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Original

Toxicology of nanoparticles: A historical perspective

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Pages 2-25 | Published online: 10 Jul 2009

References

  • Adams RJ, Bray D. Rapid transport of foreign particles microinjected into crab axons. Nature 1983; 303: 718–720
  • Amdur MO, McCarthy JF, Gill MW. Respiratory response of Guinea pigs to zinc oxide fume. Am Ind Hyg Assoc J 1982; 43: 897–889
  • Avakian MD, Dellinger B, Fiedler H, Gullet B, Koshland C, Marklund S, Oberdörster G, Safe S, Sarofim A, Smith KR, Schwartz D, Suk WA. The origin, fate, and health effects of combustion by-products: A research framework. Environ Health Perspect 2002; 110(11)1155–1162
  • Aymonier C, Schlotterbeck U, Antonietti L, Zacharias P, Thomann R, Tiller JC, Mecking S. Hybrids of silver nanoparticles with amphiphilic hyperbranched macromolecules exhibiting antimicrobial properties. Chem Commun 2002; 24: 3018–3019
  • Baker C, Pradhan A, Pakstis L, Pochan DJ, Shah SI. Synthesis and antibacterial properties of silver nanoparticles. J Nanosci Nanotechnol 2005; 5: 244–249
  • Bansal, RC, Wang, M-J, Donnet, J-B. 1993. Carbon black: Science and technology. 2nd ed. New York: Marcel Dekker. 482 pp.
  • Bawden, FC, Pirie, NW. 1937. The isolation and some properties of liquid crystalline substances from Solanaceous plants infected with three strains of tobacco mosaic virus. Proceedings of the Royal Society of London, Series B, Biological Sciences, Vol. 832, (3 August 1937). pp 274–320.
  • Beaucage G, Rane S, Schaefer DW, Long G, Fischer D. Morphology of polyethylene-carbon black composites. J Polymer Sci: Part B: Polymer Phys 1999; 37: 1105–1119
  • Beijerinck, MJ. 1898. Concerning a contagium vivum fluidum as cause of the spot disease of tobacco leaves. Verhandelingen der Koninkyke akademie Wettenschapppen te Amsterdam 65:3–21. [Phytopathological Classics Number 7, 1942. St Paul, Minnesota: American Phytopathological Society Press].
  • Bell DJ, Dong L, Nelson BJ, Golling M, Zhang L, Grutzmacher D. Fabrication and characterization of three-dimensional InGaAs/GaAs nanosprings. Nano Lett 2006; 6(4)725–729
  • Bernstein DM, Chevalier J, Smith P. Comparison of Calidria chrysotile asbestos to pure tremolite: Inhalation biopersistence and histopathology following short-term exposure. Inhal Toxicol 2003a; 15(14)1387–1419
  • Bernstein DM, Rogers R, Smith P. The biopersistence of Canadian chrysotile asbestos following inhalation. Inhal Toxicol 2003b; 15(13)1247–1274
  • Berry JP, Arnoux B, Stanislas G, Galle P, Chretien J. A microanalytic study of particles transport across the alveoli: Role of blood platelets. Biomed 1977; 27: 354–357
  • Blackburn JL, Engtrakul C, McDonald TJ, Dillon AC, Heben MJ. Effects of surfactant and boron doping on the BWF feature in the Raman spectrum of single-wall carbon nanotube aqueous dispersions. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys 2006; 110: 25551–25558
  • Biswas P, Wu C-Y. Nanoparticles and the environment. J Air Waste Manage Assoc 2005; 55: 708–746
  • Bodian, D, Howe, HA. 1941. Experimental studies on intraneural spread of poliomyelitis virus. In: JI Bordley. Bulletin of the Johns Hopkins Hospital. Baltimore: The Johns Hopkins Press. pp 248–267.
