Stem cell therapy in retinal diseases: current evidence

References

• Heath Jeffery RC, Mukhtar SA, McAllister IL, et al. Inherited retinal diseases are the most common cause of blindness in the working-age population in Australia. Ophthalmic Genet. 2021;42(4):431–439. doi: 10.1080/13816810.2021.1913610
   PubMed Web of Science ®Google Scholar
• Sharma A, Jaganathan BG. Stem cell therapy for retinal degeneration: the evidence to date. Biologics. 2021;15:299–306. doi: 10.2147/BTT.S290331
   PubMed Web of Science ®Google Scholar
• Chung SH, Frick SL, Yiu G. Targeting vascular endothelial growth factor using retinal gene therapy. Ann Transl Med. 2021;9(15):1277. doi: 10.21037/atm-20-4417
   PubMed Web of Science ®Google Scholar
• West EL, Ribeiro J, Ali RR. Development of stem cell therapies for retinal degeneration. Cold Spring Harb Perspect Biol. 2020;12(8):a035683. doi: 10.1101/cshperspect.a035683
   PubMed Web of Science ®Google Scholar
• Zacharias DG, Nelson TJ, Mueller PS, et al. The science and ethics of induced pluripotency: what will become of embryonic stem cells? Mayo Clin Proc. 2011;86(7):634–640. doi: 10.4065/mcp.2011.0054
   PubMed Web of Science ®Google Scholar
• Vazin T, Freed WJ. Human embryonic stem cells: derivation, culture, and differentiation: a review. Restor Neurol Neurosci. 2010;28(4):589–603. doi: 10.3233/RNN-2010-0543
   PubMed Web of Science ®Google Scholar
• German OL, Vallese-Maurizi H, Soto TB, et al. Retina stem cells, hopes and obstacles. World J Stem Cells. 2021;13(10):1446–1479. doi: 10.4252/wjsc.v13.i10.1446
   PubMed Web of Science ®Google Scholar
• Semi K, Takashima Y. Pluripotent stem cells for the study of early human embryology. Dev Growth Differ. 2021;63(2):104–115. doi: 10.1111/dgd.12715
   PubMed Web of Science ®Google Scholar
• Ye L, Swingen C, Zhang J. Induced pluripotent stem cells and their potential for basic and clinical sciences. Curr Cardiol Rev. 2013;9(1):63–72. doi: 10.2174/1573403X11309010008
   PubMedGoogle Scholar
• Liu G, David BT, Trawczynski M, et al. Advances in pluripotent stem cells: history, mechanisms, technologies, and applications. Stem Cell Rev And Rep. 2020;16(1):3–32. doi: 10.1007/s12015-019-09935-x
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–676. doi: 10.1016/j.cell.2006.07.024
   PubMed Web of Science ®Google Scholar
• Nicholson MW, Ting CY, Chan DZH, et al. Utility of iPSC-Derived cells for disease modeling, drug development, and cell therapy. Cells. 2022;11(11):1853. doi: 10.3390/cells11111853
   PubMed Web of Science ®Google Scholar
• Aladdad AM, Kador KE. Adult stem cells, tools for repairing the retina. Curr Ophthalmol Rep. 2019;7(1):21–29. doi: 10.1007/s40135-019-00195-z
   PubMedGoogle Scholar
• Gill KP, Hewitt AW, Davidson KC, et al. Methods of retinal ganglion cell differentiation from pluripotent stem cells. Transl Vis Sci Technol. 2014;3(4):7. doi: 10.1167/tvst.3.3.7
   PubMed Web of Science ®Google Scholar
• Lu B, Morgans CW, Girman S, et al. Neural stem cells derived by small molecules preserve vision. Transl Vis Sci Technol. 2013;2(1):1. doi: 10.1167/tvst.2.1.1
   PubMed Web of Science ®Google Scholar
• Goldman D. Müller glial cell reprogramming and retina regeneration. Nat Rev Neurosci. 2014;15(7):431–42. doi: 10.1038/nrn3723
   PubMed Web of Science ®Google Scholar
