A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines

References

• Moeti M, Gao GF, Herrman H. Global pandemic perspectives: public health, mental health, and lessons for the future. Lancet. 2022;400(10353):e3–33. doi:10.1016/S0140-6736(22)01328-9.
   PubMed Web of Science ®Google Scholar
• Frenk J, Godal T, Gómez-Dantés O, Store JG. A reinvigorated multilateralism in health: lessons and innovations from the COVID-19 pandemic. Lancet. 2022;400(10363):1565–1568. doi:10.1016/S0140-6736(22)01943-2.
   PubMed Web of Science ®Google Scholar
• Bollyky TJ, Castro E, Aravkin AY, Bhangdia K, Dalos J, Hulland EN, Kiernan S, Lastuka A, McHugh TA, Ostroff SM, et al. Assessing COVID-19 pandemic policies and behaviours and their economic and educational trade-offs across US states from Jan 1, 2020, to July 31, 2022: an observational analysis. Lancet. 2023;401(10385):1341–1360. doi:10.1016/S0140-6736(23)00461-0.
   PubMed Web of Science ®Google Scholar
• Jack RH, Joseph RM, Coupland CA, Hall CL, Hollis C. Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study. EClinicalMed. 2023;57:101857. doi:10.1016/j.eclinm.2023.101857.
   PubMedGoogle Scholar
• Ianiro G, Mullish BH, Hvas CL, Segal JP, Kuijper EJ, Costello SP, Kelly CR, Allegretti JR, Fischer M, Iqbal TH, et al. SARS-CoV-2 vaccines and donor recruitment for FMT. Lancet Gastroenterol Hepatol. 2021;6(4):264–266. doi:10.1016/S2468-1253(21)00032-7.
   PubMed Web of Science ®Google Scholar
• Goncalves JIB, Borges TJ, de Souza APD. Microbiota and the response to vaccines against respiratory virus. Front Immunol. 2022;13:889945. doi:10.3389/fimmu.2022.889945.
   PubMed Web of Science ®Google Scholar
• Han M, Huang Y, Gui H, Xiao Y, He M, Liu J, Cao X, Zheng M, Lu M, Jia W, et al. Dynamic changes in host immune system and gut microbiota are associated with the production of SARS-CoV-2 antibodies. Gut. 2022. doi:10.1136/gutjnl-2022-327561.
   Google Scholar
• Liu Q, Su Q, Zhang F, Tun HM, Mak JWY, Lui GCY, Ng SSS, Ching JYL, Li A, Lu W, et al. Multi-kingdom gut microbiota analyses define COVID-19 severity and post-acute COVID-19 syndrome. Nat Commun. 2022;13(1):6806. doi:10.1038/s41467-022-34535-8.
   PubMed Web of Science ®Google Scholar
• Mazzarelli A, Giancola ML, Fontana A, Piselli P, Binda E, Trivieri N, Mencarelli G, Marchioni L, Vulcano A, De Giuli C, et al. Gut microbiota composition in COVID-19 hospitalized patients with mild or severe symptoms. Front Microbiol. 2022;13:1049215. doi:10.3389/fmicb.2022.1049215.
   PubMedGoogle Scholar
• Primieri C, Bietta C, Giacchetta I, Chiavarini M, De Waure C. Determinants of COVID-19 vaccination acceptance or hesitancy in Italy: an overview of the current evidence. Ann Ist Super Sanita. 2023;59(1):10–25. doi:10.4415/ANN_23_01_03.
   PubMed Web of Science ®Google Scholar
• Lefrancois T, Malvy D, Atlani-Duault L, Benamouzig D, Druais PL, Yazdanpanah Y, Delfraissy JF, Lina B. After 2 years of the COVID-19 pandemic, translating one health into action is urgent. Lancet. 2023;401(10378):789–794. doi:10.1016/S0140-6736(22)01840-2.
   PubMed Web of Science ®Google Scholar
• Zhu J, Jain S, Sha J, Batra H, Ananthaswamy N, Kilgore PB, Hendrix EK, Hosakote YM, Wu X, Olano JP, et al. A bacteriophage-based, highly efficacious, needle- and adjuvant-free, mucosal COVID-19 vaccine. mBio. 2022;13(4):e0182222. doi:10.1128/mbio.01822-22.
   PubMed Web of Science ®Google Scholar
• VanBlargan L, Errico JM, Halfmann PJ, Zost SJ, Crowe JE, Purcell LA, Kawaoka Y, Corti D, Fremont DH, Diamond MS. An infectious SARS-CoV-2 B.1.1.529 omicron virus escapes neutralization by therapeutic monoclonal antibodies. Res Sq. 2021. doi:10.21203/rs.3.rs-1175516/v1.
   Google Scholar
• Kelly JD, Leonard S, Hoggatt KJ, Boscardin WJ, Lum EN, Moss-Vazquez TA, Andino R, Wong JK, Byers A, Bravata DM, et al. Incidence of severe COVID-19 illness following vaccination and booster with BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines. JAMA. 2022;328(14):1427–1437. doi:10.1001/jama.2022.17985.
