- Aerssens J, van Audekercke R, Talalaj M, Geusens P, Bramm E, Dequeker J. Effect of 1alpha-vitamin D3 and estrogen therapy on cortical bone mechanical properties in the ovariectomized rat model. Endocrinology 1996; 137: 1358–64
- Bak B, Andreassen T T. The effect of growth hormone on fracture healing in old rats. Bone 1991; 12: 151–4
- Bak B, Jensen K S. Standardization of tibial fractures in the rat. Bone 1992; 13: 289–95
- Bak B, Jorgensen P H, Andreassen T T. Dose response of growth hormone on fracture healing in the rat. Acta Orthop Scand 1990; 61: 54–7
- Barrios C, Brostrom L A, Stark A, Walheim G. Healing complications after internal fixation of trochanteric hip fractures: the prognostic value of osteoporosis. J Orthop Trauma 1993; 7: 438–42
- Black J, Perdigon P, Brown N, Pollack S R. Stiffness and strength of fracture callus Relative rates of mechanical maturation as evaluated by a uniaxial tensile test. Clin Orthop 1984, 182: 278–88
- Boden S D, Joyce M E, Oliver B, Heydemann A, Bolander M E. Estrogen receptor mRNA expression in callus during fracture healing in the rat. Calcif Tissue Int 1989; 45: 324–5
- Buckwalter J A, Einhorn T A, Bolander M E, Cruess R L. Healing of the Musculoskeletal Tissues. Fractures in adults4th, C A Rockwood, D P Green, R W Bucholz, J D Heckman. Lippincott-Raven, Philadelphia 1996
- Cao Y, Mori S, Mashiba T, Westmore M S, Ma L, Sato M, Akiyama T, Shi L, Komatsubara S, Miyamoto K, Norimatsu H. Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats. J Bone Miner Res 2002; 17: 2237–46
- Carter D R, Beaupre G S, Giori N J, Helms J A. Mechanobiology of skeletal regeneration. Clin Orthop (Suppl) 1998, 355: 41–55
- Danielsen C C, Mosekilde L, Svenstrup B. Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int 1993; 52: 26–33
- Dixon T, Mitchell P, Beringer T, Gallacher S, Moniz C, Patel S, Pearson G, Ryan P. An overview of the prevalence of 25-hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom. Curr Med Res Opin 2006; 22: 405–15
- Dupont W D, Plummer W D. Power and sample size calculations for studies involving linear regression. Control Clin Trials 1998; 19: 589–601
- Egermann M, Goldhahn J, Schneider E. Animal models for fracture treatment in osteoporosis. Osteoporos Int (Suppl 2) 2005; 16: 129–38
- Einhorn T A. The cell and molecular biology of fracture healing. Clin Orthop (Suppl) 1998, 355: 7–21
- Ekeland A, Engesaeter L B, Langeland N. Mechanical properties of fractured and intact rat femora evaluated by bending, torsional and tensile tests. Acta Orthop Scand 1981; 52: 605–13
- Engesaeter L B, Ekeland A, Langeland N. Methods for testing the mechanical properties of the rat femur. Acta Orthop Scand 1978; 49: 512–8
- Fraser D R. Vitamin D Lancet. 1995; 345: 104–7
- Gardner M J, van der Meulen M C, Demetrakopoulos D, Wright T M, Myers E R, Bostrom M P. In vivo cyclic axial compression affects bone healing in the mouse tibia. J Orthop Res 2006; 24: 1679–86
- Gray J M, Wade G N. Food intake, body weight, and adiposity in female rats: actions and interactions of progestins and antiestrogens. Am J Physiol 1981; 240: 474–81
- Hill E L, Kraus K, Lapierre K P, Ryan S, Smith T, Martin R B, Finkelman R D. Ovariectomy impairs fracture healing after 21 days. Trans Orthop Res Soc 1995; 20: 230
- Jee W S, Mori S, Li X J, Chan S. Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats. Bone 1990; 11: 253–66
- Jee W S, Yao W. Overview: animal models of osteopenia and osteoporosis. J Musculoskelet Neuronal Interact 2001; 1: 193–207
- Kaastad T S, Reikeras O, Halvorsen V, Falch J A, Obrant K J, Nordsletten L. Vitamin D deficiency and ovariectomy reduced the strength of the femoral neck in rats. Calcif Tissue Int 2001; 69: 102–8
- Kalu D N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 1991; 15: 175–91
- Kanis J A. Assessment of fracture risk and its application to ascreening for postmenopausal osteoporosis: synopsis of a WHO report WHO Study Group. Osteoporos Int 1994; 4: 368–81
- Kimmel D. Animal models for in vivo experimentation in osteoporosis research Osteoporosis 2 vols. R Marcus, D Feldman, J Kelsey. Academic Press, San Diego 1996
