Dietary fluted pumpkin seeds induce reversible oligospermia and androgen insufficiency in adult rats

References

• Abarikwu SO. 2014. Protective effect of quercetin on atrazine-induced oxidative stress in the liver, kidney, brain, and heart of adult Wistar rats. Toxicol Int. 21(2):148–155.
   PubMedGoogle Scholar
• Abarikwu SO, Adesiyan AC, Oyeloja TO, Oyeyemi MO, Farombi EO. 2010. Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine. Arch Environ Contam Toxicol. 58(3):874–882.
   PubMed Web of Science ®Google Scholar
• Abarikwu SO, Akiri OF, Durojaiye MA, Adenike A. 2015. Combined effects of repeated administration of Bretmont Wipeout (glyphosate) and UltraZin (atrazine) on testosterone, oxidative stress and sperm quality of Wistar rats. Toxicol Mech Methods. 25(1):70–80.
   PubMed Web of Science ®Google Scholar
• Abarikwu SO, Njoku RC, Onuah CL. 2018. Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats. J Basic Clin Physiol Pharmacol. 29(4):365–376.
   PubMedGoogle Scholar
• Abarikwu SO, Ogunlaja A, Otuechere CA, Gideon O. 2017. Effect of ethanolic extract from seeds or pods of Xylopia aethiopica (dunal) a. rich (annonaceae) on the testicular function of adult male rats. Indian J Clin Biochem. 32(4):420–428.
   PubMed Web of Science ®Google Scholar
• Abarikwu SO, Otuechere CA, Ekor M, Monwuba K, Osobu D. 2012. Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats. Toxicol Int. 19(2):207–214.
   PubMedGoogle Scholar
• Abdel-Magied EM, Abdel-Rahman HA, Harraz FM. 2001. The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. J Ethnopharmacol. 75(1):1–4.
   PubMed Web of Science ®Google Scholar
• Adisa WA, Okhiai O, Bankole JK, Iyamu OA, Aigbe O. 2014. Testicular damage in Telfairia occidentalis extract treated Wista rats. Am J Med Biol Res. 2(2):37–45.
   Google Scholar
• Aghaei S, Nikzad H, Taghizadeh M, Tameh AA, Taherian A, Moravveji A. 2014. Protective effect of pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with cyclophosphamide. Andrologia. 46(8):927–935.
   PubMed Web of Science ®Google Scholar
• Ain QU, David M, Shah Q, Ahmad M, Jahan S. 2018. Antifertility effect of methanolic leaf extract of Chenopodium ambrosioides hook in male Sprague Dawley rats. Andrologia. 50(10):e13129.
   PubMed Web of Science ®Google Scholar
• Aitken RJ, Roman SD. 2008. Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev. 1(1):15–24.
   PubMed Web of Science ®Google Scholar
• Akang E, Oremosu A, Dosumu O, Ejiwunmi A. 2011. Telfairia occidentalis, a prophylactic medicine for alcohol‘s damaging effect on the testis. Maced J Med Sci. 4(4):380–387.
   Google Scholar
• Akoroda MO. 1990. Ethnobotany of Telfairia occidentalis (cucurbitaceae) among Igbos of Nigeria. Econ bot. 44(1):29–39.
   Web of Science ®Google Scholar
• Akwaowo EU, Ndon BA, Etuk EU. 2000. Minerals and antinutrients in fluted pumpkin (Telfairia occidentalis Hook f.). Food Chemistry. 70(2):235–240.
   Web of Science ®Google Scholar
• Amory JK. 2016. Male contraception. Fertil Steril. 106(6):1303–1309.
   PubMed Web of Science ®Google Scholar
• Anawalt BD, Amory JK. 2001. Advances in male hormonal contraception. Ann Med. 33(9):587–595.
   PubMed Web of Science ®Google Scholar
• Chauhan A, Agarwal M. 2010. Evaluating the antifertility potential of an aqueous extract from cassia fistula seeds in male rats. Fertil Steril. 93(5):1706–1710.
   PubMed Web of Science ®Google Scholar
• Clairborne A. 1995. Catalase activity. In: Greewald AR, editor. Handbook of methods for oxygen radical research. Boca Raton (FL): CRC Press; p. 237–242.
   Google Scholar
• Coutinho EM. 2002. Gossypol: a contraceptive for men. Contraception. 65(4):259–263.
   PubMed Web of Science ®Google Scholar
• D‘Cruz SC, Vaithinathan S, Jubendradass R, Mathur PP. 2010. Effects of plants and plant products on the testis. Asian J Androl. 12(4):468–479.
   PubMed Web of Science ®Google Scholar
• Diemer T, Allen JA, Hales KH, Hales DB. 2003. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinol. 144(7):2882–2891.