• Todd L, Hooper MJ, Haugan AK, et al. Efficient stimulation of retinal regeneration from müller glia in adult mice using combinations of proneural bHLH transcription factors. Cell Rep. 2021;37(3):109857. doi: 10.1016/j.celrep.2021.109857
   PubMed Web of Science ®Google Scholar
• Frøen R, Johnsen EO, Nicolaissen B, et al. Does the adult human ciliary body epithelium contain “true” retinal stem cells? Biomed Res Int. 2013;2013:531579. doi: 10.1155/2013/531579
   PubMed Web of Science ®Google Scholar
• Jeon S, Oh IH. Regeneration of the retina: toward stem cell therapy for degenerative retinal diseases. BMB Rep. 2015;48(4):193–199. doi: 10.5483/BMBRep.2015.48.4.276
   PubMed Web of Science ®Google Scholar
• Kuriyan AE, Albini TA, Townsend JH, et al. Vision loss after intravitreal injection of autologous “stem cells” for AMD. N Engl J Med. 2017;376(11):1047–1053. doi: 10.1056/NEJMoa1609583
   PubMed Web of Science ®Google Scholar
• Wang Z, Gao F, Zhang M, et al. Intravitreal injection of human retinal progenitor cells for treatment of retinal degeneration. Med Sci Monit. 2020;26:e921184. doi: 10.12659/MSM.921184
   PubMed Web of Science ®Google Scholar
• Gao H, Ni N, Zhang D, et al. miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1. Cell Cycle. 2020;19(14):1754–1767. doi: 10.1080/15384101.2020.1777805
   PubMed Web of Science ®Google Scholar
• Sun N, Zhang D, Ni N, et al. miR-17 regulates the proliferation and differentiation of retinal progenitor cells by targeting CHMP1A. Biochem Biophys Res Commun. 2020;523(2):493–499. doi: 10.1016/j.bbrc.2019.11.108
   PubMed Web of Science ®Google Scholar
• Shen B, Gao H, Zhang D, et al. miR-124-3p regulates the proliferation and differentiation of retinal progenitor cells through SEPT10. Cell Tissue Res. 2023;392(3):689–704. doi: 10.1007/s00441-023-03750-0
   PubMed Web of Science ®Google Scholar
• Sarsenova M, Kim Y, Raziyeva K, et al. Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells. Front Immunol. 2022;13:1010399. doi: 10.3389/fimmu.2022.1010399
   PubMed Web of Science ®Google Scholar
• Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol Sci. 2020;41(9):653–664. doi: 10.1016/j.tips.2020.06.009
   PubMed Web of Science ®Google Scholar
• Zhu D, Xie M, Gademann F, et al. Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease. Stem Cell Res Ther. 2020;11(1):98. doi: 10.1186/s13287-020-01608-8
   PubMed Web of Science ®Google Scholar
• Hertz J, Qu B, Hu Y, et al. Survival and integration of developing and progenitor-derived retinal ganglion cells following transplantation. Cell Transplant. 2014;23(7):855–872. doi: 10.3727/096368913X667024
   PubMed Web of Science ®Google Scholar
• Tu HY, Watanabe T, Shirai H, et al. Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration. EBioMedicine. 2019;39:562–574. doi: 10.1016/j.ebiom.2018.11.028
   PubMed Web of Science ®Google Scholar
• Petrus-Reurer S, Kumar P, Padrell Sánchez S, et al. Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration. Stem Cells Transl Med. 2020;9(8):936–953. doi: 10.1002/sctm.19-0396
   PubMed Web of Science ®Google Scholar
• Mazzilli JL, Snook JD, Simmons K, et al. A preclinical safety study of human embryonic stem cell-derived retinal pigment epithelial cells for macular degeneration. J Ocular Pharmacol Ther. 2020;36(1):65–69. doi: 10.1089/jop.2019.0039
   PubMed Web of Science ®Google Scholar
