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Review

Liver transplantation for perihilar cholangiocarcinoma: patient selection and outcomes

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Pages 555-566 | Received 09 Jan 2021, Accepted 11 Feb 2021, Published online: 26 Feb 2021

References

  • Mansour JC, Aloia TA, Crane CH, et al. Hilar cholangiocarcinoma: expert consensus statement. HPB (Oxford). 2015 Aug;17(8):691–699.
  • Society AC Bile duct cancer: about bile duct cancers - key statistics for bile duct cancer. 2020 [cited 2020 Dec 1]. Available from: https://www.cancer.org/cancer/bile-duct-cancer/about/key-statistics.html
  • DeOliveira ML, Cunningham SC, Cameron JL, et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg. 2007 May;245(5):755–762.
  • Poruk KE, Pawlik TM, Weiss MJ. Perioperative management of hilar cholangiocarcinoma. J Gastrointest Surg. 2015 Oct;19(10):1889–1899.
  • Nagino M, Ebata T, Yokoyama Y, et al. Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections. Ann Surg. 2013 July;258(1):129–140.
  • Jarnagin WR, Fong Y, DeMatteo RP, et al. Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg. 2001 Oct;234(4):507–17; discussion 517–9.
  • Cho MS, Kim SH, Park SW, et al. Surgical outcomes and predicting factors of curative resection in patients with hilar cholangiocarcinoma: 10-year single-institution experience. J Gastrointest Surg. 2012 Sept;16(9):1672–1679.
  • Baltatzis M, Jegatheeswaran S, Siriwardena AK. Neoadjuvant chemoradiotherapy before resection of perihilar cholangiocarcinoma: a systematic review. Hepatobiliary Pancreat Dis Int. 2020 Apr;19(2):103–108.
  • Frosio F, Mocchegiani F, Conte G, et al. Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma: review of the literature. World J Gastrointest Surg. 2019 June 27;11(6):279–286.
  • Ben-Josef E, Guthrie KA, El-Khoueiry AB, et al. SWOG S0809: a phase II intergroup trial of adjuvant capecitabine and gemcitabine followed by radiotherapy and concurrent capecitabine in extrahepatic cholangiocarcinoma and gallbladder carcinoma. J Clin Oncol. 2015 Aug 20;33(24):2617–2622.
  • Turgeon MK, Maithel SK. Cholangiocarcinoma: a site-specific update on the current state of surgical management and multi-modality therapy. Chin Clin Oncol. 2020 Feb;9(1):4.
  • Murakami Y, Uemura K, Sudo T, et al. Gemcitabine-based adjuvant chemotherapy improves survival after aggressive surgery for hilar cholangiocarcinoma. J Gastrointest Surg. 2009 Aug;13(8):1470–1479.
  • Valle JW, Wasan H, Johnson P, et al. Gemcitabine alone or in combination with cisplatin in patients with advanced or metastatic cholangiocarcinomas or other biliary tract tumours: a multicentre randomised phase II study - The UK ABC-01 Study. Br J Cancer. 2009 Aug 18;101(4):621–627.
  • Stieber AC, Marino IR, Iwatsuki S, et al. Cholangiocarcinoma in sclerosing cholangitis. The role of liver transplantation. Int Surg. 1989 Jan-Mar;74(1):1–3.
  • Meyer CG, Penn I, James L. Liver transplantation for cholangiocarcinoma: results in 207 patients. Transplantation. 2000 Apr 27;69(8):1633–1637.
  • Shimoda M, Farmer DG, Colquhoun SD, et al. Liver transplantation for cholangiocellular carcinoma: analysis of a single-center experience and review of the literature. Liver Transpl. 2001 Dec;7(12):1023–1033.
  • Robles R, Figueras J, Turrion VS, et al. Spanish experience in liver transplantation for hilar and peripheral cholangiocarcinoma. Ann Surg. 2004 Feb;239(2):265–271.
  • Alden ME, Mohiuddin M. The impact of radiation dose in combined external beam and intraluminal Ir-192 brachytherapy for bile duct cancer. Int J Radiat Oncol Biol Phys. 1994 Mar 1;28(4):945–951.
  • Rosen CB, Heimbach JK, Gores GJ. Liver transplantation for cholangiocarcinoma. Transpl Int. 2010 July;23(7):692–697.
  • Heimbach JK, Haddock MG, Alberts SR, et al. Transplantation for hilar cholangiocarcinoma. Liver Transpl. 2004 Oct;10(10 Suppl 2):S65–8.
  • Brandsaeter B, Isoniemi H, Broome U, et al. Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy. J Hepatol. 2004 May;40(5):815–822.
  • Matsuo K, Rocha FG, Ito K, et al. The Blumgart preoperative staging system for hilar cholangiocarcinoma: analysis of resectability and outcomes in 380 patients. J Am Coll Surg. 2012 Sept;215(3):343–355.
  • Tan EK, Taner T, Heimbach JK, et al. Liver transplantation for peri-hilar cholangiocarcinoma. J Gastrointest Surg. 2020 Nov;24(11):2679–2685.
  • Darwish Murad S, Kim WR, Harnois DM, et al. Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers. Gastroenterology. 2012 July;143(1):88–98 e3; quiz e14.
