 20 (17-18): 2305–2315. https://doi.org/10.1089/ten.TEA.2013.0328
   PubMed Web of Science ®Google Scholar
• Choma, D., J. P. Daurès, X. Quantin, and J. L. Pujol. 2001. “Aneuploidy and Prognosis of Non-Small-Cell Lung Cancer: A Meta-Analysis of Published Data.” British Journal of Cancer 85 (1): 14–22. https://doi.org/10.1054/bjoc.2001.1892
   PubMed Web of Science ®Google Scholar
• Conway, E. M., L. A. Pikor, S. H. Kung, M. J. Hamilton, S. Lam, W. L. Lam, and K. L. Bennewith. 2016. “Macrophages, Inflammation, and Lung Cancer.” American Journal of Respiratory and Critical Care Medicine 193 (2): 116–130. https://doi.org/10.1164/rccm.201508-1545CI
   PubMed Web of Science ®Google Scholar
• Coussens, L. M., and Z. Werb. 2002. “Inflammation and Cancer.” Nature 420 (6917): 860–867. https://doi.org/10.1038/nature01322
   PubMed Web of Science ®Google Scholar
• De Volder, M. F., S. H. Tawfick, R. H. Baughman, and A. J. Hart. 2013. “Carbon Nanotubes: Present and Future Commercial Applications.” Science (New York, N.Y.) 339 (6119): 535–539. https://doi.org/10.1126/science.1222453
   PubMed Web of Science ®Google Scholar
• Devereux, T. R., M. W. Anderson, and S. A. Belinsky. 1991. “Role of Ras Protooncogene Activation in the Formation of Spontaneous and Nitrosamine-Induced Lung Tumors in the Resistant c3h Mouse.” Carcinogenesis 12 (2): 299–303. https://doi.org/10.1093/carcin/12.2.299
   PubMed Web of Science ®Google Scholar
• Donaldson, K., F. A. Murphy, R. Duffin, and C. A. Poland. 2010. “Asbestos, Carbon Nanotubes and the Pleural Mesothelium: A Review of the Hypothesis Regarding the Role of Long Fibre Retention in the Parietal Pleura, Inflammation and Mesothelioma.” Particle and Fibre Toxicology 7 (1): 5. https://doi.org/10.1186/1743-8977-7-5
   PubMed Web of Science ®Google Scholar
• Dong, J., and Q. Ma. 2018. “Macrophage Polarization and Activation at the Interface of Multi-Walled Carbon Nanotube-Induced Pulmonary Inflammation and Fibrosis.” Nanotoxicology 12 (2): 153–168. https://doi.org/10.1080/17435390.2018.1425501
   PubMed Web of Science ®Google Scholar
• Ema, M., T. Imamura, H. Suzuki, N. Kobayashi, M. Naya, and J. Nakanishi. 2012. “Evaluation of Genotoxicity of Multi-Walled Carbon Nanotubes in a Battery of In Vitro and In Vivo Assays.” Regulatory Toxicology and Pharmacology: RTP 63 (2): 188–195. https://doi.org/10.1016/j.yrtph.2012.03.014
   PubMed Web of Science ®Google Scholar
• Engels, E. A. 2008. “Inflammation in the Development of Lung Cancer: Epidemiological Evidence.” Expert Review of Anticancer Therapy 8 (4): 605–615. https://doi.org/10.1586/14737140.8.4.605
   PubMed Web of Science ®Google Scholar
• Erdely, Aaron, Matthew Dahm, Bean T. Chen, Patti C. Zeidler-Erdely, Joseph E. Fernback, M. Eileen Birch, Douglas E. Evans, et al. 2013. “Carbon Nanotube Dosimetry: From Workplace Exposure Assessment to Inhalation Toxicology.” Particle and Fibre Toxicology 10 (1): 53. https://doi.org/10.1186/1743-8977-10-53
   PubMedGoogle Scholar
• Fraser, Kelly, Ann Hubbs, Naveena Yanamala, Robert R. Mercer, Todd A. Stueckle, Jake Jensen, Tracy Eye, et al. 2021. “Histopathology of the Broad Class of Carbon Nanotubes and Nanofibers Used or Produced in Us Facilities in a Murine Model.” Particle and Fibre Toxicology 18 (1): 47. https://doi.org/10.1186/s12989-021-00440-z
   PubMed Web of Science ®Google Scholar
