152
Views
1
CrossRef citations to date
0
Altmetric
Articles

ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway

&
Pages 129-136 | Received 06 Aug 2021, Accepted 08 Dec 2021, Published online: 03 Jan 2022

References

  • Finnerty CC, Jeschke MG, Branski LK, et al. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet. 2016;388(10052):1427–1436.
  • Trace AP, Enos CW, Mantel A, et al. Keloids and hypertrophic scars: a spectrum of clinical challenges. Am J Clin Dermatol. 2016;17(3):201–223.
  • Mari W, Alsabri SG, Tabal N, et al. Novel insights on understanding of keloid scar: article review. J Am Coll Clin Wound Spec. 2015;7(1–3):1–7.
  • Verhaegen PD, Marle JV, Kuehne A, et al. Collagen bundle morphometry in skin and scar tissue: a novel distance mapping method provides superior measurements compared to Fourier analysis. J Microsc. 2012;245(1):82–89.
  • Liu W, Huang X, Liang X, et al. Identification of key modules and hub genes of keloids with weighted gene coexpression network analysis. Plast Reconstr Surg. 2017;139(2):376–390.
  • Shi K, Qiu X, Zheng W, et al. MiR-203 regulates keloid fibroblast proliferation, invasion, and extracellular matrix expression by targeting EGR1 and FGF2. Biomed Pharmacother. 2018;108:1282–1288.
  • Hsu CK, Lin HH, Harn HI, et al. Caveolin-1 controls hyperresponsiveness to mechanical stimuli and fibrogenesis-associated RUNX2 activation in keloid fibroblasts. J Invest Dermatol. 2018;138(1):208–218.
  • Shou ZX, Jin X, Zhao ZS. Upregulated expression of ADAM17 is a prognostic marker for patients with gastric cancer. Ann Surg. 2012;256(6):1014–1022.
  • Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010;37(4):551–566.
  • Grotzinger J, Lorenzen I, Dusterhoft S. Molecular insights into the multilayered regulation of ADAM17: the role of the extracellular region. Biochim Biophys Acta Mol Cell Res. 2017;1864(11):2088–2095.
  • Franzke CW, Cobzaru C, Triantafyllopoulou A, et al. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med. 2012;209(6):1105–1119.
  • Chen J, Chen JK, Nagai K, et al. EGFR signaling promotes TGFbeta-dependent renal fibrosis. J Am Soc Nephrol. 2012;23(2):215–224.
  • Hahn JM, McFarland KL, Combs KA, et al. Partial epithelial–mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-beta1. Burns Trauma. 2016;4(1):30.
  • Chen HY, Lin CH, Chen BC. ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts. Exp Cell Res. 2018;370(1):39–45.
  • Clark JA, Turner ML, Howard L, et al. Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneity. BMC Dermatol. 2009;9:8.
  • Rang Z, Wang ZY, Pang QY, Wang YW, et al. MiR-181a targets PHLPP2 to augment AKT signaling and regulate proliferation and apoptosis in human keloid fibroblasts. Cell Physiol Biochem. 2016;40(3–4):796–806.
  • Cui J, Li Z, Jin C, et al. Knockdown of fibronectin extra domain B suppresses TGF-beta1-mediated cell proliferation and collagen deposition in keloid fibroblasts via AKT/ERK signaling pathway. Biochem Biophys Res Commun. 2020;526(4):1131–1137.
  • Gao MQ, Kim BG, Kang S, et al. Human breast cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-alpha cleavage by ADAM17. Cancer Lett. 2013;336(1):240–246.
  • Kawasaki K, Freimuth J, Meyer DS, et al. Genetic variants of Adam17 differentially regulate TGFbeta signaling to modify vascular pathology in mice and humans. Proc Natl Acad Sci U S A. 2014;111(21):7723–7728.
  • Chen JY, Lin CH, Chen BC. Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBPbeta activation in human lung fibroblasts. Mol Immunol. 2017;88:155–163.
  • Charbonneau M, Harper K, Grondin F, et al. Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. J Biol Chem. 2007;282(46):33714–33724.
  • Lei R, Li J, Liu F, et al. HIF-1alpha promotes the keloid development through the activation of TGF-beta/smad and TLR4/MyD88/NF-kappaB pathways. Cell Cycle. 2019;18(23):3239–3250.
  • Kawaguchi M, Suzuki T. Gene expression and in situ localization of ADAM17 during skin wound healing. Int J Dermatol. 2014;53(3):e229–e231.
  • Shu DY, Wojciechowski M, Lovicu FJ. ERK1/2-mediated EGFR-signaling is required for TGFbeta-induced lens epithelial–mesenchymal transition. Exp Eye Res. 2019;178:108–121.
  • Lee DC, Sunnarborg SW, Hinkle CL, et al. TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci. 2003;995:22–38.
  • Eke I, Storch K, Krause M, et al. Cetuximab attenuates its cytotoxic and radiosensitizing potential by inducing fibronectin biosynthesis. Cancer Res. 2013;73(19):5869–5879.
  • Sun Y, Liu WZ, Liu T, et al. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015;35(6):600–604.
  • Campbell PM. Oncogenic Ras pushes (and pulls) cell cycle progression through ERK activation. Methods Mol Biol. 2014;1170:155–163.
  • Zeng SY, Yang L, Hong CL, et al. Evidence that ADAM17 mediates the protective action of CGRP against angiotensin II-Induced inflammation in vascular smooth muscle cells. Mediators Inflamm. 2018;2018:2109352.
  • Wu CS, Wu PH, Fang AH, et al. FK506 inhibits the enhancing effects of transforming growth factor (TGF)-beta1 on collagen expression and TGF-beta/smad signalling in keloid fibroblasts: implication for new therapeutic approach. Br J Dermatol. 2012;167(3):532–541.
  • Ren M, Wang B, Zhang J, et al. Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming growth factor beta1. Mol Med Rep. 2011;4(3):561–567.
  • Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-beta: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12(6):325–338.
  • Wang L, Chi YF, Yuan ZT, et al. Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-beta/smad signaling pathway in vivo and in vitro. Exp Biol Med. 2014;239(10):1310–1324.
  • Wang JC, Sonnylal S, Arnett FC, et al. Attenuation of expression of extracellular matrix genes with siRNAs to Sparc and Ctgf in skin fibroblasts of CTGF transgenic mice. Int J Immunopathol Pharmacol. 2011;24(3):595–601.
  • Ou SC, Bai KJ, Cheng WH, et al. TGF-beta induced CTGF expression in human lung epithelial cells through ERK, ADAM17, RSK1, and C/EBPbeta pathways. Int J Mol Sci. 2020;21(23):9084.
  • Liu Y, Li Y, Li N, et al. TGF-beta1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21. Sci Rep. 2016;6:32231.
  • Muthusubramaniam L, Zaitseva T, Paukshto M, et al. Effect of collagen nanotopography on keloid fibroblast proliferation and matrix synthesis: implications for dermal wound healing. Tissue Eng Part A. 2014;20(19–20):2728–2736.
  • Shih B, Garside E, McGrouther DA, et al. Molecular dissection of abnormal wound healing processes resulting in keloid disease. Wound Repair Regen. 2010;18(2):139–153.
  • Xiao LJ, Lin P, Lin F, et al. ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion. Int J Oncol. 2012;40(5):1714–1724.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.