  • Borm PA, Kreyling W. Toxicological hazards of inhaled nanoparticles – potential implication for drug delivery. J Nanosci Nanotechnol 2004; 4(5)521–531
  • Brant J, Lecoanet H, Hotze M, Wiesner M. Comparison of electrokinetic properties of colloidal fullerenes (n-C60) formed using two procedures. Environ Sci Technol 2005; 39: 6343–6351
  • Brody AR, Warheit DB, Chang LY, Roe MW, George G, Hill LH. Initial deposition pattern of inhaled minerals and consequent pathogenic events at the alveolar level. Ann NY Acad Sci 1984; 428: 108–120
  • Brody AR, Hill LH, Warheit DB. Induction of early alveolar injury by inhaled asbestos and silica. Federation Proc 1985; 44: 2596–2601
  • Brown RC, Bellmann B, Muhle H, Davis JM, Maxim LD. Survey of the biological effects of refractory ceramic fibres: Overload and its possible consequences. Ann Occup Hyg 2005; 49(4)295–307
  • Brown JS, Zeman KL, Bennett WD. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 2002; 166: 1240–1247
  • Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 2001; 175: 191–199
  • Cedervall T, Lynch I, Lindman S, Tulin E, Nilsson H, Dawson KA, Linse S. Novel methods to quantify binding rates and affinities of proteins to nanoparticles: Effects of nanoparticle composition and size. PNAS 2007; 104: 2050–2055
  • Chen B-X, Wilson SR, Das M, Coughlin DJ, Erlanger BF. Antigenicity of fullerenes. Antibodies specific for fullerenes and their characteristics. PNAS USA 1998; 95: 10809–10813
  • Chen M, von Mikecz A. Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Experim Cell Res 2005; 305(1)51–62
  • Churg A, Green F. Pathology of occupational lung disease2nd ed. Williams and Wilkins, Baltimore 1999
  • Czerniawska A. Experimental investigations on the penetration of 198Au from nasal mucous membrane into cerebrospinal fluid. Acta Otolaryng 1970; 70: 58–61
  • Colvin VL. The potential environmental impact of engineered nanomaterials. Nature Biotechnol 2003; 21: 1166–1170
  • Dalal NS, Jafari B, Petersen M, Green FY, Vallyathan V. Presence of stable coal radicals in autopsied coal-miners lungs and its possible correlation to coal-workers pneumoconiosis. Arch Environ Health 1991; 46: 366–372
  • Dalal NS, Newman J, Pack D, Leonard S, Vallyathan V. Hydroxyl radical generation by coal mine dust: possible implication to coal workers’ pneumoconiosis (CWP). Free Radic Biol Med 1995; 18(1)11–20
  • Da Ros, T, Prato, M. 1999. Medicinal chemistry with fullerenes and fullerene derivatives. Chemical Communications. 663–669.
  • Davis JM, Addison J, Bolton RE, Donaldson K, Jones AD, Smith T. The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol 1986; 67(3)415–430
  • Davis JM, Brown DM, Cullen RT, Donaldson K, Jones A, Miller A, McIntosh BG, Searl A. A comparison of methods for determining and predicting the pathogenicity of mineral fibres. Inhal Toxicol 1996; 8: 747–770
  • DeLorenzo A. The olfactory neuron and the blood-brain barrier. Taste and smell in vertebrates, G Wolstenholme, J Knight. J. & A. Churchill, London 1970; 151–176
  • Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Letters 2004; 4(1)11–18
  • Donaldson K, Golyasnya N. Cytogenetic and pathogenic effects of long and short amosite asbestos. J Pathol 1995; 177: 303–307
  • Donaldson K, Beswick PH, Gilmour PS. Free radical activity associated with the surface of particles: A unifying factor in determining biological activity?. Toxicol Lett 1996; 88(1–3)293–298
  • Donaldson K, Li XY, MacNee W. Ultrafine (nanometre) particle mediated lung injury. J Aerosol Sci 1998; 29(5/6)553–560
  • Donaldson K, Brown D, Clouter A, Duffin R, MacNee W, Renwick L, Tran L, Stone V. The pulmonary toxicology of ultrafine particles. J Aerosol Med – Deposition Clearance & Effects in the Lung 2002; 15(2)213–220
  • Donaldson K, Stone V, Tran CL, Kreyling W, Borm PJ. Nanotoxicology 188. Occup Environ Med 2004; 61(9)727–728
  • Donaldson, K, Tran, L, Jimenez, LA, Duffin, R, Newby, DE, Miles, N, MacNee, W, Stone, V. 2005. Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Particle Fibre Toxicol 2(1):10 (on line; doi: 10.1186/1743-8977-2-10).
