Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine

References

• Bolte LA, Vich Vila A, Imhann F, Collij V, Gacesa R, Peters V, Wijmenga C, Kurilshikov A, Campmans-Kuijpers MJE, Fu J, et al. Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut. 2021;70(7):1287–17. doi:10.1136/gutjnl-2020-322670.
   PubMed Web of Science ®Google Scholar
• Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55–71. doi:10.1038/s41579-020-0433-9.
   PubMed Web of Science ®Google Scholar
• Zmora N, Suez J, Elinav E. You are what you eat: diet, health and the gut microbiota. Nat Rev Gastroenterol Hepatol. 2019;16(1):35–56. doi:10.1038/s41575-018-0061-2.
   PubMed Web of Science ®Google Scholar
• Boutari C, Mantzoros CS. A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on. Metabolism. 2022;133:155217. doi:10.1016/j.metabol.2022.155217.
   PubMedGoogle Scholar
• Tiwari A, Balasundaram P. Public Health Considerations Regarding Obesity. StatPearls. Treasure Island (FL): StatPearls Publishing
   Google Scholar
• Shapiro H, Suez J, Elinav E. Personalized microbiome-based approaches to metabolic syndrome management and prevention. J Diabetes. 2017;9(3):226–36. doi:10.1111/1753-0407.12501.
   PubMed Web of Science ®Google Scholar
• Tang WHW, Li DY, Hazen SL. Dietary metabolism, the gut microbiome, and heart failure. Nat Rev Cardiol 2019;16:137–54.
   Google Scholar
• Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell. 2016;165(1):111–24. doi:10.1016/j.cell.2016.02.011.
   PubMed Web of Science ®Google Scholar
• Koh A, Molinaro A, Ståhlman M, Khan MT, Schmidt C, Mannerås-Holm L, Wu H, Carreras A, Jeong H, Olofsson LE, et al. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell. 2018;175(4):947–61.e17. doi:10.1016/j.cell.2018.09.055.
   PubMed Web of Science ®Google Scholar
• Molinaro A, Nemet I, Bel Lassen P, Chakaroun R, Nielsen T, Aron-Wisnewsky J, Bergh P-O, Li L, Henricsson M, Køber L, et al. Microbially produced imidazole propionate is associated with heart failure and mortality. JACC Heart Fail. 2023;11(7):810–21. doi:10.1016/j.jchf.2023.03.008.
   PubMed Web of Science ®Google Scholar
• Cosme P, Rodriguez AB, Espino J, Garrido M. Plant phenolics: bioavailability as a key determinant of their potential health-promoting applications. Antioxid (Basel). 2020;9(12):1263. doi:10.3390/antiox9121263.
   PubMedGoogle Scholar
• Kumar Singh A, Cabral C, Kumar R, Ganguly R, Kumar Rana H, Gupta A, Rosaria Lauro M, Carbone C, Reis F, Pandey AK, et al. Beneficial effects of dietary polyphenols on gut microbiota and strategies to improve delivery efficiency. Nutrients. 2019;11(9):11. doi:10.3390/nu11092216.
   Web of Science ®Google Scholar
• Anhe FF, Pilon G, Roy D, Desjardins Y, Levy E, Marette A. Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome? Gut Microbes 2016; 7:146-53.
   Google Scholar
• Wan MLY, Co VA, El-Nezami H. Dietary polyphenol impact on gut health and microbiota. Crit Rev Food Sci Nutr. 2021;61(4):690–711. doi:10.1080/10408398.2020.1744512.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Daza MC, Pulido-Mateos EC, Lupien-Meilleur J, Guyonnet D, Desjardins Y, Roy D. Polyphenol-mediated gut microbiota modulation: toward prebiotics and further. Front Nutr. 2021;8:689456. doi:10.3389/fnut.2021.689456.
   PubMed Web of Science ®Google Scholar
• Wang X, Qi Y, Zheng H. Dietary polyphenol, gut microbiota, and health benefits. Antioxid (Basel). 2022;11(6):11. doi:10.3390/antiox11061212.