   PubMed Web of Science ®Google Scholar
• Hulme WJ, Horne EM, Parker EP, Keogh RH, Williamson EJ, Walker V, Palmer TM, Curtis HJ, Walker AJ, Andrews CD, et al. Comparative effectiveness of BNT162b2 versus mRNA-1273 COVID-19 vaccine boosting in England: matched cohort study in OpenSAFELY-TPP. BMJ. 2023;380:e072808. doi:10.1136/bmj-2022-072808.
   PubMedGoogle Scholar
• Voigt EA, Ovsyannikova, IG, Kennedy, RB, Grill, DE, Goergen, KM, Schaid, DJ, Poland, GA Sex differences in older adults’ immune responses to seasonal influenza vaccination. Front Immunol. 2019;10:180. doi:10.3389/fimmu.2019.00180.
   PubMed Web of Science ®Google Scholar
• Agrawal U, Bedston S, McCowan C, Oke J, Patterson L, Robertson C, Akbari A, Azcoaga-Lorenzo A, Bradley DT, Fagbamigbe AF, et al. Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. Lancet. 2022;400(10360):1305–1320. doi:10.1016/S0140-6736(22)01656-7.
   PubMed Web of Science ®Google Scholar
• Chalkias S, Harper C, Vrbicky K, Walsh SR, Essink B, Brosz A, McGhee N, Tomassini JE, Chen X, Chang Y, et al. A bivalent omicron-containing booster vaccine against covid-19. N Engl J Med. 2022;387(14):1279–1291. doi:10.1056/NEJMoa2208343.
   PubMed Web of Science ®Google Scholar
• Kunisawa J. Future prospects for food research in the post-microbiome era. J Nutr Sci Vitaminol (Tokyo). 2022;68(Supplement):S23–S25. doi:10.3177/jnsv.68.S23.
   PubMedGoogle Scholar
• Adams K, Rhoads JP, Surie D, Gaglani M, Ginde AA, McNeal T, Talbot HK, Casey JD, Zepeski A, Shapiro NI, et al. Vaccine effectiveness of primary series and booster doses against COVID-19 associated hospital admissions in the United States: living test negative design study. BMJ. 2022;379:e072065. doi:10.1136/bmj-2022-072065.
   PubMedGoogle Scholar
• Yuki Y, Nojima M, Hosono O, Tanaka H, Kimura Y, Satoh T, Imoto S, Uematsu S, Kurokawa S, Kashima K, et al. Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial. Lancet Microbe. 2021;2(9):e429–e440. doi:10.1016/S2666-5247(20)30196-8.
   PubMedGoogle Scholar
• Colton H, Hodgson D, Hornsby H, Brown R, Mckenzie J, Bradley KL, James C, Lindsey BB, Birch S, Marsh L, et al. Risk factors for SARS-CoV-2 seroprevalence following the first pandemic wave in UK healthcare workers in a large NHS foundation trust. Wellcome Open Res. 2021;6:220. doi:10.12688/wellcomeopenres.17143.1.
   PubMedGoogle Scholar
• Yang J, Won G, Baek JY, Lee YH, Kim H, Huh K, Cho SY, Kang CI, Chung DR, Peck KR, et al. Neutralizing activity against omicron BA.5 after tixagevimab/cilgavimab administration comparable to those after omicron BA.1/BA.2 breakthrough infections. Front Immunol. 2023;14:1139980. doi:10.3389/fimmu.2023.1139980.
   PubMed Web of Science ®Google Scholar
• Moola S, Gudi N, Nambiar D, Dumka N, Ahmed T, Sonawane IR, Kotwal A. A rapid review of evidence on the determinants of and strategies for COVID-19 vaccine acceptance in low- and middle-income countries. J Glob Health. 2021;11:05027. doi:10.7189/jogh.11.05027.
   PubMed Web of Science ®Google Scholar
• Moore SC, Kronsteiner B, Longet S, Adele S, Deeks AS, Liu C, Dejnirattisai W, Reyes LS, Meardon N, Faustini S, et al. Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens. Med. 2023;4(3):191–215. doi:10.1016/j.medj.2023.02.004.
   PubMedGoogle Scholar
• Modenese A, Loney T, Gobba F. COVID-19-related mortality amongst physicians in Italy: Trend pre- and post-SARS-CoV-2 vaccination campaign. Healthcare (Basel). 2022;10(7):7. doi:10.3390/healthcare10071187.
   Google Scholar
• Farrah K, Young K, Tunis MC, Zhao L. Risk of bias tools in systematic reviews of health interventions: an analysis of PROSPERO-registered protocols. Syst Rev. 2019;8(1):280. doi:10.1186/s13643-019-1172-8.
   PubMed Web of Science ®Google Scholar
• Das S, Tiwari S, Xaviar S. An audit of the quality of reporting and bias of studies on yoga in epilepsy. Neurol India. 2022;70(5):2009–2014. doi:10.4103/0028-3886.359244.
   PubMed Web of Science ®Google Scholar
• Kim SY. Suggestion of more suitable study designs and the corresponding reporting guidelines in articles published in the journal of educational evaluation for health professions from 2021 to September 2022: a descriptive study. J Educ Eval Health Prof. 2022;19:36. doi:10.3352/jeehp.2022.19.36.
