Neuroimaging in primary lateral sclerosis

References

• Stark FM, Moersch FP. Primary lateral sclerosis: a distinct clinical entity. J Nervous Mental Dis. 1945;102:332–7.
   Web of Science ®Google Scholar
• Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC. Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain 1992;115:495–520.
   PubMed Web of Science ®Google Scholar
• Gordon PH, Cheng B, Katz IB, Pinto M, Hays AP, Mitsumoto H, et al. The natural history of primary lateral sclerosis. Neurology 2006;66:647–53.
   PubMed Web of Science ®Google Scholar
• Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, et al. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry. 2020;91:373–7.
   PubMed Web of Science ®Google Scholar
• Finegan E, Li Hi Shing S, Siah WF, Chipika RH, Chang KM, McKenna MC, et al. Evolving diagnostic criteria in primary lateral sclerosis: the clinical and radiological basis of “probable PLS”. J Neurol Sci. 2020;417:117052.
   PubMed Web of Science ®Google Scholar
• Finegan E, Siah WF, Shing SLH, Chipika RH, Chang KM, McKenna MC, et al. Imaging and clinical data indicate considerable disease burden in “‘probable’ PLS: patients with UMN symptoms for 2-4 years”. Data Brief. 2020;32:106247.
   PubMed Web of Science ®Google Scholar
• de Vries BS, Rustemeijer LMM, van der Kooi AJ, Raaphorst J, Schröder CD, Nijboer TCW, et al. A case series of PLS patients with frontotemporal dementia and overview of the literature. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18:534–48.
   PubMed Web of Science ®Google Scholar
• Finegan E, Chipika RH, Shing SLH, Hardiman O, Bede P. Primary lateral sclerosis: a distinct entity or part of the ALS spectrum? Amyotroph Lateral Scler Frontotemporal Degener. 2019;20:133–45.
   PubMed Web of Science ®Google Scholar
• Finegan E, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, et al. The clinical and radiological profile of primary lateral sclerosis: a population-based study. J Neurol. 2019;266:2718–33.
   PubMed Web of Science ®Google Scholar
• Bede P, Querin G, Pradat P-F. The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools. Curr Opin Neurol. 2018;31:431–8.
   PubMed Web of Science ®Google Scholar
• Bede P, Iyer PM, Finegan E, Omer T, Hardiman O. Virtual brain biopsies in amyotrophic lateral sclerosis: diagnostic classification based on in vivo pathological patterns. Neuroimage Clin. 2017;15:653–8.
   PubMed Web of Science ®Google Scholar
• Turner MR, Agosta F, Bede P, Govind V, Lulé D, Verstraete E. Neuroimaging in amyotrophic lateral sclerosis. Biomark Med. 2012;6:319–37.
   PubMed Web of Science ®Google Scholar
• Rajagopalan V, Pioro EP. Unbiased MRI analyses identify micropathologic differences between upper motor neuron-predominant ALS phenotypes. Front Neurosci. 2019;13:704.
   PubMed Web of Science ®Google Scholar
• Rajagopalan V, Yue GH, Pioro EP. Brain white matter diffusion tensor metrics from clinical 1.5T MRI distinguish between ALS phenotypes. J Neurol. 2013;260:2532–40.
   PubMed Web of Science ®Google Scholar
• Bede P, Hardiman O. Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration. Amyotroph Lateral Scler Frontotemporal Degener. 2018;19:232–41.
   PubMed Web of Science ®Google Scholar
• Menke R. a L, Proudfoot M, Talbot K, Turner MR. The two-year progression of structural and functional cerebral MRI in amyotrophic lateral sclerosis. Neuroimage Clin. 2018;17:953–61.
   PubMed Web of Science ®Google Scholar
• Müller H-P, Turner MR, Grosskreutz J, Abrahams S, Bede P, Govind V, et al. A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2016;87:570–9.
   PubMed Web of Science ®Google Scholar
• Turner MR, Grosskreutz J, Kassubek J, Abrahams S, Agosta F, Benatar M, et al. Towards a neuroimaging biomarker for amyotrophic lateral sclerosis. Lancet Neurol. 2011;10:400–3.
   PubMed Web of Science ®Google Scholar
• Bede P, Hardiman O. Lessons of ALS imaging: pitfalls and future directions - a critical review. Neuroimage Clin. 2014;4:436–43.