• Alsaeedi HA, Koh AE, Lam C, et al. Dental pulp stem cells therapy overcomes photoreceptor cell death and protects the retina in a rat model of sodium iodate-induced retinal degeneration. J Photochem Photobiol B. 2019;198:111561. doi: 10.1016/j.jphotobiol.2019.111561
   PubMed Web of Science ®Google Scholar
• Liu X, Xie J, Yang L, et al. Bone marrow mesenchymal stem cells enhance autophagy and help protect cells under hypoxic and retinal detachment conditions. J Cell Mol Med. 2020;24(6):3346–3358. doi: 10.1111/jcmm.15008
   PubMed Web of Science ®Google Scholar
• Rajashekhar G, Ramadan A, Abburi C, et al. Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PLoS One. 2014;9(1):e84671. doi: 10.1371/journal.pone.0084671
   PubMed Web of Science ®Google Scholar
• Prokhorova TA, Harkness LM, Frandsen U, et al. Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of matrigel. Stem Cells Dev. 2009;18(1):47–54. doi: 10.1089/scd.2007.0266
   PubMed Web of Science ®Google Scholar
• Ma M, Li B, Zhang M, et al. Therapeutic effects of mesenchymal stem cell-derived exosomes on retinal detachment. Exp Eye Res. 2020;191:107899. doi: 10.1016/j.exer.2019.107899
   PubMed Web of Science ®Google Scholar
• Moisseiev E, Anderson JD, Oltjen S, et al. Protective Effect of intravitreal administration of exosomes derived from mesenchymal stem cells on retinal ischemia. Curr Eye Res. 2017;42(10):1358–1367. doi: 10.1080/02713683.2017.1319491
   PubMed Web of Science ®Google Scholar
• Caplan H, Olson SD, Kumar A, et al. Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application. Front Immunol. 2019;10:1645. doi: 10.3389/fimmu.2019.01645
   PubMed Web of Science ®Google Scholar
• Kooreman NG, Wu JC. Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging. J R Soc Interface. 2010;7(Suppl 6):S753–S763. doi: 10.1098/rsif.2010.0353.focus
   PubMedGoogle Scholar
• Móvio MI, de Lima-Vasconcellos TH, Dos Santos GB, et al. Retinal organoids from human-induced pluripotent stem cells: from studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease. Semin Cell Dev Biol. 2023;144:77–86. doi: 10.1016/j.semcdb.2022.09.011
   PubMed Web of Science ®Google Scholar
• Mehat MS, Sundaram V, Ripamonti C, et al. Transplantation of human embryonic stem Cell-derived retinal pigment epithelial cells in macular degeneration. Ophthalmol. 2018;125(11):1765–1775. doi: 10.1016/j.ophtha.2018.04.037
   PubMed Web of Science ®Google Scholar
• Schwartz SD, Hubschman JP, Heilwell G, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet. 2012;379(9817):713–720. doi: 10.1016/S0140-6736(12)60028-2
   PubMed Web of Science ®Google Scholar
• Song WK, Park KM, Kim HJ, et al. Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients. Stem Cell Rep. 2015;4(5):860–872. doi: 10.1016/j.stemcr.2015.04.005
   PubMed Web of Science ®Google Scholar
• A Phase I/IIa, open-label, single-center, prospective study to determine the safety and tolerability of sub-retinal transplantation of human embryonic stem cell derived retinal pigmented Epithelial(MA09-hRPE) cells in patients with advanced dry age-related macular degeneration(AMD). Available from: https://classic.clinicaltrials.gov/ct2/show/NCT01674829
   Google Scholar
• Sung Y, Lee MJ, Choi J, et al. Long-term safety and tolerability of subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium in Asian stargardt disease patients. Br J Ophthalmol. 2021;105(6):829–837. doi: 10.1136/bjophthalmol-2020-316225
