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Expert Opinion on Drug Discovery Volume 15, 2020 - Issue 3: Women in Drug Discovery
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Editorial

How can we better realize the potential of immobilized artificial membrane chromatography in drug discovery and development?

Anna Tsantili-KakoulidouDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, GreeceCorrespondence[email protected]
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Pages 273-276 | Received 24 Sep 2019, Accepted 15 Jan 2020, Published online: 18 Feb 2020

References

  • Leo A, Hansch C, Elkins D. Partition coefficients and their uses. Chem Rev. 1971;71:525–616.
  • Giaginis C, Tsantili-Kakoulidou A. Alternative measures of lipophilicity: from octanol–water partitioning to IAM retention. J Pharm Sci. 2008;97:2984–3004.
  • Conradi R, Burton PS, Borschardt RT. Physico-chemical and biological factors that influence a drug’s cellular permeability by passive diffusion. In: Pliska V, Testa B, van de Waterbeemd H, editors. Lipophilicity in drug action and toxicology. Weinheim: VCH Publishers; 1996. p. 233–252.
  • Chen B, Siepmannn JI. Microscopic structure and solvation in dry and wet octanol. J Phys Chem B. 2006;110:3555–3563.
  • Krämer S. Liposomes/water partitioning: theory techniques and applications. In: Testa B, van de Waterbeemd H, Folkers G, et al., editors. Pharmacokinetic optimization in drug research, Verlag Helvetica Chimica Acta, Zürich and Wiley, Weinheim: VCH; 2001. p. 401–428.
  • Volpe DA. Variability in Caco-2 and MDCK cell-based intestinal permeability assays. J Pharm Sci. 2008;97:712–725.
  • Pidgeon C, Venkataram UV. Immobilized artificial membrane chromatography: supports composed of membrane lipids. Anal Biochem. 1989;176:36–47.
  • Scheme of a liposome formed by phospholipids in an aqueous solution. Wikipedia. [cited 2019 Sep 03]. Available from: https://en.wikipedia.org/wiki/Liposome#/media/File:Liposome_scheme-en.svg
  • IAM Drug Discovery Columns. Regis Technologies Inc. [cited 2019 Sep 03]. Available from: https://www.registech.com/chromatography/iam-chromatography/iam-drug-discovery-columns
  • Tsopelas F, Vallianatou T, Tsantili-Kakoulidou A. Advances in immobilized artificial membrane (IAM) chromatography for novel drug discovery. Expert Opin Drug Discov. 2016;11:473–488.
  • 8210 Austin Avenue, IL 60053, USA: Regis Technologies, INC., [ cited 2019 Aug 13]. Available from: http://www.registech.com
  • Tsopelas F, Vallianatou T, Tsantili- Kakoulidou A. The potential of immobilized artificial membrane chromatography to predict human oral absorption. Eur J Pharm Sci. 2016;81:82–93.
  • Valko K, Du CM, Bevan CD, et al. Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures. J Pharm Sci. 2000;89:1085–1096.
  • Grumetto L, Russo G, Barbato F. Indexes of polar interactions between ionizable drugs and membrane phospholipids measured by IAM–HPLC: their relationships with data of blood–brain barrier passage. Eur J Pharm Sci. 2014;65:139–146.
  • Yoon CH, Kim SJ, Shin BS, et al. Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography. J Biomol Screen. 2006;11:13–20.
  • Barbato F, Cappello B, Miro A, et al. Chromatographic indexes on immobilized artificial membranes for the prediction of transdermal transport of drugs. Farmaco. 1998;53:655–661.
  • Tsopelas F, Giaginis C, Tsantili-Kakoulidou A. Lipophilicity and biomimetic properties to support drug discovery. Expert Opin Drug Discov. 2017;12:885–896.
  • Valko K. Lipophilicity and biomimetic properties measured by HPLC to support drug discovery. J Pharm Biomed Anal. 2016;130:35–54.
  • Valko K, Chiarparin E, Nunhuck S, et al. In vitro measurement of drug efficiency index to aid early lead optimization. J Pharm Sci. 2012;101:4155–4169.
  • Zhao X, Chen W, Liu Z, et al. A novel mixed phospholipid functionalized monolithic column for early screening of drug induced phospholipidosis risk. J Chromatogr A. 2014;1367:99–108.
  • Gordon LJ, Allen M, Artursson P, et al. Direct measurement of intracellular compound concentration by rapidfire mass spectrometry offers insights into cell permeability. J Biomol Screen. 2016;21:156–164.
  • Lazaro E, Rafols C, Abraham MH, et al. Chromatographic estimation of drug disposition properties by means of immobilized artificial membranes (IAM) and C18 columns. J Med Chem. 2006;49:4861–4870.
  • Russo G, Grumetto L, Barbato F, et al. Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors. Eur J Pharm Sci. 2017;99:173–184.

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