Ecological insights into hematopoiesis regulation: unraveling the influence of gut microbiota

References

• Collins A, Mitchell CA, Passegué E. Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis. J Exp Med. 2021;218(7). doi:10.1084/jem.20201545.
   Web of Science ®Google Scholar
• Baquero F, Nombela C. The microbiome as a human organ. Clin Microbiol Infect. 2012;18(Suppl 4):2–23. doi:10.1111/j.1469-0691.2012.03916.x.
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S. Host-gut microbiota metabolic interactions. Science. 2012;336(6086):1262–1267. doi:10.1126/science.1223813.
   PubMed Web of Science ®Google Scholar
• Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Develop. 1999;126(22):5073–5084. doi:10.1242/dev.126.22.5073.
   PubMed Web of Science ®Google Scholar
• Yokota T, Huang J, Tavian M, Nagai Y, Hirose J, Züñiga-Pflücker J-C, Péault B, Kincade PW. Tracing the first waves of lymphopoiesis in mice. Develop. 2006;133(10):2041–2051. doi:10.1242/dev.02349.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Wei H, Yamanashi T, Azevedo Portilho N, Cornelius S, Valiente N, Nishida C, Cheng H, Latorre A, Zheng WJ. et al. HSC-independent definitive hematopoiesis persists into adult life. Cell Rep. 2023;42(3):112239. doi:10.1016/j.celrep.2023.112239.
   PubMed Web of Science ®Google Scholar
• Iturri L, Freyer L, Biton A, Dardenne P, Lallemand Y, Gomez Perdiguero E. Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation. Immunity. 2021;54(7):1433–1446.e5. doi:10.1016/j.immuni.2021.04.026.
   PubMed Web of Science ®Google Scholar
• Palis J. Hematopoietic stem cell-independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo. FEBS Lett. 2016;590(22):3965–3974. doi:10.1002/1873-3468.12459.
   PubMed Web of Science ®Google Scholar
• Choi K, Kennedy M, Kazarov A. A common precursor for hematopoietic and endothelial cells. Development. 1998;125(4):725–732. doi:10.1242/dev.125.4.725.
   PubMed Web of Science ®Google Scholar
• Dzierzak E, Speck NA. Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol. 2008;9(2):129–136. doi:10.1038/ni1560.
   PubMed Web of Science ®Google Scholar
• Wu Y, Hirschi KK. Regulation of hemogenic endothelial cell development and function. Annu Rev Physiol. 2021;83(1):17–37. doi:10.1146/annurev-physiol-021119-034352.
   PubMedGoogle Scholar
• Canu G, Ruhrberg C. First blood: the endothelial origins of hematopoietic progenitors. Angiogen. 2021;24(2):199–211. doi:10.1007/s10456-021-09783-9.
   PubMed Web of Science ®Google Scholar
• Samarakkody AS, Cantor AB. Opening the window for endothelial-to-hematopoietic transition. Genes Dev. 2021;35(21–22):1398–1400. doi:10.1101/gad.349056.121.
   PubMed Web of Science ®Google Scholar
• Kissa K, Herbomel P. Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature. 2010;464(7285):112–115. doi:10.1038/nature08761.
   PubMed Web of Science ®Google Scholar
• Ruiz-Herguido C, Guiu J, D’Altri T, Inglés-Esteve J, Dzierzak E, Espinosa L, Bigas A. Hematopoietic stem cell development requires transient Wnt/β-catenin activity. J Exp Med. 2012;209(8):1457–1468. doi:10.1084/jem.20120225.
   PubMed Web of Science ®Google Scholar
• Gao X, Xu C, Asada N, Frenette PS. The hematopoietic stem cell niche: from embryo to adult. Develop. 2018;145(2). doi:10.1242/dev.139691.
   Web of Science ®Google Scholar
• Patel SH, Christodoulou C, Weinreb C, Yu Q, da Rocha EL, Pepe-Mooney BJ, Bowling S, Li L, Osorio FG, Daley GQ. et al. Lifelong multilineage contribution by embryonic-born blood progenitors. Nature. 2022;606(7915):747–753. doi:10.1038/s41586-022-04804-z.
   PubMed Web of Science ®Google Scholar
• Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978;4:7–25.
   PubMedGoogle Scholar
• Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841–846. doi:10.1038/nature02040.
   PubMed Web of Science ®Google Scholar
• Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481(7382):457–462. doi:10.1038/nature10783.
   PubMed Web of Science ®Google Scholar
• Hooper AT, Butler JM, Nolan DJ, Kranz A, Iida K, Kobayashi M, Kopp H-G, Shido K, Petit I, Yanger K. et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell. 2009;4(3):263–274. doi:10.1016/j.stem.2009.01.006.
   PubMed Web of Science ®Google Scholar
• Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M. et al. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010;6(3):251–264. doi:10.1016/j.stem.2010.02.001.
   PubMed Web of Science ®Google Scholar
• Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M. et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007;131(2):324–336. doi:10.1016/j.cell.2007.08.025.
