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Research Paper

Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial

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Article: 2197837 | Received 16 Nov 2022, Accepted 29 Mar 2023, Published online: 20 Apr 2023

References

  • Vriesman MH, Koppen IJN, Camilleri M, Di Lorenzo C, Benninga MA. Management of functional constipation in children and adults. Nat Rev Gastroenterol Hepatol. 2020;17(1):21–15. doi:10.1038/s41575-019-0222-y.
  • Barberio B, Judge C, Savarino EV, Ford AC. Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysis. The Lancet Gastroenterol Hepatol. 2021;6(8):638–648. doi:10.1016/S2468-1253(21)00111-4.
  • Nag A, Martin SA, Mladsi D, Olayinka-Amao O, Purser M, Vekaria RM. The humanistic and economic burden of chronic idiopathic constipation in the USA: a systematic literature review. Clin Exp Gastroenterol. 2020;13:255–265. doi:10.2147/CEG.S239205.
  • Huang L, Jiang H, Zhu M, Wang B, Tong M, Li H, Lin MB. Prevalence and risk factors of chronic constipation among women aged 50 years and older in Shanghai, China. Med Sci Monit. 2017;23:2660–2667. doi:10.12659/MSM.904040.
  • Gill SK, Rossi M, Bajka B, Whelan K. Dietary fibre in gastrointestinal health and disease. Nat Rev Gastroenterol Hepatol. 2021;18(2):101–116. doi:10.1038/s41575-020-00375-4.
  • Shen L, Huang C, Lu X, Xu X, Jiang Z, Zhu C. Lower dietary fibre intake, but not total water consumption, is associated with constipation: a population-based analysis. J Hum Nutr Diet. 2019;32(4):422–431. doi:10.1111/jhn.12589.
  • Markland AD, Palsson O, Goode PS, Burgio KL, Busby-Whitehead J, Whitehead WE. Association of low dietary intake of fiber and liquids with constipation: evidence from the national health and nutrition examination survey. Am J Gastroenterol. 2013;108(5):796–803. doi:10.1038/ajg.2013.73.
  • McRorie JW, Fahey GC, Gibb RD, Chey WD. Laxative effects of wheat bran and psyllium: resolving enduring misconceptions about fiber in treatment guidelines for chronic idiopathic constipation. J Am Assoc Nurse Pract. 2020;32(1):15–23. doi:10.1097/JXX.0000000000000346.
  • Belorio M, Gomez M. Psyllium: a useful functional ingredient in food systems. Crit Rev Food Sci Nutr. 2022;62(2):527–538. doi:10.1080/10408398.2020.1822276.
  • Stevenson L, Phillips F, O’sullivan K, Walton J. Wheat bran: its composition and benefits to health, a European perspective. Int J Food Sci Nutr. 2012;63(8):1001–1013. doi:10.3109/09637486.2012.687366.
  • Yang C, Liu S, Li H, Bai X, Shan S, Gao P, Dong X. The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis. Aging (Albany NY). 2021;13(11):15366–15383. doi:10.18632/aging.203095.
  • Noureddin S, Mohsen J, Payman A. Effects of psyllium vs. placebo on constipation, weight, glycemia, and lipids: a randomized trial in patients with type 2 diabetes and chronic constipation. Complement Ther Med. 2018;40:1–7. doi:10.1016/j.ctim.2018.07.004.
  • Muller M, Hermes GDA, Emanuel EC, Holst JJ, Zoetendal EG, Smidt H, Troost F, Schaap FG, Damink SO, Jocken JWE, et al. Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit. Gut Microbes. 2020;12(1):1704141. doi:10.1080/19490976.2019.1704141.
  • Wang JK, Yao SK, Ağagündüz D. Roles of gut microbiota and metabolites in pathogenesis of functional constipation. Evid Based Complement Alternat Med. 2021;2021:5560310. doi:10.1155/2021/5560310.
  • Ibarra A, Pelipyagina T, Rueffer M, Evans M, Ouwehand AC. Efficacy of polydextrose supplementation on colonic transit time, bowel movements, and gastrointestinal symptoms in adults: a double-blind, randomized, placebo-controlled trial. Nutr. 2019;11(2):11. doi:10.3390/nu11020439.
  • Finegold SM, Li Z, Summanen PH, Downes J, Thames G, Corbett K, Dowd S, Krak M, Heber D. Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food Funct. 2014;5(3):436–445. doi:10.1039/c3fo60348b.
  • Wang L, Tian P, Wang B, Cui S, Zhao J, Zhang H, Qian L, Wang Q, Chen W, Wang G, et al. A randomised, double-blind, placebo-controlled trial of bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct. 2022;13(3):1628–1640.
  • Erdogan A, Rao SSC, Thiruvaiyaru D, Lee YY, Coss Adame E, Valestin J, O’Banion M. Randomised clinical trial: mixed soluble/insoluble fibre vs. psyllium for chronic constipation. Alimentary Pharmacol Therapeutics. 2016;44(1):35–44. doi:10.1111/apt.13647.