   PubMed Web of Science ®Google Scholar
• Jiao J, Shen Y, Wang P, Zuo K, Yang X, Chen M, Dong Y, Li J. Characterization of the intestinal microbiome in healthy adults over Sars-Cov-2 vaccination. Front Biosci. 2022;27(10):280. doi:10.31083/j.fbl2710280.
   Web of Science ®Google Scholar
• Singer J, Tunbridge M, Perkins GB, Salehi T, Ying T, Wu H, Coates PT, Chadban SJ. Rapamycin and inulin for third-dose vaccine response stimulation (RIVASTIM): Inulin - study protocol for a pilot, multicentre, randomised, double-blinded, controlled trial of dietary inulin to improve SARS-CoV-2 vaccine response in kidney transplant recipients. BMJ Open. 2022;12(12):e062747. doi:10.1136/bmjopen-2022-062747.
   PubMedGoogle Scholar
• Alexander JL, Mullish BH, Danckert NP, Liu Z, Olbei ML, Saifuddin A, Torkizadeh M, Ibraheim H, Blanco JM, Roberts LA, et al. The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients. EBioMedicine. 2023;88:104430. doi:10.1016/j.ebiom.2022.104430.
   PubMed Web of Science ®Google Scholar
• Jia L, Weng S, Wu J, Tian X, Zhang Y, Wang X, Wang J, Yan D, Wang W, Fang F, et al. Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity. Gut Microbes. 2022;14(1):2117503. doi:10.1080/19490976.2022.2117503.
   PubMed Web of Science ®Google Scholar
• Geanes ES, LeMaster C, Fraley ER, Khanal S, McLennan R, Grundberg E, Selvarangan R, Bradley T. Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination. Sci Rep. 2022;12(1):6496. doi:10.1038/s41598-022-10230-y.
   PubMed Web of Science ®Google Scholar
• Xu J, Ren Z, Cao K, Li X, Yang J, Luo X, Zhu L, Wang X, Ding L, Liang J, et al. Boosting vaccine-elicited respiratory mucosal and systemic COVID-19 immunity in mice with the oral lactobacillus plantarum. Front Nutr. 2021;8:789242. doi:10.3389/fnut.2021.789242.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Blanque R, Sánchez-García JC, Cobos-Vargas Á, Aguilar Quesada A, Maldonado-Lobón JA, Olivares M, Blanco-Rojo R. Evaluation of the effect of Loigolactobacillus coryniformis K8 CECT 5711 consumption in health care workers exposed to COVID-19. Front Nutr. 2022;9:962566. doi:10.3389/fnut.2022.962566.
   PubMed Web of Science ®Google Scholar
• Wong MCS, Zhang L, Ching JYL, Mak JWY, Huang J, Wang S, Mok CKP, Wong A, Chiu OL, Fung YT, et al. Effects of gut microbiome modulation on reducing adverse health outcomes among elderly and diabetes patients during the COVID-19 pandemic: A randomised, double-blind, placebo-controlled trial (IMPACT study). Nutr. 2023;15(8):8. doi:10.3390/nu15081982.
   Google Scholar
• Rodriguez JAM, Bifano M, Roca Goma E, Plasencia CM, Torralba AO, Font MS, Millán PR. Effect and tolerability of a nutritional supplement based on a synergistic combination of beta-glucans and selenium- and zinc-enriched saccharomyces cerevisiae (ABB C1((R))) in volunteers receiving the influenza or the COVID-19 vaccine: A randomized, double-blind, placebo-controlled study. Nutr. 2021;13(12):4347.
   Google Scholar
• Cheung KS, Lam LK, Zhang R, Ooi PH, Tan JT, To WP, Hui CH, Chan KH, Seto WK, Hung IFN, et al. Association between recent usage of antibiotics and immunogenicity within six months after COVID-19 vaccination. Vaccines (Basel). 2022;10(7):7. doi:10.3390/vaccines10071122.
   Web of Science ®Google Scholar
• Su Q, Liu Q, Zhang L, Xu Z, Liu C, Lu W, Ching JY, Li A, Mak JWY, Lui GCY, et al. Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients. Gut Microbes. 2022;14(1):2128603. doi:10.1080/19490976.2022.2128603.
   PubMed Web of Science ®Google Scholar
• Amrouche T, Chikindas ML. Probiotics for immunomodulation in prevention against respiratory viral infections with special emphasis on COVID-19. AIMS Microbiol. 2022;8(3):338–356. doi:10.3934/microbiol.2022024.
   PubMed Web of Science ®Google Scholar
• Ng SC, Peng Y, Zhang L, Mok CK, Zhao S, Li A, Ching JY, Liu Y, Yan S, Chan DL, et al. Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events. Gut. 2022;71(6):1106–1116. doi:10.1136/gutjnl-2021-326563.
   PubMed Web of Science ®Google Scholar
• Malan-Muller S, Valles-Colomer M, Palomo T, Leza JC. The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles. Gut Microbes. 2023;15(1):2162306. doi:10.1080/19490976.2022.2162306.