• Fraser, Kelly, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, et al. 2020. “Physicochemical Characterization and Genotoxicity of the Broad Class of Carbon Nanotubes and Nanofibers Used or Produced in U.S. Facilities.” Particle and Fibre Toxicology 17 (1): 62. https://doi.org/10.1186/s12989-020-00392-w
   PubMed Web of Science ®Google Scholar
• Giam, M., and G. Rancati. 2015. “Aneuploidy and Chromosomal Instability in Cancer: A Jackpot to Chaos.” Cell Division 10 (1): 3. https://doi.org/10.1186/s13008-015-0009-7
   PubMedGoogle Scholar
• Gisselsson, D. 2005. “Mitotic Instability in Cancer: Is There Method in the Madness?” Cell Cycle (Georgetown, Tex.) 4 (8): 1007–1010. https://doi.org/10.4161/cc.4.8.1884
   PubMed Web of Science ®Google Scholar
• Gisselsson, D., T. Jonson, C. Yu, C. Martins, N. Mandahl, J. Wiegant, Y. Jin, F. Mertens, and C. Jin. 2002. “Centrosomal Abnormalities, Multipolar Mitoses, and Chromosomal Instability in Head and Neck Tumours with Dysfunctional Telomeres.” British Journal of Cancer 87 (2): 202–207. https://doi.org/10.1038/sj.bjc.6600438
   PubMed Web of Science ®Google Scholar
• Harasymiw, L. A., D. Tank, M. McClellan, N. Panigrahy, and M. K. Gardner. 2019. “Centromere Mechanical Maturation During Mammalian Cell Mitosis.” Nature Communications 10 (1): 1761. https://doi.org/10.1038/s41467-019-09578-z
   PubMedGoogle Scholar
• Horibata, K., A. Ukai, A. Ogata, D. Nakae, H. Ando, Y. Kubo, A. Nagasawa, K. Yuzawa, and M. Honma. 2017. “Absence of In Vivo Mutagenicity of Multi-Walled Carbon Nanotubes in Single Intratracheal Instillation Study Using f344 GPT Delta Rats.” Genes and Environment. 39: 4. https://doi.org/10.1186/s41021-016-0065-5
   PubMedGoogle Scholar
• Hu, H., Y. Ni, V. Montana, R. C. Haddon, and V. Parpura. 2004. “Chemically Functionalized Carbon Nanotubes as Substrates for Neuronal Growth.” Nano Letters 4 (3): 507–511. https://doi.org/10.1021/nl035193d
   PubMed Web of Science ®Google Scholar
• Hubbs, A. F., F. F. Hahn, and D. G. Thomassen. 1989. “Increased Resistance to Transforming Growth Factor Beta Accompanies Neoplastic Progression of Rat Tracheal Epithelial Cells.” Carcinogenesis 10 (9): 1599–1605. https://doi.org/10.1093/carcin/10.9.1599
   PubMed Web of Science ®Google Scholar
• Huff, J. 1999. “Long-Term Chemical Carcinogenesis Bioassays Predict Human Cancer Hazards. Issues, Controversies, and Uncertainties.” Annals of the New York Academy of Sciences 895 (1): 56–79. https://doi.org/10.1111/j.1749-6632.1999.tb08077.x
   PubMedGoogle Scholar
• Huff, J. E., S. L. Eustis, and J. K. Haseman. 1989. “Occurrence and Relevance of Chemically Induced Benign Neoplasms in Long-Term Carcinogenicity Studies.” Cancer Metastasis Reviews 8 (1): 1–22. https://doi.org/10.1007/BF00047055
   PubMed Web of Science ®Google Scholar
• Hutt, J. A., B. R. Vuillemenot, E. B. Barr, M. J. Grimes, F. F. Hahn, C. H. Hobbs, T. H. March, et al. 2005. “Life-Span Inhalation Exposure to Mainstream Cigarette Smoke Induces Lung Cancer in b6c3f1 Mice Through Genetic and Epigenetic Pathways.” Carcinogenesis 26 (11): 1999–2009. https://doi.org/10.1093/carcin/bgi150
   PubMed Web of Science ®Google Scholar
• Jeffrey, A. M., R. M. Santella, D. Wong, L. L. Hsieh, V. Heisig, G. Doskocil, and S. Ghayourmanesh. 1990. “Metabolic Activation of Nitropyrenes and Diesel Particulate Extracts.” Res Rep Health Eff Inst (34): 1–30.
