A new photodynamic therapy photosensitizer (p1) promotes apoptosis of keloid fibroblasts by targeting caspase-8

References

• Cheraghi N, Cognetta A Jr, Goldberg D. Radiation therapy for the adjunctive treatment of surgically excised keloids: a review. J Clin Aesthet Dermatol. 2017;10(8):12–15.
   PubMedGoogle Scholar
• Dolmans DEJGJ, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3(5):380–387.
   PubMed Web of Science ®Google Scholar
• Dougherty TJ, Henderson BW, Gomer CJ, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90(12):889–905.
   PubMed Web of Science ®Google Scholar
• Nie Z. Is photodynamic therapy a solution for keloid? G Ital Dermatol Venereol. 2011;146(6):463–472.
   PubMed Web of Science ®Google Scholar
• Zhang MZ, Liu YF, Ding N, et al. 2-Methoxyestradiol improves the apoptosis level in keloid fibroblasts through caspase-dependent mechanisms in vitro. Am J Transl Res. 2018;10(12):4017–4029.
   PubMed Web of Science ®Google Scholar
• Vangipuram M, Ting D, Kim S, et al. Skin punch biopsy explant culture for derivation of primary human fibroblasts. J Vis Exp. 2013;7(77):e3779–e3781.
   Google Scholar
• Zhang MZ, Dong XH, Guan EL, et al. A comparison of apoptosis levels in keloid tissue, physiological scars and normal skin. Am J Transl Res. 2017;9(12):5548–5557.
   PubMed Web of Science ®Google Scholar
• Kassi K, Kouame K, Kouassi A, et al. Quality of life in Black African patients with keloid scars. Dermatol Reports. 2020;12(2):8312–8315.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Jang YJ. Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. IJMS. 2018;19(3):711–739.
   Google Scholar
• Marneros AG, Krieg T. Keloids-clinical diagnosis, pathogenesis, and treatment options. J Dtsch Dermatol Ges. 2004;2(11):905–913.
   PubMedGoogle Scholar
• Zhang MZ, Dong XH, Zhang WC, et al. A comparison of proliferation levels in normal skin, physiological scar and keloid tissue. J Plast Surg Hand Surg. 2021;29:1–7.
   Google Scholar
• Dobson J, de Queiroz GF, Golding JP. Photodynamic therapy and diagnosis: principles and comparative aspects. Vet J. 2018;233:8–18.
   PubMed Web of Science ®Google Scholar
• Donohoe C, Senge MO, Arnaut LG, et al. Cell death in photodynamic therapy: from oxidative stress to anti-tumor immunity. Biochim Biophys Acta Rev Cancer. 2019;1872(2):188308.
   PubMed Web of Science ®Google Scholar
• Rkein AM, Ozog DM. Photodynamic therapy. Dermatol Clin. 2014;32(3):415–425.
   PubMed Web of Science ®Google Scholar
• Hou YJ, Yang XX, Liu RQ, et al. Pathological mechanism of photodynamic therapy and photothermal therapy based on nanoparticles. Int J Nanomed. 2020;15:6827–6838.
   PubMed Web of Science ®Google Scholar
• Liu D, Zhao S, Li J, et al. The application of physical pretreatment in photodynamic therapy for skin diseases. Lasers Med Sci. 2021;36(7):1369–1377.
   PubMed Web of Science ®Google Scholar
• Zou H, Wang F, Zhou JJ, et al. Application of photodynamic therapy for liver malignancies. J Gastrointest Oncol. 2020;11(2):431–442.
   PubMed Web of Science ®Google Scholar
• Yan J, Wang C, Jiang X, et al. Application of phototherapeutic-based nanoparticles in colorectal cancer. Int J Biol Sci. 2021;17(5):1361–1381.
   PubMed Web of Science ®Google Scholar
• Nie Z, Bayat A, Behzad F, et al. Positive response of a recurrent keloid scar to topical methyl aminolevulinate-photodynamic therapy. Photodermatol Photoimmunol Photomed. 2010;26(6):330–332.
   PubMed Web of Science ®Google Scholar
• Ud-Din S, Thomas G, Morris J, et al. Photodynamic therapy: an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools. Arch Dermatol Res. 2013;305(3):205–214.
   PubMed Web of Science ®Google Scholar
• Tosa M, Ogawa R. Photodynamic therapy for keloids and hypertrophic scars: a review. Scars Burn Heal. 2020;6:1–8.
   Google Scholar
• Fang Y, Liu T, Zou Q, et al. Water-soluble benzylidene cyclopentanone based photosensitizers for in vitro and in vivo antimicrobial photodynamic therapy. Sci Rep. 2016;6:28357.
   PubMed Web of Science ®Google Scholar
• Fang Y, Liu T, Zou Q, et al. Cationic benzylidene cyclopentanone photosensitizers for selective photodynamic inactivation of bacteria over mammalian cells. RSC Adv. 2015;5(69):56067–56074.
   Web of Science ®Google Scholar
• Ming L, Cheng K, Cheng Y, et al. Enhancement of tumor lethality of ROS in photodynamic therapy. Cancer Med. 2021;10(1):257–268.
   PubMed Web of Science ®Google Scholar
• Estaquier J, Vallette F, Vayssiere JL, et al. The mitochondrial pathways of apoptosis. Adv Exp Med Biol. 2012;942:157–183.
   PubMed Web of Science ®Google Scholar
• Jeong SY, Seol DW. The role of mitochondria in apoptosis. BMB Rep. 2008;41(1):11–22.
   PubMed Web of Science ®Google Scholar
• Li YN, Ning N, Song L, et al. Derivatives of deoxypodophyllotoxin induce apoptosis through bcl-2/bax proteins expression. Anticancer Agents Med Chem. 2021;21(5):611–620.
   PubMedGoogle Scholar
• Cui X, Zhu J, Wu X, et al. Hematoporphyrin monomethyl ether-mediated photodynamic therapy inhibits the growth of keloid graft by promoting fibroblast apoptosis and reducing vessel formation. Photochem Photobiol Sci. 2020;19(1):114–125.
   PubMed Web of Science ®Google Scholar
• Li B, Dou SX, Yuan JW, et al. Intracellular transport is accelerated in early apoptotic cells. Proc Natl Acad Sci USA. 2018;115(48):12118–12123.
   PubMed Web of Science ®Google Scholar