  • Dimidi E, Christodoulides S, Fragkos KC, Scott SM, Whelan K. The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2014;100(4):1075–1084. doi:10.3945/ajcn.114.089151.
  • Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler C, Ismagilov R, Mazmanian S, Hsiao E. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264–276. doi:10.1016/j.cell.2015.02.047.
  • Shekhar C, Monaghan PJ, Morris J, Issa B, Whorwell PJ, Keevil B, Houghton LA. Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin. Gastroenterol. 2013;145(749–57 quiz):e13–4. doi:10.1053/j.gastro.2013.07.014.
  • Tatsuoka M, Osaki Y, Ohsaka F, Tsuruta T, Kadota Y, Tochio T, Hino S, Morita T, Sonoyama K. Consumption of indigestible saccharides and administration of bifidobacterium pseudolongum reduce mucosal serotonin in murine colonic mucosa. Br J Nutr. 2022;127(4):513–525. doi:10.1017/S0007114521001306.
  • Lamichhane S, Yde CC, Forssten S, Ouwehand AC, Saarinen M, Jensen HM, Gibson GR, Rastall R, Fava F, Bertram HC. Impact of dietary polydextrose fiber on the human gut metabolome. J Agric Food Chem. 2014;62(40):9944–9951. doi:10.1021/jf5031218.
  • Picard C, Fioramonti J, Francois A, Robinson T, Neant F, Matuchansky C. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther. 2005;22(6):495–512. doi:10.1111/j.1365-2036.2005.02615.x.
  • Li N, Wang J, Liu P, Li J, Xu C. Multi-omics reveals that bifidobacterium breve M-16V may alleviate the immune dysregulation caused by nanopolystyrene. Environ Int. 2022;163:107191. doi:10.1016/j.envint.2022.107191.
  • Terzo S, Mule F, Caldara GF, Baldassano S, Puleio R, Vitale M, Cassata G, Ferrantelli V, Amato A. Pistachio consumption alleviates inflammation and improves gut microbiota composition in mice fed a high-fat diet. Int J Mol Sci. 2020;21(1):21. doi:10.3390/ijms21010365.
  • Bui TPN, Manneras-Holm L, Puschmann R, Wu H, Troise AD, Nijsse B, Boeren S, Bäckhed F, Fiedler D, deVos WM. Conversion of dietary inositol into propionate and acetate by commensal anaerostipes associates with host health. Nat Commun. 2021;12(1):4798. doi:10.1038/s41467-021-25081-w.
  • Sugitani Y, Inoue R, Inatomi O, Nishida A, Morishima S, Imai T, Kawahara M, Naito Y, Andoh A. Mucosa-associated gut microbiome in Japanese patients with functional constipation. J Clin Biochem Nutr. 2021;68(2):187–192. doi:10.3164/jcbn.20-93.
  • Tian H, Ye C, Yang B, Cui J, Zheng Z, Wu C, Zhou S, Lv X, Qin N, Qin H, et al. Gut metagenome as a potential diagnostic and predictive biomarker in slow transit constipation. Frontiers in Medicine. 2022;8. doi:10.3389/fmed.2021.777961.
  • Zhang C, Jiang J, Tian F, Zhao J, Zhang H, Zhai Q, Chen W. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutrition. 2020;39(10):2960–2969. doi:10.1016/j.clnu.2020.01.005.
  • Chinese Nutrition Society. Dietary guidelines for Chinese residents. Beijing: Renmin Wei Sheng Chu Ban She; 2016.
  • Gastrointestinal Dynamics Group of Gastroenterology Branch of Chinese Medical Association, Collaborative Group of Functional Gastrointestinal Diseases. Expert consensus on chronic constipation in China (2019, Guangzhou). Zhong Hua Xiao Hua Bing Za Zhi. 2019;39:577–598.
  • Zhang B, Baibing M, Wentao W, Guoshuai S, Suhang S, Yezhou L, Xiangyu GA, Shaonong DA, Xiangyu GA, Hong YA, et al. Application of research electronic data capture in an interactive online survey system for monitoring hypertension risk factors during pregnancy. Xi’an Jiao Tong da Xue Xue Bao Yi Xue Ban. 2020;41(4):612-616.
  • Riegler G, Esposito I. Bristol scale stool form. A still valid help in medical practice and clinical research. Tech Coloproctol. 2001;5(3):163–164. doi:10.1007/s101510100019.
  • Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: a double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes. 2018;9(3):236–251. doi:10.1080/19490976.2017.1412908.
  • Futschik ME, Carlisle B. Noise-robust soft clustering of gene expression time-course data. J Bioinform Comput Biol. 2005;3(04):965–988. doi:10.1142/S0219720005001375.
  • Kumar L, Futschik M. Mfuzz: a software package for soft clustering of microarray data. Bioinformat. 2007;2(1):5–7. doi:10.6026/97320630002005.