- Kubo T, Shiga T, Hashimoto J, Yoshioka M, Honjo H, Urabe M, Kitajima I, Semba I, Hirasawa Y. Osteoporosis influences the late period of fracture healing in a rat model prepared by ovariectomy and low calcium diet. J Steroid Biochem Mol Biol 1999; 68: 197–202
- Lee P A, Witchel S F. The influence of estrogen on growth. Curr Opin Pediatr 1997; 9: 431–6
- Lindgren J U, Narechania R G, McBeath A A, Lange T A, DeLuca H F. Effects of 1,24 dihydroxyvitamin D3 and calcitonin on fracture healing in adult rats Clin Orthop. 1981, 160: 304–8
- Lips P, Vitamin D. deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22: 477–501
- McKibbin B. The biology of fracture healing in long bones. J Bone Joint Surg Br 1978; 60: 150–62
- Miller S C, Bowman B M, Miller M A, Bagi C M. Calcium absorption and osseous organ-, tissue-, and envelope-spe-cific changes following ovariectomy in rats. Bone 1991; 12: 439–46
- Moniz C, Dew T, Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin 2005; 21: 1891–4
- Mosekilde L. Vitamin D and the elderly. Clin Endocrin 2005; 62: 265–81
- Namkung-Matthai H, Appleyard R, Jansen J, Hao Lin J, Maastricht S, Swain M, Mason R S, Murell G A, Diwan A D, Diamond T. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone 2001; 28: 80–6
- Nordsletten L, Kaastad T S, Narum S, Madsen J E, Haug E, Reikeras O. Training increases the in vivo strength of the lower leg: an experimental study in the rat. J Bone Miner Res 1993; 8: 1089–95
- Nordsletten L, Kaastad T S, Madsen J E, Reikeras O, Ovstebo R, Stromme J H, Falch J. The development of femoral osteopenia in ovariectomized rats is not reduced by high intensity treadmill training: a mechanical and densitometric study. Calcif Tissue Int 1994a; 55: 436–42
- Nordsletten L, Madsen J E, Almaas R, Rootwelt T, Halse J, Konttinen Y T, Hukkanen M, Santavirta S. The neuronal regulation of fracture healing - effects of sciatic nerve resection in rat tibia. Acta Orthop Scand 1994b; 65: 299–304
- Nurmi I, Kaukonen J P, Luthje P, Naboulsi H, Tanninen S, Kataja M, Kallio M L, Leppilampi M. Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int 2005; 16: 2018–24
- Omeroglu S, Erdogan D, Omeroglu H. Effects of single high-dose vitamin D3 on fracture healing. An ultrastructural study in healthy guinea pigs. Arch Orthop Trauma Surg 1997; 116: 37–40
- Ooms M E, Lips P, Roos J C, van der Vijgh W J, Popp-Sni-jders C, Bezemer P D, Bouter L M. Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res 1995; 10: 1177–84
- Pan Z, Jee W S, Ma Y F, McOsker J E, Li X J. Intermittent treatments of prostaglandin E2 plus risedronate and prostaglandin E2 alone are equally anabolic on tibial shaft of ovariectomized rats. Bone. 1995; 17(4 Suppl)291–6
- Peng Z, Tuukkanen J, Vaananen H K. Exercise can provide protection against bone loss and prevent the decrease in mechanical strength of femoral neck in ovariectomized rats. J Bone Miner Res 1994; 9: 1559–64
- Sato M, McClintock C, Kim J, Turner C H, Bryant H U, Magee D, Slemenda C W. Dual energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. J Bone Miner Res 1994; 9: 715–24
- The North American Menopause Society. Management of osteoporosis in postmenopausal women: 2006 position statement of The North American Menopause Society. Menopause 2006; 13: 340–67
- Thompson Z, Miclau T, Hu D, Helms J A. A model for intramembranous ossification during fracture healing. J Orthop Res 2002; 20: 1091–8
- Turner R T, Vandersteenhoven J J, Bell N H. The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res 1987; 2: 115–22
- Uusitalo H, Rantakokko J, Vuorio E, Aro H T. Bone defect repair in immobilization induced osteopenia: a pQCT, biomechanical, and molecular biologic study in the mouse femur. Bone 2005; 36: 142–9
- Wade G N, Heller H W. Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats. Am J Physiol 1993; 264: 1219–23
- Walsh W R, Sherman P, Howlett C R, Sonnabend D H, Ehrlich M G. Fracture healing in a rat osteopenia model. Clin Orthop 1997; 342: 218–27
- Waynforth H B. Experimental and surgical technique in the rat. Academic Press, London 1980
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Experimental osteoporosis induced by ovariectomy and vitamin D deficiency does not markedly affect fracture healing in rats
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