   PubMed Web of Science ®Google Scholar
• Tang B, Tang L, He W, Jiang X, Hu C, Li Y, Zhang Y, Pang K, Lei Y, Li S, et al. Correlation of gut microbiota and metabolic functions with the antibody response to the BBIBP-CorV vaccine. Cell Rep Med. 2022;3(10):100752. doi:10.1016/j.xcrm.2022.100752.
   PubMedGoogle Scholar
• Zhang F, Lau RI, Liu Q, Su Q, Chan FK, Ng SC. Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications. Nat Rev Gastroenterol Hepatol. 2023;20(5):323–337. doi:10.1038/s41575-022-00698-4.
   PubMed Web of Science ®Google Scholar
• Cosola C, Rocchetti MT, Gesualdo L. Gut microbiota, the immune system, and cytotoxic T lymphocytes. Methods Mol Biol. 2021;2325:229–241.
   PubMedGoogle Scholar
• Bulut O, Kilic G, Dominguez-Andres J. Immune memory in aging: a wide perspective covering microbiota, brain, metabolism, and epigenetics. Clin Rev Allergy Immunol. 2022;63(3):499–529. doi:10.1007/s12016-021-08905-x.
   PubMed Web of Science ®Google Scholar
• Amimo JO, Michael H, Chepngeno J, Raev SA, Saif LJ, Vlasova AN. Immune impairment associated with vitamin a deficiency: Insights from clinical studies and animal model research. Nutr. 2022;14:23. doi:10.3390/nu14235038.
   Google Scholar
• Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, et al. Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. J Hepatol. 2023;79(1):150–166. doi:10.1016/j.jhep.2023.02.026.
   PubMed Web of Science ®Google Scholar
• Wolfe AE, Markey KA. The contribution of the intestinal microbiome to immune recovery after HCT. Front Immunol. 2022;13:988121. doi:10.3389/fimmu.2022.988121.
   PubMed Web of Science ®Google Scholar
• Papotto PH, Yilmaz B, Pimenta G, Mensurado S, Cunha C, Fiala GJ, Gomes da Costa D, Gonçalves-Sousa N, Chan BHK, Blankenhaus B, et al. Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner. Cell Reports. 2023;42(2):112074. doi:10.1016/j.celrep.2023.112074.
   PubMed Web of Science ®Google Scholar
• Rupawate PS, Roylawar P, Khandagale K, Gawande S, Ade AB, Jaiswal DK, Borgave S. Role of gut symbionts of insect pests: A novel target for insect-pest control. Front Microbiol. 2023;14:1146390. doi:10.3389/fmicb.2023.1146390.
   PubMed Web of Science ®Google Scholar
• Huang Z, Zhou J, Zhang Z, He H, Wei C. A study on symbiotic systems of cicadas provides new insights into distribution of microbial symbionts and improves fluorescence in situ hybridization technique. IJMS. 2023;24(3):3. doi:10.3390/ijms24032434.
   Google Scholar
• Xie R, Dong C, Wang S, Danso B, Dar MA, Pandit RS, Pawar KD, Geng A, Zhu D, Li X, et al. Host-specific diversity of culturable bacteria in the gut systems of fungus-growing termites and their potential functions towards lignocellulose bioconversion. Insects. 2023;14(4):4. doi:10.3390/insects14040403.
   Web of Science ®Google Scholar
• Hinks TSC, Zhang XW. MAIT cell activation and functions. Front Immunol. 2020;11:1014. doi:10.3389/fimmu.2020.01014.
   PubMed Web of Science ®Google Scholar
• Tang JS, Compton BJ, Marshall A, Anderson R, Li Y, van der Woude H, Hermans IF, Painter GF, Gasser O. Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells. Food Funct. 2020;11(7):5782–5787. doi:10.1039/D0FO01153C.
   PubMed Web of Science ®Google Scholar
• Ioannidis M, Cerundolo V, Salio M. The immune modulating properties of mucosal-associated invariant T cells. Front Immunol. 2020;11:1556. doi:10.3389/fimmu.2020.01556.
   PubMed Web of Science ®Google Scholar
• Jabeen MF, Hinks TSC. MAIT cells and the microbiome. Front Immunol. 2023;14:1127588. doi:10.3389/fimmu.2023.1127588.
   PubMed Web of Science ®Google Scholar
• Gargano F, Guerrera G, Piras E, Serafini B, Di Paola M, Rizzetto L, Buscarinu MC, Annibali V, Vuotto C, De Bardi M, et al. Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain. Front Immunol. 2022;13:890298. doi:10.3389/fimmu.2022.890298.
   PubMed Web of Science ®Google Scholar
• Veneziani I, Alicata C, Moretta L, Maggi E. The latest approach of immunotherapy with endosomal TLR agonists improving NK cell function: an overview. Biomed. 2022;11(1):1. doi:10.3390/biomedicines11010064.
   Google Scholar
• Shen CF, Yen CL, Fu YC, Cheng CM, Shen TC, Chang PD, Cheng KH, Liu CC, Chang YT, Chen PL, et al. Innate immune responses of vaccinees determine early neutralizing antibody production after ChAdOx1nCoV-19 vaccination. Front Immunol. 2022;13:807454. doi:10.3389/fimmu.2022.807454.