   Google Scholar
• Kasai, T., Y. Umeda, M. Ohnishi, T. Mine, H. Kondo, T. Takeuchi, M. Matsumoto, and S. Fukushima. 2016. “Lung Carcinogenicity of Inhaled Multi-Walled Carbon Nanotube in Rats.” Particle and Fibre Toxicology 13 (1): 53. https://doi.org/10.1186/s12989-016-0164-2
   PubMed Web of Science ®Google Scholar
• Kim, Y. A., T. Hayashi, M. Endo, Y. Kaburagi, T. Tsukada, J. Shan, K. Osato, and S. Tsuruoka. 2005. “Synthesis and Structural Characterization of Thin Multi-Walledcarbon Nanotubes with a Partially Facetted Cross Sectionby a Floating Reactant Method.” Carbon 43 (11): 2243–2250. https://doi.org/10.1016/j.carbon.2005.03.039
   Web of Science ®Google Scholar
• Kishimoto, Y., K. Sugio, J. Y. Hung, A. K. Virmani, D. D. McIntire, J. D. Minna, and A. F. Gazdar. 1995. “Allele-Specific Loss in Chromosome 9p Loci in Preneoplastic Lesions Accompanying Non-Small-Cell Lung Cancers.” Journal of the National Cancer Institute 87 (16): 1224–1229. https://doi.org/10.1093/jnci/87.16.1224
   PubMedGoogle Scholar
• Koutsami, M. K., P. K. Tsantoulis, M. Kouloukoussa, K. Apostolopoulou, I. S. Pateras, Z. Spartinou, A. Drougou, et al. 2006. “Centrosome Abnormalities Are Frequently Observed in Non-Small-Cell Lung Cancer and Are Associated with Aneuploidy and Cyclin e Overexpression.” The Journal of Pathology 209 (4): 512–521. https://doi.org/10.1002/path.2005
   PubMed Web of Science ®Google Scholar
• Lalwani, G., A. Gopalan, M. D’Agati, J. S. Sankaran, S. Judex, Y. X. Qin, and B. Sitharaman. 2015. “Porous Three-Dimensional Carbon Nanotube Scaffolds for Tissue Engineering.” Journal of Biomedical Materials Research. Part A 103 (10): 3212–3225. https://doi.org/10.1002/jbm.a.35449
   PubMed Web of Science ®Google Scholar
• Laube, B., S. Michaelsen, V. Meischner, A. Hartwig, B. Epe, and M. Schwarz. 2019. “Classification or Non-Classification of Substances with Positive Tumor Findings in Animal Studies: Guidance by the German Mak Commission.” Regulatory Toxicology and Pharmacology: RTP 108: 104444. https://doi.org/10.1016/j.yrtph.2019.104444
   PubMed Web of Science ®Google Scholar
• Lim, Chol Seung, Dale W. Porter, Marlene S. Orandle, Brett J. Green, Mark A. Barnes, Tara L. Croston, Michael G. Wolfarth, et al. 2020. “Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization.” Frontiers in Immunology 11: 1186. https://doi.org/10.3389/fimmu.2020.01186
   PubMed Web of Science ®Google Scholar
• Lingle, W. L., and J. L. Salisbury. 1999. “Altered Centrosome Structure is Associated with Abnormal Mitoses in Human Breast Tumors.” The American Journal of Pathology 155 (6): 1941–1951. https://doi.org/10.1016/S0002-9440(10)65513-7
   PubMed Web of Science ®Google Scholar
• Luebeck, E. G., and S. H. Moolgavkar. 2002. “Multistage Carcinogenesis and the Incidence of Colorectal Cancer.” Proceedings of the National Academy of Sciences of the United States of America 99 (23): 15095–15100. https://doi.org/10.1073/pnas.222118199
   PubMed Web of Science ®Google Scholar
