The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset

References

• Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol. 2015;16:45–17. PMID:25521684. doi:10.1038/ni.3049.
   PubMed Web of Science ®Google Scholar
• Fernando DM, Donata V. Asthma Lancet. 2013;382:1360–1372. PMID: 24041942. doi:10.1016/S0140-6736(13)61536-6
   PubMed Web of Science ®Google Scholar
• Conrad LA, Cabana MD, Rastogi D. Defining pediatric asthma: phenotypes to endotypes and beyond. Pediatr Res. 2021;90:45–51. PMID:33173175. doi:10.1038/s41390-020-01231-6.
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol. 2017;18:1076–1083. PMID: 28926539. doi:10.1038/ni.3829.
   PubMed Web of Science ®Google Scholar
• Loss G, Depner M, Ulfman LH, van Neerven RJ, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Kaulek V, Roduit C, et al. Consumption of unprocessed cow’s milk protects infants from common respiratory infections. J Allergy Clin Immunol. 2015;135:56–62. PMID: 25442645. doi:10.1016/j.jaci.2014.08.044.
   PubMed Web of Science ®Google Scholar
• Martin R, Makino H, Cetinyurek Yavuz A, Ben-Amor K, Roelofs M, Ishikawa E, Kubota H, Swinkels S, Sakai T, Oishi K, et al. Early-life events, including mode of delivery and type of feeding, siblings and gender, shape the developing gut microbiota. Plos One. 2016;11:e0158498. PMID: 27362264. doi:10.1371/journal.pone.0158498.
   PubMed Web of Science ®Google Scholar
• Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, et al. Exposure to household furry pets influences the gut microbiota of infants at 3–4 months following various birth scenarios. Microbiome. 2017;5:40. PMID: 28381231. doi:10.1186/s40168-017-0254-x.
   PubMed Web of Science ®Google Scholar
• Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015;7:307ra152. PMID: 26424567. doi:10.1126/scitranslmed.aab2271.
   PubMed Web of Science ®Google Scholar
• Bisgaard H, Li N, Bonnelykke K, Chawes BL, Skov T, Paludan-Müller G, Stokholm J, Smith B, Krogfelt KA. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol. 2011;128:646–652. PMID: 21782228. doi:10.1016/j.jaci.2011.04.060.
   PubMed Web of Science ®Google Scholar
• Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016;16:341–352. PMID 27231050. doi:10.1038/nri.2016.42.
   PubMed Web of Science ®Google Scholar
• Hosseini E, Grootaert C, Verstraete W, Van de Wiele T. Propionate as a health-promoting microbial metabolite in the human gut. Nutr Rev. 2011;69:245–258. PMID: 21521227. doi:10.1111/j.1753-4887.2011.00388.x.
   PubMed Web of Science ®Google Scholar
• Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, et al. Short-chain fatty acid propionate protects from hypertensive cardiovascular damage. Circulation. 2019;139:1407–1421. PMID 30586752. doi:10.1161/CIRCULATIONAHA.118.036652.
   PubMed Web of Science ®Google Scholar
• Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS. The microbial metabolites, SCFAs, regulate colonic cc cell homeostasis. Science. 2013;341:569–573. PMID: 23828891. doi:10.1126/science.1241165.
   PubMed Web of Science ®Google Scholar
• Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003;278:11312–11319. PMID: 12496283. doi:10.1074/jbc.M211609200.
   PubMed Web of Science ®Google Scholar
• Nakano T, Ochiai S, Suzuki S, Yamaide F, Morita Y, Inoue Y, Arima T, Kojima H, Suzuki H, Nagai K, et al. Breastfeeding promote egg white sensitization in early infancy. Pediatr Allergy Immunol. 2020;31:315–318. PMID:31925979. doi:10.1111/pai.13208.
   PubMed Web of Science ®Google Scholar
• Biagini Myers JM, Schauberger E, He H, Martin LJ, Kroner J, Hill GM, Ryan PH, LeMasters GK, Bernstein DI, Lockey JE, et al. A pediatric asthma risk score to better predict asthma development in young children. J Allergy Clin Immunol. 2019;143:1803–1810 e2. PMID: 30554722. doi:10.1016/j.jaci.2018.09.037.
   PubMed Web of Science ®Google Scholar
• Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, et al. Baseline features of the Severe Asthma Research Program (SARP III) cohort: differences with age. J Allergy Clin Immunol Pract. 2018;6:545–554.e4. PMID: 28866107. doi:10.1016/j.jaip.2017.05.032.