   Google Scholar
• Kerry RG, Patra JK, Gouda S, Park Y, Shin HS, Das G. Benefaction of probiotics for human health: a review. J Food Drug Anal. 2018;26(3):927–39. doi:10.1016/j.jfda.2018.01.002.
   PubMed Web of Science ®Google Scholar
• Roager H M, Licht T R. (2018). Microbial tryptophan catabolites in health and disease. Nat Commun, 9(1), 3294 10.1038/s41467-018-05470-4
   PubMedGoogle Scholar
• Cani PD, Knauf C. A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion. Cell Metab. 2021;33(6):1073–5. doi:10.1016/j.cmet.2021.05.004.
   PubMed Web of Science ®Google Scholar
• Markowiak-Kopeć P, Śliżewska K. The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome. Nutrients. 2020;12(4):12. doi:10.3390/nu12041107.
   Web of Science ®Google Scholar
• Donadio S, Monciardini P, Alduina R, Mazza P, Chiocchini C, Cavaletti L, Sosio M, Puglia AM. Microbial technologies for the discovery of novel bioactive metabolites. J Biotechnol. 2002;99(3):187–198. doi:10.1016/S0168-1656(02)00209-2.
   PubMed Web of Science ®Google Scholar
• Ma Y, Liu X, Wang J. Small molecules in the big picture of gut microbiome-host cross-talk. EBioMedicine. 2022;81:104085. doi:10.1016/j.ebiom.2022.104085.
   PubMed Web of Science ®Google Scholar
• Fobofou SA, Savidge T. Microbial metabolites: cause or consequence in gastrointestinal disease? Am J Physiol Gastrointest Liver Physiol. 2022;322(6):G535–G52. doi:10.1152/ajpgi.00008.2022.
   PubMed Web of Science ®Google Scholar
• Abdel-Razek AS, El-Naggar ME, Allam A, Morsy OM, Othman SI. Microbial natural products in drug discovery. Processes. 2020;8(4). doi: 10.3390/pr8040470.
   Web of Science ®Google Scholar
• Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients. 2017;9(9):1021. doi:10.3390/nu9091021.
   PubMed Web of Science ®Google Scholar
• Ohland CL, Macnaughton WK. Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol. 2010;298(6):G807–19. doi:10.1152/ajpgi.00243.2009.
   PubMed Web of Science ®Google Scholar
• Rinschen MM, Ivanisevic J, Giera M, Siuzdak G. Identification of bioactive metabolites using activity metabolomics. Nat Rev Mol Cell Biol. 2019;20(6):353–67. doi:10.1038/s41580-019-0108-4.
   PubMed Web of Science ®Google Scholar
• Lyu Q, Kuo TH, Sun C, Chen K, Hsu CC, Li X. Comprehensive structural characterization of phenolics in litchi pulp using tandem mass spectral molecular networking. Food Chem. 2019;282:9–17. doi:10.1016/j.foodchem.2019.01.001.
   PubMed Web of Science ®Google Scholar
• Ibrahim SR, Mohamed GA. Litchi chinensis: medicinal uses, phytochemistry, and pharmacology. J Ethnopharmacol. 2015;174:492–513. doi:10.1016/j.jep.2015.08.054.
   PubMed Web of Science ®Google Scholar
• Chukwuma CI, Izu GO, Chukwuma MS, Samson MS, Makhafola TJ, Erukainure OL. A review on the medicinal potential, toxicology, and phytochemistry of litchi fruit peel and seed. J Food Biochem. 2021;45(12):e13997. doi:10.1111/jfbc.13997.
   PubMed Web of Science ®Google Scholar
• Schellekens H, Torres-Fuentes C, van de Wouw M, Long-Smith CM, Mitchell A, Strain C, Berding K, Bastiaanssen TFS, Rea K, Golubeva AV, et al. Bifidobacterium longum counters the effects of obesity: partial successful translation from rodent to human. EBioMedicine. 2021;63:103176. doi:10.1016/j.ebiom.2020.103176.
   PubMed Web of Science ®Google Scholar
• Maldonado-Gomez MX, Martinez I, Bottacini F, O’Callaghan A, Ventura M, van Sinderen D, Hillmann B, Vangay P, Knights D, Hutkins R, et al. Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host & Microbe. 2016;20(4):515–26. doi:10.1016/j.chom.2016.09.001.