   PubMed Web of Science ®Google Scholar
• Cordeiro Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-Ichi S, Schlenner S, Richie E, Rodewald H-R. et al. Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation. Immunity. 2016;45(6):1219–1231. doi:10.1016/j.immuni.2016.11.004.
   PubMed Web of Science ®Google Scholar
• Yu L, Tu Q, Han Q, Zhang L, Sui L, Zheng L, Meng S, Tang Y, Xuan D, Zhang J. et al. Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes. Stem Cells. 2015;33:240–252. doi:10.1002/stem.1844.
   PubMed Web of Science ®Google Scholar
• Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature. 2009;460(7252):259–263. doi:10.1038/nature08099.
   PubMed Web of Science ®Google Scholar
• Mattiucci D, Maurizi G, Izzi V, Cenci L, Ciarlantini M, Mancini S, Mensà E, Pascarella R, Vivarelli M, Olivieri A. et al. Bone marrow adipocytes support hematopoietic stem cell survival. J Cellular Physiol. 2018;233(2):1500–1511. doi:10.1002/jcp.26037.
   PubMed Web of Science ®Google Scholar
• Zhou BO, Yu H, Yue R, Zhao Z, Rios JJ, Naveiras O, Morrison SJ. Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF. Nat Cell Biol. 2017;19(8):891–903. doi:10.1038/ncb3570.
   PubMed Web of Science ®Google Scholar
• Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, MacArthur BD, Lira SA, Scadden DT, Ma’ayan A, Enikolopov GN, Frenette PS. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829–834. doi:10.1038/nature09262.
   PubMed Web of Science ®Google Scholar
• Wei Q, Frenette PS. Niches for hematopoietic stem cells and their progeny. Immunity. 2018;48(4):632–648. doi:10.1016/j.immuni.2018.03.024.
   PubMed Web of Science ®Google Scholar
• Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP. et al. Distinct bone marrow sources of pleiotrophin control hematopoietic stem cell maintenance and regeneration. Cell Stem Cell. 2018;23(3):370–381.e5. doi:10.1016/j.stem.2018.07.003.
   PubMed Web of Science ®Google Scholar
• Comazzetto S, Murphy MM, Berto S, Jeffery E, Zhao Z, Morrison SJ. Restricted hematopoietic progenitors and erythropoiesis require SCF from leptin Receptor+ niche cells in the bone marrow. Cell Stem Cell. 2019;24(3):477–486.e6. doi:10.1016/j.stem.2018.11.022.
   PubMed Web of Science ®Google Scholar
• Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K. et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502(7473):637–643. doi:10.1038/nature12612.
   PubMed Web of Science ®Google Scholar
• Bernal A, Arranz L. Nestin-expressing progenitor cells: function, identity and therapeutic implications. Cell Mol Life Sci. 2018;75(12):2177–2195. doi:10.1007/s00018-018-2794-z.
   PubMed Web of Science ®Google Scholar
• Sakamoto T, Obara N, Nishikii H, Kato T, Cao-Sy L, Fujimura R, Yagita H, Sakata-Yanagimoto M, Takahashi S, Chiba S. Notch signaling in Nestin-Expressing cells in the bone marrow maintains erythropoiesis via macrophage integrity. Stem Cells. 2019;37(7):924–936. doi:10.1002/stem.3011.
   PubMed Web of Science ®Google Scholar
• Xie L, Zeng X, Hu J, Chen Q. Characterization of nestin, a selective marker for bone marrow derived mesenchymal stem cells. Stem Cells Int. 2015;2015:1–9. doi:10.1155/2015/762098.
   Web of Science ®Google Scholar
• Isern J, Méndez-Ferrer S. Stem cell interactions in a bone marrow niche. Curr Osteoporos Rep. 2011;9(4):210–218. doi:10.1007/s11914-011-0075-y.
   PubMedGoogle Scholar
• Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, Frenette PS. PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exper Med. 2013;210(7):1351–1367. doi:10.1084/jem.20122252.
   PubMed Web of Science ®Google Scholar
• Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez N, Birbrair A, Ma’ayan A, Frenette P. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol. 2017;19(3):214–223. doi:10.1038/ncb3475.
   PubMed Web of Science ®Google Scholar
• Gerosa RC, Boettcher S, Kovtonyuk LV, Hausmann A, Hardt W-D, Hidalgo J, Nombela-Arrieta C, Manz MG. CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis. Blood Adv. 2021;5(23):5002–5015. doi:10.1182/bloodadvances.2021005531.
   PubMed Web of Science ®Google Scholar
• Galán-Díez M, Kousteni S. A bone marrow niche-derived molecular switch between osteogenesis and hematopoiesis. Genes Dev. 2018;32(5–6):324–326. doi:10.1101/gad.314013.118.
   PubMed Web of Science ®Google Scholar
• Zhang J, Niu C, Ye L, Huang H, He X, Tong W-G, Ross J, Haug J, Johnson T, Feng JQ. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425(6960):836–841. doi:10.1038/nature02041.
