642
Views
0
CrossRef citations to date
0
Altmetric
Commentary and View

From a hunger-regulating hormone to an antimicrobial peptide: gastrointestinal derived circulating endocrine hormone-peptide YY exerts exocrine antimicrobial effects against selective gut microbiota

, ORCID Icon & ORCID Icon

References

  • Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG. et al. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science. 2023;381(6657):502–6. doi:10.1126/science.abq3178.
  • Hansen HH, Grønlund RV, Baader-Pagler T, Haebel P, Tammen H, Larsen LK, Jelsing J, Vrang N, Klein T. Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice. Sci Rep. 2021;11(1):8060. doi:10.1038/s41598-021-87539-7.
  • Bliss ES, Whiteside E. The gut-brain axis, the human gut microbiota and their integration in the development of obesity. Front Physiol. 2018;9:900. doi:10.3389/fphys.2018.00900.
  • Wang SL, Shao B-Z, Zhao S-B, Fang J, Gu L, Miao C-Y, Li Z-S, Bai Y. Impact of paneth cell autophagy on inflammatory bowel disease. Front Immunol. 2018;9:693. doi:10.3389/fimmu.2018.00693.
  • Adolph TE, Tomczak MF, Niederreiter L, Ko H-J, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S. et al. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013;503(7475):272–6. doi:10.1038/nature12599.
  • Cui C, Wang X, Li L, Wei H, Peng J. Multifaceted involvements of paneth cells in various diseases within intestine and systemically. Front Immunol. 2023;14:1115552. doi:10.3389/fimmu.2023.1115552.
  • Balleza D. Peptide flexibility and the hydrophobic moment are determinants to evaluate the clinical potential of magainins. J Membr Biol. 2023;256(4–6):317–330. doi:10.1007/s00232-023-00286-w.
  • Di Somma A, Cané C, Moretta A, Illiano A, Pinto G, Cavasso D, Amoresano A, Paduano L, Duilio A. The antimicrobial peptide magainin-2 interacts with BamA impairing folding of E. coli membrane proteins. Front Chem. 2022;10:1013788. doi:10.3389/fchem.2022.1013788.
  • Sokol H, Leducq V, Aschard H, Pham H-P, Jegou S, Landman C, Cohen D, Liguori G, Bourrier A, Nion-Larmurier I. et al. Fungal microbiota dysbiosis in IBD. Gut. 2017;66(6):1039–1048. doi:10.1136/gutjnl-2015-310746.
  • Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM. Candida albicans morphogenesis programs control the balance between gut commensalism and invasive infection. Cell Host Microbe. 2019;25(3):432–443 e6. doi:10.1016/j.chom.2019.02.008.
  • Mukherjee S, Hooper LV. Antimicrobial defense of the intestine. Immunity. 2015;42(1):28–39. doi:10.1016/j.immuni.2014.12.028.
  • Guida C, McCulloch LJ, Godazgar M, Stephen SD, Baker C, Basco D, Dong J, Chen D, Clark A, Ramracheya RD. et al. Sitagliptin and roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY. Diabetes Obes Metab. 2018;20(3):571–581. doi:10.1111/dom.13113.
  • Wu Y, He H, Cheng Z, Bai Y, Ma X. The role of neuropeptide Y and peptide YY in the development of obesity via gut-brain axis. Curr Protein Pept Sci. 2019;20(7):750–758. doi:10.2174/1389203720666190125105401.
  • Holzer P, Reichmann F, Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides. 2012;46(6):261–274. doi:10.1016/j.npep.2012.08.005.
  • Verbiest A, Wauters L, Vanuytsel T. Enterohormone therapy for short bowel syndrome. Curr Opin Endocrinol Diabetes Obes. 2022;29(2):207–218. doi:10.1097/MED.0000000000000710.
  • Min C, Ohta K, Kajiya M, Zhu T, Sharma K, Shin J, Mawardi H, Howait M, Hirschfeld J, Bahammam L. et al. The antimicrobial activity of the appetite peptide hormone ghrelin. Peptides. 2012;36(2):151–6. doi:10.1016/j.peptides.2012.05.006.
  • Chiba M, Sanada Y, Kawano S, Murofushi M, Okada I, Yoshizawa Y, Gomi A, Yatsuzuka M, Toki A, Hirai Y. et al. Glicentin inhibits internalization of enteric bacteria by cultured INT-407 enterocytes. Pediatr Surg Int. 2007;23(6):551–4. doi:10.1007/s00383-007-1895-9.
  • Hegazy WAH, Rajab AAH, Abu Lila AS, Abbas HA. Anti-diabetics and antimicrobials: harmony of mutual interplay. World J Diabetes. 2021;12(11):1832–1855. doi:10.4239/wjd.v12.i11.1832.
  • Abdalla MMI, Mohanraj J, Somanath SD. Adiponectin as a therapeutic target for diabetic foot ulcer. World J Diabetes. 2023;14(6):758–782. doi:10.4239/wjd.v14.i6.758.
  • He F, Liu Y, Li P, Wu X, Xia Y, Zhang D, Li N, Peng Y, Zhu G, Hardeland R. et al. Melatonin inhibits gram-negative pathogens by targeting citrate synthase. Sci China Life Sci. 2022;65(7):1430–1444. doi:10.1007/s11427-021-2032-9.
  • Fawkner-Corbett D, Antanaviciute A, Parikh K, Jagielowicz M, Gerós AS, Gupta T, Ashley N, Khamis D, Fowler D, Morrissey E. et al. Spatiotemporal analysis of human intestinal development at single-cell resolution. Cell. 2021;184(3):810–826 e23. doi:10.1016/j.cell.2020.12.016.
  • Wiarda JE, Becker SR, Sivasankaran SK, Loving CL. Regional epithelial cell diversity in the small intestine of pigs. J Anim Sci. 2023;101:101. doi:10.1093/jas/skac318.
  • Han L, Wei X, Liu C, Volpe G, Zhuang Z, Zou X, Wang Z, Pan T, Yuan Y, Zhang X. et al. Cell transcriptomic atlas of the non-human primate Macaca fascicularis. Nature. 2022;604(7907):723–731. doi:10.1038/s41586-022-04587-3.
  • Wang R, Zhang P, Wang J, Ma L, E W, Suo S, Jiang M, Li J, Chen H, Sun H. et al. Construction of a cross-species cell landscape at single-cell level. Nucleic Acids Res. 2023;51(2):501–516. doi:10.1093/nar/gkac633.
  • Ma Y, Guo Z, Xia B, Zhang Y, Liu X, Yu Y, Tang N, Tong X, Wang M, Ye X. et al. Identification of antimicrobial peptides from the human gut microbiome using deep learning. Nat Biotechnol. 2022;40(6):921–931. doi:10.1038/s41587-022-01226-0.