The mechanism of α2-macroglobulin against oxidative stress and promoting cell proliferation in intervertebral disc degeneration

References

• Daly C, Ghosh P, Jenkin G, et al. A review of animal models of intervertebral disc degeneration: pathophysiology, regeneration, and translation to the clinic. Biomed Res Int. 2016;2016:5952165. Epub 2016 May 22. PMID: 27314030; PMCID: PMC4893450.
   PubMed Web of Science ®Google Scholar
• Feng C, Liu H, Yang M, et al. Disc cell senescence in intervertebral disc degeneration: causes and molecular pathways. Cell Cycle. 2016Jul2;15(13):1674–1684. Epub 2016 May 18. PMID: 27192096; PMCID: PMC4957599.
   PubMed Web of Science ®Google Scholar
• Bowles RD, Setton LA. Biomaterials for intervertebral disc regeneration and repair. Biomaterials. 2017Jun;129:54–67 Epub 2017 Mar 15. PMID: 28324865; PMCID: PMC5627607.
   PubMed Web of Science ®Google Scholar
• Dowdell J, Erwin M, Choma T, et al. Intervertebral disk degeneration and repair. Neurosurgery. 2017Mar1;80(3S):S46–S54. Erratum in: Neurosurgery. 2018 Nov 1;83(5):1084.PMID: 28350945; PMCID: PMC5585783.
   PubMed Web of Science ®Google Scholar
• Wang F, Cai F, Shi R, et al. Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage. 2016Mar;24(3):398–408. Epub 2015 Oct 9. PMID: 26455958.
   PubMed Web of Science ®Google Scholar
• Özcan-Ekşi EE, Mş E, Akçal MA. severe lumbar intervertebral disc degeneration is associated with modic changes and fatty infiltration in the paraspinal muscles at all lumbar levels, except for L1-L2: a cross-sectional analysis of 50 symptomatic women and 50 age-matched symptomatic men. World Neurosurg. 2019Feb;122:e1069–e1077 Epub 2018 Nov 9. PMID: 30415054.
   PubMed Web of Science ®Google Scholar
• Mş E, Özcan-Ekşi EE, Özmen BB, et al. Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain. J Pediatr Orthop B. 2020 Nov27; 10.1097/BPB.0000000000000833. Epub ahead of print. PMID: 33252539.
   Web of Science ®Google Scholar
• Wei Q, Zhang X, Zhou C, et al. Roles of large aggregating proteoglycans in human intervertebral disc degeneration. Connect Tissue Res. 2019May;60(3):209–218. Epub 2018 Aug 9. PMID: 29992840.
   PubMed Web of Science ®Google Scholar
• Cuéllar JM, Cuéllar VG, Scuderi GJ. α2-Macroglobulin: autologous protease inhibition technology. Phys Med Rehabil Clin N Am. 2016Nov;27(4):909–918. PMID: 27788907.
   PubMed Web of Science ®Google Scholar
• Garcia-Ferrer I, Marrero A, Gomis-Rüth FX, et al. α2-Macroglobulins: structure and function. Subcell Biochem. 2017;83:149–183. PMID: 28271476.
   PubMedGoogle Scholar
• Rosenfeld MA, Vasilyeva AD, Yurina LV, et al. Oxidation of proteins: is it a programmed process? Free Radic Res. 2018Jan;52(1):14–38. Epub 2017 Dec 28. PMID: 29284315.
   PubMed Web of Science ®Google Scholar
• Goulas T, Garcia-Ferrer I, Marrero A, et al. Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins. Biol Chem. 2017Aug28;398(9):975–994. PMID: 28253193.
   PubMed Web of Science ®Google Scholar
• Jakab L. Csontszövet: Újdonképződés és inflammatio [Bone tissue: rebuilding and inflammation]. Orv Hetil. 2014 Oct 5;155(40):1575–1583. Hungarian. PMID: 25261988.
   PubMedGoogle Scholar
• Newell N, Little JP, Christou A, et al. Biomechanics of the human intervertebral disc: a review of testing techniques and results. J Mech Behav Biomed Mater. 2017May;69:420–434 Epub 2017 Jan 31. PMID: 28262607.
   PubMed Web of Science ®Google Scholar
• Ma K, Chen S, Li Z, et al. Mechanisms of endogenous repair failure during intervertebral disc degeneration. Osteoarthritis Cartilage. 2019Jan;27(1):41–48. Epub 2018 Sep 19. PMID: 30243946.
   PubMed Web of Science ®Google Scholar
• Richardson SM, Kalamegam G, Pushparaj PN, et al. Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration. Methods. 2016 Apr 15;99:69–80. Epub 2015 Sep 15. PMID: 26384579.
   PubMed Web of Science ®Google Scholar
• Liu Z, Zheng Z, Qi J, et al. CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration. J Biol Eng. 2018Dec22;12(1):35. PMID: 30598696; PMCID: PMC6303933.
   PubMedGoogle Scholar
• Minogue BM, Richardson SM, Zeef LA, et al. Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther. 2010;12(1):R22. Epub 2010 Feb 11. PMID: 20149220; PMCID: PMC2875656.
   PubMed Web of Science ®Google Scholar
• Linhardt O, Grifka J, Benditz A. Besteht ein zusammenhang zwischen der degenerativen bandscheibenveränderung und dem auftreten von lumbalen bandscheibenvorfällen? [are there correlations between disc degeneration and the appearance of lumbar disc herniations?]. Z Orthop Unfall. 2016 Dec;154(6):595–600.
   PubMedGoogle Scholar
• Miller J, Sasso R, Anderson P, et al. Adjacent level degeneration: bryan total disc arthroplasty versus anterior cervical discectomy and fusion. Clin Spine Surg. 2018Mar;31(2):E98–E101. PMID: 29189218.
   PubMed Web of Science ®Google Scholar
• Sharma A. The role of adipokines in intervertebral disc degeneration. Med Sci (Basel). 2018Apr24;6(2):34. PMID: 29695079; PMCID: PMC6024372.
   PubMedGoogle Scholar
• Basso M, Cavagnaro L, Zanirato A, et al. What is the clinical evidence on regenerative medicine in intervertebral disc degeneration? Musculoskelet Surg. 2017Aug;101(2):93–104. Epub 2017 Feb 13. PMID: 28191592.
   PubMedGoogle Scholar
• Hulshof AM, Hemker HC, Spronk HMH, et al. Thrombin-Fibrin(ogen) interactions, host defense and risk of thrombosis. Int J Mol Sci. 2021Mar4;22(5):2590. PMID: 33806700; PMCID: PMC7961882.
   PubMed Web of Science ®Google Scholar
• Wang C, Yu X, Yan Y, et al. Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration. Acta Biochim Biophys Sin (Shanghai). 2017Jan;49(1):1–13. Epub 2016 Nov 17. PMID: 27864283.
   PubMed Web of Science ®Google Scholar