  • Donaldson K, Aitken R, Tran L, Stone V, Duffin R, Forest G, Alexander A. Carbon nanotubes: A review of their properties in relation to pulmonarytoxicology and workplace safety. Toxicological Sci 2006; 92(1)5–22
  • Douglas T, Young M. Viruses: Making friends with old foes. Science 2006; 312: 873–875
  • Drinker P, Thomson RM, Finn JL. Metal fume fever: II. Resistance acquired by inhalation of zinc oxide on two successive days. J Ind Hyg Tox 1927a; 9(3)98–105
  • Drinker P, Thomson RM, Finn JL. Metal fume fever: IV. Threshold doses of zinc oxide preventive measures and the chronic effects of repeated exposures. J Ind Hyg Tox 1927b; 9: 331–345
  • Ehrenberg M, McGrath JL. Binding between particles and proteins in extracts: Implications for microrheology and toxicity. Acta Biomaterialia 2005; 1: 305–315
  • Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 2006; 114: 1172–1178
  • Elimelech M. Effect of particle size on the kinetics of particle deposition under attractive double layer interactions. J Colloid Interface Sci 1994; 164: 190–199
  • EPA. 2004. Air quality criteria for particulate matter (Vol. III) 600/P-95-001cF. Washington, DC 20460: Office of Research and Development.
  • Erlanger BF, Chen B-X, Zhu M, Brus L. Binding of an anti-fullerene IgG monoclonal antibody to single wall carbon nanotubes. Nano Lett 2005; 1(9)465–467
  • European Commission. 2005. Research needs on nanoparticles. In: R Tomellini, de Villepin, C. Proceedings of workshop held in Brussels on 25–26 January 2005. ( www.cordis.lu/nanotechnology). 96 pp.
  • Faux SP, Michelangeli F, Levy LS. Calcium chelator Quin-2 prevents crocidolite-induced DNA strand breakage in human white blood cells. Mutat Res 1994; 311(2)209–215
  • Ferin J, Oberdörster G, Penney DP, Soderholm SC, Gelein R, Piper HC. Increased pulmonary toxicity of ultrafine particles? I. Particle clearance, translocation, morphology. J Aerosol Sci 1990; 21: 381–384
  • Fiorito S, Serafino A, Andreola F, Bernier P. Effects of fullerenes and single-wall carbon nanotubes on murine and human macrophages. Carbon 2006; 44(6)1100–1105
  • Fortner JD, Lyon DY, Sayes CM, Boyd AM, Falkner JC, Hotze EM, Alemany LB, Tao YJ, Guo W, Ausman KD, Colvin VL, Hughes JB. C60 in water: nanocrystal formation and microbial response. Environ Sci Technol 2005; 39: 4307–4316
  • Fujishima A, Honda K. Electrochemical photolysis of water at a semiconductor electrode. Nature 1972; 238: 37–38
  • Furno F, Morley KS, Wong B, Sharp BL, Arnold PL, Howdle SM, Bayston R, Brown PD, Winship PD, Reid HJ. Silver nanoparticles and polymeric medical devices: A new approach to prevention of infection?. J Antimicrob Chemother 2004; 54: 1019–1024
  • Gabor S, Anca Z. Effect of asbestos on lipid peroxidation in the red cells. Br J Ind Med 1975; 32(1)39–41
  • Gardner, LU. 1938.Experimental Pneumoconiosis . In: AJ Lanza. Silicosis and asbestosis. New York: Oxford University Press.
  • Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005; 113: 1555–1560
  • Gharbi N, Pressac M, Hadchouel M, Szwarc H, Wilson SR, Moussa F. 60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett 2005; 5(12)2578–2585
  • Gilmour PS, Brown DM, Lindsay TG, Beswick PH, MacNee W, Donaldson K. Adverse health-effects of PM(10) Particles – involvement of iron in generation of hydroxyl radical. Occupat Environ Med 1996; 53: 817–822
  • Gilmour PS, Brown DM, Beswick PH, MacNee W, Rahman I, Donaldson K. Free radical activity of industrial fibers: Role of iron in oxidative stress and activation of transcription factors. Environ Health Perspect 1997; 105: 1313–1317
  • Gopinath PG, Gopinath G, Kumar A. Target site of intranasally sprayed substances and their transport across the nasal mucosa: A new insight into the intranasal route of drug delivery. Curr Therapeutic Res 1978; 23(5)596–607
  • Gordon T, Chen LC, Fine JM, Schlesinger RB, Su WY, Kimmel TA, Amdur MO. Pulmonary effects of inhaled zinc oxide in human subjects, guinea pigs, rats, and rabbits. Am Ind Hyg Assoc J 1992; 53(8)503–509
  • Gulyaev AE, Gelperina SE, Skidan IN, Antropov AS, Kivman GY, Kreuter J. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm Res 1999; 16: 1564–1569
  • Halford B. Fullerene for the face. Chemical & Engineering News 2006; 84: 47
  • Heckel K, Kiefmann R, Dorger M, Stoeckelhuber M, Goetz AE. Colloidal gold particles as a new in vivo marker of early acute lung injury. Am J Physiol Lung Cell Mol Physiol 2004; 287: L867–878
  • Hoet PHM, Bruske-Hohlfeld I, Salata OV. Nanoparticles – known and unknown health risks. J Nanobiotechnol 2004; 2(12)12–27
  • Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, Yasuhara M, Suzuki K., Yamamoto K. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 2004; 4(11)2163–2169
  • Howe HA, Bodian D. Portals of entry of poliomyelitis virus in the chimpanzee. Proc Soc Exp Biol Med 1940; 43: 718–721
  • Huang L, Li DQ, Lin YJ, Wei M, Evans DG, Duan X. Controllable preparation of Nano-MgO and investigation of its bactericidal properties. J Inorg Biochem 2005; 99: 986–993
  • IARC. 2006. Baan, R, Straif, K, Grosse, Y, . on behalf of the WHO International Agency for Research on Cancer Monograph Working Group, et al. Carcingenicity of carbon black; titanium dioxide, and talc. The Lancet. 7:295–296.
  • International Commission on Radiological Protection (ICRP). 1994. Annals of the ICRP: Human respiratory tract model for radiological protection. H Smith. ICRP Publication 66. Vol. 24, Nos. 1–3, OxfordUK: Pergamon.
  • International Commission on Radiological Protection (ICRP). 1966. Deposition and retention models for internal dosimetry of the human respiratory tract. Task Group on Lung Dynamics. Health Phys. 12:173–208.
  • International Life Sciences Institute (ILSI). 2005. Oberdörster et al. and a report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group. Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Particle Fibre Toxicol 2005(2):8.
  • Ito A, Kuga Y, Honda H, Kikkawa H, Horiuchi A, Watanabe Y, Kobayashi T. Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia. Cancer Lett 2004; 212: 167–175
  • Jackson BP, Ranville JF, Bertsch PM, Sowder AG. Characterization of colloidal and humic-bound Ni and U in the “dissolved” fraction of contaminated sediment extracts. Environ Sci Technol 2005; 39: 2478–2485
  • Janssen YM, Barchowsky A, Treadwell M, Driscoll KE, Mossman BT. Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells. Proc Natl Acad Sci USA 1995; 92(18)8458–8462
  • Jia, G, Wang, H, Yan, L, Wang, X, Pei, R, Yan, T, Zhao, YL, Guo, X. 2005. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol, 39: 1378–1383.
  • Johnson NF. Phagosomal pH and glass fiber dissolution in cultured nasal epithelial cells and alveolar macrophages: a preliminary study. Environ. Health Perspectives 1994; 102(suppl. 5)97–102
  • Jötten KW, Klosterkötter W. Die Bedeutung der Löslichkeit der Kieselsäure in der Lunge von Kaninchen. Arch Hyg 1952; 136: 451–467
  • Kagan, VE, Tyurina, YY, Tyurin, VA, Konduru, NV, Potapovich, AI, Osipov, AN, Kisin, ER, Schwegler-Berry, D, Mercer, R, Castranova, V, Shvedova, AA. 2006. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron. Toxicol Lett. 165(1):88–100.