   PubMed Web of Science ®Google Scholar
• Matsuzaki C, Shiraishi T, Chiou TY, Nakashima Y, Higashimura Y, Yokota SI, Yamamoto K, Takahashi T. Role of lipoteichoic acid from the genus apilactobacillus in inducing a strong IgA response. Appl Environ Microbiol. 2022;88(8):e0019022. doi:10.1128/aem.00190-22.
   PubMed Web of Science ®Google Scholar
• He Y, Yu W, Shen L, Yan W, Xiao L, Qi J, Hu T. A SARS-CoV-2 vaccine based on conjugation of SARS-CoV-2 RBD with IC28 peptide and mannan. Int J Biol Macromol. 2022;222(Pt A):661–670. doi:10.1016/j.ijbiomac.2022.09.180.
   PubMedGoogle Scholar
• Negi S, Das DK, Pahari S, Nadeem S, Agrewala JN. Potential role of gut microbiota in induction and regulation of innate immune memory. Front Immunol. 2019;10:2441. doi:10.3389/fimmu.2019.02441.
   PubMed Web of Science ®Google Scholar
• Gasmi A, Tippairote T, Mujawdiya PK, Peana M, Menzel A, Dadar M, Gasmi Benahmed A, Bjørklund G. The microbiota-mediated dietary and nutritional interventions for COVID-19. Clin Immunol. 2021;226:108725. doi:10.1016/j.clim.2021.108725.
   PubMed Web of Science ®Google Scholar
• Bartenslager AC, Althuge ND, Loy JD, Hille MM, Spangler ML, Fernando SC. Longitudinal assessment of the bovine ocular bacterial community dynamics in calves. Anim Microbiome. 2021;3(1):16. doi:10.1186/s42523-021-00079-3.
   PubMedGoogle Scholar
• Smeekens JM, Johnson-Weaver BT, Hinton AL, Azcarate-Peril MA, Moran TP, Immormino RM, Kesselring JR, Steinbach EC, Orgel KA, Staats HF, et al. Fecal IgA, antigen absorption, and gut microbiome composition are associated with food antigen sensitization in genetically susceptible mice. Front Immunol. 2020;11:599637. doi:10.3389/fimmu.2020.599637.
   PubMed Web of Science ®Google Scholar
• Wu RY, Abdullah M, Määttänen P, Pilar AVC, Scruten E, Johnson-Henry KC, Napper S, O’Brien C, Jones NL, Sherman PM, et al. Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function. Sci Rep. 2017;7(1):40820. doi:10.1038/srep40820.
   PubMedGoogle Scholar
• Antunes KH, Cassão G, Santos LD, Borges SG, Poppe J, Gonçalves JB, Nunes EDS, Recacho GF, Sousa VB, Da Silva GS, et al. Airway administration of bacterial lysate OM-85 protects mice against respiratory syncytial virus infection. Front Immunol. 2022;13:867022. doi:10.3389/fimmu.2022.867022.
   PubMed Web of Science ®Google Scholar
• Di Luccia B, Ahern PP, Griffin NW, Cheng J, Guruge JL, Byrne AE, Rodionov DA, Leyn SA, Osterman AL, Ahmed T, et al. Combined prebiotic and microbial intervention improves oral cholera vaccination responses in a mouse model of childhood undernutrition. Cell Host & Microbe. 2020;27(6):899–908. doi:10.1016/j.chom.2020.04.008.
   PubMed Web of Science ®Google Scholar
• Uzzan M, Corcos O, Martin JC, Treton X, Bouhnik Y. Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics – lung axis hypothesis. Med Hypoth. 2020;144:110023. doi:10.1016/j.mehy.2020.110023.
   PubMed Web of Science ®Google Scholar
• Kohmer N, Stein S, Schenk B, Grikscheit K, Metzler M, Rabenau HF, Widera M, Herrmann E, Wicker S, Ciesek S, et al. Heterologous prime-boost immunization with ChAdOx1-S and BNT162b2: reactogenicity and immunogenicity in a prospective cohort study. Int J Infect Dis. 2023;128:166–175. doi:10.1016/j.ijid.2022.12.034.
   PubMed Web of Science ®Google Scholar
• Detweiler CS. A new way to beat intestinal pathogens. Trends Microbiol. 2017;25(3):169–170. doi:10.1016/j.tim.2017.01.003.
   PubMed Web of Science ®Google Scholar
• Hagerbrand K, Westlund J, Yrlid U, Agace W, Johansson-Lindbom B. MyD88 signaling regulates steady-state migration of intestinal CD103+ dendritic cells independently of TNF-α and the gut microbiota. Journal Immunol. 2015;195(6):2888–2899. doi:10.4049/jimmunol.1500210.
   PubMed Web of Science ®Google Scholar
• Fryer HA, Hartley GE, Edwards ES, O’Hehir RE, van Zelm MC. Humoral immunity and B-cell memory in response to SARS-CoV-2 infection and vaccination. Biochem Soc Trans. 2022;50(6):1643–1658. doi:10.1042/BST20220415.
   PubMedGoogle Scholar
• Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, et al. Antigen-specific mucosal immunity regulates development of intestinal bacteria-mediated diseases. Gastroenterol. 2019;157(6):1530–1543.e4. doi:10.1053/j.gastro.2019.08.021.