• MacDonald, R. A., B. F. Laurenzi, G. Viswanathan, P. M. Ajayan, and J. P. Stegemann. 2005. “Collagen-Carbon Nanotube Composite Materials as Scaffolds in Tissue Engineering.” Journal of Biomedical Materials Research. Part A 74 (3): 489–496. https://doi.org/10.1002/jbm.a.30386
   PubMed Web of Science ®Google Scholar
• Malkinson, A. M. 1989. “The Genetic Basis of Susceptibility to Lung Tumors in Mice.” Toxicology 54 (3): 241–271. https://doi.org/10.1016/0300-483x(89)90062-0
   PubMed Web of Science ®Google Scholar
• Malkinson, A. M., K. M. Koski, W. A. Evans, and M. F. Festing. 1997. “Butylated Hydroxytoluene Exposure is Necessary to Induce Lung Tumors in Balb Mice Treated with 3-Methylcholanthrene.” Cancer Research 57 (14): 2832–2834.
   PubMed Web of Science ®Google Scholar
• Mann, Peter C., John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, et al. 2012. “International Harmonization of Toxicologic Pathology Nomenclature: An Overview and Review of Basic Principles.” Toxicologic Pathology 40 (4 Suppl): 7S–13S. https://doi.org/10.1177/0192623312438738
   PubMed Web of Science ®Google Scholar
• McKinney, W., B. Chen, and D. Frazer. 2009. “Computer Controlled Multi-Walled Carbon Nanotube Inhalation Exposure System.” Inhalation Toxicology 21 (12): 1053–1061. https://doi.org/10.1080/08958370802712713
   PubMed Web of Science ®Google Scholar
• Mercer, R. R., A. F. Hubbs, J. F. Scabilloni, L. Wang, L. A. Battelli, S. Friend, V. Castranova, and D. W. Porter. 2011. “Pulmonary Fibrotic Response to Aspiration of Multi-Walled Carbon Nanotubes.” Particle and Fibre Toxicology 8 (1): 21. https://doi.org/10.1186/1743-8977-8-21
   PubMedGoogle Scholar
• Mercer, R. R., A. F. Hubbs, J. F. Scabilloni, L. Wang, L. A. Battelli, D. Schwegler-Berry, V. Castranova, and D. W. Porter. 2010. “Distribution and Persistence of Pleural Penetrations by Multi-Walled Carbon Nanotubes.” Particle and Fibre Toxicology 7 (1): 28. https://doi.org/10.1186/1743-8977-7-28
   PubMedGoogle Scholar
• Mercer, R. R., J. F. Scabilloni, A. F. Hubbs, L. Wang, L. A. Battelli, W. McKinney, V. Castranova, and D. W. Porter. 2013. “Extrapulmonary Transport of Mwcnt following Inhalation Exposure.” Particle and Fibre Toxicology 10 (1): 38. https://doi.org/10.1186/1743-8977-10-38
   PubMedGoogle Scholar
• Muller, H., J. Gil, Jr., and I. A. Drinnenberg. 2019. “The Impact of Centromeres on Spatial Genome Architecture.” Trends in Genetics: TIG 35 (8): 565–578. https://doi.org/10.1016/j.tig.2019.05.003
   PubMed Web of Science ®Google Scholar
• NTP (National Toxicology Program). 2006. “NTP Historical Controls Report by Route and Vehicle Mice-2006.” https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2006/m_hcrpt_rte2006_508.pdf.
   Google Scholar
• NTP (National Toxicology Program). 2007a. “NTP Historical Controls Report by Route and Vehicle Mice.” March 2007. https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2007/m_hcrpt_rte20070300_508.pdf.
   Google Scholar
• NTP (National Toxicology Program). 2007b. “NTP Historical Controls Report by Route and Vehicle Mice.” October 2007. https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2007/m_hcrpt_rte20071000_508.pdf.