  • Network OOPaT. Organ procurement and transplantation network: liver: bile duct cancer. 2020 [cited 2020 Dec 1]. Available from: https://optn.transplant.hrsa.gov/data/organ-datasource/liver/andhttps://optn.transplant.hrsa.gov/media/1200/optn_policies.pdf
  • Rosen CB, Heimbach JK, Gores GJ. Surgery for cholangiocarcinoma: the role of liver transplantation. HPB (Oxford). 2008;10(3):186–189.
  • Sudan D, DeRoover A, Chinnakotla S, et al. Radiochemotherapy and transplantation allow long-term survival for nonresectable hilar cholangiocarcinoma. Am J Transplant. 2002 Sept;2(8):774–779.
  • De Vreede I, Steers JL, Burch PA, et al. Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma. Liver Transpl. 2000 May;6(3):309–316.
  • Rea DJ, Heimbach JK, Rosen CB, et al. Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma. Ann Surg. 2005 Sept;242(3):451–8; discussion 458–61.
  • Rosen CB, Darwish Murad S, Heimbach JK, et al. Neoadjuvant therapy and liver transplantation for hilar cholangiocarcinoma: is pretreatment pathological confirmation of diagnosis necessary? J Am Coll Surg. 2012 July;215(1):31–8; discussion 38–40.
  • Darwish Murad S, Kim WR, Therneau T, et al. Predictors of pretransplant dropout and posttransplant recurrence in patients with perihilar cholangiocarcinoma. Hepatology. 2012 Sept;56(3):972–981.
  • Machairas N, Kostakis ID, Tsilimigras DI, et al. Liver transplantation for hilar cholangiocarcinoma: a systematic review. Transplant Rev (Orlando). 2020 Jan;34(1):100516.
  • Singhi AD, Nikiforova MN, Chennat J, et al. Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures. Gut. 2020 Jan;69(1):52–61.
  • Clayton RA, Clarke DL, Currie EJ, et al. Incidence of benign pathology in patients undergoing hepatic resection for suspected malignancy. Surgeon. 2003 Feb;1(1):32–38.
  • Wakai T, Shirai Y, Sakata J, et al. Clinicopathological features of benign biliary strictures masquerading as biliary malignancy. Am Surg. 2012 Dec;78(12):1388–1391.
  • Tan EK, Rosen CB, Heimbach JK, et al. Living Donor Liver Transplantation for Perihilar Cholangiocarcinoma: outcomes and Complications. J Am Coll Surg. 2020 July;231(1):98–110.
  • Croome KP, Rosen CB, Heimbach JK, et al. Is liver transplantation appropriate for patients with potentially resectable de novo hilar cholangiocarcinoma? J Am Coll Surg. 2015 July;221(1):130–139.
  • Lehrke HD, Heimbach JK, Wu TT, et al. Prognostic significance of the histologic response of perihilar cholangiocarcinoma to preoperative neoadjuvant chemoradiation in liver explants. Am J Surg Pathol. 2016;40:510–518
  • Hong JC, Petrowsky H, Kaldas FM, et al. Predictive index for tumor recurrence after liver transplantation for locally advanced intrahepatic and hilar cholangiocarcinoma. J Am Coll Surg. 2011 Apr;212(4):514–20; discussion 520–1.
  • Zaborowski A, Heneghan HM, Fiore B, et al. Neoadjuvant chemoradiotherapy and liver transplantation for unresectable hilar cholangiocarcinoma: the Irish experience of the Mayo protocol. Transplantation. 2020 Oct;104(10):2097–2104.
  • Heimbach JK, Gores GJ, Haddock MG, et al. Predictors of disease recurrence following neoadjuvant chemoradiotherapy and liver transplantation for unresectable perihilar cholangiocarcinoma. Transplantation. 2006 Dec 27;82(12):1703–1707.
  • Ethun CG, Lopez-Aguiar AG, Anderson DJ, et al. Transplantation versus resection for hilar cholangiocarcinoma: an argument for shifting treatment paradigms for resectable disease. Ann Surg. 2018 May;267(5):797–805.
  • Moris D, Kostakis ID, Machairas N, et al. Comparison between liver transplantation and resection for hilar cholangiocarcinoma: a systematic review and meta-analysis. PLoS One. 2019;14(7):e0220527.
  • Hidalgo E, Asthana S, Nishio H, et al. Surgery for hilar cholangiocarcinoma: the Leeds experience. Eur J Surg Oncol. 2008 July;34(7):787–794.
  • Ramanan P, Cummins NW, Wilhelm MP, et al. Epidemiology, risk factors, and outcomes of infections in patients undergoing liver transplantation for hilar cholangiocarcinoma. Clin Transplant. 2017 Aug;31(8). DOI:10.1111/ctr.13023
  • Mantel HT, Rosen CB, Heimbach JK, et al. Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma. Liver Transpl. 2007 Oct;13(10):1372–1381
  • Mantel HT, Westerkamp AC, Adam R, et al. Strict selection alone of patients undergoing liver transplantation for hilar cholangiocarcinoma is associated with improved survival. PLoS One. 2016;11(6):e0156127.

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