   PubMed Web of Science ®Google Scholar
• Stutz MR, Dylla NP, Pearson SD, Lecompte-Osorio P, Nayak R, Khalid M, Adler E, Boissiere J, Lin H, Leiter W, et al. Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure. Nat Commun. 2022;13(1):6615. doi:10.1038/s41467-022-34260-2.
   PubMed Web of Science ®Google Scholar
• Baradaran Ghavami S, Pourhamzeh M, Farmani M, Raftar SKA, Shahrokh S, Shpichka A, Asadzadeh Aghdaei H, Hakemi-Vala M, Hossein-Khannazer N, Timashev P, et al. Cross-talk between immune system and microbiota in COVID-19. Expert Rev Gastroenterol Hepatol. 2021;15(11):1281–1294. doi:10.1080/17474124.2021.1991311.
   PubMed Web of Science ®Google Scholar
• Hernandez-Flores TJ, Pedraza-Brindis EJ, Cárdenas-Bedoya J, Ruíz-Carrillo JD, Méndez-Clemente AS, Martínez-Guzmán MA, Iñiguez-Gutiérrez L. Role of micronutrients and gut microbiota-derived metabolites in COVID-19 recovery. IJMS. 2022;23(20):12324. doi:10.3390/ijms232012324.
   Google Scholar
• Brown JA, Sanidad KZ, Lucotti S, Lieber CM, Cox RM, Ananthanarayanan A, Basu S, Chen J, Shan M, Amir M, et al. Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection. Gut Microbes. 2022;14(1):2105609. doi:10.1080/19490976.2022.2105609.
   PubMed Web of Science ®Google Scholar
• Arunachalam PS, Lai L, Samaha H, Feng Y, Hu M, Hui HSY, Wali B, Ellis M, Davis-Gardner ME, Huerta C, et al. Durability of immune responses to the booster mRNA vaccination against COVID-19. J Clin Invest. 2023;133(10). doi:10.1172/JCI167955.
   PubMed Web of Science ®Google Scholar
• Yang QY, Yang YL, Tang YX, Qin P, Wang G, Xie JY, Chen SX, Ding C, Huang YW, Zhu SJ. Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids. PLoS Pathog. 2022;18(6):e1010620. doi:10.1371/journal.ppat.1010620.
   PubMed Web of Science ®Google Scholar
• Wang B, Zhang L, Wang Y, Dai T, Qin Z, Zhou F, Zhang L. Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions. Signal Transduct Target Therap. 2022;7(1):143. doi:10.1038/s41392-022-00986-0.
   PubMed Web of Science ®Google Scholar
• Arunachalam PS, Lai L, Samaha H, Feng Y, Hu M, Hui HS, Wali B, Ellis M, Huerta C, Bechnack K, et al. Durability of immune responses to the booster mRNA vaccination against COVID-19. medRxiv. 2022;12(02):22282921.
   Google Scholar
• Kim CY, Lee M, Yang S, Kim K, Yong D, Kim HR, Lee I. Human reference gut microbiome catalog including newly assembled genomes from under-represented Asian metagenomes. Genome Med. 2021;13(1):134. doi:10.1186/s13073-021-00950-7.
   PubMed Web of Science ®Google Scholar
• Kitamura K, Shionoya H, Suzuki S, Fukai R, Uda S, Abe C, Takemori H, Nishimura K, Baba H, Katayama K, et al. Oral and intestinal bacterial substances associated with disease activities in patients with rheumatoid arthritis: a cross-sectional clinical study. J Immunol Res. 2022;2022:1–13. doi:10.1155/2022/6839356.
   Web of Science ®Google Scholar
• Prasad R, Patton MJ, Floyd JL, Fortmann S, DuPont M, Harbour A, Wright J, Lamendella R, Stevens BR, Oudit GY, et al. Plasma microbiome in COVID-19 subjects: an indicator of gut barrier defects and dysbiosis. IJMS. 2022;23(16):16. doi:10.3390/ijms23169141.
   Google Scholar
• Lozano CP, Wilkens LR, Shvetsov YB, Maskarinec G, Park S-Y, Shepherd JA, Boushey CJ, Hebert JR, Wirth MD, Ernst T, et al. Associations of the dietary inflammatory index with total adiposity and ectopic fat through the gut microbiota, LPS, and C-reactive protein in the multiethnic cohort–adiposity phenotype study. Am J Clin Nutr. 2022;115(5):1344–1356. doi:10.1093/ajcn/nqab398.
   PubMed Web of Science ®Google Scholar
• Patrick S. A tale of two habitats: Bacteroides fragilis, a lethal pathogen and resident in the human gastrointestinal microbiome. Microbiol. 2022;168(4):4. doi:10.1099/mic.0.001156.
   Web of Science ®Google Scholar
• Zitvogel L, Kroemer G. Cross-reactivity between microbial and tumor antigens. Curr Opin Immunol. 2022;75:102171. doi:10.1016/j.coi.2022.102171.
   PubMed Web of Science ®Google Scholar
• Karl JP. Gut microbiota-targeted interventions for reducing the incidence, duration, and severity of respiratory tract infections in healthy non-elderly adults. Mil Med. 2021;186(3–4):e310–e318. doi:10.1093/milmed/usaa261.
