Parental Age at Conception and the Relationship with Severity of Autism Symptoms

References

• Matson JL. Current status of differential diagnosis for children with autism spectrum disorders. Res Dev Disabil. 2007;28(2):109–18. doi:10.1016/j.ridd.2005.07.005.
   PubMed Web of Science ®Google Scholar
• Tidmarsh L, Volkmar FR. Diagnosis and epidemiology of autism spectrum disorders. Canadian J Psychiatry. 2003;48:517. doi:10.1177/070674370304800803.
   PubMed Web of Science ®Google Scholar
• Kanner L. Autistic distubances of affective contact. Nerv Child. 1943;2:217–50.
   Google Scholar
• Brereton AV, Tonge BJ, Einfeld SL. Psychopathology in children and adolescents with autism compared to young people with intellectual disability. J Autism Dev Disord. 2006;36:863–70. doi:10.1007/s10803-006-0125-y.
   PubMed Web of Science ®Google Scholar
• Leekam SR, Prior MR, Uljarevic M. Restricted and repetitive behaviors in autism spectrum disorders: a review of research in the last decade. Psychol Bull. 2011;137:562–93. doi:10.1037/a0023341.
   PubMed Web of Science ®Google Scholar
• Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z, Kurzius-Spencer M, Zahorodny W, Robinson Rosenberg C, White T, et al. Prevalence of autism spectrum disorder among children aged 8 years – autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveill Summ. 2018;67(No. SS–6):1–23. doi:10.15585/mmwr.ss6706a1.
   PubMed Web of Science ®Google Scholar
• Matson JL, Kozlowski AM. The increasing prevalence of autism spectrum disorders. Res Autism Spectr Disord. 2011;5:418–25. doi:10.1016/j.rasd.2010.06.004.
   Web of Science ®Google Scholar
• Hansen SN, Schendel DE, Parner ET. Explaining the increase in the prevalence of autism spectrum disorders: the proportion attirubutable to change in reporting practices. JAMA Pediatr. 2015;169:56–62. doi:10.1001/jamapediatrics.2014.1893.
   PubMed Web of Science ®Google Scholar
• Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Miller J, Fedele A, Collins J, Smith K, et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry. 2011;68:1095–102. doi:10.1001/archgenpsychiatry.2011.76.
   PubMed Web of Science ®Google Scholar
• Despert JL. Some considerations relating to the genesis of autistic behavior in children. Am J Orthopsychiatry. 1951;21:335–50.
   PubMed Web of Science ®Google Scholar
• Eveloff HH. The autistic child. Arch Gen Psychiatry. 1960;3:66–81.
   PubMed Web of Science ®Google Scholar
• Yassa HA. Autism: a form of lead and mercury toxicity. Environ Toxicol Pharmacol. 2014;38:1016–1024.
   PubMed Web of Science ®Google Scholar
• Roberts EM, English PB, Grether JK, Windham GC, Somberg L, Wolff C. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the california central valley. Environ Health Perspect. 2007;115:1482–89. doi:10.1289/ehp.10168.
   PubMed Web of Science ®Google Scholar
• Chase S. Autism in children with congenital rubella. J Autism Child Schizophr. 1971;1:33–47.
   PubMedGoogle Scholar
• Fatemi SH, Folsom TD, Reutiman TJ, Abu-Odeh D, Mori S, Huang H, Oishi K. Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice. Schizophr Res. 2009;112:46–53. doi:10.1016/j.schres.2009.04.014.
   PubMed Web of Science ®Google Scholar
• Sullivan KM. Iodine deficiency as a cause of autism. J Neurol Sci. 2009;276:202. doi:10.1016/j.jns.2008.09.016.
   PubMed Web of Science ®Google Scholar
• Roman GC. Autism: transient in utero hypothyroxinemia related to maternal flavanoid ingestion during pregnancy and to other environmental antithyroid agents. J Neurol Sci. 2007;262:15–26. doi:10.1016/j.jns.2007.06.023.
   PubMed Web of Science ®Google Scholar
• Andersen SL, Laurberg P, Wu C, Olsen J. Attention deficity hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study. BJOG: Int J Obstetrics Gynaecology. 2014;121:1365–74. doi:10.1111/1471-0528.12681.
   PubMed Web of Science ®Google Scholar
• Mathews TJ, Hamilton BE. Delayed child bearing: more women are having their first child later in life. Hyattsville (MD): National Center for Health Statistics; 2009. NCHS data brief, 2. 1–8.
   Google Scholar
• Hediger ML, Bell EM, Druschel CM, Buck Louis GM. Assisted reproductive technologies and children’s neurodevelopmental outcomes. Fertil Steril. 2013;99:311–17. doi:10.1016/j.fertnstert.2012.12.013.
   PubMed Web of Science ®Google Scholar
• Hook EB, Cross PK, Schreinemachers DM. Chromosomal abmormality rates at amniocentesis and in live-born infants. J Am Med Assoc. 1983;249:2034–38.