   PubMed Web of Science ®Google Scholar
• Smith CD. Serial MRI findings in a case of primary lateral sclerosis. Neurology 2002;58:647–9.
   PubMed Web of Science ®Google Scholar
• Kiernan JA, Hudson AJ. Frontal lobe atrophy in motor neuron diseases. Brain 1994;117:747–57.
   PubMed Web of Science ®Google Scholar
• Kuipers-Upmeijer J, de Jager AE, Hew JM, Snoek JW, van Weerden TW. Primary lateral sclerosis: clinical, neurophysiological, and magnetic resonance findings. J Neurol Neurosurg Psychiatry. 2001;71:615–20.
   PubMed Web of Science ®Google Scholar
• Canu E, Agosta F, Galantucci S, Chiò A, Riva N, Silani V, et al. Extramotor damage is associated with cognition in primary lateral sclerosis patients. PLoS One. 2013;8:e82017.
   PubMed Web of Science ®Google Scholar
• Meoded A, Kwan JY, Peters TL, Huey ED, Danielian LE, Wiggs E, et al. Imaging findings associated with cognitive performance in primary lateral sclerosis and amyotrophic lateral sclerosis. Dement Geriatr Cogn Dis Extra. 2013;3:233–50.
   PubMedGoogle Scholar
• Martí-Fàbregas J, Pujol J. Selective involvement of the pyramidal tract on magnetic resonance imaging in primary lateral sclerosis. Neurology 1990;40:1799–800.
   PubMed Web of Science ®Google Scholar
• Mascalchi M, Salvi F, Valzania F, Marcacci G, Bartolozzi C, Tassinari CA. Corticospinal tract degeneration in motor neuron disease. AJNR Am J Neuroradiol. 1995;16:878–80.
   PubMed Web of Science ®Google Scholar
• Jimenez-Caballero PE, Alvarez-Tejerina A. Degeneration of the corticospinal pathway in primary lateral sclerosis. Rev Neurol. 2003;36:898.
   PubMed Web of Science ®Google Scholar
• Paliwal VK, Rahi SK, Singh P, Gupta RK. “Wine-glass appearance” of pyramidal tracts in a patient with primary lateral sclerosis. Neurol India. 2012;60:110–1.
   PubMed Web of Science ®Google Scholar
• Pioro EP. Neuroimaging in motor neuron disorders. In: Shaw PJ, Strong MJ, eds. Blue books of practical neurology. Philadelphia, PA: Elsevier; 2003:73–108.
   Google Scholar
• Suh S-I, Song I-C, Koh S-B. Primary lateral sclerosis with MR diffusion tensor image and tract tracking. Am J Phys Med Rehabil. 2006;85:863–4.
   PubMed Web of Science ®Google Scholar
• Tzarouchi LC, Kyritsis AP, Giannopoulos S, Astrakas LG, Diakou M, Argyropoulou MI. Voxel-based diffusion tensor imaging detects pyramidal tract degeneration in primary lateral sclerosis. Br J Radiol. 2011;84:78–80.
   PubMed Web of Science ®Google Scholar
• Salameh JS, Patel N, Zheng S, Cauley KA. Focal absence of diffusion tensor tracts from primary motor cortex in primary lateral sclerosis. Eur J Neurol. 2013;20:e63–4.
   PubMed Web of Science ®Google Scholar
• Chipika RH, Finegan ELH, Shing S, Hardiman O, Bede P. Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS. Front Neurol. 2019;10:229.
   PubMed Web of Science ®Google Scholar
• Müller H-P, Gorges M, Kassubek R, Dorst J, Ludolph AC, Kassubek J. Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: a tract of interest-based MRI study. Neuroimage Clin. 2018;18:762–9.
   PubMed Web of Science ®Google Scholar
• Müller H-P, Agosta F, Gorges M, Kassubek R, Spinelli EG, Riva N, et al. Cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: a two-centre tract of interest-based DTI analysis. Neuroimage Clin. 2018;20:1062–9.
   PubMed Web of Science ®Google Scholar
• Tartaglia MC, Laluz V, Rowe A, Findlater K, Lee DH, Kennedy K, et al. Brain atrophy in primary lateral sclerosis. Neurology 2009;72:1236–41.
   PubMed Web of Science ®Google Scholar
• van der Graaff MM, Sage CA, Caan MWA, Akkerman EM, Lavini C, Majoie CB, et al. Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study. Brain. 2011;134:1211–28.
