Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum

References

• Agrawal M, Allin KH, Petralia F, Colombel JF, Jess T. Multiomics to elucidate inflammatory bowel disease risk factors and pathways. Nat Rev Gastro Hepat. 2022;19(6):399–13. doi:10.1038/s41575-022-00593-y.
   PubMed Web of Science ®Google Scholar
• Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastro Hepat. 2015;12(12):720–7. doi:10.1038/nrgastro.2015.150.
   PubMed Web of Science ®Google Scholar
• Mao R, Chen M. Precision medicine in IBD: genes, drugs, bugs and omics. Nat Rev Gastro Hepat. 2022;19(2):81–2. doi:10.1038/s41575-021-00555-w.
   PubMed Web of Science ®Google Scholar
• Lee M, Chang EB. Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues. Gastroenterology. 2021;160(2):524–537. doi:10.1053/j.gastro.2020.09.056.
   PubMed Web of Science ®Google Scholar
• Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology. 2004;126(6):1620–33. doi:10.1053/j.gastro.2004.03.024.
   PubMed Web of Science ®Google Scholar
• Shan Y, Lee M, Chang EB. The gut microbiome and inflammatory bowel diseases. Annu Rev Med. 2022;73(1):455–68. doi:10.1146/annurev-med-042320-021020.
   PubMedGoogle Scholar
• Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R. et al. Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet. 2017;389(10075):1218–28. doi:10.1016/S0140-6736(17)30182-4.
   PubMed Web of Science ®Google Scholar
• Paramsothy S, Nielsen S, Kamm MA, Deshpande NP, Faith JJ, Clemente JC, Paramsothy R, Walsh AJ, van den Bogaerde J, Samuel D. et al. Specific bacteria and metabolites associated with response to fecal microbiota transplantation in patients with ulcerative colitis. Gastroenterology. 2019;156(5):1440–54.e2. doi:10.1053/j.gastro.2018.12.001.
   PubMed Web of Science ®Google Scholar
• Russo E, Giudici F, Fiorindi C, Ficari F, Scaringi S, Amedei A. Immunomodulating activity and therapeutic effects of short chain fatty acids and tryptophan post-biotics in Inflammatory bowel disease. Front Immunol. 2019;10:2754. doi:10.3389/fimmu.2019.02754.
   PubMed Web of Science ®Google Scholar
• Lavelle A, Sokol H. Gut microbiota-derived metabolites as key actors in inflammatory bowel disease. Nat Rev Gastro Hepat. 2020;17(4):223–37. doi:10.1038/s41575-019-0258-z.
   PubMed Web of Science ®Google Scholar
• Sun M, Ma N, He T, Johnston LJ, Ma X. Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR). Crit Rev Food Sci Nutr. 2020;60(10):1760–8. doi:10.1080/10408398.2019.1598334.
   PubMed Web of Science ®Google Scholar
• Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, Stärkel P, Ho SB, Gao B, Fiehn O. et al. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 2019;68(8):1504–15. doi:10.1136/gutjnl-2018-317232.
   PubMed Web of Science ®Google Scholar
• Ji Y, Gao Y, Chen H, Yin Y, Zhang W. Indole-3-acetic acid alleviates nonalcoholic fatty liver disease in mice via attenuation of hepatic lipogenesis, and oxidative and inflammatory stress. Nutrients. 2019;11(9):2062. doi:10.3390/nu11092062.
   PubMed Web of Science ®Google Scholar
• Xu X, Sun S, Liang L, Lou C, He Q, Ran M, Zhang L, Zhang J, Yan C, Yuan H. et al. Role of the aryl hydrocarbon receptor and gut microbiota-derived metabolites indole-3-acetic acid in sulforaphane alleviates hepatic steatosis in mice. Front Nutr. 2021;8:756565. doi:10.3389/fnut.2021.756565.
   PubMed Web of Science ®Google Scholar
• Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13(1):3–10. doi:10.1016/j.autrev.2013.06.004.
   PubMed Web of Science ®Google Scholar
• Franzosa EA, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser HJ, Reinker S, Vatanen T, Hall AB, Mallick H, McIver LJ. et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. 2019;4(2):293–305. doi:10.1038/s41564-018-0306-4.
   PubMed Web of Science ®Google Scholar
• Mayo B, Vázquez L, AB F. Equol: a bacterial metabolite from the daidzein isoflavone and its presumed beneficial health effects. Nutrients. 2019;11(9):2231. doi:10.3390/nu11092231.
   PubMed Web of Science ®Google Scholar
• Setchell KD, Clerici C. Equol: history, chemistry, and formation. J Nutr. 2010;140(7):1355s–1362s. doi:10.3945/jn.109.119776.
   PubMed Web of Science ®Google Scholar
• Mustafa SE, Mustafa S, Abas F, Manap M, Ismail A, Amid M, Elzen S. Optimization of culture conditions of soymilk for equol production by Bifidobacterium breve 15700 and Bifidobacterium longum BB536. Food Chem. 2019;278:767–772. doi:10.1016/j.foodchem.2018.11.107.
   PubMed Web of Science ®Google Scholar
• Clough JN, Omer OS, Tasker S, Lord GM, Irving PM. Regulatory T-cell therapy in Crohn’s disease: challenges and advances. Gut. 2020;69(5):942–52. doi:10.1136/gutjnl-2019-319850.