   PubMed Web of Science ®Google Scholar
• Deciphering Developmental Disorders Study. Prevalence and architecture of de novo mutations in developmental disorders. Nature. 2017;542:433–38. doi:10.1038/nature21062.
   PubMed Web of Science ®Google Scholar
• Jónsson H, Sulem P, Kehr B, Kristmundsdottir S, Zink F, Hjartarson E, Stefansson K. Parental influence on human germline de novo mutations in 1,548 trios from Iceland. Nature. 2017;549:519–22. doi:10.1038/nature24018.
   PubMed Web of Science ®Google Scholar
• Gaugler T, Klei L, Sanders SJ, Bodea CA, Goldberg AP, Lee AB, Buxbaum JD. Most genetic risk for autism resides with common variations. Nat Genet. 2014;46:881–85. doi:10.1038/ng.3039.
   PubMed Web of Science ®Google Scholar
• Itzchak EB, Lahat E, Zachor DA. Advanced parental ages and low birth weight in autism spectrum disorders: rates and effect on functioning. Res Dev Disabil. 2011;32:1776–81. doi:10.1016/j.ridd.2011.03.004.
   PubMed Web of Science ®Google Scholar
• Steffenburg S, Gillberg C, Hellgren L, Andersson L, Gillberg IC, Jakobsson G, Bohman M. A twin study of autism in denmark, finland, iceland, norway, and sweden. J Child Psychol Psychiatry. 1989;30:405–16.
   PubMed Web of Science ®Google Scholar
• Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Risch N. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry. 2011;68:1095–102. doi:10.1001/archgenpsychiatry.2011.76.
   PubMed Web of Science ®Google Scholar
• McGrath JJ, Petersen L, Agerbo E, Mors O, Mortensen PB, Pedersen CB. A comprehensive assessment of parental age and psychiatric disorders. JAMA Psychiatry. 2014;71(3):301–09. doi:10.1001/jamapsychiatry.2013.4081.
   PubMed Web of Science ®Google Scholar
• Lampi KM, Hinkka-Yli-Salomaki S, Lehti V, Helenius H, Gissler M, Brown AS, Sourander A. Parental age and risk of autism spectrum disorders in a Finnish naitonal birth cohort. J Autism Dev Disord. 2013;43:2526–35. doi:10.1007/s10803-013-1801-3.
   PubMed Web of Science ®Google Scholar
• Shelton JF, Tancredi DJ, Hertz-Picciotto I. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Res. 2010;3:30–39. doi:10.1002/aur.116.
   PubMed Web of Science ®Google Scholar
• Gabis L, Raz R, Kesner-Baruch Y. Paternal age in autism spectrum disorders and ADHD. Pediatr Neurol. 2010;43:300–02. doi:10.1016/j.pediatrneurol.2010.05.022.
   PubMed Web of Science ®Google Scholar
• Parner ET, Baron-Cohen S, Lauritsen MB, Jorgensen M, Schieve LA, Yeargin-Allsopp M, Obel C. Parental age and autism spectrum disorders. Ann Epidemiol. 2012;22:143–50. doi:10.1016/j.annepidem.2011.12.006.
   PubMed Web of Science ®Google Scholar
• Matson JL, Gonzalez ML. Autism spectrum disoders – child version. Baton Rouge (LA): Disability Consultants, LLC; 2007.
   Google Scholar
• Matson JL, Gonzalez ML, Wilkins J, Rivet TT. Reliability of the autism spectrum disoder-diagnosis for children (ASD-DC). Res Autism Spectr Disord. 2007;2:533–45. doi:10.1016/j.rasd.2007.11.001.
   Web of Science ®Google Scholar
• Schopler E, Reichler RJ, DeVellis RF, Daly K. Toward objective classification of childhood autism: childhood autism rating scale (CARS). J Autism Dev Disord. 1980;10:91–103.
   PubMed Web of Science ®Google Scholar
• Lord C, Rutter M. Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994;24:659–85. doi:10.1007/BF02172145.
   PubMed Web of Science ®Google Scholar
• Matson JL, Mahan S, Hess JA, Fodstad JC, Neal D. Convergent validity of the autism spectrum disorder-diagnostic for children (ASD-DC) and childhood autism rating scales (SCARS). Res Autism Spectr Disord. 2010;4:633–38. doi:10.1016/j.rasd.2009.12.007.
   Web of Science ®Google Scholar
• Matson JL, Gonzalez ML, Wilkins J. Validity study of the autism specturm disorders – diagnostic for children (ASD-DC). Res Autism Spectr Disord. 2009;3:196–206. doi:10.1016/j.rasd.2008.05.005.
   Web of Science ®Google Scholar
• Rubin LH, Witkiewitz K, St. Andre J, Reilly S. Methods for handling missing data in the behavioral nuerosciences: don’t throw the baby rat out with the bath water. J Undergrad Neurosci Educ. 2007;5:A71–A77.
   PubMedGoogle Scholar
• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.
   PubMed Web of Science ®Google Scholar
• Field AP. Discovering statistics using SPSS. 3rd. Los Angeles (CA): SAGE Publications; 2009.
   Google Scholar