   Google Scholar
• NTP (National Toxicology Program). 2019a. “NTP Historical Controls Report by Route and Vehicle Mice.” April 2019. https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2019/m_hcrpt_rte20190400.pdf
   Google Scholar
• NTP (National Toxicology Program). 2019b. “NTP Technical Report on the Toxicity Studies of 1020 Long Multiwalled Carbon Nanotubes Administered by Inhalation to Sprague Dawley (hsd:Sprague dawley® sd®) Rats and b6c3f1/n Mice.” Toxicity report 94. https://www.ncbi.nlm.nih.gov/books/NBK551602/
   Google Scholar
• NIOSH (National Institute for Occupational Safety and Health). 2013. Occupational Exposure to Carbon Nanotubes and Nanofibers. Cincinnati, OH: Department of Health and Human Services, Centers for Disease and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 2014-106.
   Google Scholar
• Numano, T., H. Higuchi, D. B. Alexander, W. T. Alexander, M. Abdelgied, A. M. El-Gazzar, D. Saleh, et al. 2019. “Mwcnt-7 Administered to the Lung by Intratracheal Instillation Induces Development of Pleural Mesothelioma in f344 Rats.” Cancer Science 110 (8): 2485–2492. https://doi.org/10.1111/cas.14121
   PubMed Web of Science ®Google Scholar
• Oberdörster, Günter, Eva Oberdörster, and Jan Oberdörster. 2005. “Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles.” Environmental Health Perspectives 113 (7): 823–839. https://doi.org/10.1289/ehp.7339
   PubMed Web of Science ®Google Scholar
• Pandiri, Arun R., Robert C. Sills, Vincent Ziglioli, Thai-Vu T. Ton, Hue-Hua L. Hong, Stephanie A. Lahousse, Kevin E. Gerrish, et al. 2012. “Differential Transcriptomic Analysis of Spontaneous Lung Tumors in b6c3f1 Mice: Comparison to Human Non-Small Cell Lung Cancer.” Toxicologic Pathology 40 (8): 1141–1159. https://doi.org/10.1177/0192623312447543
   PubMed Web of Science ®Google Scholar
• Pihan, G. A., J. Wallace, Y. Zhou, and S. J. Doxsey. 2003. “Centrosome Abnormalities and Chromosome Instability Occur Together in Pre-Invasive Carcinomas.” Cancer Research 63 (6): 1398–1404.
   PubMed Web of Science ®Google Scholar
• Pitot, H. C. 1993a. “The Molecular Biology of Carcinogenesis.” Cancer 72 (S3): 962–970. https://doi.org/10.1002/1097-0142(19930801)72:3+<962::AID-CNCR2820721303>3.0.CO;2-H
   PubMedGoogle Scholar
• Pitot, H. C. 1993b. “Multistage Carcinogenesis–Genetic and Epigenetic Mechanisms in Relation to Cancer Prevention.” Cancer Detection and Prevention 17 (6): 567–573.