   PubMed Web of Science ®Google Scholar
• da Cruz L, Fynes K, Georgiadis O, et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018;36(4):328–337. doi: 10.1038/nbt.4114
   PubMed Web of Science ®Google Scholar
• A study of implantation of retinal pigment epithelium in subjects with acute wet age related macular degeneration. Available from: https://clinicaltrials.gov/ct2/show/NCT01691261
   Google Scholar
• Kashani AH, Lebkowski JS, Rahhal FM, et al. One-year follow-up in a Phase 1/2a clinical trial of an allogeneic RPE cell bioengineered implant for advanced dry age-related macular degeneration. Transl Vis Sci Technol. 2021;10(10):13. doi: 10.1167/tvst.10.10.13
   PubMed Web of Science ®Google Scholar
• Kashani AH, Lebkowski JS, Hinton DR, et al. Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration. Stem Cell Rep. 2022;17(3):448–458. doi: 10.1016/j.stemcr.2022.01.001
   PubMed Web of Science ®Google Scholar
• Aweidah H, Matsevich C, Khaner H, et al. Survival of neural progenitors derived from human embryonic stem cells following subretinal transplantation in rodents. J Ocul Pharmacol Ther. 2022;39(5):347–358. doi: 10.1089/jop.2022.0161
   Web of Science ®Google Scholar
• Mandai M, Watanabe A, Kurimoto Y, et al. Autologous induced stem-cell-derived retinal cells for macular degeneration. N Engl J Med. 2017;376(11):1038–1046. doi: 10.1056/NEJMoa1608368
   PubMed Web of Science ®Google Scholar
• Cyranoski D. Japanese man is first to receive ‘reprogrammed’ stem cells from another person. Nature. 2017;10:1038. doi:10.1038/nature.2017.21730
   Google Scholar
• Park SS, Bauer G, Abedi M, et al. Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: preliminary Phase 1 clinical trial findings. Investig Opthalmol Vis Sci. 2014;56:81–89. doi: 10.1167/iovs.14-15415
   PubMed Web of Science ®Google Scholar
• Siqueira RC, Messias A, Voltarelli JC, et al. Intravitreal injection of autologous bone marrow–derived mononuclear cells for hereditary retinal dystrophy. Retina. 2011;31(6):1207–1214. doi: 10.1097/IAE.0b013e3181f9c242
   PubMed Web of Science ®Google Scholar
• Gu X, Yu X, Zhao C, et al. Efficacy and safety of autologous bone marrow mesenchymal stem cell transplantation in patients with diabetic retinopathy. Cell Physiol Biochem. 2018;49:40–52. doi: 10.1159/000492838
   PubMedGoogle Scholar
• Oumlzmert E, Arslan U. Management of retinitis pigmentosa by Wharton’s jelly-derived mesenchymal stem cells: prospective analysis of 1-year results. Stem Cell Res Ther. 2020;11:353. doi: 10.1186/s13287-020-01870-w
   PubMed Web of Science ®Google Scholar
• Saraf SS, Cunningham MA, Kuriyan AE, et al. Bilateral retinal detachments after intravitreal injection of adipose-derived ‘stem cells’ in a patient with exudative macular degeneration. Ophthalmic Surg Lasers Imaging Retina. 2017;48(9):772–775. doi: 10.3928/23258160-20170829-16
   PubMed Web of Science ®Google Scholar
• Leung EH, HW F Jr, Albini TA, et al. Retinal detachment after subretinal stem cell transplantation. Ophthalmic Surg Lasers Imaging Retina. 2016;47(6):600–601. doi: 10.3928/23258160-20160601-16
   PubMed Web of Science ®Google Scholar
• Hu C, La H, Wei X, et al. Transplantation site affects the outcomes of adipose-derived stem cell-based therapy for retinal degeneration. Stem Cells Int. 2020;2020:9625798. doi: 10.1155/2020/9625798