   PubMed Web of Science ®Google Scholar
• Eseyin OA, Daniel A, Paul TS, Attih E, Emmanuel E, Ekarika J, Zubaid ASM, Ashfaq A, Afzal S, Ukeme A. 2018. Phytochemical analysis and antioxidant activity of the seed of Telfairia occidentalis Hook (Cucurbitaceae). Nat. Prod Res. 32(4):444–447.
   PubMed Web of Science ®Google Scholar
• Foster WG, Maharaj-Briceño S, Cyr DG. 2010. Dioxin-induced changes in epididymal sperm count and spermatogenesis. Environ Health Perspect. 118(4):458–464.
   PubMed Web of Science ®Google Scholar
• França LR, Leal MC, Sasso-Cerri E, Vasconcelos A, Debeljuk L, Russell LD. 2000. Cimetidine (Tagamet) is a reproductive toxicant in male rats affecting peritubular cells. Biol Reprod. 63(5):1403–1412.
   PubMed Web of Science ®Google Scholar
• Ghosh A, Jana K, Pakhira BP, Tripathy A, Ghosh D. 2015. Anti-fertility effect of aqueous-ethanolic (1:1) extract of the fruit of Terminalia chebula: rising approach towards herbal contraception. Asian Pac J Reprod. 4(3):201–207.
   Google Scholar
• Herdiman J, Nakash A, Beedham T. 2006. Male contraception: past, present and future. J Obstet Gynaecol. 26(8):721–727.
   PubMedGoogle Scholar
• Hu X, Ge X, Liang W, Shao Y, Jing J, Wang C, Zeng R, Yao B. 2018. Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis. Syst Biol Reprod Med. 64(5):368–380.
   PubMed Web of Science ®Google Scholar
• Domínguez-Vías G, Segarra AB, Martínez-Cañamero M, Ramírez-Sánchez M, Prieto I. 2017. Influence of a virgin olive oil versus butter plus cholesterol-enriched diet on testicular enzymatic activities in adult male rats. Int J Mol Sci. 18(8):1701–1711.
   Web of Science ®Google Scholar
• Jana K, Samanta PK, De DK. 2010. Nicotine diminishes testicular gametogenesis, steroidogenesis, and steroidogenic acute regulatory protein expression in adult albino rats: possible influence on pituitary gonadotropins and alteration of testicular antioxidant status. Toxicol Sci. 116(2):647–659.
   PubMed Web of Science ®Google Scholar
• Jing X, Cheng W, Guo S, Zou Y, Zhang T, He L. 2017. Toxic effects of Tripterygium wilfordii Hook F on the reproductive system of adolescent male rats. Biomed Pharmacother. 95:1338–1345.
   PubMed Web of Science ®Google Scholar
• Kanakis GA, Goulis DD. 2015. Male contraception: a clinically-oriented review. Hormones. 14(4):598–614.
   PubMedGoogle Scholar
• Kumar D, Kumar A, Prakash O. 2012. Potential antifertility agents from plants: a comprehensive review. J Ethnopharmacol. 140(1):1–32.
   PubMed Web of Science ®Google Scholar
• Lim W, Ham J, Park S, Bae H, You S, Song G. 2019. Gossypol induces disruption of spermatogenesis and steroidogenesis in male mice. J Agric Food Chem. 67(7):2075–2085.
   PubMed Web of Science ®Google Scholar
• Lohiya NK, Manivannan B, Mishra PK, Pathak N, Sriram S, Bhande SS, Panneerdoss S. 2002. Chloroform extract of Carica papaya seeds induces long-term reversible azoospermia in langur monkey. Asian J Androl. 4(1):17–26.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem. 193:265–275.
   PubMed Web of Science ®Google Scholar
• Meistrich ML, Shetty G. 2003. Inhibition of spermatogonial differentiation by testosterone. J Androl. 24(2):135–148.
   PubMedGoogle Scholar
• Meriggiola MC, Pelusi G. 2006. Advances in male hormonal contraception. Expert Opin Investig Drugs. 15(4):389–397.
   PubMed Web of Science ®Google Scholar
• Mishra RK, Singh SK. 2005. Effect of aqueous leaf extract of Azadirachta indica on the reproductive organs in male mice. Indian J Exp Biol. 43(11):1093–1103.
   PubMedGoogle Scholar
• Moron MS, Depierre JW, Mannervik B. 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 582(1):67–78.
   PubMed Web of Science ®Google Scholar
• Naik BS, Dangi NB, Sapkota HP, Wagle N, Nagarjuna S, Sankaranand R. 2016. Phytochemical screening and evaluation of anti-fertility activity of Dactyloctenium aegyptium in male albino rats. Asian Pac J Reprod. 5(1):51–57.