   PubMed Web of Science ®Google Scholar
• Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM. et al. N-Cadherin-expressing bone and marrow stromal progenitor cells maintain reserve hematopoietic stem cells. Cell Rep. 2019;26(3):652–669.e6. doi:10.1016/j.celrep.2018.12.093.
   PubMed Web of Science ®Google Scholar
• Yu Z, Yang W, He X, Chen C, Li W, Zhao L, Liu L, Liu J, Xie L, Zhang Y. et al. Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches. Blood. 2022;139(10):1529–1540. doi:10.1182/blood.2021011644.
   PubMed Web of Science ®Google Scholar
• Reddy K, Zhou Z, Schadler K, Jia SF, Kleinerman ES. Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing’s tumor vessels. Molecular Cancer Res. 2008;6(6):929–936. doi:10.1158/1541-7786.Mcr-07-2189.
   PubMed Web of Science ®Google Scholar
• Perlin JR, Sporrij A, Zon LI. Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment. J Mol Med (Berl). 2017;95(8):809–819. doi:10.1007/s00109-017-1559-8.
   PubMed Web of Science ®Google Scholar
• Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature. 2014;505(7483):327–334. doi:10.1038/nature12984.
   PubMed Web of Science ®Google Scholar
• Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grünewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR. et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Experiment Med. 2005;201(11):1781–1791. doi:10.1084/jem.20041992.
   PubMed Web of Science ®Google Scholar
• Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immun. 2006;25(6):977–988. doi:10.1016/j.immuni.2006.10.016.
   Google Scholar
• Zhu RJ, Wu MQ, Li ZJ, Zhang Y, Liu KY. Hematopoietic recovery following chemotherapy is improved by BADGE-induced inhibition of adipogenesis. Int J Hematol. 2013;97(1):58–72. doi:10.1007/s12185-012-1233-4.
   PubMed Web of Science ®Google Scholar
• Stone AP, Nascimento TF, Barrachina MN. The bone marrow niche from the inside out: how megakaryocytes are shaped by and shape hematopoiesis. Blood. 2022;139(4):483–491. doi:10.1182/blood.2021012827.
   PubMed Web of Science ®Google Scholar
• Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med. 2014;20(11):1321–1326. doi:10.1038/nm.3706.
   PubMed Web of Science ®Google Scholar
• Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A. et al. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med. 2014;20(11):1315–1320. doi:10.1038/nm.3707.
   PubMed Web of Science ®Google Scholar
• Pinho S, Marchand T, Yang E, Wei Q, Nerlov C, Frenette PS. Lineage-Biased hematopoietic stem cells are regulated by distinct niches. Dev Cell. 2018;44(5):634–641.e4. doi:10.1016/j.devcel.2018.01.016.
   PubMed Web of Science ®Google Scholar
• Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A. et al. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife. 2019;8. doi:10.7554/eLife.44031.
   PubMed Web of Science ®Google Scholar
• Li Z, Mariani S, Rodriguez-Seoane C, He W, Ning X, Liu B, Vink CS, Dzierzak EA. A role for macrophages in hematopoiesis in the embryonic head. Blood. 2019;134:1929–1940. doi:10.1182/blood.2018881243.
   PubMed Web of Science ®Google Scholar
• Fischer L, Herkner C, Kitte R, Dohnke S, Riewaldt J, Kretschmer K, Garbe AI. Foxp3(+) regulatory T cells in bone and hematopoietic homeostasis. Front Endocrinol (Lausanne). 2019;10:578. doi:10.3389/fendo.2019.00578.
   PubMed Web of Science ®Google Scholar
• Hirata Y, Furuhashi K, Ishii H, Li HW, Pinho S, Ding L, Robson SC, Frenette PS, Fujisaki J. CD150(high) bone marrow tregs maintain hematopoietic stem cell quiescence and immune privilege via Adenosine. Cell Stem Cell. 2018;22(3):445–453.e445. doi:10.1016/j.stem.2018.01.017.
   PubMed Web of Science ®Google Scholar
• Yamazaki S, Nakauchi H. Bone marrow Schwann cells induce hematopoietic stem cell hibernation. Int J Hematol. 2014;99(6):695–698. doi:10.1007/s12185-014-1588-9.
   PubMed Web of Science ®Google Scholar
• Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo M, Karlsson S, Iwama A, Nakauchi H. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell. 2011;147(5):1146–1158. doi:10.1016/j.cell.2011.09.053.
   PubMed Web of Science ®Google Scholar
• Park MH, Jin HK, Min W-K, Lee WW, Lee JE, Akiyama H, Herzog H, Enikolopov GN, Schuchman EH, Bae J-S. et al. Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow. Embo J. 2015;34(12):1648–1660. doi:10.15252/embj.201490174.
   PubMed Web of Science ®Google Scholar
• Asada N, Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T. et al. Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. Cell Stem Cell. 2013;12(6):737–747. doi:10.1016/j.stem.2013.05.001.