   PubMed Web of Science ®Google Scholar
• Safety of a single, intravitreal injection of human retinal progenitor cells (jCell) in retinitis pigmentosa. Available from: https://classic.clinicaltrials.gov/ct2/show/NCT02320812
   Google Scholar
• Safety and efficacy of IIntravitreal injection of human retinal progenitor cells in adults with retinitis pigmentosa. Available from: https://classic.clinicaltrials.gov/ct2/show/NCT03073733
   Google Scholar
• Safety and tolerability of hRPC in retinitis pigmentosa. Available from: https://classic.clinicaltrials.gov/ct2/show/NCT02464436
   Google Scholar
• Liu Y, Chen SJ, Li SY, et al. Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients. Stem Cell Res Ther. 2017;8(1):209. doi: 10.1186/s13287-017-0661-8
   PubMedGoogle Scholar
• Dosmar E, Walsh J, Doyel M, et al. Targeting ocular drug delivery: an examination of local anatomy and Current approaches. Bioeng. 2022;9(1):41. doi: 10.3390/bioengineering9010041
   PubMedGoogle Scholar
• Irigoyen C, Amenabar Alonso A, Sanchez-Molina J, et al. Subretinal injection techniques for retinal disease: a review. J Clin Med. 2022;11(16):4717. doi: 10.3390/jcm11164717
   PubMed Web of Science ®Google Scholar
• Kashani AH, Lebkowski JS, Rahhal FM, et al. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med. 2018;10(435):eaao4097. doi: 10.1126/scitranslmed.aao4097
   PubMed Web of Science ®Google Scholar
• AC MH, Chang TS, Samuel M, et al. Experience with a subretinal cell-based therapy in patients with geographic atrophy secondary to age-related macular degeneration. Am J Ophthalmol. 2017;179:67–80. doi: 10.1016/j.ajo.2017.04.006
   PubMed Web of Science ®Google Scholar
• Zhang X, Bok D. Transplantation of retinal pigment epithelial cells and immune response in the subretinal space. Invest Ophthalmol Vis Sci. 1998;39(6):1021–1027.
   PubMed Web of Science ®Google Scholar
• Casella AM, Taba KE, Kimura H, et al. Retinal pigment epithelial cells are heterogeneous in their expression of MHC-II after stimulation with interferon-gamma. Exp Eye Res. 1999;68(4):423–430. doi: 10.1006/exer.1998.0621
   PubMed Web of Science ®Google Scholar
• Chen M, Luo C, Zhao J, et al. Immune regulation in the aging retina. Prog Retin Eye Res. 2019;69:159–172. doi: 10.1016/j.preteyeres.2018.10.003
   PubMed Web of Science ®Google Scholar
• Kaur G, Singh NK. Inflammation and retinal degenerative diseases. Neural Regen Res. 2023;18(3):513–518. doi: 10.4103/1673-5374.350192
   PubMed Web of Science ®Google Scholar
• Sugita S, Mandai M, Kamao H, et al. Immunological aspects of RPE cell transplantation. Prog Retin Eye Res. 2021;84:100950. doi: 10.1016/j.preteyeres.2021.100950
   PubMed Web of Science ®Google Scholar
• Meneghini M, Bestard O, Grinyo JM. Immunosuppressive drugs modes of action. Best Pract Res Clin Gastroenterol. 2021;54-55:101757. doi: 10.1016/j.bpg.2021.101757
   PubMed Web of Science ®Google Scholar
• Petrus-Reurer S, Romano M, Howlett S, et al. Immunological considerations and challenges for regenerative cellular therapies. Commun Biol. 2021;4(1):798. doi: 10.1038/s42003-021-02237-4
   PubMed Web of Science ®Google Scholar
• Meissner TB, Schulze HS, Dale SM. Immune editing: overcoming immune barriers in stem cell transplantation. Curr Stem Cell Rep. 2022;8(4):206–218. doi: 10.1007/s40778-022-00221-0