   PubMed Web of Science ®Google Scholar
• Wang YZ, Zhou JG, Lu YM, Hu H, Xiao FF, Ge T, Wang X, Zheng L, Yu LH, Le J, et al. Altered gut microbiota composition in children and their caregivers infected with the SARS-CoV-2 omicron variant. World J Pediatr. 2023;19(5):1–11. doi:10.1007/s12519-022-00659-6.
   PubMedGoogle Scholar
• Bajinka O, Tan Y, Darboe A, Ighaede-Edwards IG, Abdelhalim KA. The gut microbiota pathway mechanisms of diabetes. AMB Express. 2023;13(1):16. doi:10.1186/s13568-023-01520-3.
   PubMed Web of Science ®Google Scholar
• Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy. Lancet Microbe. 2022;3(10):e787–e794. doi:10.1016/S2666-5247(22)00185-9.
   PubMedGoogle Scholar
• Kwon A, Park YS. Immunostimulatory activity of synbiotics using Lactococcus lactis SG-030 and glucooligosaccharides from weissella cibaria YRK005. Microorgan. 2021;9(12). doi:10.3390/microorganisms9122437.
   Web of Science ®Google Scholar
• Zhang Q, Zhao W, Zhao Y, Duan S, Liu WH, Zhang C, Sun S, Wang T, Wang X, Hung WL, et al. In vitro study of bifidobacterium lactis BL-99 with fructooligosaccharide synbiotics effected on the intestinal microbiota. Front Nutr. 2022;9:890316. doi:10.3389/fnut.2022.890316.
   PubMed Web of Science ®Google Scholar
• Spacova I, Patusco R, Lebeer S, Jensen MG. Influence of biotic interventions on the immune response to vaccines in young and older adults. Clin Nutr. 2023;42(2):216–226. doi:10.1016/j.clnu.2023.01.001.
   PubMed Web of Science ®Google Scholar
• Zarate-Blades CR, Horai R, Mattapallil MJ, Ajami NJ, Wong M, Petrosino JF, Itoh K, Chan CC, Caspi RR. Gut microbiota as a source of a surrogate antigen that triggers autoimmunity in an immune privileged site. Gut Microbes. 2017;8(1):59–66. doi:10.1080/19490976.2016.1273996.
   PubMed Web of Science ®Google Scholar
• Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun. 2011;25(3):397–407. doi:10.1016/j.bbi.2010.10.023.
   PubMed Web of Science ®Google Scholar
• Shinde T, Hansbro PM, Sohal SS, Dingle P, Eri R, Stanley R. Microbiota modulating nutritional approaches to countering the effects of viral respiratory infections including SARS-CoV-2 through promoting metabolic and immune fitness with probiotics and plant bioactives. Microorgan. 2020;8(6):6. doi:10.3390/microorganisms8060921.
   Web of Science ®Google Scholar
• Dalile B, Vervliet B, Bergonzelli G, Verbeke K, Van Oudenhove L. Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial. Neuropsychopharmacol. 2020;45(13):2257–2266. doi:10.1038/s41386-020-0732-x.
   PubMed Web of Science ®Google Scholar
• Karolkiewicz J, Nieman DC, Cisoń T, Szurkowska J, Gałęcka M, Sitkowski D, Szygula Z. No effects of a 4-week post-exercise sauna bathing on targeted gut microbiota and intestinal barrier function, and hsCRP in healthy men: a pilot randomized controlled trial. BMC Sports Sci Med Rehabil. 2022;14(1):107. doi:10.1186/s13102-022-00497-z.
   PubMed Web of Science ®Google Scholar
• Kasperek MC, Mailing L, Piccolo BD, Moody B, Lan R, Gao X, Hernandez‐Saavedra D, Woods JA, Adams SH, Allen JM, et al. Exercise training modifies xenometabolites in gut and circulation of lean and obese adults. Physiol Rep. 2023;11(6):e15638. doi:10.14814/phy2.15638.
   PubMed Web of Science ®Google Scholar
• Ding Z, Du L. Swimming exercise ameliorates depressive-like behavior by anti-inflammation activity, rebalancing gut Escherichia coli and lactobacilli. Brain Res. 2022;1797:148113. doi:10.1016/j.brainres.2022.148113.
   PubMed Web of Science ®Google Scholar
• Zarate-Blades CR, Horai R, Caspi RR. Regulation of autoimmunity by the microbiome. DNA Cell Biol. 2016;35(9):455–458. doi:10.1089/dna.2016.3432.
   PubMed Web of Science ®Google Scholar
• Xiang Q, Wu X, Pan Y, Wang L, Cui C, Guo Y, Zhu L, Peng J, Wei H. Early-life intervention using fecal microbiota combined with probiotics promotes gut microbiota maturation, regulates immune system development, and alleviates weaning stress in piglets. IJMS. 2020;21:2. doi:10.3390/ijms21020503.
   Google Scholar
• Yitbarek A, Astill J, Hodgins DC, Parkinson J, Nagy É, Sharif S. Commensal gut microbiota can modulate adaptive immune responses in chickens vaccinated with whole inactivated avian influenza virus subtype H9N2. Vaccine. 2019;37(44):6640–6647. doi:10.1016/j.vaccine.2019.09.046.
