Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages

References

• Yoshino T, Arnold D, Taniguchi H, Pentheroudakis G, Yamazaki K, Xu RH, Kim TW, Ismail F, Tan IB, Yeh KH. et al. Pan-asian adapted esmo consensus guidelines for the management of patients with metastatic colorectal cancer: a JSMO-ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS. Ann Oncol. 2018;29(1):44–22. doi:10.1093/annonc/mdx738.
   PubMed Web of Science ®Google Scholar
• Abu-Sbeih H, Mallepally N, Goldstein R, Chen E, Tang T, Dike UK, Al-Asadi M, Westin S, Halperin D, Wang Y. Gastrointestinal toxic effects in patients with cancer receiving platinum-based therapy. J Cancer. 2020;11(11):3144–3150. doi:10.7150/jca.37777.
   PubMed Web of Science ®Google Scholar
• Kang L, Tian Y, Xu S, Chen H. Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment. J Neurol. 2021;268(9):3269–3282. doi:10.1007/s00415-020-09942-w.
   PubMed Web of Science ®Google Scholar
• Stack A, Khanal R, Denlinger CS. Oxaliplatin-induced immune thrombocytopenia: a case report and literature review. Clin Colorectal Cancer. 2021;20(1):e1–e4. doi:10.1016/j.clcc.2020.07.007.
   PubMed Web of Science ®Google Scholar
• Cheng WY, Wu CY, Yu J. The role of gut microbiota in cancer treatment: friend or foe? Gut. 2020;69(10):1867–1876. doi:10.1136/gutjnl-2020-321153.
   PubMed Web of Science ®Google Scholar
• Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM. et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370(6516). doi:10.1126/science.aay9097
   Web of Science ®Google Scholar
• Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, Dupont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC. et al. Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis. Nat Med. 2018;24(12):1804–1808. doi:10.1038/s41591-018-0238-9.
   PubMed Web of Science ®Google Scholar
• De Pietri S, Ingham AC, Frandsen TL, Rathe M, Krych L, Castro-Mejía JL, Nielsen DS, Nersting J, Wehner PS, Schmiegelow K. et al. Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: the impact of the gut microbiota. Int J Cancer. 2020;147(7):1953–1962. doi:10.1002/ijc.32942.
   PubMed Web of Science ®Google Scholar
• Ding C, Tang W, Fan X, Wu G. Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics. Onco Targets Ther. 2018;11:4797–4810. doi:10.2147/OTT.S170626.
   PubMed Web of Science ®Google Scholar
• Grant CV, Loman BR, Bailey MT, Pyter LM. Manipulations of the gut microbiome alter chemotherapy-induced inflammation and behavioral side effects in female mice. Brain Behav Immun. 2021;95:401–412. doi:10.1016/j.bbi.2021.04.014.
   PubMed Web of Science ®Google Scholar
• Berthold DL, Jones K, Udalova IA. Regional specialization of macrophages along the gastrointestinal tract. Trends Immunol. 2021;42(9):795–806. doi:10.1016/j.it.2021.07.006.
   PubMed Web of Science ®Google Scholar
• Yang Y, Li L, Xu C, Wang Y, Wang Z, Chen M, Jiang Z, Pan J, Yang C, Li X. et al. Cross-talk between the gut microbiota and monocyte-like macrophages mediates an inflammatory response to promote colitis-associated tumourigenesis. Gut. 2020;70(8):1495–1506. doi:10.1136/gutjnl-2020-320777.
   PubMed Web of Science ®Google Scholar
• Li M, Chen J, Liu S, Sun X, Xu H, Gao Q, Chen X, Xi C, Huang D, Deng Y. et al. Spermine-related DNA hypermethylation and elevated expression of genes for collagen formation are susceptible factors for chemotherapy-induced hand-foot syndrome in Chinese colorectal cancer patients. Front Pharmacol. 2021;12:746910. doi:10.3389/fphar.2021.746910.
   PubMed Web of Science ®Google Scholar
• Chen LX, Qi YL, Qi Z, Gao K, Gong RZ, Shao ZJ, Liu SX, Li SS, Sun YS. A comparative study on the effects of different parts of panax ginseng on the immune activity of cyclophosphamide-induced immunosuppressed mice. Molecules. 2019;24(6):1096. doi:10.3390/molecules24061096.
   PubMed Web of Science ®Google Scholar
• Aston WJ, Hope DE, Nowak AK, Robinson BW, Lake RA, Lesterhuis WJ. A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice. BMC Cancer. 2017;17(1):684. doi:10.1186/s12885-017-3677-7.