  • Kamat JP, Devasagayam TPA, Priyadarsini KI, Mohan H, Mittal JP. Oxidative damage induced by the fullerene C-60 on photosensitization in rat liver microsomes. Chemico-Biological Interactions 1998; 114: 145–159
  • Kanti ST, Khilar KC. Review on subsurface colloids and colloid-associated contaminant transport in saturated porous media. Adv Colloid Interface Sci 2006; 119: 71–96
  • Kato T, Yashiro T, Murata Y, Herbert DC, Oshikawwa K, Bando M, Ohno S, Sugiyama Y. Evidence that exogenous substances can be phagocytized by alveolar epithelial cells and transported into blood capillaries. Cell Tiss Res 2003; 311: 47–51
  • Katz LC, Burkhalter A, Dreyer WJ. Fluorescent latex microspheres as a retrograde neuronal marker for in vivo and in vitro studies of visual cortex. Nature 1984; 310: 498–500
  • Kausche GA, Pfankuch E, Ruska H. Die Sichtbarmachung von pflanzlichem Virus im Übermikroskop. Naturwissenschaften 1939; 27: 292–299
  • Kennedy TP, Dodson R, Rao NV, Hopkins C, Baser M, Tolley E, Hoidal J. Dusts causing pneumoconiosis generate OH and produce hemolysis by acting as Fenton catalysts. Biochemistry and Biophysics 1989; 269: 359–364
  • Kirchner C, Liedl T, Kudera S, Pellegrino T, Javier AM, Gaub HE, Stolzle S, Fertig N, Parak WJ. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005; 5(2)331–338
  • Konig MF, Lucocq JM, Weibel ER. Demonstration of pulmonary vascular perfusion by electron and light microscropy. J Appl Physiol 1993; 75(4)1877–1883
  • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Delivery Rev 2001; 47: 65–81
  • Kreyling W, Semmler M, Erbe, Mayer P, Takenaka S, Schulz H, Oberdörster G, Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health 2003; 65A(20)1513–1530
  • Kreyling WG, Semmler M, Moller W. Dosimetry and toxicology of ultrafine particles. J Aerosol Med 2004; 17(2)140–152
  • Kroto HW, Heath JR, Obrien SC, Curl RF, Smalley RE. C-60-Buckminsterfullerene. Nature 1985; 318: 162–163
  • Lam CW, James JT, McCluskey R, Hunter RL. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicological Sci 2004; 77: 126–134
  • Lam CW, James J, McCluskey R, Sivaram A, Hunter R. A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 2006; 36(3)189–217
  • Lead JR, Muirhead D, Gibson CT. Characterization of freshwater natural aquatic colloids by atomic force microscopy (AFM). Environ Sci Technol 2005; 39: 6930–6936
  • Lee S-H. Inactivation of bacterial endospores by photocatalytic nanocomposites. Colloid Surface 2005; 40: 93–98
  • Li N, Sioutas C, Cho A, Schmiz D, Misra C, Sempf J, Wang M, Oberley T, Froines JR, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental Health Perspectives 2003; 111(4)455–460
  • Lisunova MO, Lebovka NI, Melezhyk OV, Boiko YP. Stability of the aqueous suspensions of nanotubes in the presence of nonionic surfactant. J Colloid Interface Sci 2006; 299: 740–746
  • Lovern SB, Klaper RD. Daphia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles. Environ Toxicol Chem 2006; 25: 1132–1137
  • Lundborg M, Eklund A, Lind B, Camner P. Dissolution of metals by human and rabbit alveolar macrophages. Brit J Ind Med 1985; 42: 642–645
  • Malsch, I, Oud, M. 2004. Outcome of the Open Consultation on the European Strategy for Nanotechnology. December, 2004; www.nanoforum.org.
  • Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V. Exposure to carbon nanotube material: Aerosol release during the handling of unrefined single walled carbon nanotube material. J Toxicol Environ Health 2004; A67: 87–107
  • McCarthy JF, Yurek GJ, Elliott JF, Amdur MO. Generation and characterization of submicron aerosols of zinc oxide. Am Ind Hyg Assoc J 1982; 43: 880–886
  • McCarthy JF, Zachara JM. Subsurface transport of contaminants: mobile colloids in the subsurface environment may alter the transport of contaminants. Environ Sci Technol 1989; 23: 496–502
  • McConnell EE, Axten C, Hesterberg TW, Chevalier J, Miller WC, Everitt J, Oberdörster G, Chase GR, Thevenaz P, Kotin P. Studies on the inhalation toxicology of two Fiberglasses and Amosite Asbestos in the Syrian Golden Hamster. Part II. Results of chronic exposure 1. Inhal Toxicol 1999; 11(9)785–835
  • Mehta D, Bhattacharya J, Matthay MA, Malik AB. Integrated control of lung fluid balance. Am J Physiol Lung Cell Mol Physiol 2004; 287: L1081–1090
  • Meyer M, Schreck R, Baeuerle PA. H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 1993; 12(5)2005–2015
  • Mills A, Hunte SLJ. An overview of semiconductor photocatalysis. J Photochem Photobiol A: Chem 1997; 108: 1–35
  • Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, MacNee W, Millar AM, Donaldson K, Newby DE. Do inhaled carbon nanoparticles translocate directly into the circulation in humans?. Am J Respir Crit Care Med 2006; 173: 426–431
  • Mossman B, Landesman J. Importance of oxygen free radicals in asbestos-induced injury to airway epithelial cells. CHEST 1983; 83: 50S–51
  • Mossman B, Marsh J, Shatos M. Alteration of superoxide dismutase activity in tracheal epithelialcells by asbestos and inhibition of cytotoxicity by antioxidants. Lab Invest 1986; 54: 204–212
  • Mossman BT, Marsh JP, Sesko A, Hill S, Shatos MA, Doherty J, Petruska J, Adler KB, Hemenway D, Mickey R, Vacek P, Kagan E. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am Rev Respiratory Dis 1990; 141: 1266–1271
  • Müller RH, Keck CM. Drug delivery to the brain – realization by novel drug carriers. J Nanosci Nanotechnol 2004; 4: 471–483
  • Muller J, Huaux F, Moreau N, Misson P, Heilier J-F, Delos M, Arras M, Fonseca A, Nagy JB, Lison D. Respiratory toxicity of multi-all carbon nanotubes. Toxicol Appl Pharmacol 2005; 207: 221–231
  • National Nanotechnology Initiative (NNI). 2006. NNI: Environmental, Health and Safety Research Needs for Engineered Nanoscale Materials. NNI White paper issued by the Office of the President of the United States, September, 2006.
  • Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nano level. Science 2006; 311(5761)622–627
  • Nemmar A, Hoet PHM, Vanquickenborne B, et al. Passage of inhaled particles into the blood circulation in humans. Circulation 2002; 105: 411–414
  • Nemmar A, Hoylaerts MF, Hoet PHM, Nemery B. Possible mechanism of the cardiovascular effects of inhaled particles: Systemic translocation and prothrombotic effects. Toxicol Lett 2004; 149: 243–253
  • Oberdörster E. Manufactured nanomaterials (Fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 2004; 112: 1058–1062
  • Oberdörster G, Hochrainer D, Ma RH. Zinc oxide aerosols: Generation, lung clearance and effects of lung clearance. Gesellschaft für Aerosolforschung 1979; 7: 132–137
  • Oberdörster G, Ferin J, Finkelstein J, Wade P, Corson N. Increased pulmonary toxicity of ultrafine particles? II. Lung lavage studies. J Aerosol Sci 1990; 21: 384–387
  • Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. Role of the alveolar macrophage in lung injury: Studies with ultrafine particles. Environ Health Perspect 1992; 97: 193–197
  • Oberdörster, G, Ferin, J. 1992. Metal compounds used in new technologies: Metal oxides of ultrafine particles have increased pulmonary toxicity. In:. E Merian, Haerdi, W. Metal compounds in environment & life. Vol. 4. Science & Technology Letters. NorthwoodUK: Science Reviews. pp 443–450.
  • Oberdörster G, Gelein R, Ferin J, Weiss B. Association of particulate air pollution and acute mortality: Involvement of ultrafine particles?. Inhalation Toxicol 1995; 7: 111–124
  • Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicol 2004; 16(6/7)437–445
  • Oberdörster G, Oberdörster E, Oberdörster J. Invited review: Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005; 113: 823–839
  • Oberdörster E, Zhu S, Blickley TM, McClellan-Green P, Haasch ML. Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms. Carbon 2006; 44(6)1112–1120
  • Panté N, Kann M. Nuclear pore complex is able to transport macromolecules with diameters of ∼39 nm. Molec Biol Cell 2002; 13: 425–434
  • Peters A, von Klot S, Heier M, Trentinaglia I, Hörmann A, Wichmann HE, Löwel H. Exposure to traffic and the onset of myocardial infarction. N Eng J Med 2004; 351: 1721–1730
  • Quinlan TR, Marsh JP, Janssen YW, Borm PA, Mossman BT. Oxygen radicals and asbestos-mediated disease. Environ Health Perspect 1994; 102: 107–110
  • Roco, MC. 2003a. The future of the National Nanotechnology Initiative. ( http://www.nano.gov/html/res/slides.pdf).
