609
Views
0
CrossRef citations to date
0
Altmetric
Special Report

Recent insights into extracorporeal photopheresis for graft-versus-host disease

&
Pages 339-348 | Received 29 Sep 2023, Accepted 12 Dec 2023, Published online: 20 Feb 2024

References

  • Edelson R, Berger C, Gasparro F, et al. Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary Results N Engl J Med. 1987;316(6):297–303. doi: 10.1056/NEJM198702053160603
  • Tatsuno K, Yamazaki T, Hanlon D, et al. Extracorporeal photochemotherapy induces bona fide immunogenic cell death. Cell Death Dis. 2019;10(8):578. doi: 10.1038/s41419-019-1819-3
  • Sakellari I, Gavriilaki E, Batsis I, et al. Favorable impact of extracorporeal photopheresis in acute and chronic graft versus host disease: prospective single-center study. J Clin Apheresis. 2018;33(6):654–660. doi: 10.1002/jca.21660
  • Abu-Dalle I, Reljic T, Nishihori T, et al. Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies. Biol Blood Marrow Transplant. 2014;20(11):1677–1686. doi: 10.1016/j.bbmt.2014.05.017
  • Knobler R, Arenberger P, Arun A, et al. European dermatology forum - updated guidelines on the use of extracorporeal photopheresis 2020 - part 1. J Eur Acad Dermatol Venereol. 2020;34(12):2693–2716. doi: 10.1111/jdv.16890
  • Berger C, Hoffmann K, Vasquez JG, et al. Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy. Blood. 2010;116(23):4838–4847. doi: 10.1182/blood-2009-11-256040
  • Salhotra A, Sandhu K, O’Hearn J, et al. A critical review of belumosudil in adult and pediatric patients with chronic graft-versus-host disease. Expert Rev Clin Immunol. 2023;19(3):241–251. doi: 10.1080/1744666X.2023.2152330
  • Biagi E, Di Biaso I, Leoni V, et al. Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+ functional regulatory T-cells in patients with graft-versus-host disease. Transplant. (abbreviation). 2007;84(1):31–39. doi: 10.1097/01.tp.0000267785.52567.9c
  • Gatza E, Rogers CE, Clouthier SG, et al. Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood. 2008;112(4):1515–1521. doi: 10.1182/blood-2007-11-125542
  • Lopes SM, Roncon S, Pinho AC, et al. Should we use extracorporeal photopheresis more often? evidence from graft-versus-host disease patients monitored with treg as a biomarker. Future Sci OA. 2020;6(8):FSO623–FSO. doi: 10.2144/fsoa-2020-0107
  • Gandelman JS, Song DJ, Chen H, et al. A prospective trial of extracorporeal photopheresis for chronic graft-versus-host disease reveals significant disease response and no association with frequency of regulatory T cells. Biol Blood Marrow Transplant. 2018;24(12):2373–2380. doi: 10.1016/j.bbmt.2018.06.035
  • Denney HA, Whittle RJ, Lai J, et al. Regulatory T cells in chronic graft-versus-host disease after extracorporeal photopheresis: correlation with skin and global organ responses, and ability to taper steroids. Transplant. (abbreviation). 2017;101(1):204–211. doi: 10.1097/TP.0000000000001165
  • Wang L, Ni M, Hückelhoven-Krauss A, et al. Modulation of B cells and homing marker on NK cells through extracorporeal photopheresis in patients with steroid-refractory/Resistant graft-vs.-host disease without hampering anti-viral/Anti-leukemic effects. Front Immunol. 2018 Oct 8;9:2207. doi: 10.3389/fimmu.2018.02207
  • Ren HG, Adom D, Paczesny S. The search for drug-targetable diagnostic, prognostic and predictive biomarkers in chronic graft-versus-host disease. Expert Rev Clin Immunol. 2018;14(5):389–404. doi: 10.1080/1744666X.2018.1463159
  • Vajari MK, Moradinasab S, Yousefi AM, et al. Noncoding RNAs in diagnosis and prognosis of graft-versus-host disease (GVHD). J Cell Physiol. 2022;237(9):3480–3495. doi: 10.1002/jcp.30830
  • Montoya RT, López-Godino O, Garcia-Barbera N, et al. Identification of circulating microRNA signatures as potential noninvasive biomarkers for prediction to response to extracorporeal photoapheresis in patients with graft versus host disease. Blood. 2019;134(Supplement_1):4466. doi: 10.1182/blood-2019-121655