   PubMedGoogle Scholar
• Pitot, H. C., H. A. Campbell, R. Maronpot, N. Bawa, T. A. Rizvi, Y. H. Xu, L. Sargent, Y. Dragan, and M. Pyron. 1989. “Critical Parameters in the Quantitation of the Stages of Initiation, Promotion, and Progression in One Model of Hepatocarcinogenesis in the Rat.” Toxicologic Pathology 17 (4 Pt 1): 594–612. discussion 611-592. https://doi.org/10.1177/0192623389017004105
   PubMedGoogle Scholar
• Pollard, J. W. 2004. “Tumour-Educated Macrophages Promote Tumour Progression and Metastasis.” Nature Reviews. Cancer 4 (1): 71–78. https://doi.org/10.1038/nrc1256
   PubMed Web of Science ®Google Scholar
• Porter, D. W., A. F. Hubbs, R. R. Mercer, N. Wu, M. G. Wolfarth, K. Sriram, S. Leonard, L. Battelli, D. Schwegler-Berry, and S. Friend. 2010. “Mouse Pulmonary Dose- and Time Course-Responses Induced by Exposure to Multi-Walled Carbon Nanotubes.” Toxicology 269 (2–3): 136–147. https://doi.org/10.1016/j.tox.2009.10.017
   PubMed Web of Science ®Google Scholar
• Porter, D. W., N. Wu, A. F. Hubbs, R. R. Mercer, K. Funk, F. Meng, J. Li, et al. 2013. “Differential Mouse Pulmonary Dose and Time Course Responses to Titanium Dioxide Nanospheres and Nanobelts.” Toxicological Sciences: An Official Journal of the Society of Toxicology 131 (1): 179–193. https://doi.org/10.1093/toxsci/kfs261
   PubMed Web of Science ®Google Scholar
• Riediker, M., D. Zink, W. Kreyling, G. Oberdörster, A. Elder, U. Graham, I. Lynch, et al. 2019. “Particle Toxicology and Health - Where Are We?” Particle and Fibre Toxicology 16 (1): 19. https://doi.org/10.1186/s12989-019-0302-8
   PubMedGoogle Scholar
• Rittinghausen, S., A. Hackbarth, O. Creutzenberg, H. Ernst, U. Heinrich, A. Leonhardt, and D. Schaudien. 2014. “The Carcinogenic Effect of Various Multi-Walled Carbon Nanotubes (MWCNTS) After Intraperitoneal Injection in Rats.” Particle and Fibre Toxicology 11 (1): 59. https://doi.org/10.1186/s12989-014-0059-z
   PubMedGoogle Scholar
• Rondini, E. A., D. M. Walters, and A. K. Bauer. 2010. “Vanadium Pentoxide Induces Pulmonary Inflammation and Tumor Promotion in a Strain-Dependent Manner.” Particle and Fibre Toxicology 7 (1): 9. https://doi.org/10.1186/1743-8977-7-9
   PubMedGoogle Scholar
• Ryman-Rasmussen, J. P., M. F. Cesta, A. R. Brody, J. K. Shipley-Phillips, J. I. Everitt, E. W. Tewksbury, O. R. Moss, et al. 2009. “Inhaled Carbon Nanotubes Reach the Subpleural Tissue in Mice.” Nature Nanotechnology 4 (11): 747–751. https://doi.org/10.1038/nnano.2009.305
   PubMed Web of Science ®Google Scholar
• Sakamoto, Y., D. Nakae, N. Fukumori, K. Tayama, A. Maekawa, K. Imai, A. Hirose, T. Nishimura, N. Ohashi, and A. Ogata. 2009. “Induction of Mesothelioma by a Single Intrascrotal Administration of Multi-Wall Carbon Nanotube in Intact Male Fischer 344 Rats.” The Journal of Toxicological Sciences 34 (1): 65–76. https://doi.org/10.2131/jts.34.65
   PubMed Web of Science ®Google Scholar
• Saleh, D. M., W. T. Alexander, T. Numano, O. H. M. Ahmed, S. Gunasekaran, D. B. Alexander, M. Abdelgied, et al. 2020. “Comparative Carcinogenicity Study of a Thick, Straight-Type and a Thin, Tangled-Type Multi-Walled Carbon Nanotube Administered by Intra-Tracheal Instillation in the Rat.” Particle and Fibre Toxicology 17 (1): 48. https://doi.org/10.1186/s12989-020-00382-y