   Google Scholar
• Nelson SK, Bose SK, Grunwald GK, Myhill P, McCord JM. 2006. The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. Free Radic Biol Med. 40(2):341–347.
   PubMed Web of Science ®Google Scholar
• Nieschlag E, Zitzmann M, Kamischke A. 2003. Use of progestins in male contraception. Steroids. 68(10–13):965–972.
   PubMed Web of Science ®Google Scholar
• Njoku RCC, Abarikwu SO, Uwakwe AA, Mgbudom‐Okah CJ. 2018. Telfairia occidentalis‐supplemented diet induces changes in sperm parameters and testosterone level in rats. Andrologia. 50:e13044.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95(2):351–358.
   PubMed Web of Science ®Google Scholar
• Plana O. 2017. Male contraception: research, new methods, and implications for marginalized populations. Am J Men’s Health. 11(4):1182–1189.
   PubMed Web of Science ®Google Scholar
• Qian SZ. 1987. Tripterygium wilfordii, a Chinese herb effective in male fertility regulation, Contraception. 36(3):335–345.
   PubMed Web of Science ®Google Scholar
• Rajalakshmi M. 1992. Regulation of male fertility: epididymis as a potential extragonadal site. In: Ghosh D, Sengupta J, editors. Frontiers in reproductive physiology. New Delhi: Wiley Eastern Limited; p. 63–66.
   Google Scholar
• Ribeiro CT, Milhomem R, De Souza DB, Costa WS, Sampaio FJ, Pereira-Sampaio MA. 2014. Effect of antioxidants on outcome of testicular torsion in rats of different ages. J Urol. 191(5):1578–1585.
   PubMed Web of Science ®Google Scholar
• Saalu LC, Kpela T, Benebo AS, Oyewopo AO, Anifowope EO, Oguntola JA. 2010. The dose-dependent testiculoprotective and testiculotoxic potentials of Telfairia occidentalis Hook f. leaves extract in rat. Int J Appl Res Nat Prod. 3(3):27–38.
   Google Scholar
• Santana AT, Guelfi M, Medeiros HC, Travares MA, Bizerra PF, Mingatto FE. 2015. Mechanisms involved in reproductive damage caused by gossypol in rats and protective effect of vitamin E. Biol Res. 48(1):43–51.
   PubMedGoogle Scholar
• Shaha C, Tripathi R, Mishra DP. 2010. Male germ cell apoptosis: regulation and biology. Philos Trans R Soc Lond B Biol Sci. 365(1546):1501–1515.
   PubMed Web of Science ®Google Scholar
• Sofikitis N, Giotitsas N, Tsounapi P, Baltogiannis D, Giannakis D, Pardalidis N. 2008. Hormonal regulation of spermatogenesis and spermiogenesis. Steroid Biochem Mol Biol. 109(3–5):323–330.
   PubMed Web of Science ®Google Scholar
• Szasz G. 1969. A kinetic photometric method for serum γ-glutamyl transpeptidase. Clin Chem. 15(2):124–136.
   PubMed Web of Science ®Google Scholar
• Thakur M, Gupta H, Singh D, Mohanty IR, Maheswari U, Vanage G, Joshi DS. 2014. Histopathological and ultra structural effects of nanoparticles on rat testis following 90 days (Chronic study) of repeated oral administration. J Nanobiotechnol. 12(1):42–55.
   PubMedGoogle Scholar
• Upgade A, Bhaskar A. 2013. Characterization and medicinal importance of phytoconstituents of C. papaya from down south Indian region using gas chromatography and mass spectroscopy. Asian J Pharm Clin Res. 6(4):101–106.
   Google Scholar
• Verma HP, Singh SK. 2017. Antifertility efficacy of Coccinia indica in male mice and its possible mechanisms of action on spermatogenesis. Gen Comp Endocrinol. 241:89–99.
   PubMed Web of Science ®Google Scholar
• Xie S, Li G, Qu L, Zhong R, Chen P, Lu Z, Zhou J, Guo X, Li Z, Ma A, et al. 2017. Podophyllotoxin extracted from Juniperus sabina fruit inhibits rat sperm maturation and fertility by promoting epididymal epithelial cell apoptosis. Evid Based Complement Alternat Med. 2017:6958982.
   PubMed Web of Science ®Google Scholar
• Yakubu MT, Akanji MA, Oladiji AT. 2008. Effects of oral administration of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem on some testicular function indices of male rats. J Ethnopharmacol. 115(2):288–292.
   PubMed Web of Science ®Google Scholar