1,940
Views
3
CrossRef citations to date
0
Altmetric
Clinical Corner: Communication

Insulin resistance in patients with recurrent pregnancy loss is associated with lymphocyte population aberration

, , , &
Pages 397-404 | Received 01 Mar 2017, Accepted 27 Jul 2017, Published online: 31 Oct 2017

References

  • ASRM (2013) Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril 99: 63.
  • Abu Hashim, H. (2016) Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence? Reprod Biomed Online 32: 44–53.
  • Al-biate, M.A. (2015) Effect of metformin on early pregnancy loss in women with polycystic ovary syndrome. Taiwan J Obstet Gynecol 54: 266–269.
  • Aljiffry, M., Hassanain, M., Schricker, T., Shaheen, M., Nouh, T., Lattermann, R., et al. (2016) Effect of Insulin Therapy using Hyper-insulinemic Normoglycemic Clamp on Inflammatory Response in Brain Dead Organ Donors. Exp Clin Endocrinol Diabetes 124: 318–323.
  • Banu, J., Fatima, P., Sultana, P., Chowdhury, M.A., Begum, N., Anwary, S.A., et al. (2014) Association of infertile patients having polycystic ovarian syndrome with recurrent miscarriage. Mymensingh Med J 23: 770–773.
  • Chakraborty, P., Goswami, S.K., Rajani, S., Sharma, S., Kabir, S.N., Chakravarty, B, et al. (2013) Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance. PLoS One 8: e64446.
  • Chen, X., Yang, D., Li, L., Feng, S. and Wang, L. (2006) Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome. Hum Reprod 21: 2027–2032.
  • Ghaffarzad, A., Amani, R., Mehrzad Sadaghiani, M., Darabi, M. and Cheraghian, B. (2016) Correlation of Serum Lipoprotein Ratios with Insulin Resistance in Infertile Women with Polycystic Ovarian Syndrome: A Case Control Study. Int J Fertil Steril 10: 29–35.
  • Gonzalez, F. (2012) Inflammation in Polycystic Ovary Syndrome: underpinning of insulin resistance and ovarian dysfunction. Steroids 77: 300–305.
  • Gunton, J.E., Delhanty, P.J., Takahashi, S. and Baxter, R.C. (2003) Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J Clin Endocrinol Metab 88: 1323–1332.
  • Jinno, M., Kondou, K. and Teruya, K. (2010) Low-dose metformin improves pregnancy rate in in vitro fertilization repeaters without polycystic ovary syndrome: prediction of effectiveness by multiple parameters related to insulin resistance. Hormones (Athens) 9: 161–170.
  • Kanninen, T.T., DeAndrade Ramos, B.R., Jaffe, S., Bongiovanni, A.M., Linhares, I.M., Renzo, G.C., et al. (2013) Inhibition of autophagy by sera from pregnant women. Reprod Sci 20: 1327–1331.
  • Kaur, R. and Gupta, K. (2016) Endocrine dysfunction and recurrent spontaneous abortion: An overview. Int J Appl Basic Med Res 6: 79–83.
  • Kim, D.J., Lee, S.K., Kim, J.Y., Na, B.J., Hur, S.E., Lee, M., et al. (2014) Intravenous immunoglobulin G modulates peripheral blood Th17 and Foxp3(+) regulatory T cells in pregnant women with recurrent pregnancy loss. Am J Reprod Immunol 71: 441–450.
  • Konopka, A.R., Esponda, R.R., Robinson, M.M., Johnson, M.L., Carter, R.E., Schiavon, M., et al. (2016) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 15: 1394–1400.
  • Kumagai, J., Hirahara, K. and Nakayama, T. (2016) Pathogenic Th cell subsets in chronic inflammatory diseases. Nihon Rinsho Meneki Gakkai Kaishi 39: 114–123.
  • Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. and Turner, R.C. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412–419.
  • Miehle, K., Stepan, H. and Fasshauer, M. (2012) Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia. Clin Endocrinol (Oxf) 76: 2–11.
  • Nakagawa, K., Kwak-Kim, J., Ota, K., Kuroda, K., Hisano, M., Sugiyama, R., et al. (2015) Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. Am J Reprod Immunol 73: 353–361.
  • Narender, T., Khaliq, T., Singh, A.B., Joshi, M.D., Mishra, P., Chaturvedi, J.P., et al. (2009) Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity. Eur J Med Chem 44: 1215–1222.
  • Perez Leiros, C. and Ramhorst, R. (2013) Tolerance induction at the early maternal-placental interface through selective cell recruitment and targeting by immune polypeptides. Am J Reprod Immunol 69: 359–368.
  • Rojas, L.B. and Gomes, M.B. (2013) Metformin: an old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr 5: 6.
  • Sainz, N., Gonzalez-Navarro, C.J., Martinez, J.A. and Moreno-Aliaga, M.J. (2015) Leptin signaling as a therapeutic target of obesity. Expert Opin Ther Targets 19: 893–909.
  • Saxena, P., Prakash, A. and Nigam, A. (2011) Efficacy of 2-hour post glucose insulin levels in predicting insulin resistance in polycystic ovarian syndrome with infertility. J Hum Reprod Sci 4: 20–22.
  • Serdynska-Szuster, M., Banaszewska, B., Spaczynski, R. and Pawelczyk, L. (2011) [Effects of metformin therapy on markers of coagulation disorders in hyperinsulinemic women with polycystic ovary syndrome]. Ginekol Pol 82: 259–264.
  • Sereshki, N., Gharagozloo, M., Ostadi, V., Ghahiri, A., Roghaei, M.A., Mehrabian, F., et al. (2014) Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion. Int J Fertil Steril 8: 59–66.
  • Shankarkumar, U., Pradhan, V.D., Patwardhan, M.M., Shankarkumar, A. and Ghosh, K. (2011) Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients. Niger Med J 52: 163–166.
  • Shi, X.B., Zhang, J.F., and Fu, S.X. (2008) Correlation of peripheral T lymphocyte subsets and steroid hormone in patients of PCOS. China Journal of Modern Medicine 18: 2362–2365.
  • Solano, M.E., Sander, V.A., Ho, H., Motta, A.B. and Arck, P.C. (2011) Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS). J Reprod Immunol 92: 33–44.
  • Tomczynska, M., Bijak, M. and Saluk, J. (2016) Metformin - the drug for the treatment of autoimmune diseases; a new use of a known anti-diabetic drug. Curr Top Med Chem 16: 2223–2230.
  • Wang, Q., Guo, T., Tao, Y., Wang, Q., Song, Y. and Huang, W. (2011) Association between serum adipocyte factor level and insulin resistance in polycystic ovarian syndrome. Gynecol Endocrinol 27: 931–934.
  • Yamada, H., Morikawa, M., Kato, E.H., Shimada, S., Kobashi, G. and Minakami, H. (2003) Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype. Am J Reprod Immunol 50: 351–354.
  • Zawiejska, A., Wender-Ozegowska, E., Grewling-Szmit, K., Brazert, M. and Brazert, J. (2016) Short-term antidiabetic treatment with insulin or metformin has a similar impact on the components of metabolic syndrome in women with gestational diabetes mellitus requiring antidiabetic agents: results of a prospective, randomised study. J Physiol Pharmacol 67: 227–233.
  • Zhu, L.Y., Chen, X., Xu, Z.Z., Xu, L., Mao, T. and Zhang, H. (2015) Changes and clinical significance of peripheral blood helper T lymphocyte and natural killer (NK) cells in unexplained recurrent spontaneous abortion (URSA) patients after abortion and successful pregnancy. Clin Exp Obstet Gynecol 42: 62–66.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.