   PubMed Web of Science ®Google Scholar
• Sargent, L. M., D. W. Porter, L. M. Staska, A. F. Hubbs, D. T. Lowry, L. Battelli, K. J. Siegrist, et al. 2014. “Promotion of Lung Adenocarcinoma following Inhalation Exposure to Multi-Walled Carbon Nanotubes.” Particle and Fibre Toxicology 11 (1): 3. https://doi.org/10.1186/1743-8977-11-3
   PubMed Web of Science ®Google Scholar
• Service, R. F. 2004. “Nanotoxicology: Nanotechnology Grows Up.” Science (New York, N.Y.) 304 (5678): 1732–1734. https://doi.org/10.1126/science.304.5678.1732
   PubMed Web of Science ®Google Scholar
• Shvedova, A. A., E. R. Kisin, R. Mercer, A. R. Murray, V. J. Johnson, A. I. Potapovich, Y. Y. Tyurina, et al. 2005. “Unusual Inflammatory and Fibrogenic Pulmonary Responses to Single-Walled Carbon Nanotubes in Mice.” American Journal of Physiology. Lung Cellular and Molecular Physiology 289 (5): L698–708. https://doi.org/10.1152/ajplung.00084.2005
   PubMed Web of Science ®Google Scholar
• Sica, A., T. Schioppa, A. Mantovani, and P. Allavena. 2006. “Tumour-Associated Macrophages Are a Distinct m2 Polarised Population Promoting Tumour Progression: Potential Targets of Anti-Cancer Therapy.” European Journal of Cancer (Oxford, England: 1990) 42 (6): 717–727. https://doi.org/10.1016/j.ejca.2006.01.003
   PubMed Web of Science ®Google Scholar
• Siegrist, K. J., S. H. Reynolds, M. L. Kashon, D. T. Lowry, C. Dong, A. F. Hubbs, S. H. Young, et al. 2014. “Genotoxicity of Multi-Walled Carbon Nanotubes at Occupationally Relevant Doses.” Particle and Fibre Toxicology 11 (1): 6. https://doi.org/10.1186/1743-8977-11-6
   PubMedGoogle Scholar
• Siegrist, Katelyn J., Steven H. Reynolds, Dale W. Porter, Robert R. Mercer, Alison K. Bauer, David Lowry, Lorenzo Cena, et al. 2019. “Mitsui-7, Heat-Treated, and Nitrogen-Doped Multi-Walled Carbon Nanotubes Elicit Genotoxicity in Human Lung Epithelial Cells.” Particle and Fibre Toxicology 16 (1): 36. https://doi.org/10.1186/s12989-019-0318-0
   PubMed Web of Science ®Google Scholar
• Smith, A. L., J. Hung, L. Walker, T. E. Rogers, F. Vuitch, E. Lee, and A. F. Gazdar. 1996. “Extensive Areas of Aneuploidy Are Present in the Respiratory Epithelium of Lung Cancer Patients.” British Journal of Cancer 73 (2): 203–209. https://doi.org/10.1038/bjc.1996.36
   PubMed Web of Science ®Google Scholar
• Soh, J., S. Toyooka, S. Ichihara, H. Asano, N. Kobayashi, H. Suehisa, H. Otani, et al. 2008. “Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas of the Lung.” Journal of Thoracic Oncology: official Publication of the International Association for the Study of Lung Cancer 3 (4): 340–347. https://doi.org/10.1097/JTO.0b013e318168d20a
   PubMed Web of Science ®Google Scholar
• Stanton, M. F., M. Layard, A. Tegeris, E. Miller, M. May, E. Morgan, and A. Smith. 1981. “Relation of Particle Dimension to Carcinogenicity in Amphibole Asbestoses and Other Fibrous Minerals.” Journal of the National Cancer Institute 67 (5): 965–975.