   PubMed Web of Science ®Google Scholar
• Flahou C, Morishima T, Takizawa H, et al. Fit-for-all iPSC-Derived cell therapies and their evaluation in humanized mice with NK cell immunity. Front Immunol. 2021;12:662360. doi: 10.3389/fimmu.2021.662360
   PubMed Web of Science ®Google Scholar
• Sugita S, Iwasaki Y, Makabe K, et al. Successful transplantation of retinal pigment epithelial cells from MHC homozygote iPscs in MHC-Matched models. Stem Cell Rep. 2016;7(4):635–648. doi: 10.1016/j.stemcr.2016.08.010
   PubMed Web of Science ®Google Scholar
• Morizane A, Kikuchi T, Hayashi T, et al. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat Commun. 2017;8(1):385. doi: 10.1038/s41467-017-00926-5
   PubMedGoogle Scholar
• Pilat N, Sayegh MH, Wekerle T. Costimulatory pathways in transplantation. Semin Immunol. 2011;23(4):293–303. doi: 10.1016/j.smim.2011.04.002
   PubMed Web of Science ®Google Scholar
• Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283–296. doi: 10.1016/j.ccr.2012.03.003
   PubMed Web of Science ®Google Scholar
• Fong CY, Gauthaman K, Bongso A. Teratomas from pluripotent stem cells: a clinical hurdle. J Cell Biochem. 2010;111(4):769–781.
   PubMed Web of Science ®Google Scholar
• Fortress AM, Miyagishima KJ, Reed AA, et al. Stem cell sources and characterization in the development of cell-based products for treating retinal disease: an NEI Town Hall report. Stem Cell Res Ther. 2023;14(1):53. doi: 10.1186/s13287-023-03282-y
   PubMed Web of Science ®Google Scholar
• Leach LL, Clegg DO. Concise review: making stem cells retinal: methods for deriving retinal pigment epithelium and implications for patients with ocular disease. Stem Cells. 2015;33(8):2363–2373. doi: 10.1002/stem.2010
   PubMed Web of Science ®Google Scholar
• Choudhary P, Booth H, Gutteridge A, et al. Directing differentiation of pluripotent stem cells toward retinal pigment epithelium lineage. Stem Cells Transl Med. 2017;6(2):490–501. doi: 10.5966/sctm.2016-0088
   PubMed Web of Science ®Google Scholar
• Idelson M, Alper R, Obolensky A, et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell. 2009;5(4):396–408. doi: 10.1016/j.stem.2009.07.002
   PubMed Web of Science ®Google Scholar
• Otonkoski T, Beattie GM, Mally MI, et al. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest. 1993;92(3):1459–1466. doi: 10.1172/JCI116723
   PubMed Web of Science ®Google Scholar
• Kuroda T, Yasuda S, Kusakawa S, et al. Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human iPS cells. PLoS One. 2012;7(5):e37342. doi: 10.1371/journal.pone.0037342
   PubMed Web of Science ®Google Scholar
• Kuroda T, Yasuda S, Sato Y. In vitro detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human induced pluripotent stem cells. Methods Mol Biol. 2014;1210:183–192.
   PubMedGoogle Scholar
• Lamba DA, McUsic A, Hirata RK, et al. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010;5(1):e8763. doi: 10.1371/journal.pone.0008763
   PubMed Web of Science ®Google Scholar
• Koss MJ, Falabella P, Stefanini FR, et al. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016;254(8):1553–1565. doi: 10.1007/s00417-016-3386-y
   PubMed Web of Science ®Google Scholar
• Kashani AH, Martynova A, Koss M, et al. Subretinal implantation of a human embryonic stem cell-derived retinal pigment epithelium monolayer in a porcine model. Adv Exp Med Biol. 2019;1185:569–574.
