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Gut Microbes Volume 11, 2020 - Issue 6
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Brief report

Stool processing speed and storage duration do not impact the clinical effectiveness of fecal microbiota transplantation

Jessica R. Allegrettia Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA, USACorrespondence[email protected]
,
Ryan J. Elliottb OpenBiome, Cambridge, MA, USA
,
Alim Ladhab OpenBiome, Cambridge, MA, USA;c Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USAORCID Iconhttps://orcid.org/0000-0003-3945-7924
ORCID Icon,
Mary Njengab OpenBiome, Cambridge, MA, USA
,
Kurt Warrenb OpenBiome, Cambridge, MA, USA
,
Kelsey O’Brienb OpenBiome, Cambridge, MA, USA
,
Shrish Budreeb OpenBiome, Cambridge, MA, USA;d Finch Therapeutics, Somerville, MA, USAORCID Iconhttps://orcid.org/0000-0001-8345-7548
ORCID Icon,
Majdi Osmanb OpenBiome, Cambridge, MA, USA
,
Monika Fischere Division of Gastroenterology, Indiana University, Indianapolis, IN, USA
,
Colleen R. Kellyf Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA
&
Zain Kassamd Finch Therapeutics, Somerville, MA, USA
 show all
Pages 1806-1808 | Received 03 Jan 2020, Accepted 17 Apr 2020, Published online: 18 Jun 2020

References

  • Mullish BH, Quraishi MN, Segal JP, McCune VL, Baxter M, Marsden GL, Moore DJ, Colville A, Bhala N, Iqbal TH, et al. The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines. Gut. 2018;67(11):1920–1941. doi:10.1136/gutjnl-2018-316818.
  • McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, et al. Clinical practice guidelines for clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):987–994. doi:10.1093/cid/ciy149.
  • Smith M, Kassam Z, Edelstein C, Burgess J, Alm E. OpenBiome remains open to serve the medical community. Nat Biotechnol. 2014;32:867. doi:10.1038/nbt.3006.
  • Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A, Weese JS, Collins S, Moayyedi P, Crowther M, et al. Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent clostridium difficile infection: a randomized clinical trial. Jama. 2016;315:142–149. doi:10.1001/jama.2015.18098.
  • Cammarota G, Ianiro G, Kelly CR, Mullish BH, Allegretti JR, Kassam Z, Putignani L, Fischer M, Keller JJ, Costello SP, et al. International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. Gut. 2019;68(12):2111–2121. doi:10.1136/gutjnl-2019-319548.
  • Chu ND, Smith MB, Perrotta AR, Kassam Z, Alm EJ, Zoetendal EG. Profiling living bacteria informs preparation of fecal microbiota transplantations. PLoS One. 2017;12(1):e0170922. doi:10.1371/journal.pone.0170922.

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