   PubMed Web of Science ®Google Scholar
• Ahmed N, Ghannoum M, Gallogly M, de Lima M, Malek E. Influence of gut microbiome on multiple myeloma: friend or foe? J Immunother Cancer. 2020;8(1):e000576. doi:10.1136/jitc-2020-000576.
   PubMed Web of Science ®Google Scholar
• Wang T, Ye Y, Ji J, Yang X, Xu J, Wang J-S, Han X, Zhang T, Sun X. Diet composition affects long-term zearalenone exposure on the gut–blood–liver axis metabolic dysfunction in mice. Ecotoxicol Environ Saf. 2022;236:113466. doi:10.1016/j.ecoenv.2022.113466.
   PubMed Web of Science ®Google Scholar
• Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL. et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20(2):159–166. doi:10.1038/nm.3444.
   PubMed Web of Science ®Google Scholar
• Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang J-E, Scheiermann C. et al. Neutrophil ageing is regulated by the microbiome. Nature. 2015;525(7570):528–532. doi:10.1038/nature15367.
   PubMed Web of Science ®Google Scholar
• Lee S, Kim H, You G, Kim Y-M, Lee S, Le V-H, Kwon O, Im S-H, Kim Y-M, Kim KS. et al. Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice. Blood. 2019;134(16):1312–1322. doi:10.1182/blood.2019000495.
   PubMed Web of Science ®Google Scholar
• Josefsdottir KS, Baldridge MT, Kadmon CS, King KY. Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota. Blood. 2017;129(6):729–739. doi:10.1182/blood-2016-03-708594.
   PubMed Web of Science ®Google Scholar
• McCoy KD, Thomson CA. The impact of maternal microbes and microbial colonization in early life on hematopoiesis. J Immunol. 2018;200(8):2519–2526. doi:10.4049/jimmunol.1701776.
   PubMed Web of Science ®Google Scholar
• Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, van den Brandt PA, Stobberingh EE. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118(2):511–521. doi:10.1542/peds.2005-2824.
   PubMed Web of Science ®Google Scholar
• Arancibia SA, Beltrán CJ, Aguirre IM, Silva P, Peralta AL, Malinarich F, Hermoso MA. Toll-like receptors are key participants in innate immune responses. Biol Res. 2007;40(2):97–112. doi:10.4067/S0716-97602007000200001.
   PubMed Web of Science ®Google Scholar
• Chen JQ, Szodoray P, Zeher M. Toll-like receptor pathways in autoimmune diseases. Clinic Rev Allerg Immunol. 2016;50(1):1–17. doi:10.1007/s12016-015-8473-z.
   PubMed Web of Science ®Google Scholar
• von Ossowski I, Pietilä TE, Rintahaka J, Nummenmaa E, Mäkinen V-M, Reunanen J, Satokari R, de Vos WM, Palva I, Palva A. et al. Using recombinant Lactococci as an approach to dissect the immunomodulating capacity of surface piliation in probiotic lactobacillus rhamnosus GG. PLoS One. 2013;8(5):e64416. doi:10.1371/journal.pone.0064416.
   PubMed Web of Science ®Google Scholar
• Kolypetri P, Weiner HL. Monocyte regulation by gut microbial signals. Trends Microbiol. 2023;31(10):1044–1057. doi:10.1016/j.tim.2023.05.006.
   PubMed Web of Science ®Google Scholar
• Sioud M, Fløisand Y, Forfang L, Lund-Johansen F. Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage. J Mol Biol. 2006;364(5):945–954. doi:10.1016/j.jmb.2006.09.054.
   PubMed Web of Science ®Google Scholar
• MegíMegíAs J, Yáñez A, Moriano S, O’Connor J-E, Gozalbo D, Gil M-L. Direct toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages. Stem Cells. 2012;30(7):1486–1495. doi:10.1002/stem.1110.
   PubMed Web of Science ®Google Scholar
• Sioud M. Microbial sensing by haematopoietic stem and progenitor cells: vigilance against infections and immune education of myeloid cells. Scand J Immunol. 2020;92(5):e12957. doi:10.1111/sji.12957.
   PubMed Web of Science ®Google Scholar
• De Luca K, Frances-Duvert V, Asensio M-J, Ihsani R, Debien E, Taillardet M, Verhoeyen E, Bella C, Lantheaume S, Genestier L. et al. The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fate. Leukemia. 2009;23(11):2063–2074. doi:10.1038/leu.2009.155.
   PubMed Web of Science ®Google Scholar
• Wang X, Cheng Q, Li L, Wang J, Xia L, Xu X, Sun Z. Toll-like receptors 2 and 4 mediate the capacity of mesenchymal stromal cells to support the proliferation and differentiation of CD34+ cells. Exp Cell Res. 2012;318(3):196–206. doi:10.1016/j.yexcr.2011.11.001.
   PubMed Web of Science ®Google Scholar
• Ziegler P, Boettcher S, Takizawa H, Manz MG, Brümmendorf TH. LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance. Ann Hematol. 2016;95(2):173–178. doi:10.1007/s00277-015-2550-5.