  • Roco MC. Converging science and technology at the nanoscale: Opportunities for education and training. Nat Biotechnol 2003b; 21: 1247–1249
  • Rosenkranz, P, Fernandes, TF, Ford, AT, Chaudhry, Q, Stone, V. Uptake and fate of fluorescent nanoparticles in aquatic invertebrates. SETAC abstract, The Hague May 2006.
  • Rouse, JG, Yang, J, Ryman-Rasmusen, JP, Barrow, AR, Monteior-Riviere, NA. 2007. Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. NanoLetters. 7(1):155–160
  • Royal Society and Royal Academy of Engineers. 2004. Nanoscience and nanotechnologies: opportunities and uncertainties. 2004. London, The Royal Society.
  • Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A. Air pollution and Markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 2006; 173: 432–441
  • Ruska H, von Borries B, Ruska E. Die Bedeutung der Übermikroskopie für die Virusforschung. Arch Ges Virusforsch 1940; 1: 155–169
  • Ryman-Rasmussen, JP, Riviere, JE, Monteiro-Riviere, NA. 2006. Penetration of intact skin by quantum dots with diverse physiochemical properties. Tox Sci. 91:159–165.
  • Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). 2005. http://files.nanobio-raise.org/Downloads/scenihr.pdf, , accessed 22/01/2007.
  • Sato Y, Yokoyama A, Shibata K, Akimoto Y, Ogino S, Nodasaka Y, Kohgo T, Tamura K, Akasaka T, Uo M, Motomiya K, Jeyadevan B, Ishiguro M, Hatakeyama R, Watari F, Tohji K. Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. Mol Biosyst 2005; 1(2)176–182
  • Sayes CM, Fortner JD, Guo W, Lyon D, Boyd AM, Ausman KD, Tao YJ, Sithaaraman B, Wilson LJ, Hughes JB, West JL, Colvin VL. The differential cytotoxicity of water-soluble fullerenes. Nano Lett 2004; 4(10)1881–1887
  • Sayes, CM, Liang, F, Hudson, JL, Mendez, J, Guo, W, Beach, JM, Moore, VC, Doyle, CD, West, JL, Billups, WE, Ausman, KD. 2005. Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett. 161(2): 135–142.
  • Schiller CF, Gebhart J, Heydeer J, Rudolf G, Stahlhofen W. Factors influencing total deposition of ultrafine aerosol particles in the human respiratory tract. J Aerosol Sci 1986; 17(3)328–332
  • Schreck R, Albermann K, Baeuerle PA. Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 1992; 17(4)221–237
  • Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet 1995; 345(Jan. 21)176–178
  • Selikoff IJ, Lee DHK. Asbestos and disease. Academic Press, New York 1978
  • Semmler M, Seitz J, Erbe F, Mayer P, Heyder J, Oberdörster G, Kreyling W. Long-term clearance kineic of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhalation Toxicol 2004; 16(6/7)453–459
  • Shen Z, Parker VD, Aust AE. Mediated, thin-layer cell, coulometric determination of redox-active iron on the surface of asbestos fibers. Anal Chem 1995; 67(2)307–311
  • Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini J, Evans DE, Ku BK, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron P. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005; 289(5)L698–708
  • Silva VM, Corson N, Elder A, Oberdörster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP). Toxicological Sci 2005; 85: 983–989
  • Smith AE, Helenius A. How viruses enter animal cells. Science 2004; 304: 237–242
  • Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: A case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci 2004; 275: 177–182
  • Spadaro JA, Berger TJ, Barranco SD, Chapin SE, Becker RO. Antibacterial effects of silver electrodes with weak-direct current. Microb Agents Chemother 1974; 6: 637–642
  • Stanley WM. Isoltion of a crystalline protein assessing the properties of tobacco mosaic virus. Science 1935; 81(2113)644–645
  • Stone V, Shaw J, Brown DM, MacNee W, Faux SP, Donaldson K. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicol In Vitro 1998; 12: 649–659