   PubMed Web of Science ®Google Scholar
• Butman J, Floeter M. Decreased thickness of primary motor cortex in primary lateral sclerosis. AJNR Am J Neuroradiol. 2007;28:87–91.
   PubMed Web of Science ®Google Scholar
• Schuster C, Kasper E, Machts J, Bittner D, Kaufmann J, Benecke R, et al. Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study. J Neurol. 2013;260:2856–64.
   PubMed Web of Science ®Google Scholar
• Finegan E, Li Hi Shing S, Chipika RH, Doherty MA, Hengeveld JC, Vajda A, et al. Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling. Neuroimage Clin. 2019;24:102089.
   PubMed Web of Science ®Google Scholar
• Schuster C, Hardiman O, Bede P. Survival prediction in amyotrophic lateral sclerosis based on MRI measures and clinical characteristics. BMC Neurol. 2017;17:73.
   PubMed Web of Science ®Google Scholar
• Schuster C, Hardiman O, Bede P. Development of an automated MRI-based diagnostic protocol for amyotrophic lateral sclerosis using disease-specific pathognomonic features: a quantitative disease-state classification study. PLoS One. 2016;11:e0167331.
   PubMed Web of Science ®Google Scholar
• Grollemund V, Pradat P-F, Querin G, Delbot F, Le Chat G, Pradat-Peyre J-F, et al. Machine learning in amyotrophic lateral sclerosis: achievements, pitfalls, and future directions. Front Neurosci. 2019;13:135.
   PubMed Web of Science ®Google Scholar
• Welsh RC, Jelsone-Swain LM, Foerster BR. The utility of independent component analysis and machine learning in the identification of the amyotrophic lateral sclerosis diseased brain. Front Hum Neurosci. 2013;7:251.
   PubMedGoogle Scholar
• Querin G, El Mendili M-M, Bede P, Delphine S, Lenglet T, Marchand-Pauvert V, et al. Multimodal spinal cord MRI offers accurate diagnostic classification in ALS. J Neurol Neurosurg Psychiatry. 2018;89:1220–1.
   PubMed Web of Science ®Google Scholar
• Bede P, Chipika RH, Finegan E, Shing SLH, Doherty MA, Hengeveld JC, et al. Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: a longitudinal neuroimaging study. Neuroimage Clin. 2019;24:102054.
   PubMed Web of Science ®Google Scholar
• Christidi F, Karavasilis E, Rentzos M, Kelekis N, Evdokimidis I, Bede P. Clinical and radiological markers of extra-motor deficits in amyotrophic lateral sclerosis. Front Neurol 2018;9:1005.
   PubMed Web of Science ®Google Scholar
• Bede P, Finegan E. Revisiting the pathoanatomy of pseudobulbar affect: mechanisms beyond corticobulbar dysfunction. Amyotroph Lateral Scler Frontotemporal Degener 2018;19:4–6.
   PubMed Web of Science ®Google Scholar
• Müller H-P, Unrath A, Huppertz H-J, Ludolph AC, Kassubek J. Neuroanatomical patterns of cerebral white matter involvement in different motor neuron diseases as studied by diffusion tensor imaging analysis. Amyotroph Lateral Scler. 2012;13:254–64.
   PubMed Web of Science ®Google Scholar
• Chipika RH, Christidi F, Finegan E, Li Hi Shing S, McKenna MC, Chang KM, et al. Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. J Neurol Sci. 2020;417:117039.
   PubMed Web of Science ®Google Scholar
• Finegan E, Hi Shing SL, Chipika RH, McKenna MC, Doherty MA, Hengeveld JC, et al. Thalamic, hippocampal and basal ganglia pathology in primary lateral sclerosis and amyotrophic lateral sclerosis: evidence from quantitative imaging data. Data Brief. 2020;29:105115.
   PubMed Web of Science ®Google Scholar
• Chipika RH, Finegan E, Li Hi Shing S, McKenna MC, Christidi F, Chang KM, et al. “Switchboard” malfunction in motor neuron diseases: selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Neuroimage Clin. 2020;27:102300.
   PubMed Web of Science ®Google Scholar
• Chipika RH, Siah WF, Shing SLH, Finegan E, McKenna MC, Christidi F, et al. MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Data Brief. 2020;32:106246.