   PubMed Web of Science ®Google Scholar
• Khosravi A, Yáñez A, Price J, Chow A, Merad M, Goodridge H, Mazmanian S. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host & Microbe. 2014;15(3):374–381. doi:10.1016/j.chom.2014.02.006.
   PubMed Web of Science ®Google Scholar
• Balmer ML, Schürch CM, Saito Y, Geuking MB, Li H, Cuenca M, Kovtonyuk LV, McCoy KD, Hapfelmeier S, Ochsenbein AF. et al. Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. J Immunol. 2014;193(10):5273–5283. doi:10.4049/jimmunol.1400762.
   PubMed Web of Science ®Google Scholar
• Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA. The Lineage−c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells. 2008;26(7):1778–1786. doi:10.1634/stemcells.2007-1027.
   PubMed Web of Science ®Google Scholar
• Czernik PJ, Golonka RM, Chakraborty S, Yeoh BS, Abokor AA, Saha P, Yeo J-Y, Mell B, Cheng X, Baroi S. et al. Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content. Physiol Genomic. 2021;53(12):518–533. doi:10.1152/physiolgenomics.00017.2021.
   PubMed Web of Science ®Google Scholar
• Dürholz K, Schmid E, Frech M, Azizov V, Otterbein N, Lucas S, Rauh M, Schett G, Bruns H, Zaiss MM. et al. Microbiota-derived propionate modulates megakaryopoiesis and platelet function. Front Immunol. 2022;13:908174. doi:10.3389/fimmu.2022.908174.
   PubMed Web of Science ®Google Scholar
• Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge JJ. Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging. J Experiment Med. 2016;213(11):2259–2267. doi:10.1084/jem.20160168.
   PubMed Web of Science ®Google Scholar
• Krambs JR, Monlish DA, Gao F, Schuettpelz LG, Link DC. Microbiota signals suppress B lymphopoiesis with aging in mice. Front Immunol. 2021;12:767267. doi:10.3389/fimmu.2021.767267.
   PubMed Web of Science ®Google Scholar
• Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122(1):107–118. doi:10.1016/j.cell.2005.05.007.
   PubMed Web of Science ®Google Scholar
• Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, Begum-Haque S, Kasper DL, Kasper LH. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39 + Foxp3 + T cells and T reg function. Gut Microbes. 2015;6(4):234–242. doi:10.1080/19490976.2015.1056973.
   PubMed Web of Science ®Google Scholar
• Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010;107(27):12204–12209. doi:10.1073/pnas.0909122107.
   PubMed Web of Science ®Google Scholar
• Gul L, Modos D, Fonseca S, Madgwick M, Thomas JP, Sudhakar P, Booth C, Stentz R, Carding SR, Korcsmaros T. et al. Extracellular vesicles produced by the human commensal gut bacterium bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease. J Extracell Vesicles. 2022;11(1):e12189. doi:10.1002/jev2.12189.
   PubMed Web of Science ®Google Scholar
• Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121–141. doi:10.1016/j.cell.2014.03.011.
   PubMed Web of Science ®Google Scholar
• Gray J, Oehrle K, Worthen G, Alenghat T, Whitsett J, Deshmukh H. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Sci Transl Med. 2017;9(376). doi:10.1126/scitranslmed.aaf9412.
   Web of Science ®Google Scholar
• Andrlova H, Miltiadous O, Dai A, Gardner R, El Daker S, Slingerland JB, Giardina PA, Clurman A, Gomes ALC, Nguyen CL. et al. MAIT and Vδ2 unconventional T cells predict favorable outcome after allogeneic HCT and are supported by a diverse intestinal microbiome. Blood. 2021;138(Supplement 1):331–331. doi:10.1182/blood-2021-151412.
   PubMedGoogle Scholar
• Michaudel C, Sokol H. The gut microbiota at the service of immunometabolism. Cell Metab. 2020;32(4):514–523. doi:10.1016/j.cmet.2020.09.004.
   PubMed Web of Science ®Google Scholar
• Brown EM, Kenny DJ, Xavier RJ. Gut microbiota regulation of T cells during inflammation and autoimmunity. Annu Rev Immunol. 2019;37(1):599–624. doi:10.1146/annurev-immunol-042718-041841.
   PubMed Web of Science ®Google Scholar
• Kim M, Galan C, Hill AA, Wu W-J, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS. et al. Critical role for the microbiota in CX3CR1+ intestinal mononuclear phagocyte regulation of intestinal T cell responses. Immun. 2018;49(1):151–163.e5. doi:10.1016/j.immuni.2018.05.009.
   Google Scholar
• Mittrucker HW, Seidel D, Bland PW, Zarzycka A, Kaufmann SHE, Visekruna A, Steinhoff U. Lack of microbiota reduces innate responses and enhances adaptive immunity against listeria monocytogenes infection. Eur J Immunol. 2014;44(6):1710–1715. doi:10.1002/eji.201343927.