   PubMed Web of Science ®Google Scholar
• Rajendran Nair DS, Seiler MJ, Patel KH, et al. Tissue Engineering Strategies for Retina Regeneration. Appl Sci. 2021;11(5):2154. doi: 10.3390/app11052154
   Google Scholar
• Yao J, Tao SL, Young MJ. Synthetic polymer scaffolds for stem cell transplantation in retinal tissue engineering. Polymers. 2011;3(2):899–914. doi: 10.3390/polym3020899
   Web of Science ®Google Scholar
• Ru L, Wu N, Wei K, et al. Improving cell survival and engraftment in vivo via layer-by-layer nanocoating of hESC-derived RPE cells. Stem Cell Res Ther. 2020;11(1):495. doi: 10.1186/s13287-020-01986-z
   PubMed Web of Science ®Google Scholar
• Warre-Cornish K, Barber AC, Sowden JC, et al. Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. Stem Cells Dev. 2014 1;23(9):941–954. doi: 10.1089/scd.2013.0471
   PubMed Web of Science ®Google Scholar
• Pearson RA, Hippert C, Graca AB, et al. Photoreceptor replacement therapy: challenges presented by the diseased recipient retinal environment. Vis Neurosci. 2014;31(4–5):333–344. doi: 10.1017/S0952523814000200
   PubMed Web of Science ®Google Scholar
• Santos-Ferreira T, Postel K, Stutzki H, et al. Daylight vision repair by cell transplantation. Stem Cells. 2015;33(1):79–90. doi: 10.1002/stem.1824
   PubMed Web of Science ®Google Scholar
• Zhang Z, Xu Z, Yuan F, et al. Retinal organoid technology: where are we Now? Int J Mol Sci. 2021 23;22(19):10244. doi: 10.3390/ijms221910244
   PubMed Web of Science ®Google Scholar
• Lin B, McLelland BT, Aramant RB, et al. Retina organoid transplants develop photoreceptors and improve visual function in RCS rats with RPE dysfunction. Invest Ophthalmol Vis Sci. 2020 1;61(11):34. doi: 10.1167/iovs.61.11.34
   PubMed Web of Science ®Google Scholar
• Rajendran Nair DS, Zhu D, Sharma R, et al. Long-term transplant effects of iPSC-RPE monolayer in immunodeficient RCS rats. Cells. 2021;10(11):2951. doi: 10.3390/cells10112951
   PubMed Web of Science ®Google Scholar
• Dose escalation study to evaluate the safety/tolerability and efficacy of EA-2353 in subjects with retinitis pigmentosa. Available from: https://classic.clinicaltrials.gov/ct2/show/NCT05392751.
   Google Scholar
• NIH. Grants & funding: NIH human embryonic stem cell registry [internet]. [cited 2023 Sep 26]. Available from: http://grants.nih.gov/stem_cells/registry/current.htm.
   Google Scholar
• Verginer L, Riccaboni M. Stem cell legislation and its impact on the geographic preferences of stem cell researchers. Eurasian Bus Rev. 2021;11:1603–189. doi: 10.1007/s40821-021-00182-0
   Web of Science ®Google Scholar
• Mathews DJ, Donovan PJ, Harris J, et al. Pluripotent stem cell-derived gametes: truth and (potential) consequences. Cell Stem Cell. 2009;5(1):11–14. doi: 10.1016/j.stem.2009.06.005
   PubMed Web of Science ®Google Scholar
• Liang G, Zhang Y. Genetic and epigenetic variations in iPscs: potential causes and implications for application. Cell Stem Cell. 2013;13(2):149–159. doi: 10.1016/j.stem.2013.07.001
   PubMed Web of Science ®Google Scholar
• Blasco MA, Serrano M, Fernandez-Capetillo O. Genomic instability in iPS: time for a break. EMBO J. 2011;30(6):991–993. doi: 10.1038/emboj.2011.50
   PubMed Web of Science ®Google Scholar
• Haridhasapavalan KK, Borgohain MP, Dey C, et al. An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells. Gene. 2019;686:146–159. doi: 10.1016/j.gene.2018.11.069
   PubMed Web of Science ®Google Scholar
• Aly RM. Current state of stem cell-based therapies: an overview. Stem Cell Investig. 2020;157:8. doi: 10.21037/sci-2020-001
   Google Scholar