   PubMed Web of Science ®Google Scholar
• McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002;359:386–391. PMID: 11844508. doi:10.1016/S0140-6736(02)07597-9.
   PubMed Web of Science ®Google Scholar
• Stinson LF, Gay MCL, Koleva PT, Eggesbø M, Johnson CC, Wegienka G, du Toit E, Shimojo N, Munblit D, Campbell DE, et al. Human milk from atopic mothers has lower levels of short chain fatty acids. Front Immunol. 2020;111427. doi: 10.3389/fimmu.2020.01427. PMID: 32903327.
   PubMed Web of Science ®Google Scholar
• Gill SK, Rossi M, Bajka B, Whelan K. Dietary fibre in gastrointestinal health and disease. Nat Rev Gastroenterol Hepatol. 2021;18:101–116. PMID: 33208922. doi:10.1038/s41575-020-00375-4.
   PubMed Web of Science ®Google Scholar
• Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 2016;165:1332–1345. PMID: 27259147. doi:10.1016/j.cell.2016.05.041.
   PubMed Web of Science ®Google Scholar
• Luu M, Monning H, Visekruna A Exploring the molecular mechanisms underlying the protective effects of microbial SCFAs on intestinal tolerance and food allergy. Front Immunol. 2020;111225. doi:10.3389/fimmu.2020.01225. PMID: 32612610.
   PubMed Web of Science ®Google Scholar
• Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, Schmausser-Hechfellner E, Roduit C, Frei R, Lauener R, et al. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat Med. 2020;26:1766–1775. PMID: 33139948. doi:10.1038/s41591-020-1095-x.
   PubMed Web of Science ®Google Scholar
• Russell SL, Gold MJ, Willing BP, Thorson L, McNagny KM, Finlay BB. Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma. Gut Microbes. 2013;4:158–164. PMID: 23333861. doi:10.4161/gmic.23567.
   PubMed Web of Science ®Google Scholar
• Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012;336:489–493. PMID: 22442383. doi:10.1126/science.1219328.
   PubMed Web of Science ®Google Scholar
• Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20:159–166. doi:10.1038/nm.3444. PMID: 24390308.
   PubMed Web of Science ®Google Scholar
• Nastasi C, Candela M, Bonefeld CM, Geisler C, Hansen M, Krejsgaard T, Biagi E, Andersen MH, Brigidi P, Ødum N, et al. The effect of short-chain fatty acids on human monocyte-derived dendritic cells. Sci Rep. 2015;5:16148. PMID: 26541096. doi:10.1038/srep16148.
   PubMed Web of Science ®Google Scholar
• Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A. 2011;108:8030–8035. PMID: 21518883. doi:10.1073/pnas.1016088108.
   PubMed Web of Science ®Google Scholar
• D’Souza WN, Douangpanya J, Mu S, Jaeckel P, Zhang M, Maxwell JR, Rottman JB, Labitzke K, Willee A, Beckmann H, et al. Differing roles for SCFAs and GPR43 agonism in the regulation of intestinal barrier function and immune responses. Plos One. 2017;12:e0180190. PMID: 28727837. doi:10.1371/journal.pone.0180190.
   PubMed Web of Science ®Google Scholar
• Ang Z, Ding JL. GPR41 and GPR43 in obesity and inflammation - protective or causative? Front Immunol. 2016;7:28. PMID: 26870043. doi:10.3389/fimmu.2016.00028.
   PubMed Web of Science ®Google Scholar
• Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology. 2013;145:396-406.e1–10. PMID: 23665276. doi:10.1053/j.gastro.2013.04.056.
   Google Scholar
• Natarajan N, Hori D, Flavahan S, Steppan J, Flavahan NA, Berkowitz DE, Pluznick JL. Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41. Physiol Genomics. 2016;48:826–834. PMID: 27664183. doi:10.1152/physiolgenomics.00089.2016.
   PubMed Web of Science ®Google Scholar
• Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4:499–511. PMID: 15229469. doi:10.1038/nri1391.
   PubMed Web of Science ®Google Scholar
• Zakeri A, Russo M Dual role of toll-like receptors in human and experimental asthma models. Front Immunol. 2018;9, 1027. doi:10.3389/fimmu.2018.01027. PMID: 29867994.
   PubMed Web of Science ®Google Scholar
• Iwata-Yoshikawa N, Uda A, Suzuki T, Tsunetsugu-Yokota Y, Sato Y, Morikawa S, Tashiro M, Sata T, Hasegawa H, Nagata N, et al. Effects of toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-Inactivated severe acute respiratory syndrome-related coronavirus vaccine. J Virol. 2014;88:8597–8614. doi:10.1128/JVI.00983-14. PMID: 24850731.