   PubMed Web of Science ®Google Scholar
• Goldszmid RS, Dzutsev A, Trinchieri G. Host immune response to infection and cancer: unexpected commonalities. Cell Host & Microbe. 2014;15(3):295–305. doi:10.1016/j.chom.2014.02.003.
   PubMed Web of Science ®Google Scholar
• Das NK, Schwartz AJ, Barthel G, Inohara N, Liu Q, Sankar A, Hill DR, Ma X, Lamberg O, Schnizlein MK. et al. Microbial metabolite signaling is required for systemic iron homeostasis. Cell Metabol. 2020;31(1):115–130.e6. doi:10.1016/j.cmet.2019.10.005.
   PubMed Web of Science ®Google Scholar
• Zhang D, Gao X, Li H, Borger DK, Wei Q, Yang E, Xu C, Pinho S, Frenette PS. The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow. Cell Stem Cell. 2022;29(2):232–247.e7. doi:10.1016/j.stem.2021.12.009.
   PubMed Web of Science ®Google Scholar
• Cao Y, Liu B, Li W, Geng F, Gao X, Yue L, Liu H, Liu C, Su Z, Lü J. et al. Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide-induced immunosuppression mice. MedComm. 2023;4(2):e222. doi:10.1002/mco2.222.
   PubMedGoogle Scholar
• Staffas A, Burgos da Silva M, van den Brink MR. The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease. Blood. 2017;129(8):927–933. doi:10.1182/blood-2016-09-691394.
   PubMed Web of Science ®Google Scholar
• Gavriilaki M, Sakellari I, Anagnostopoulos A, Gavriilaki E. The impact of antibiotic-mediated modification of the intestinal microbiome on outcomes of allogeneic hematopoietic cell transplantation: systematic review and meta-analysis. Biol Blood Marrow Transplant. 2020;26(9):1738–1746. doi:10.1016/j.bbmt.2020.05.011.
   PubMed Web of Science ®Google Scholar
• Payen M, Nicolis I, Robin M, Michonneau D, Delannoye J, Mayeur C, Kapel N, Berçot B, Butel M-J, Le Goff J. et al. Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severity. Blood Adv. 2020;4(9):1824–1832. doi:10.1182/bloodadvances.2020001531.
   PubMed Web of Science ®Google Scholar
• Khan N, Lindner S, Gomes ALC, Devlin SM, Shah GL, Sung AD, Sauter CS, Landau HJ, Dahi PB, Perales M-A. et al. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study. Blood. 2021;137(11):1527–1537. doi:10.1182/blood.2020006923.
   PubMed Web of Science ®Google Scholar
• Ingham AC, Kielsen K, Cilieborg MS, Lund O, Holmes S, Aarestrup FM, Müller KG, Pamp SJ. Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation. Microbiome. 2019;7(1):131. doi:10.1186/s40168-019-0745-z.
   PubMed Web of Science ®Google Scholar
• Miltiadous O, Waters NR, Andrlová H, Dai A, Nguyen CL, Burgos da Silva M, Lindner S, Slingerland J, Giardina P, Clurman A. et al. Early intestinal microbial features are associated with CD4 T-cell recovery after allogeneic hematopoietic transplant. Blood. 2022;139(18):2758–2769. doi:10.1182/blood.2021014255.
   PubMed Web of Science ®Google Scholar
• Schluter J, Peled JU, Taylor BP, Markey KA, Smith M, Taur Y, Niehus R, Staffas A, Dai A, Fontana E. et al. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020;588(7837):303–307. doi:10.1038/s41586-020-2971-8.
   PubMed Web of Science ®Google Scholar
• Luo Y, Chen G-L, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A. et al. Microbiota from obese mice regulate hematopoietic stem cell differentiation by altering the bone niche. Cell Metab. 2015;22(5):886–894. doi:10.1016/j.cmet.2015.08.020.
   PubMed Web of Science ®Google Scholar
• Strober W, Murray PJ, Kitani A, Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006;6(1):9–20. doi:10.1038/nri1747.
   PubMed Web of Science ®Google Scholar
• Kufer TA, Banks DJ, Philpott DJ. Innate immune sensing of microbes by nod proteins. Ann N Y Acad Sci. 2006;1072(1):19–27. doi:10.1196/annals.1326.020.
   PubMedGoogle Scholar
• Iwamura C, Bouladoux N, Belkaid Y, Sher A, Jankovic D. Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis. Blood. 2017;129(2):171–176. doi:10.1182/blood-2016-06-723742.
   PubMed Web of Science ®Google Scholar
• Lee YS, Kim T-Y, Kim Y, Kim S, Lee S-H, Seo S-U, Zhou BO, Eunju O, Kim KS, Kweon M-N. Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Exp Mol Med. 2021;53(9):1319–1331. doi:10.1038/s12276-021-00667-y.
   PubMed Web of Science ®Google Scholar
• Porcari S, Benech N, Valles-Colomer M, Segata N, Gasbarrini A, Cammarota G, Sokol H, Ianiro G. Key determinants of success in fecal microbiota transplantation: from microbiome to clinic. Cell Host & Microbe. 2023;31(5):712–733. doi:10.1016/j.chom.2023.03.020.
