98
Views
0
CrossRef citations to date
0
Altmetric
Meta-analysis

The effect of different levothyroxine administration regimens on thyroid hormone levels: a systematic review, pairwise, and network meta-analysis

ORCID Icon, , , , &
Pages 275-291 | Received 06 Nov 2023, Accepted 30 Jan 2024, Published online: 05 Feb 2024

References

  • Taylor PN, Albrecht D, Scholz A, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14(5):301–316. doi: 10.1038/nrendo.2018.18
  • Vanderpump M. The epidemiology of thyroid disease. Br Med Bull. 2011;99(1):39–51. doi: 10.1093/bmb/ldr030
  • Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid Off J Am Thyroid Assoc. 2014;24(12):1670–1751. doi: 10.1089/thy.2014.0028
  • Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of clinical Endocrinologists and the American thyroid Association. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2012;18(6):988–1028. doi: 10.4158/EP12280.GL
  • Wiesner A, Gajewska D, Paśko P. Levothyroxine interactions with food and dietary supplements–a systematic review. Pharmaceuticals. 2021;14(3):206. doi: 10.3390/ph14030206
  • Alorda MB, Squillace C, Álvarez P, et al. Drug treatment adherence in adult women with primary hypothyroidism. Rev Argent Endocrinol Metab. 2015;52:66–72.
  • Lee KP, Ah Y-M, Choi HD. Comparison on Efficacy of Administration Time of Levothyroxine in patients with hypothyroidism: a meta-analysis. Korean J Clin Pharm. 2020;30(2):87–91. doi: 10.24304/kjcp.2020.30.2.87
  • Pang X, Pu T, Xu L, et al. Effect of l ‐thyroxine administration before breakfast vs at bedtime on hypothyroidism: a meta‐analysis. Clin Endocrinol (Oxf). 2020;92(5):475–481. doi: 10.1111/cen.14172
  • Chiu HH, Larrazabal R, Uy AB, et al. Weekly versus daily levothyroxine tablet replacement in adults with hypothyroidism: a meta-analyis. J ASEAN Fed Endocr Soc. 2021 [cited 2023 May 20];36(2). doi: 10.15605/jafes.036.02.07
  • Dutta D, Jindal R, Kumar M, et al. Efficacy and safety of once weekly thyroxine as compared to daily thyroxine in managing primary hypothyroidism: a systematic review and meta-analysis. Indian J Endocr Metab. 2021;25(2):76. doi: 10.4103/ijem.IJEM_789_20
  • Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ. 2021;372:n160. doi: 10.1136/bmj.n160
  • Ouzzani M, Hammady H, Fedorowicz Z, et al. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. doi: 10.1186/s13643-016-0384-4
  • Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. doi: 10.1136/bmj.l4898
  • Elbourne DR, Altman DG, Higgins JPT, et al. Meta-analyses involving cross-over trials: methodological issues. Int J Epidemiol. 2002;31(1):140–149. doi: 10.1093/ije/31.1.140
  • Lu G, Ades AE. Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med. 2004;23(20):3105–3124. doi: 10.1002/sim.1875
  • GRADE handbook [Internet]. [cited 2023 Jul 25]. Available from: https://gdt.gradepro.org/app/handbook/handbook.html.
  • Belur J, Tompson L, Thornton A, et al. Interrater Reliability in systematic review methodology: exploring variation in coder decision-making. 2021 [cited 2023 May 20]; Available from: https://journals.sagepub.com/doi/full/10.1177/0049124118799372.
  • Bach-Huynh T-G, Nayak B, Loh J, et al. Timing of levothyroxine administration affects serum thyrotropin concentration. J Clin Endocrinol Metab. 2009;94(10):3905–3912. doi: 10.1210/jc.2009-0860
  • Bolk N. Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial. Arch Intern Med. 2010;170(22):1996. doi: 10.1001/archinternmed.2010.436