  • Amat P, López-Corral L, Goterris R, et al. Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid-resistant acute and chronic graft-vs-host disease after allogenic hematopoietic stem cell transplant. J Clin Apheresis. 2021;36(5):697–710. doi: 10.1002/jca.21918
  • Piccirillo N, Putzulu R, Massini G, et al. Mononuclear cell collection for extracorporeal photopheresis: concentrate characteristics for off-line UV-A irradiation procedure. J Clin Apheresis. 2018 Jun;33(3):217–221. Epub 2017 Aug 22. PMID: 28833438. doi: 10.1002/jca.21574
  • Helmberg W, Sipurzynski S, Groselje-Strehle A, et al. Does offline beat inline treatment: investigation into extracorporeal photopheresis. Transfus Med Hemother. 2020;47(3):198–204. doi: 10.1159/000506750
  • Radwanski K, Burgstaler E, Weitgenant J, et al. Pilot study of a new online extracorporeal photopheresis system in patients with steroid refractory or dependent chronic graft vs host disease. J Clin Apheresis. 2020;35(4):342–350. doi: 10.1002/jca.21804
  • Laulhé M, Lefebvre S, Le Broc-Ryckewaert D, et al. A standardized methodical approach to characterize the influence of key parameters on the in vitro efficacy of extracorporeal photopheresis. PLoS One. 2019 1;14(3):e0212835. doi: 10.1371/journal.pone.0212835
  • Franklin C, Bruderek K, Schilling B, et al. Chemoirradiated neutrophils and T cells differentially affect immune functions of APCs. J Leukocyte Biol. 2019;106(2):481–493. doi: 10.1002/JLB.5A0618-242R
  • Cid J, Carbassé G, Suárez-Lledó M, et al. Efficacy and safety of one-day offline extracorporeal photopheresis schedule processing one total blood volume for treating patients with graft-versus-host disease. Transfus (Abbreviation). 2019;59(8):2636–2642. doi: 10.1111/trf.15384
  • Gambichler T, Chatzipantazi M, Stranzenbach R, et al. Impact of extracorporeal photopheresis on blood and coagulation parameters. Dermatol Ther. 2022;35(5):e15366. doi: 10.1111/dth.15366
  • Hackstein H, Amoros JJ, Bein G, et al. Successful use of miniphotopheresis for the treatment of graft-versus-host disease. Transfus (Abbreviation). 2014;54(8):2022–7. doi: 10.1111/trf.12596
  • Verdú-Amorós J, Woessmann W, Maecker-Kolhoff B, et al. Mini photopheresis for refractory chronic graft-versus-host disease in children and adolescents. Transfus (Abbreviation). 2018;58(11):2495–2500. doi: 10.1111/trf.14880
  • Matic T, Bojanic I, Mazic S, et al. An automated mini buffy coat preparation method for use in mini extracorporeal photopheresis treatment of graft-vs-host-disease in a low body weight pediatric patient. J Clin Apheresis. 2019;34(4):468–473. doi: 10.1002/jca.21700
  • Perseghin P, Galimberti S, Balduzzi A, et al. Extracorporeal photochemotherapy for the treatment of chronic graft-versus-host disease: trend for a possible cell dose-related effect? Ther Apher Dial. 2007;11(2):85–93. doi: 10.1111/j.1744-9987.2007.00421.x
  • Bertani G, Santoleri L, Ferri U, et al. Response of steroid-refractory chronic graft-versus-host disease to extracorporeal photopheresis correlates with the dose of CD3+ lymphocytes harvested during early treatment cycles. Transfus (Abbreviation). 2016;56(2):505–510. doi: 10.1111/trf.13369
  • Worel N, Lehner E, Führer H, et al. Extracorporeal photopheresis as second-line therapy for patients with acute graft-versus-host disease: does the number of cells treated matter? Transfus (Abbreviation). 2018 Apr;58(4):1045–1053. doi: 10.1111/trf.14506
  • Del Fante C, Scudeller L, Viarengo G, et al. Response and survival of patients with chronic graft-versus-host disease treated by extracorporeal photochemotherapy: a retrospective study according to classical and national institutes of health classifications. Transfus (Abbreviation). 2012;52(9):2007–15. doi: 10.1111/j.1537-2995.2011.03542.x
  • Perotti C, Del Fante C, Tinelli C, et al. Extracorporeal photochemotherapy in graft-versus-host disease: a longitudinal study on factors influencing the response and survival in pediatric patients. Transfu (Abbreviation). 2010;50(6):1359–1369. doi: 10.1111/j.1537-2995.2009.02577.x