   PubMed Web of Science ®Google Scholar
• Nivet C, Duhalde V, Beaurain M, Delobel P, Quelven I, Alric L. Fecal microbiota transplantation for refractory clostridioides difficile infection is effective and well tolerated even in very old subjects: a real-life study. J Nutrition Health Aging. 2022;26(3):290–296. doi:10.1007/s12603-022-1756-1.
   PubMed Web of Science ®Google Scholar
• Zeng X, Li X, Li X, Wei C, Shi C, Hu K, Kong D, Luo Q, Xu Y, Shan W. et al. Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation. Blood. 2023;141(14):1691–1707. doi:10.1182/blood.2022017514.
   PubMed Web of Science ®Google Scholar
• Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Kazadi D, Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X. et al. Randomized double-blind phase II trial of fecal microbiota transplantation versus placebo in allogeneic hematopoietic cell transplantation and AML. J Clin Oncol. 2023;2202366(34):5306–5319. doi:10.1200/JCO.22.02366.
   Google Scholar
• van Lier YF, Vos J, Blom B, Hazenberg MD. Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease. Gut Microbes. 2023;15(1):2178805. doi:10.1080/19490976.2023.2178805.
   PubMed Web of Science ®Google Scholar
• Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ. et al. Nutritional support from the intestinal microbiota improves hematopoietic reconstitution after bone marrow transplantation in mice. Cell Host Microbe. 2018;23(4):447–457.e4. doi:10.1016/j.chom.2018.03.002.
   PubMed Web of Science ®Google Scholar
• Shono Y, van den Brink MRM. Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer. 2018;18(5):283–295. doi:10.1038/nrc.2018.10.
   PubMed Web of Science ®Google Scholar
• Vaitkute G, Panic G, Alber DG, Faizura-Yeop I, Cloutman-Green E, Swann J, Veys P, Standing JF, Klein N, Bajaj-Elliott M. et al. Linking gastrointestinal microbiota and metabolome dynamics to clinical outcomes in paediatric haematopoietic stem cell transplantation. Microbiome. 2022;10(1). doi:10.1186/s40168-022-01270-7.
   PubMed Web of Science ®Google Scholar
• Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S. et al. Expert consensus document. The International scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506–514. doi:10.1038/nrgastro.2014.66.
   PubMed Web of Science ®Google Scholar
• Espín-Palazón R, Stachura D, Campbell C, García-Moreno D, Del Cid N, Kim A, Candel S, Meseguer J, Mulero V, Traver D. Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014;159(5):1070–1085. doi:10.1016/j.cell.2014.10.031.
   PubMed Web of Science ®Google Scholar
• Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu H-C, Orkin SH, Tucker HO, Daley GQ. Interferon-α signaling promotes embryonic HSC maturation. Blood. 2016;128(2):204–216. doi:10.1182/blood-2016-01-689281.
   PubMed Web of Science ®Google Scholar
• Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion. Nat Med. 2009;15(6):696–700. doi:10.1038/nm.1973.
   PubMed Web of Science ®Google Scholar
• Yamashita M, Passegué E. TNF-α coordinates hematopoietic stem cell survival and myeloid regeneration. Cell Stem Cell. 2019;25(3):357–372.e7. doi:10.1016/j.stem.2019.05.019.
   PubMed Web of Science ®Google Scholar
• Rezzoug F, Huang Y, Tanner MK, Wysoczynski M, Schanie CL, Chilton PM, Ratajczak MZ, Fugier-Vivier IJ, Ildstad ST. TNF-α is critical to facilitate hemopoietic stem cell engraftment and function. J Immunol. 2008;180(1):49–57. doi:10.4049/jimmunol.180.1.49.
   PubMed Web of Science ®Google Scholar
• Bowers E, Slaughter A, Frenette PS, Kuick R, Pello OM, Lucas D. Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow. Nat Med. 2018;24(1):95–102. doi:10.1038/nm.4448.
   PubMed Web of Science ®Google Scholar
• Bousounis P, Bergo V, Trompouki E. Inflammation, aging and Hematopoiesis: a complex relationship. Cells. 2021;10(6):1386. doi:10.3390/cells10061386.
   PubMed Web of Science ®Google Scholar
• Dybedal I, Bryder D, Fossum A, Rusten LS, Jacobsen SE. Tumor necrosis factor (TNF)–mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells. Blood. 2001;98(6):1782–1791. doi:10.1182/blood.V98.6.1782.
   PubMed Web of Science ®Google Scholar
• Senyuk V, Patel P, Mahmud N, Rondelli D. Blockade of TNFα to improve human CD34+ cell repopulating activity in allogeneic stem cell transplantation. Front Immunol. 2018;9:3186. doi:10.3389/fimmu.2018.03186.
   PubMed Web of Science ®Google Scholar
• Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O’Leary CE, Oliver PM, Kolls JK, Weiser JN, Worthen GS. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nat Med. 2014;20(5):524–530. doi:10.1038/nm.3542.