   PubMed Web of Science ®Google Scholar
• Anderson RC, Cookson AL, McNabb WC, Park Z, McCann MJ, Kelly WJ, Roy NC. Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiol. 2010;10(1):316. doi:10.1186/1471-2180-10-316.
   PubMedGoogle Scholar
• Mazloom K, Siddiqi I, Covasa M. Probiotics: how effective are they in the fight against obesity? Nutrients. 2019;11(2):11. doi:10.3390/nu11020258.
   Web of Science ®Google Scholar
• O’Shea EF, Cotter PD, Stanton C, Ross RP, Hill C. Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: bacteriocins and conjugated linoleic acid. Int J Food Microbiol. 2012;152(3):189–205. doi:10.1016/j.ijfoodmicro.2011.05.025.
   PubMed Web of Science ®Google Scholar
• Yoon SJ, Yu JS, Min BH, Gupta H, Won SM, Park HJ, Han SH, Kim B-Y, Kim KH, Kim BK, et al. Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis. Front Microbiol. 2023;14:1129904. doi:10.3389/fmicb.2023.1129904.
   PubMed Web of Science ®Google Scholar
• Hevia H, Varela-Rey M, Corrales FJ, Berasain C, Martinez-Chantar ML, Latasa MU, Lu SC, Mato JM, García-Trevijano ER, Avila MA, et al. 5′-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes. Hepatology. 2004;39(4):1088–1098. doi:10.1002/hep.20154.
   PubMed Web of Science ®Google Scholar
• Li Z, Wang F, Liang B, Su Y, Sun S, Xia S, Shao J, Zhang Z, Hong M, Zhang F, et al. Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication. Signal Transduct Target Ther. 2020;5(1):280. doi:10.1038/s41392-020-00349-7.
   PubMed Web of Science ®Google Scholar
• Li Y, Wang Y, Wu P. 5’-methylthioadenosine and cancer: old molecules, new understanding. J Cancer. 2019;10(4):927–36. doi:10.7150/jca.27160.
   PubMed Web of Science ®Google Scholar
• Andreu-Pérez P, Hernandez-Losa J, Moliné T, Gil R, Grueso J, Pujol A, Cortés J, Avila MA, Recio JA. Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth. BMC Cancer. 2010;10(1):265. doi:10.1186/1471-2407-10-265.
   PubMedGoogle Scholar
• Cirulli ET, Guo L, Leon Swisher C, Shah N, Huang L, Napier LA, Kirkness EF, Spector TD, Caskey CT, Thorens B, et al. Profound perturbation of the metabolome in obesity is associated with health risk. Cell Metab. 2019;29(2):488–500.e2. doi:10.1016/j.cmet.2018.09.022.
   PubMed Web of Science ®Google Scholar
• Perng W, Hector EC, Song PXK, Tellez Rojo MM, Raskind S, Kachman M, Cantoral A, Burant CF, Peterson KE. Metabolomic determinants of metabolic risk in Mexican adolescents. Obesity (Silver Spring). 2017;25(9):1594–1602. doi:10.1002/oby.21926.
   PubMed Web of Science ®Google Scholar
• Simile MM, Banni S, Angioni E, Carta G, De Miglio MR, Muroni MR, Calvisi DF, Carru A, Pascale RM, Feo F, et al. 5′-methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication. J Hepatol. 2001;34(3):386–394. doi:10.1016/S0168-8278(00)00078-7.
   PubMed Web of Science ®Google Scholar
• Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, et al. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab. 2021;48:101210. doi:10.1016/j.molmet.2021.101210.
   PubMed Web of Science ®Google Scholar
• Dong XY, Tang SQ. Insulin-induced gene: a new regulator in lipid metabolism. Peptides. 2010;31(11):2145–50. doi:10.1016/j.peptides.2010.07.020.
   PubMed Web of Science ®Google Scholar
• Krapivner S, Popov S, Chernogubova E, Hellenius ML, Fisher RM, Hamsten A, van’t Hooft FM. Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. J Clin Endocrinol Metab. 2008;93(5):1995–2001. doi:10.1210/jc.2007-1850.