  • FDA Examining Patient Deaths Associated With Extracorporeal Photopheresis Treatment. ASH clinical news. 2018 Apr.Available from: https://ashpublications.org/ashclinicalnews/news/3778/FDA-Examining-Patient-Deaths-Associated-With-Extracorporeal-Photopheresis
  • Schwede K, Nagel S, Simon JC, et al. How to perform extracorporeal photopheresis via port catheter. Transfu (Abbreviation). 2017;57(11):2567–2570. doi: 10.1111/trf.14265
  • Adamski J. Vascular access considerations for extracorporeal photopheresis. Transfu (Abbreviation). 2018;58(Suppl1):590–597. doi: 10.1111/trf.14500
  • Szymanski J, Shah P, Dynis M, et al. An ex vivo comparison of vascular access devices used in extracorporeal photopheresis. Transfu (Abbreviation). 2018;58(Suppl 1):609–613. doi: 10.1111/trf.14482
  • Söderström A, Nørgaard MS, Thomsen AE, et al. Ultrasound-guidance of peripheral venous catheterization in apheresis minimizes the need for central venous catheters. J Clin Apheresis. 2020;35(3):200–205. doi: 10.1002/jca.21780
  • Pochon C, Reppel L, Halle P, et al. Cryopreservation as a way to maintain extracorporeal photopheresis regimen for GvHD treatment while circumventing patient temporary inability to undergo apheresis. Bone Marrow Transplant. 2017;52(1):167–170. doi: 10.1038/bmt.2016.240
  • Asensi Cantó P, Sanz Caballer J, Fuentes Socorro C, et al. Role of extracorporeal photopheresis in the management of children with graft-vs-host disease. J Clin Apheresis. 2022;37(6):573–583. doi: 10.1002/jca.22012
  • Sebastián E, Andrés Esteban EM, González-Vicent M, et al. Extracorporeal photopheresis in paediatric patients: a retrospective comparison between different ‘off-line’ protocols. Vox Sang. 2022;117(10):1220–1229. doi: 10.1111/vox.13346
  • Malard F, Holler E, Sandmaier BM, et al. Acute graft-versus-host disease. Nat Rev Dis Primers. 2023 8;9(1):27. doi: 10.1038/s41572-023-00438-1
  • Jagasia M, Arora M, Flowers ME, et al. Risk factors for acute GVHD and survival after hematopoietic cell transplantation. Blood. 2012 5;119(1):296–307. doi: 10.1182/blood-2011-06-364265
  • Gooptu M, Koreth J. Translational and clinical advances in acute graft-versus-host disease. Haematologica. 2020;105(11):2550–2560. doi: 10.3324/haematol.2019.240309
  • Patel DA, Crain M, Pusic I, et al. Acute Graft-versus-Host Disease: An Update on New Treatment Options. Drugs. 2023;83(10):893–907. doi: 10.1007/s40265-023-01889-2
  • Zeiser R, von Bubnoff N, Butler Jet al.REACH2 Trial GroupRuxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host DiseaseN Engl J Med. 2020 7; 382191800–1810. doi: 10.1056/NEJMoa1917635
  • Dall’amico R, Messina C. Extracorporeal photochemotherapy for the treatment of graft-versus-host disease. Ther Apher. 2002;6(4):296–304. doi: 10.1046/j.1526-0968.2002.00448.x
  • Berger M, Albiani R, Sini B, et al. Extracorporeal photopheresis for graft-versus-host disease: the role of patient, transplant, and classification criteria and hematologic values on outcome-results from a large single-center study. Transfu (Abbreviation). 2015;55(4):736–47. doi: 10.1111/trf.12900
  • Sestili S, Eder S, Belhocine R, et al. F. Extracorporeal photopheresis as first-line strategy in the treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: a single-center experience. Cytotherapy. 2020;22(8):445–449. doi: 10.1016/j.jcyt.2020.03.003
  • Connelly-Smith L, Alquist CR, Aqui NA, et al. Guidelines on the use of therapeutic Apheresis in clinical practice - evidence-based approach from the writing committee of the american society for Apheresis: the ninth special issue. J Clin Apheresis. 2023;38(2):77–278. doi: 10.1002/jca.22043
  • Castagna L, Morabito L, Mauro E, et al. First-line extracorporeal photochemotherapy for acute GVHD after unmanipulated haploidentical BMT following nonmyeloablative conditioning and post transplantation CY. Bone Marrow Transplant. 2014;49(2):317–318. doi: 10.1038/bmt.2013.174