   PubMed Web of Science ®Google Scholar
• Sun T, Liu X, Su Y, Wang Z, Cheng B, Dong N, Wang J, Shan A. The efficacy of anti-proteolytic peptide R7I in intestinal inflammation, function, microbiota, and metabolites by multi-omics analysis in murine bacterial enteritis. Bioeng Transl Med. 2023;8(2):e10446. doi:10.1002/btm2.10446.
   PubMed Web of Science ®Google Scholar
• Li Z, Ke H, Wang Y, Chen S, Liu X, Lin Q, Wang P, Chen Y. Global trends in akkermansia muciniphila research: A bibliometric visualization. Front Microbiol. 2022;13:1037708. doi:10.3389/fmicb.2022.1037708.
   PubMed Web of Science ®Google Scholar
• Volpe MR, Velilla JA, Daniel-Ivad M, Yao JJ, Stornetta A, Villalta PW, Huang HC, Bachovchin DA, Balbo S, Gaudet R, et al. A small molecule inhibitor prevents gut bacterial genotoxin production. Nat Chem Biol. 2023;19(2):159–167. doi:10.1038/s41589-022-01147-8.
   PubMed Web of Science ®Google Scholar
• Taboe HB, Asare-Baah M, Iboi EA, Ngonghala CN. Critical assessment of the impact of vaccine-type and immunity on the burden of COVID-19. Math Biosci. 2023;108981. doi:10.1016/j.mbs.2023.108981.
   PubMed Web of Science ®Google Scholar
• Moore T, Hossain R, Doores KJ, Shankar-Hari M, Fear DJ. SARS-CoV-2-specific memory B cell responses are maintained after recovery from natural infection and postvaccination. Viral Immunol. 2022;35(6):425–436. doi:10.1089/vim.2022.0013.
   PubMed Web of Science ®Google Scholar
• Ahluwalia P, Vaibhav K, Ahluwalia M, Mondal AK, Sahajpal N, Rojiani AM, Kolhe R. Infection and immune memory: variables in robust protection by vaccines against SARS-CoV-2. Front Immunol. 2021;12:660019. doi:10.3389/fimmu.2021.660019.
   PubMed Web of Science ®Google Scholar
• Vazquez-Alejo E, Tarancon-Diez L, Espinar-Buitrago MDLS, Genebat M, Calderón A, Pérez-Cabeza G, Magro-Lopez E, Leal M, Muñoz-Fernández MÁ. Persistent exhausted T-cell immunity after severe COVID-19: 6-month evaluation in a prospective observational study. JCM. 2023;12(10):10. doi:10.3390/jcm12103539.
   Google Scholar
• Tang Z, Yu P, Guo Q, Chen M, Lei Y, Zhou L, Mai W, Chen L, Deng M, Kong W, et al. Clinical characteristics and host immunity responses of SARS-CoV-2 omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8. Virol J. 2023;20(1):106. doi:10.1186/s12985-023-02066-3.
   PubMed Web of Science ®Google Scholar
• Fabiani M, Margiotti K, Monaco F, Viola A, Cima A, Mesoraca A, Giorlandino C. Dynamics of SARS-CoV-2-specific B cell memory responses in infected and vaccinated individuals. Viral Immunol. 2023;36(5):343–350. doi:10.1089/vim.2022.0197.
   PubMed Web of Science ®Google Scholar
• Zollner A, Watschinger C, Rössler A, Farcet MR, Penner A, Böhm V, Kiechl SJ, Stampfel G, Hintenberger R, Tilg H, et al. B and T cell response to SARS-CoV-2 vaccination in health care professionals with and without previous COVID-19. EBioMedicine. 2021;70:103539. doi:10.1016/j.ebiom.2021.103539.
   PubMed Web of Science ®Google Scholar
• Sureshchandra S, Lewis SA, Doratt BM, Jankeel A, Ibraim IC, Messaoudi I. Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine. JCI Insight. 2021;6(24). doi:10.1172/jci.insight.153201.
   PubMed Web of Science ®Google Scholar
• Cheng X, Zhang Y, Li Y, Wu Q, Wu J, Park SK, Guo C, Lu J. Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases. BMC Microbiol. 2022;22(1):274. doi:10.1186/s12866-022-02686-9.
   PubMed Web of Science ®Google Scholar
• Mannan A, Hoque MN, Noyon SH, Mehedi HM, Foysal MJ, Salauddin A, Islam SM, Sharmen F, Tanni AA, Siddiki AZ, et al. SARS-CoV-2 infection alters the gut microbiome in diabetes patients: A cross-sectional study from Bangladesh. J Med Virol. 2023;95(4). doi:10.1002/jmv.28691.
   PubMed Web of Science ®Google Scholar
• Zyoud SH, Shakhshir M, Abushanab AS, Koni A, Shahwan M, Jairoun AA, Al-Jabi SW. Mapping the output of the global literature on the links between gut microbiota and COVID-19. J Health Popul Nutr. 2023;42(1):3. doi:10.1186/s41043-023-00346-w.
   PubMed Web of Science ®Google Scholar