  • Sunada K, Kikuchi Y, Hashimoto K, Fujishima A. Bactericidal and detoxification effects of TiO2 thin film photocatalysts. Environ Sci Technol 1998; 32: 726–728
  • Swift DL, Montassier N, Hopke PK, Karpen-Hayes K, Cheng Y-S, Su YF, Yeh HC, Strong JC. Inspiratory deposition of ultrafine particles in human nasal replicate cast. J Aerosol Sci 1992; 23: 65–72
  • Swift DL, Montassier N, Hopke PK, Karpen-Hayes K, Cheng Y-S, Su YF, Yeh HC, Strong JC. Inspiratory deposition of ultrafine particles in human nasal replicate cast. J Aerosol Sci 1994; 23: 65–72
  • Teague SV, Raabe OG. Generation of fume aerosols of zinc oxide. Am Ind Hyg Assoc J 1980; 41: 680–683
  • Timbrell V. Deposition and retention of fibres in the human lung. Ann Occup Hyg 1982; 26: 347–369
  • Tinkle SS, Antonini JM, Rich BA, Roberts JR, Salmen R, DePree K, Adkins EJ. Skin as a route of exposure and sensitization in chronic beryllium disease. Environ Health Perspect 2003; 111: 1202–1208
  • Tratnjek PG, Johnson RL. Nanotechnologies for environmental cleanup. Nanotoday 2006; 1: 44–48
  • Tremblay JF. Fullerenes by the ton. Chemical & Engineering News 2003; 81: 13–14
  • Tsoli M, Kuhn H, Brandau W, Esche H, Schmid G. Cellular uptake and toxicity of Au55 clusters. Small 2005; 1(8–9)841–844
  • Vicent MJ, Duncan R. Polymer conjugates: Nanosized medicines for treating cancer. Trends Biotechnol 2006; 24: 39–47
  • Vogelson CT. Advances in drug delivery systems. Mod Drug Discov 2001; 4: 49–50
  • Wagner JC, Skidmore JW, Hill RJ, Griffiths DM. Erionite exposure and mesotheliomas in rats. Br J Cancer 1985; 51(5)727–730
  • Wang IC, Tai LA, Lee DD, Kanakamma PP, Shen CK, Luh TY, Cheng CH, Hwang KC. C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation. J Med Chem 1999; 42(22)4614–4620
  • Wang ZL. Functional oxide nanobelts: Materials, properties and potential applications in nanosystems and biotechnology 4261. Annu Rev Phys Chem 2004; 55: 159–196
  • Warheit DB, Chang LY, Hill LH, Hook GR, Crapo JD, Brody AR. Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fiber deposition. Am Rev Respiratory Dis 1984; 129: 301–310
  • Warheit DB, Driscoll KE, Oberdoerster G, Walker C, Kuschner M, Hesterberg TW. Contemporary issues in fiber toxicology. Fundamental & Applied Toxicology 1995; 25(2)171–183
  • Warheit DB, Laurence BR, Reed KL, Roach DH, Reynolds GAM, Webb TR. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicological Sci 2004; 77: 117–125
  • Warheit DB, Webb TR, Sayes CM, Colvin VL, Reed KL. Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicol Sci 2006; 91(1)227–236
  • Whitby KT, Clark WE, Marple VA, Sverdrup GM, Sem GJ, Willeke K, Liu BYH, Pui DYH. Characterization of California aerosols Size distribution of freeway aerosol. Atmospheric Environ 1975; 9: 463–482
  • Wilson MR, Donaldson K, Stone V. Oxidative interactions between ultrafine particles and metals. Am J Resp Crit Care Med 2001; 163(5)A495 p
  • Xiao L, Takada H, Maeda K, Haramoto M, Miwa N. Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes. Biomed Pharmacother 2005; 59(7)351–358
  • Yang L, Watts DJ. Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles. Toxicol Lett 2005; 158: 122–132
  • Zhang W-S. Nanoscale iron particles for environmental remediation: An overview. J Nanopart Res 2003; 5: 323–332
  • Zhang Q, Kusaka Y, Sato K, Nakakuki K, Kohyama N, Donaldson K. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: Role of free radicals. J Toxicol Environ Health 1998; 53(6)423–438
  • Zhu, S, Oberdörster, E, Haasch, ML. 2006. Toxicity of an engineered nanoparticle (fullerene, C(60)) in two aquatic species, Daphnia and fathead minnow. Mar Environ Res
  • Zhuang J, Qi J, Jin Y. Retention and transport of amphiphilic colloids under unsaturated flow conditions: Effect of particle size and surface property. Environ Sci Technol 2005; 39: 7853–7859

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