  • Mehta RS, Bassett R, Rondon G, et al. Randomized phase II trial of extracorporeal phototherapy and steroids vs. steroids alone for newly diagnosed acute GVHD. Bone Marrow Transplant. 2021;56(6):1316–1324. doi: 10.1038/s41409-020-01188-4
  • Nygaard M, Karlsmark T, Andersen NS, et al. Extracorporeal photopheresis is a valuable treatment option in steroid-refractory or steroid-dependent acute graft versus host disease-experience with three different approaches. Bone Marrow Transplant. 2019 Jan;54(1):150–154. doi: 10.1038/s41409-018-0262-x
  • Zeiser R, Blazar BR, Longo DL. Pathophysiology of chronic graft-versus-host disease and therapeutic targets. N Engl J Med. 2017;377(26):2565–2579. doi: 10.1056/NEJMra1703472
  • Saidu NEB, Bonini C, Dickinson A, et al. New approaches for the treatment of chronic graft-versus-host disease: Current status and future directions. Front Immunol. 2020 9;11:578314. doi: 10.3389/fimmu.2020.578314
  • Flowers ME, Apperley JF, van Besien K, et al. A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood. 2008;112(7):2667–74. doi: 10.1182/blood-2008-03-141481
  • Dignan FL, Greenblatt D, Cox M, et al. Efficacy of bimonthly extracorporeal photopheresis in refractory chronic mucocutaneous GVHD. Bone Marrow Transplant. 2012;47(6):824–830. doi: 10.1038/bmt.2011.186
  • UVADEX Chronic GVHD Study GroupGreinix HT, van Besien K, Elmaagacli, AH, et al. Progressive improvement in cutaneous and extracutaneous chronic graft-versus-host disease after a 24-week course of extracorporeal photopheresis–results of a crossover randomized study. Biol Blood Marrow Transplant. 2011;17(12):1775–82. doi: 10.1016/j.bbmt.2011.05.004
  • Jagasia M, Scheid C, Socié G, et al.Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD. Blood Adv. 2019, 23;314: 2218–2229. doi: 10.1182/bloodadvances.2019000145
  • Bergeron A, Chevret S, Peffault de Latour R, et al. Noninfectious lung complications after allogeneic haematopoietic stem cell transplantation. Eur Respir J. 2018 3;51(5):1702617. doi: 10.1183/13993003.02617-2017
  • Grønningsæter IS, Tsykunova G, Lilleeng K, et al. Bronchiolitis obliterans syndrome in adults after allogeneic stem cell transplantation-pathophysiology, diagnostics and treatment. Expert Rev Clin Immunol. 2017;13(6):553–569. doi: 10.1080/1744666X.2017.1279053
  • Au BK, Au MA, Chien JW. Bronchiolitis obliterans syndrome epidemiology after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2011;17(7):1072–8. doi: 10.1016/j.bbmt.2010.11.018
  • Lucid CE, Savani BN, Engelhardt BG, et al. Extracorporeal photopheresis in patients with refractory bronchiolitis obliterans developing after allo-SCT. Bone Marrow Transplant. 2011;46(3):426–429. doi: 10.1038/bmt.2010.152
  • Brownback KR, Simpson SQ, Pitts LR. Effect of extracorporeal photopheresis on lung function decline for severe bronchiolitis obliterans syndrome following allogeneic stem cell transplantation. J Clin Apheresis. 2016;31(4):347–352. doi: 10.1002/jca.21404
  • Del Fante C, Galasso T, Bernasconi P, et al. Extracorporeal photopheresis as a new supportive therapy for bronchiolitis obliterans syndrome after allogeneic stem cell transplantation. Bone Marrow Transplant. 2016;51(5):728–731. doi: 10.1038/bmt.2015.324
  • Hefazi M, Langer KJ, Khera N, et al. Extracorporeal photopheresis improves survival in hematopoietic cell Transplant patients with bronchiolitis obliterans syndrome without significantly impacting measured pulmonary functions. Biol Blood Marrow Transplant. 2018;24(9):1906–1913. doi: 10.1016/j.bbmt.2018.04.012
  • Ali MM, Gedde-Dahl T, Osnes LT, et al. Extracorporeal photopheresis as graft-versus-host disease prophylaxis: a randomized controlled trial. Transplant Cell Ther. 2023;29(6):364.e1–364.e11. doi: 10.1016/j.jtct.2023.02.023
  • Shaughnessy PJ, Bolwell BJ, van Besien K, et al. Extracorporeal photopheresis for the prevention of acute GVHD in patients undergoing standard myeloablative conditioning and allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2010;45(6):1068–1076. doi: 10.1038/bmt.2009.307