   PubMedGoogle Scholar
• Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O’Neill LA, Xavier RJ. Trained immunity: a program of innate immune memory in health and disease. Science. 2016;352(6284):aaf1098. doi:10.1126/science.aaf1098.
   PubMed Web of Science ®Google Scholar
• Lee J, D’Aigle J, Atadja L, Quaicoe V, Honarpisheh P, Ganesh BP, Hassan A, Graf J, Petrosino J, Putluri N. et al. Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice. Circ Res. 2020;127(4):453–465. doi:10.1161/CIRCRESAHA.119.316448.
   PubMed Web of Science ®Google Scholar
• Jobin C. Gpr109a: the missing link between microbiome and good health? Immunity. 2014;40(1):8–10. doi:10.1016/j.immuni.2013.12.009.
   PubMed Web of Science ®Google Scholar
• Lin XB, Dieleman LA, Ketabi A, Bibova I, Sawyer MB, Xue H, Field CJ, Baracos VE, Gänzle MG, Ahmed N. Irinotecan (cpt-11) chemotherapy alters intestinal microbiota in tumour bearing rats. PloS One. 2012;7(7):e39764. doi:10.1371/journal.pone.0039764.
   PubMed Web of Science ®Google Scholar
• Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S. et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010;330(6005):831–835. doi:10.1126/science.1191175.
   PubMed Web of Science ®Google Scholar
• Pollet RM, D’Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN. et al. An atlas of β-glucuronidases in the human intestinal microbiome. Structure. 2017;25(7):967–977. doi:10.1016/j.str.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Rajagopala SV, Singh H, Yu Y, Zabokrtsky KB, Torralba MG, Moncera KJ, Frank B, Pieper R, Sender L, Nelson KE. Persistent gut microbial dysbiosis in children with acute lymphoblastic leukemia (all) during chemotherapy. Microb Ecol. 2020;79(4):1034–1043. doi:10.1007/s00248-019-01448-x.
   PubMed Web of Science ®Google Scholar
• Alexander JL, Wilson ID, Teare J, Marchesi JR, Nicholson JK, Kinross JM. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol. 2017;14(6):356–365. doi:10.1038/nrgastro.2017.20.
   PubMed Web of Science ®Google Scholar
• Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ. et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013;342(6161):971–976. doi:10.1126/science.1240537.
   PubMed Web of Science ®Google Scholar
• Dubin K, Callahan MK, Ren B, Khanin R, Viale A, Ling L, No D, Gobourne A, Littmann E, Huttenhower C. et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat Commun. 2016;7(1):10391. doi:10.1038/ncomms10391.
   PubMed Web of Science ®Google Scholar
• Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP. et al. Anticancer immunotherapy by ctla-4 blockade relies on the gut microbiota. Science. 2015;350(6264):1079–1084. doi:10.1126/science.aad1329.
   PubMed Web of Science ®Google Scholar
• Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML. et al. Commensal bifidobacterium promotes antitumor immunity and facilitates anti-pd-l1 efficacy. Science. 2015;350(6264):1084–1089. doi:10.1126/science.aac4255.
   PubMed Web of Science ®Google Scholar
• Ouyang W, O’Garra A. Il-10 family cytokines il-10 and il-22: from basic science to clinical translation. Immunity. 2019;50(4):871–891. doi:10.1016/j.immuni.2019.03.020.
   PubMed Web of Science ®Google Scholar
• Saraiva M, O’Garra A. The regulation of il-10 production by immune cells. Nat Rev Immunol. 2010;10(3):170–181. doi:10.1038/nri2711.
   PubMed Web of Science ®Google Scholar
• Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers A, Yagita H, Ohteki T. et al. A single strain of clostridium butyricum induces intestinal il-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013;13(6):711–722. doi:10.1016/j.chom.2013.05.013.
   PubMed Web of Science ®Google Scholar
• Naing A, Wong DJ, Infante JR, Korn WM, Aljumaily R, Papadopoulos KP, Autio KA, Pant S, Bauer TM, Drakaki A. et al. Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (ivy): a multicentre, multicohort, open-label, phase 1b trial. Lancet Oncol. 2019;20(11):1544–1555. doi:10.1016/S1470-2045(19)30514-5.
   PubMed Web of Science ®Google Scholar
• Costes L, Lindenbergh-Kortleve DJ, van Berkel LA, Veenbergen S, Raatgeep H, Simons-Oosterhuis Y, van Haaften DH, Karrich JJ, Escher JC, Groeneweg M. et al. Il-10 signaling prevents gluten-dependent intraepithelial cd4(+) cytotoxic t lymphocyte infiltration and epithelial damage in the small intestine. Mucosal Immunology. 2019;12(2):479–490. doi:10.1038/s41385-018-0118-0.
