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Original Article

Gemals, a new drug candidate, extends lifespan and improves electromyographic parameters in a rat model of amyotrophic lateral sclerosis

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Pages 85-90 | Received 26 Jun 2006, Accepted 22 Nov 2007, Published online: 10 Jul 2009

References

  • Rosen D. R., Siddique T., Patterson D., Figlewicz D. A., Sapp P., Hentati A., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993; 362: 59–62
  • Nagai M., Re D. B., Nagata T., Chalazonitis A., Jessell T. M., Wichterle H., et al. Astrocytes expressing ALS‐linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 2007; 10: 615–22
  • Howland D. S., Liu J., She Y., Goad B., Maragakis N. J., Kim B., et al. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant mediated amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2002; 99: 1604–9
  • Philippeau M., Manto M., Sokolow S., Laute M. A., Brion J. P., Pandolfo M., et al. Recent advances in transgenic models of ALS: electrophysiological, morphological and neurochemical characterization of hSOD‐1 G93A transgenic rats. Recent Research Developments in Physiology 2005; 3: 13–31
  • Carri M. T., Grignashi G., Bendotti C. Targets in ALS: designing multi‐drug therapies. Trends Pharmacol Sci 2006; 27: 267–73
  • Mangas A., Covenas R., Bodet D., Dabadie M. P., Glaize G., Geffard M. Evaluation of the effects of a new drug on brain leukocyte infiltration in an experimental model of autoimmune encephalomyelitis. Letters in Drug Design & Discovery 2006; 3: 138–48
  • Pimm M. V., Hudecz F. Biodistribution in tumour‐bearing mice of polycationic, amphoteric and polyanionic branched polypeptides with a poly‐L‐lysine backbone labelled with 125I and 111In: tumour accumulation less than that of labelled serum proteins. J Cancer Res Clin Oncol 1996; 122: 45–54
  • Ali M., Hicks A. E., Hellewell P. G., Thoma G., Norman K. E. Polymers bearing sLex mimetics are superior inhibitors of E‐selectin‐dependent leukocyte rolling in vivo. FASEB J 2004; 18: 152–4
  • Daube J. R. Electrodiagnostic studies in amyotrophic lateral sclerosis and other motor neuron disorders. Muscle Nerve 2000; 23: 1488–502
  • Blondeau N., Widmann C., Lazdunski M., Heurteaux C. Polyunsaturated fatty acids induce ischaemic and epileptic tolerance. Neuroscience 2002; 109: 231–41
  • Yoshida H., Yanai H., Namiki Y., Fukatsu‐Sasaki K., Furutani N., Tada N. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev 2006; 12: 9–20
  • Agar J., Durham H. Relevance of oxidative injury in the pathogenesis of motor neuron diseases. Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4: 232–42
  • Salauze L., van der Velden C., Lagroye I., Veyret B., Geffard M. Circulating antibodies to cysteinyl catecholamines in amyotrophic lateral sclerosis and Parkinson's disease patients. Amyotroph Lateral Scler Other Motor Neuron Disord 2005; 6: 226–33
  • Ferri A., Cozzolino M., Crosio C., Nencini M., Casciati A., Gralla E. B., et al. Familial ALS‐superoxide dismutases associate with mitochondria and shift their redox potentials. Proc Natl Acad Sci U S A 2006; 103: 13860–5
  • Ward R., Cirkovic‐Vellichovia T., Ledeque F., Tirizitis G., Dubars G., Datla K., et al. Neuroprotection by taurine and taurine analogues. Adv Exp Med Biol 2006; 583: 299–306
  • El Idrissi A. Taurine increases mitochondrial buffering of calcium: role in neuroprotection. Amino Acids 2008; 34: 321–8
  • Crouzin N., De Jesus Ferreira M. C., Cohen‐Solal C., Aimar R. F., Vignes M., Guiramand J. Alpha‐tocopherol‐mediated long‐lasting protection against oxidative damage involves an attenuation of calcium entry through TRP‐like channels in cultured hippocampal neurons. Free Radic Biol Med 2007; 42: 1326–37
  • Qiu S., Li L., Weeber E. J., May J. M. Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. J Neurosci Res 2007; 85: 1046–56
  • Wang W. P., Iyo A. H., Miguel‐Hidalgo J., Regunathan S., Zhu M. Y. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res 2006; 1084: 210–6
  • Matsumoto A., Okada Y., Nakamichi M., Nakamura M., Toyama Y., Sobue G., et al. Disease progression of human SOD1 (G93A) transgenic ALS model rats. J Neurosci Res 2006; 83: 119–33
  • Ravits J., Laurie P., Fan Y., Moore D. H. Implications of ALS focality: rostral‐caudal distribution of lower motor neuron loss post mortem. Neurology 2007; 68: 1576–82

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