  • Michallet M, Sobh M, Garban F, et al. Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study. Leuk Lymphoma. 2018;59(2):372–380. doi: 10.1080/10428194.2017.1334120
  • Kitko CL, Braun T, Couriel DR, et al. Combination therapy for graft-versus-host disease prophylaxis with etanercept and extracorporeal photopheresis: results of a phase II clinical trial. Biol Blood Marrow Transplant. 2016;22(5):862–868. doi: 10.1016/j.bbmt.2015.11.002
  • Abdelhakim H, Accurso A, Merkel D, et al. Peri-transplant extracorporeal photopheresis to mitigate GVHD- a pilot clinical trial. Bone Marrow Transplant. 2021;56(4):980–982. doi: 10.1038/s41409-020-01142-4
  • FM F, XV W, SM L, et al. Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902. Transfu (Abbreviation). 2020;60(8):1867–1872. doi: 10.1111/trf.15798
  • Malard F, Mohty M. Updates in chronic graft-versus-host disease management. Am J Hematol. 2023;22(10):1637–1644. Epub ahead of print. doi: 10.1002/ajh.27040
  • Modemann F, Ayuk F, Wolschke C, et al. Ruxolitinib plus extracorporeal photopheresis (ECP) for steroid refractory acute graft-versus-host disease of lower GI-tract after allogeneic stem cell transplantation leads to increased regulatory T cell level. Bone Marrow Transplant. 2020;55(12):2286–2293. doi: 10.1038/s41409-020-0952-z
  • Zeiser R, Burchert A, Lengerke C, et al. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey. Leukemia. 2015;29(10):2062–2068. doi: 10.1038/leu.2015.212
  • Maas-Bauer K, Kiote-Schmidt C, Bertz H, et al. Ruxolitinib-ECP combination treatment for refractory severe chronic graft-versus-host disease. Bone Marrow Transplant. 2021;56(4):909–916. doi: 10.1038/s41409-020-01122-8
  • Pierelli L, Perseghin P, Marchetti M, et al. Extracorporeal photopheresis for the treatment of acute and chronic graft-versus-host disease in adults and children: best practice recommendations from an Italian society of Hemapheresis and cell manipulation (SIdEM) and Italian group for Bone Marrow transplantation (GITMO) consensus process. Transfu (Abbreviation). 2013;53(10):2340–2352. doi: 10.1111/trf.12059
  • Belizaire R, Kim HT, Poryanda SJ, et al. Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease. Blood Adv. 2019;3(7):969–979. doi: 10.1182/bloodadvances.2018029124
  • Salhotra A, Talley M, Wu X, et al. Clinical and immunologic responses to extracorporeal photopheresis and low-dose IL-2 in patients with steroid refractory chronic graft-versus host disease. Bone Marrow Transplant. 2022;57:1045–47. doi: 10.1038/s41409-022-01671-0
  • Yalniz FF, Murad MH, Lee SJ, et al. Steroid refractory chronic graft-versus-host disease: cost-effectiveness analysis. Biol Blood Marrow Transplant. 2018;24(9):1920–1927. doi: 10.1016/j.bbmt.2018.03.008
  • Lopes SM, Roncon S, Pinho AC, et al. Should we use extracorporeal photopheresis more often? Evidence from graft-versus-host disease patients monitored with Treg as a biomarker. Future Sci OA. 2020 10;6(8):FSO623. doi: 10.2144/fsoa-2020-0107
  • Buchele V, Hackstein H. A simplified extracorporeal photopheresis procedure based on single high-dose ultraviolet a light irradiation shows similar in vitro efficacy. Transfu (Abbreviation). 2021 Mar;61(3):883–893. Epub 2020 Dec 10. PMID: 33300629. doi: 10.1111/trf.16209
  • Reschke R, Zimmerlich S, Döhring C, et al. Effective extracorporeal photopheresis of patients with transplantation induced acute intestinal GvHD and bronchiolitis obliterans syndrome. Biomedicines. 2022 4;10(8):1887. doi: 10.3390/biomedicines10081887
  • Del Fante C, Scudeller L, Oggionni T, et al. Long-term off-line extracorporeal photochemotherapy in patients with chronic lung allograft rejection not responsive to conventional treatment: a 10-year single-centre analysis. Respiration. 2015;90(2):118–128. doi: 10.1159/000431382
  • Del Fante C, Perotti C. Extracorporeal photopheresis for bronchiolitis obliterans syndrome after allogeneic stem cell transplant: an emerging therapeutic approach? Transfus Apher Sci. 2017;56(1):17–19. doi: 10.1016/j.transci.2016.12.010