   PubMed Web of Science ®Google Scholar
• Sumitomo, R., T. Hirai, M. Fujita, H. Murakami, Y. Otake, and C. L. Huang. 2019. “M2 Tumor-Associated Macrophages Promote Tumor Progression in Non-Small-Cell Lung Cancer.” Experimental and Therapeutic Medicine 18 (6): 4490–4498. https://doi.org/10.3892/etm.2019.8068
   PubMed Web of Science ®Google Scholar
• Sumitomo, R., T. Menju, Y. Shimazu, T. Toyazaki, N. Chiba, H. Miyamoto, Y. Hirayama, et al. 2023. “M2-Like Tumor-Associated Macrophages Promote Epithelial-Mesenchymal Transition Through the Transforming Growth Factor Beta/Smad/Zinc Finger e-Box Binding Homeobox Pathway with Increased Metastatic Potential and Tumor Cell Proliferation in Lung Squamous Cell Carcinoma.” Cancer Science 114 (12): 4521–4534. https://doi.org/10.1111/cas.15987
   PubMed Web of Science ®Google Scholar
• Suzui, M., M. Futakuchi, K. Fukamachi, T. Numano, M. Abdelgied, S. Takahashi, M. Ohnishi, et al. 2016. “Multiwalled Carbon Nanotubes Intratracheally Instilled into the Rat Lung Induce Development of Pleural Malignant Mesothelioma and Lung Tumors.” Cancer Science 107 (7): 924–935. https://doi.org/10.1111/cas.12954
   PubMed Web of Science ®Google Scholar
• Takagi, A., A. Hirose, M. Futakuchi, H. Tsuda, and J. Kanno. 2012. “Dose-Dependent Mesothelioma Induction by Intraperitoneal Administration of Multi-Wall Carbon Nanotubes in p53 Heterozygous Mice.” Cancer Science 103 (8): 1440–1444. https://doi.org/10.1111/j.1349-7006.2012.02318.x
   PubMed Web of Science ®Google Scholar
• Takagi, A., A. Hirose, T. Nishimura, N. Fukumori, A. Ogata, N. Ohashi, S. Kitajima, and J. Kanno. 2008. “Induction of Mesothelioma in p53+/− Mouse by Intraperitoneal Application of Multi-Wall Carbon Nanotube.” The Journal of Toxicological Sciences 33 (1): 105–116. https://doi.org/10.2131/jts.33.105
   PubMed Web of Science ®Google Scholar
• Wakamatsu, N., T. R. Devereux, H. H. Hong, and R. C. Sills. 2007. “Overview of the Molecular Carcinogenesis of Mouse Lung Tumor Models of Human Lung Cancer.” Toxicologic Pathology 35 (1): 75–80. https://doi.org/10.1080/01926230601059993
   PubMed Web of Science ®Google Scholar
• Weaver, B. A., A. D. Silk, C. Montagna, P. Verdier-Pinard, and D. W. Cleveland. 2007. “Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor.” Cancer Cell 11 (1): 25–36. https://doi.org/10.1016/j.ccr.2006.12.003
   PubMed Web of Science ®Google Scholar
• Wils, Regitze Sølling, Nicklas Raun Jacobsen, Ulla Vogel, Martin Roursgaard, and Peter Møller. 2021. “Inflammatory Response, Reactive Oxygen Species Production and DNA Damage in Mice after Intrapleural Exposure to Carbon Nanotubes.” Toxicological Sciences: An Official Journal of the Society of Toxicology 183 (1): 184–194. https://doi.org/10.1093/toxsci/kfab070
   PubMed Web of Science ®Google Scholar
• Witschi, H., D. Williamson, and S. Lock. 1977. “Enhancement of Urethan Tumorigenesis in Mouse Lung by Butylated Hydroxytoluene.” Journal of the National Cancer Institute 58 (2): 301–305. https://doi.org/10.1093/jnci/58.2.301
   PubMed Web of Science ®Google Scholar
• Zanello, L. P., B. Zhao, H. Hu, and R. C. Haddon. 2006. “Bone Cell Proliferation on Carbon Nanotubes.” Nano Letters 6 (3): 562–567. https://doi.org/10.1021/nl051861e
   PubMed Web of Science ®Google Scholar
• Zhang, Shuai, Dehai Che, Fang Yang, Chunling Chi, Hongxue Meng, Jing Shen, Li Qi, et al. 2017. “Tumor-Associated Macrophages Promote Tumor Metastasis Via the TGF-Beta/SOX9 Axis in Non-Small Cell Lung Cancer.” Oncotarget 8 (59): 99801–99815. https://doi.org/10.18632/oncotarget.21068
   PubMedGoogle Scholar
• Zhang, W., J. H. Mao, W. Zhu, A. K. Jain, K. Liu, J. B. Brown, and G. H. Karpen. 2016. “Centromere and Kinetochore Gene Misexpression Predicts Cancer Patient Survival and Response to Radiotherapy and Chemotherapy.” Nature Communications 7 (1): 12619. https://doi.org/10.1038/ncomms12619
   PubMedGoogle Scholar