  • Hossain S, Banerjee M, Mondal S, et al. A comparative study on effect of evening versus morning intake of levothyroxine in patients of hypothyroidism. Thyroid Res Pract. 2018;15(2):89. doi: 10.4103/trp.trp_11_18
  • Rajput R, Pathak V. The effect of daily versus weekly levothyroxine replacement on thyroid function test in hypothyroid patients at a tertiary care centre in Haryana. Eur Thyroid J. 2017;6(5):250–254. doi: 10.1159/000477348
  • Srivastava S, Sharma G, Rathore M, et al. A crossover study evaluating effect of timing of levothyroxine on thyroid hormone status in patients of hypothyroidism. J Assoc Physicians India. 2018 Sep 1;66(9):37.
  • Bornschein A, Paz-Filho G, Graf H, et al. Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study. Arq Bras Endocrinol Metabol. 2012;56(4):250–258. doi: 10.1590/S0004-27302012000400006
  • De Mello RB, Giassi K, Stahl G, et al. Evaluation of bedtime vs. Morning levothyroxine intake to control hypothyroidism in older patients: a pragmatic crossover randomized clinical trial. Front Med. 2022;9:828762. doi: 10.3389/fmed.2022.828762
  • Perez CLS, Araki FS, Graf H, et al. Serum thyrotropin levels following levothyroxine administration at breakfast. Thyroid: Offic J Am Thyroid Association. 2013;23(7):779–784. doi: 10.1089/thy.2012.0435
  • Skelin M, Lucijanić T, Liberati-Čizmek A-M, et al. Effect of timing of levothyroxine administration on the treatment of hypothyroidism: a three-period crossover randomized study. Endocrine. 2018;62(2):432–439. doi: 10.1007/s12020-018-1686-1
  • Cappelli C, Pirola I, Daffini L, et al. A double-blind placebo-controlled trial of liquid thyroxine ingested at breakfast: results of the TICO study. Thyroid: Offic J Am Thyroid Association. 2016;26(2):197–202. doi: 10.1089/thy.2015.0422
  • Morelli S, Reboldi G, Moretti S, et al. Timing of breakfast does not influence therapeutic efficacy of liquid levothyroxine formulation. Endocrine. 2016;52(3):571–578. doi: 10.1007/s12020-015-0788-2
  • Ala S, Akha O, Kashi Z, et al. Dose administration time from before breakfast to before dinner affect thyroid hormone levels? Casp J Intern Med. 2015;6:134–140. doi: 10.1155/2015/156375
  • Grebe SKG, Cooke RR, Ford HC. Treatment of hypothyroidism with Once weekly thyroxine. J Clin Endocrinol Metab. 1997;82(3):870–875. doi: 10.1210/jc.82.3.870
  • Taylor J, Williams BO, Frater J, et al. Twice-weekly dosing for thyroxine replacement in elderly patients with primary hypothyroidism. J Int Med Res. 1994;22(5):273–277. doi: 10.1177/030006059402200504
  • Murad MH, Mustafa RA, Schünemann HJ, et al. Rating the certainty in evidence in the absence of a single estimate of effect. Evid Based Med. 2017;22(3):85–87. doi: 10.1136/ebmed-2017-110668
  • Trifirò G, Parrino F, Sultana J, et al. Drug interactions with levothyroxine therapy in patients with hypothyroidism: observational study in general practice. Clin Drug Investig. 2015;35(3):187–195. doi: 10.1007/s40261-015-0271-0
  • Fallahi P, Ferrari SM, Antonelli A. Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study. Endocrine. 2016;52(3):597–601. doi: 10.1007/s12020-015-0836-y
  • Virili C, Giovanella L, Fallahi P, et al. Levothyroxine therapy: changes of TSH levels by switching patients from tablet to liquid formulation. A systematic review and meta-analysis. Front Endocrinol. 2018;9:10. doi: 10.3389/fendo.2018.00010

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.