   PubMed Web of Science ®Google Scholar
• Zadravec D, Brolinson A, Fisher RM, Carneheim C, Csikasz RI, Bertrand-Michel J, Borén J, Guillou H, Rudling M, Jacobsson A, et al. Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity. FASEB J. 2010;24(11):4366–4377. doi:10.1096/fj.09-152298.
   PubMed Web of Science ®Google Scholar
• Ali II, D’Souza C, Singh J, Adeghate E. Adropin’s role in energy homeostasis and metabolic disorders. Int J Mol Sci. 2022;23(15):23. doi:10.3390/ijms23158318.
   Web of Science ®Google Scholar
• Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD. A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology. 2013;57(2):543–54. doi:10.1002/hep.26043.
   PubMed Web of Science ®Google Scholar
• Avila MA, Garcia-Trevijano ER, Lu SC, Corrales FJ, Mato JM. Methylthioadenosine. Int J Biochem Cell Biol. 2004;36(11):2125–2130. doi:10.1016/j.biocel.2003.11.016.
   PubMed Web of Science ®Google Scholar
• Goodman AL, Kallstrom G, Faith JJ, Reyes A, Moore A, Dantas G, Gordon JI. Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc Natl Acad Sci U S A. 2011;108(15):6252–6257. doi:10.1073/pnas.1102938108.
   PubMed Web of Science ®Google Scholar
• Vichai V, Kirtikara K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc. 2006;1(3):1112–6. doi:10.1038/nprot.2006.179.
   PubMed Web of Science ®Google Scholar
• Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, et al. Sharing and community curation of mass spectrometry data with global natural products social molecular networking. Nat Biotechnol. 2016;34(8):828–837. doi:10.1038/nbt.3597.
   PubMed Web of Science ®Google Scholar
• Catalkaya G, Venema K, Lucini L, Rocchetti G, Delmas D, Daglia M, De Filippis A, Xiao H, Quiles JL, Xiao J, et al. Interaction of dietary polyphenols and gut microbiota: microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health. Food Front. 2020;1(2):109–33. doi:10.1002/fft2.25.
   Google Scholar
• Mithul Aravind S, Wichienchot S, Tsao R, Ramakrishnan S, Chakkaravarthi S. Role of dietary polyphenols on gut microbiota, their metabolites and health benefits. Food Res Int. 2021;142:142. doi:10.1016/j.foodres.2021.110189.
   Web of Science ®Google Scholar
• Correa TAF, Rogero MM, Hassimotto NMA, Lajolo FM. The two-way polyphenols-microbiota interactions and their effects on obesity and related metabolic diseases. Front Nutr. 2019;6:188. doi:10.3389/fnut.2019.00188.
   PubMed Web of Science ®Google Scholar
• Matsuki T, Watanabe K, Fujimoto J, Kado Y, Takada T, Matsumoto K, Tanaka R. Quantitative PCR with 16S rRNA-gene-targeted species-specific primers for analysis of human intestinal bifidobacteria. Appl Environ Microbiol. 2004;70(1):167–173. doi:10.1128/AEM.70.1.167-173.2004.
   PubMed Web of Science ®Google Scholar
• Rinttilä T, Kassinen A, Malinen E, Krogius L, Palva A. Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR. J Appl Microbiol. 2004;97(6):1166–77. doi:10.1111/j.1365-2672.2004.02409.x.
   PubMed Web of Science ®Google Scholar
• Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9(7):671–5. doi:10.1038/nmeth.2089.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262.
   PubMed Web of Science ®Google Scholar
• Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, et al. T cell–mediated regulation of the microbiota protects against obesity. Sci. 2019;365(6451). doi:10.1126/science.aat9351.
   PubMed Web of Science ®Google Scholar
• Sayin SI, Wahlström A, Felin J, Jäntti S, Marschall HU, Bamberg K, Angelin B, Hyötyläinen T, Orešič M, Bäckhed F, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013;17(2):225–35. doi:10.1016/j.cmet.2013.01.003.
   PubMed Web of Science ®Google Scholar
• Nothias L, et al. Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation. J Nat Prod. 2018;81(4):758–767.
   PubMed Web of Science ®Google Scholar