   PubMed Web of Science ®Google Scholar
• Coillard A, Guyonnet L, De Juan A, Cros A, Segura E. TLR or NOD receptor signaling skews monocyte fate decision via distinct mechanisms driven by mTOR and miR-155. Proc Natl Acad Sci USA. 2021;118(43). doi:10.1073/pnas.2109225118.
   PubMed Web of Science ®Google Scholar
• Postler TS, Ghosh S. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metab. 2017;26(1):110–130. doi:10.1016/j.cmet.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Hu J, Lin S, Zheng B, Cheung PCK. Short-chain fatty acids in control of energy metabolism. Crit Rev Food Sci Nutr. 2018;58(8):1243–1249. doi:10.1080/10408398.2016.1245650.
   PubMed Web of Science ®Google Scholar
• Bach Knudsen KE, Lærke H, Hedemann M, Nielsen T, Ingerslev A, Gundelund Nielsen D, Theil P, Purup S, Hald S, Schioldan A. et al. Impact of diet-modulated butyrate production on intestinal barrier function and inflammation. Nutrients. 2018;10(10):1499. doi:10.3390/nu10101499.
   PubMed Web of Science ®Google Scholar
• Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L, Ståhlman M, Olsson LM, Serino M, Planas-Fèlix M. et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nat Med. 2017;23(7):850–858. doi:10.1038/nm.4345.
   PubMed Web of Science ®Google Scholar
• Verhaar BJH, Collard D, Prodan A, Levels JHM, Zwinderman AH, Bäckhed F, Vogt L, Peters MJL, Muller M, Nieuwdorp M. et al. Associations between gut microbiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: the HELIUS study. European Heart J. 2020;41(44):4259–4267. doi:10.1093/eurheartj/ehaa704.
   PubMed Web of Science ®Google Scholar
• Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG. et al. Short-chain fatty acid propionate protects from hypertensive cardiovascular damage. Circulat. 2019;139(11):1407–1421. doi:10.1161/CIRCULATIONAHA.118.036652.
   PubMed Web of Science ®Google Scholar
• Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H. et al. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021;12(1):4077. doi:10.1038/s41467-021-24331-1.
   PubMed Web of Science ®Google Scholar
• Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ. et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504(7480):451–455. doi:10.1038/nature12726.
   PubMed Web of Science ®Google Scholar
• Ikuta T, Kan YW, Swerdlow PS, Faller DV, Perrine SP. Alterations in protein-DNA interactions in the γ-Globin gene promoter in response to butyrate therapy. Blood. 1998;92(8):2924–2933. doi:10.1182/blood.V92.8.2924.
   PubMed Web of Science ®Google Scholar
• Pace BS, White GL, Dover GJ, Boosalis MS, Faller DV, Perrine SP. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood. 2002;100(13):4640–4648. doi:10.1182/blood-2002-02-0353.
   PubMed Web of Science ®Google Scholar
• Bhatia H, Hallock JL, Dutta A, Karkashon S, Sterner LS, Miyazaki T, Dean A, Little JA. Short-chain fatty acid–mediated effects on erythropoiesis in primary definitive erythroid cells. Blood. 2009;113(25):6440–6448. doi:10.1182/blood-2008-09-171728.
   PubMed Web of Science ®Google Scholar
• Trompette A, Gollwitzer ES, Pattaroni C, Lopez-Mejia IC, Riva E, Pernot J, Ubags N, Fajas L, Nicod LP, Marsland BJ. et al. Dietary fiber confers protection against flu by shaping Ly6c− patrolling monocyte hematopoiesis and CD8+ T cell metabolism. Immun. 2018;48(5):992–1005 e1008. doi:10.1016/j.immuni.2018.04.022.
   Google Scholar
• Sinha SR, Haileselassie Y, Nguyen LP, Tropini C, Wang M, Becker LS, Sim D, Jarr K, Spear ET, Singh G. et al. Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation. Cell Host Microbe. 2020;27(4):659–670.e5. doi:10.1016/j.chom.2020.01.021.
   PubMed Web of Science ®Google Scholar
• Thompson B, Lu S, Revilla J, Uddin MJ, Oakland DN, Brovero S, Keles S, Bresnick EH, Petri WA, Burgess SL. et al. Secondary bile acids function through the vitamin D receptor in myeloid progenitors to promote myelopoiesis. Blood Adv. 2023;7(17):4970–4982. doi:10.1182/bloodadvances.2022009618.
   PubMed Web of Science ®Google Scholar
• Sigurdsson V, Takei H, Soboleva S, Radulovic V, Galeev R, Siva K, Leeb-Lundberg LM, Iida T, Nittono H, Miharada K. Bile acids protect expanding hematopoietic stem cells from unfolded protein stress in fetal liver. Cell Stem Cell. 2016;18(4):522–532. doi:10.1016/j.stem.2016.01.002.
   PubMed Web of Science ®Google Scholar