   PubMed Web of Science ®Google Scholar
• Gunasekera DC, Ma J, Vacharathit V, Shah P, Ramakrishnan A, Uprety P, Shen Z, Sheh A, Brayton CF, Whary MT. et al. The development of colitis in il10(-/-) mice is dependent on il-22. Mucosal Immunol. 2020;13(3):493–506. doi:10.1038/s41385-019-0252-3.
   PubMed Web of Science ®Google Scholar
• Zaimoku Y, Patel BA, Kajigaya S, Feng X, Alemu L, Quinones RD, Groarke EM, Young NS. Deficit of circulating cd19(+) cd24(hi) cd38(hi) regulatory b cells in severe aplastic anaemia. Br J Haematol. 2020;190(4):610–617. doi:10.1111/bjh.16651.
   PubMed Web of Science ®Google Scholar
• Feng X, Lin Z, Sun W, Hollinger MK, Desierto MJ, Keyvanfar K, Malide D, Muranski P, Chen J, Young NS. Rapamycin is highly effective in murine models of immune-mediated bone marrow failure. Haematologica. 2017;102(10):1691–1703. doi:10.3324/haematol.2017.163675.
   PubMed Web of Science ®Google Scholar
• Wei HJ, Gupta A, Kao WM, Almudallal O, Letterio JJ, Pareek TK. Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia. J Autoimmun. 2018;94:33–44. doi:10.1016/j.jaut.2018.07.005.
   PubMed Web of Science ®Google Scholar
• Agnes JP, Santos V, Das NR, Gonçalves RM, Delgobo M, Girardi CS, Lückemeyer DD, Ferreira MA, Macedo-Júnior SJ, Lopes SC. et al. Antioxidants improve oxaliplatin-induced peripheral neuropathy in tumor-bearing mice model: role of spinal cord oxidative stress and inflammation. The Journal Of Pain. 2021;22(8):996–1013. doi:10.1016/j.jpain.2021.03.142.
   PubMed Web of Science ®Google Scholar
• Wong D, Holanda R, Cajado AG, Bandeira AM, Pereira J, Amorim JO, Torres CS, Ferreira L, Lopes M, Oliveira R. et al. Tlr4 deficiency upregulates tlr9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea. Br J Pharmacol. 2021;178(20):4193–4209. doi:10.1111/bph.15609.
   PubMed Web of Science ®Google Scholar
• Karlsson M, Scherbak N, Reid G, Jass J. Lactobacillus rhamnosus gr-1 enhances nf-kappab activation in Escherichia coli-stimulated urinary bladder cells through tlr4. BMC Microbiol. 2012;12(1):15. doi:10.1186/1471-2180-12-15.
   PubMedGoogle Scholar
• Zabłocka A, Jakubczyk D, Leszczyńska K, Pacyga-Prus K, Macała J, Górska S. Studies of the impact of the bifidobacterium species on inducible nitric oxide synthase expression and nitric oxide production in murine macrophages of the bmdm cell line. Probiotics Antimicrob Proteins. 2023;10.1007/s12602–023–10093–3. doi:10.1007/s12602-023-10093-3.
   PubMed Web of Science ®Google Scholar
• Ma T, Shen X, Shi X, Sakandar HA, Quan K, Li Y, Jin H, Kwok L, Zhang H, Sun Z. Targeting gut microbiota and metabolism as the major probiotic mechanism - an evidence-based review. Trends Food Sci Technol. 2023;138:178–198. doi:10.1016/j.tifs.2023.06.013.
   Web of Science ®Google Scholar
• Mcdonald D, Jiang Y, Balaban M, Cantrell K, Zhu Q, Gonzalez A, Morton JT, Nicolaou G, Parks DH, Karst SM. et al. Author correction: Greengenes2 unifies microbial data in a single reference tree. Nat Biotechnol. 2023:10.1038/s41587–023–01845–1. doi:10.1038/s41587-023-02026-w
   Web of Science ®Google Scholar
• He Z, Wu J, Gong J, Ke J, Ding T, Zhao W, Cheng WM, Luo Z, He Q, Zeng W. et al. Microbiota in mesenteric adipose tissue from crohn’s disease promote colitis in mice. Microbiome. 2021;9(1):228. doi:10.1186/s40168-021-01178-8.
   PubMed Web of Science ®Google Scholar