   PubMed Web of Science ®Google Scholar
• Chow J, Panasevich MR, Alexander D, Vester Boler BM, Rossoni Serao MC, Faber TA, Bauer LL, Fahey GC. Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation. J Proteome Res. 2014;13:2534–2542. PMID: 24628373. doi:10.1021/pr500011w.
   PubMed Web of Science ®Google Scholar
• Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, et al. The gut microbiota suppresses insulin-mediated fat accumulation via the SCFA receptor GPR43. Nat Commun. 2013;4, 1829. doi:10.1038/ncomms2852. PMID: 23652017.
   PubMed Web of Science ®Google Scholar
• Plantinga M, Guilliams M, Vanheerswynghels M, Deswarte K, Branco-Madeira F, Toussaint W, Vanhoutte L, Neyt K, Killeen N, Malissen B, et al. Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity. 2013;38:322–335. PMID: 23352232. doi:10.1016/j.immuni.2012.10.016.
   PubMed Web of Science ®Google Scholar
• Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med. 2009;15:410–416. PMID: 19330007. doi:10.1038/nm.1946.
   PubMed Web of Science ®Google Scholar
• Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H. Dectin-1 plays an important role in house dust mite-induced allergic airway inflammation through the activation of CD11b+ dendritic cells. J Immunol. 2017;198:61–70. PMID: 27852745. doi:10.4049/jimmunol.1502393.
   PubMed Web of Science ®Google Scholar
• Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. IL-22 induces Reg3gamma and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017;214:3037–3050. PMID: 28811323. doi:10.1084/jem.20162108.
   PubMed Web of Science ®Google Scholar
• Zaiss MM, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, et al. The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation. Immunity. 2015;43:998–1010. PMID: 26522986. doi:10.1016/j.immuni.2015.09.012.
   PubMed Web of Science ®Google Scholar
• Ge SX, Son EW, Yao R. iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data. BMC Bioinform. 2018;19:534. PMID: 30567491. doi:10.1186/s12859-018-2486-6.
   PubMed Web of Science ®Google Scholar
• Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR, Ma’ayan A. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform. 2013;14:128. PMID: 23586463. doi:10.1186/1471-2105-14-128.
   PubMed Web of Science ®Google Scholar
• Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 2016;44:W90–7. PMID: 27141961. doi:10.1093/nar/gkw377.
   PubMed Web of Science ®Google Scholar
• Xie Z, Bailey A, Kuleshov MV, Clarke DJB, Evangelista JE, Jenkins SL, Lachmann A, Wojciechowicz ML, Kropiwnicki E, Jagodnik KM, et al. Gene set knowledge discovery with Enrichr. Curr Protoc. 2021;1:e90. PMID: 33780170. doi:10.1002/cpz1.90.
   PubMedGoogle Scholar
• Hamasaki Y, Kohno Y, Ebisawa M, Kondo N, Nishima S, Nishimuta T, Morikawa A. Japanese society of allergology; Japanese society of pediatric allergy and clinical immunology. Japanese guideline for childhood asthma 2014. Allergol Int. 2014;63:335–356. PMID: 25178176. doi:10.2332/allergolint.14-RAI-0767.
   Web of Science ®Google Scholar
• Sato Y, Sakurai K, Tanabe H, Kato T, Nakanishi Y, Ohno H, Mori C. Maternal gut microbiota is associated with newborn anthropometrics in a sex-specific manner. J Dev Orig Health Dis. 2019;10:659–666. PMID: 31106719. doi:10.1017/S2040174419000138.
   PubMed Web of Science ®Google Scholar
• Kato T, Fukuda S, Fujiwara A, Suda W, Hattori M, Kikuchi J, Ohno H. Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation. DNA Res. 2014;21:469–480. PMID: 24848698. doi:10.1093/dnares/dsu013.
   PubMed Web of Science ®Google Scholar
• Kim SW, Suda W, Kim S, Oshima K, Fukuda S, Ohno H, Morita H, Hattori M. Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing. DNA Res. 2013;20:241–253. PMID: 23571675. doi:10.1093/dnares/dst006.
   PubMed Web of Science ®Google Scholar
• Said HS, Suda W, Nakagome S, Chinen H, Oshima K, Kim S, Kimura R, Iraha A, Ishida H, Fujita J, et al. Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA Res. 2014;21:15–25. PMID: 24013298. doi:10.1093/dnares/dst037.
   PubMed Web of Science ®Google Scholar