   PubMed Web of Science ®Google Scholar
• Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR. et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28(4):546–58. doi:10.1016/j.immuni.2008.02.017.
   PubMed Web of Science ®Google Scholar
• Lathrop SK, Bloom SM, Rao SM, Nutsch K, Lio CW, Santacruz N, Peterson DA, Stappenbeck TS, Hsieh C-S. Peripheral education of the immune system by colonic commensal microbiota. Nature. 2011;478(7368):250–254. doi:10.1038/nature10434.
   PubMed Web of Science ®Google Scholar
• Jacobse J, Li J, Rings E, Samsom JN, Goettel JA. Intestinal regulatory T cells as specialized tissue-restricted immune cells in intestinal immune homeostasis and disease. Front Immunol. 2021;12:716499. doi:10.3389/fimmu.2021.716499.
   PubMed Web of Science ®Google Scholar
• Song X, Sun X, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C. et al. Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis. Nature. 2020;577(7790):410–415. doi:10.1038/s41586-019-1865-0.
   PubMed Web of Science ®Google Scholar
• Shim JA, Ryu JH, Jo Y, Hong C. The role of gut microbiota in T cell immunity and immune mediated disorders. Int J Biol Sci. 2023;19(4):1178–91. doi:10.7150/ijbs.79430.
   PubMedGoogle Scholar
• Bui TI, Gill AL, Mooney RA, Gill SR, Auchtung JM. Modulation of gut microbiota metabolism in obesity-related type 2 diabetes reduces osteomyelitis severity. Microbiol Spectr. 2022;10(2):e0017022. doi:10.1128/spectrum.00170-22.
   PubMed Web of Science ®Google Scholar
• Guo W, Mao B, Cui S, Tang X, Zhang Q, Zhao J, Zhang H. Protective effects of a novel probiotic bifidobacterium pseudolongum on the intestinal barrier of colitis mice via modulating the Pparγ/STAT3 pathway and intestinal microbiota. Foods. 2022;11(11):1551. doi:10.3390/foods11111551.
   PubMed Web of Science ®Google Scholar
• Paterni I, Granchi C, Katzenellenbogen JA, Minutolo F. Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. Steroids. 2014;90:13–29. doi:10.1016/j.steroids.2014.06.012.
   PubMed Web of Science ®Google Scholar
• Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics. 1997;45(3):607–17. doi:10.1006/geno.1997.4972.
   PubMed Web of Science ®Google Scholar
• Wang WJ, Liu FJ, Xin L, Hao CF, Bao HC, Qu QL, Liu X-M. Adoptive transfer of pregnancy-induced CD4+CD25+ regulatory T cells reverses the increase in abortion rate caused by interleukin 17 in the CBA/J×BALB/c mouse model. Hum Reprod. 2014;29(5):946–952. doi:10.1093/humrep/deu014.
   PubMed Web of Science ®Google Scholar
• Adurthi S, Kumar MM, Vinodkumar HS, Mukherjee G, Krishnamurthy H, Acharya KK, Bafna UD, Uma DK, Abhishekh B, Krishna S. et al. Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. Sci Rep. 2017;7(1):17289. doi:10.1038/s41598-017-17102-w.
   PubMedGoogle Scholar
• Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005;307(5715):1625–30. doi:10.1126/science.1106943.
   PubMed Web of Science ®Google Scholar
• Warner M, Huang B, Gustafsson J-A. Estrogen Receptor β as a Pharmaceutical Target. Trends Pharmacol Sci. 2017;38(1):92–9. doi:10.1016/j.tips.2016.10.006.
   PubMed Web of Science ®Google Scholar
• Saleiro D, Murillo G, Benya RV, Bissonnette M, Hart J, Mehta RG. Estrogen receptor-β protects against colitis-associated neoplasia in mice. Int J Cancer. 2012;131(11):2553–61. doi:10.1002/ijc.27578.
   PubMed Web of Science ®Google Scholar
• Guo D, Liu X, Zeng C, Cheng L, Song G, Hou X, Zhu L, Zou K. Estrogen receptor β activation ameliorates DSS-induced chronic colitis by inhibiting inflammation and promoting treg differentiation. Int Immunopharmacol. 2019;77:105971. doi:10.1016/j.intimp.2019.105971.
   PubMed Web of Science ®Google Scholar
• Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 2010;8(6):e1000412. doi:10.1371/journal.pbio.1000412.
   PubMed Web of Science ®Google Scholar
• Jang YJ, Kim WK, Han DH, Lee K, Ko G. Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota. Gut Microbes. 2019;10(6):696–711. doi:10.1080/19490976.2019.1589281.
   PubMed Web of Science ®Google Scholar
• Han X, Li M, Sun L, Liu X, Yin Y, Hao J, Zhang W. p-Hydroxybenzoic Acid Ameliorates Colitis by Improving the Mucosal Barrier in a Gut Microbiota-Dependent Manner. Nutrients. 2022;14(24):5383. doi:10.3390/nu14245383.
   PubMed Web of Science ®Google Scholar
• Want EJ, Masson P, Michopoulos F, Wilson ID, Theodoridis G, Plumb RS, Shockcor J, Loftus N, Holmes E, Nicholson JK. et al. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc. 2013;8(1):17–32. doi:10.1038/nprot.2012.135.
   PubMed Web of Science ®Google Scholar