   PubMed Web of Science ®Google Scholar
• Chan S, Shungu DC, Douglas-Akinwande A, Lange DJ, Rowland LP. Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology 1999;212:763–9.
   PubMed Web of Science ®Google Scholar
• Mitsumoto H, Ulug AM, Pullman SL, Gooch CL, Chan S, Tang M-X, et al. Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007;68:1402–10.
   PubMed Web of Science ®Google Scholar
• Zhai P, Pagan F, Statland J, Butman JA, Floeter MK. Primary lateral sclerosis: a heterogeneous disorder composed of different subtypes? Neurology 2003;60:1258–65.
   PubMed Web of Science ®Google Scholar
• van der Graaff MM, Lavini C, Akkerman EM, Majoie CB, Nederveen AJ, Zwinderman AH, et al. MR spectroscopy findings in early stages of motor neuron disease. AJNR Am J Neuroradiol. 2010;31:1799–806.
   PubMed Web of Science ®Google Scholar
• Govind V, Sharma KR, Maudsley AA, Arheart KL, Saigal G, Sheriff S. Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy. PLoS One. 2012;7:e35607.
   PubMed Web of Science ®Google Scholar
• Stagg CJ, Knight S, Talbot K, Jenkinson M, Maudsley AA, Turner MR. Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. Neurology 2013;80:610–5.
   PubMed Web of Science ®Google Scholar
• Kalra S. Magnetic resonance spectroscopy in ALS. Front Neurol 2019;10:482.
   PubMed Web of Science ®Google Scholar
• Pioro EP, Antel JP, Cashman NR, Arnold DL. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo. Neurology 1994;44:1933–8.
   PubMed Web of Science ®Google Scholar
• Agosta F, Canu E, Inuggi A, Chiò A, Riva N, Silani V, et al. Resting state functional connectivity alterations in primary lateral sclerosis. Neurobiology of Aging 2014;35:916–25.
   PubMed Web of Science ®Google Scholar
• Meoded A, Morrissette AE, Katipally R, Schanz O, Gotts SJ, Floeter MK. Cerebro-cerebellar connectivity is increased in primary lateral sclerosis. Neuroimage Clin 2015;7:288–96.
   PubMed Web of Science ®Google Scholar
• Abidi M, de Marco G, Couillandre A, Feron M, Mseddi E, Termoz N, et al. Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes. European Journal of Neurology 2020;27:121–8.
   PubMed Web of Science ®Google Scholar
• Bede P, Bokde AL, Byrne S, Elamin M, Fagan AJ, Hardiman O. Spinal cord markers in ALS: diagnostic and biomarker considerations. Amyotroph Lateral Scler 2012;13:407–15.
   PubMed Web of Science ®Google Scholar
• El Mendili MM, Querin G, Bede P, Pradat P-F. Spinal cord imaging in amyotrophic lateral sclerosis: historical concepts-novel techniques. Front Neurol 2019;10:350.
   PubMed Web of Science ®Google Scholar
• Verstraete E, Turner MR, Grosskreutz J, Filippi M, Benatar M. Mind the gap: the mismatch between clinical and imaging metrics in ALS. Amyotroph Lateral Scler Frontotemporal Degener 2015;16:524–9.
   PubMed Web of Science ®Google Scholar
• Iwata NK, Kwan JY, Danielian LE, Butman JA, Tovar-Moll F, Bayat E, et al. White matter alterations differ in primary lateral sclerosis and amyotrophic lateral sclerosis. Brain 2011;134:2642–55.
   PubMed Web of Science ®Google Scholar
• Kwan JY, Meoded A, Danielian LE, Wu T, Floeter MK. Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis. Neuroimage Clin. 2012;2:151–60.
   PubMed Web of Science ®Google Scholar
• Agosta F, Galantucci S, Riva N, Chiò A, Messina S, Iannaccone S, et al. Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS. Hum Brain Mapp. 2014;35:1710–22.
   PubMed Web of Science ®Google Scholar
• Charil A, Corbo M, Filippi M, Kesavadas C, Agosta F, Munerati E, et al. Structural and metabolic changes in the brain of patients with upper motor neuron disorders: a multiparametric MRI study. Amyotrophic Lateral Sclerosis. 2009;10:269–79.
   PubMed Web of Science ®Google Scholar
• Mitsumoto H, Nagy PL, Gennings C, Murphy J, Andrews H, Goetz R, et al. Phenotypic and molecular analyses of primary lateral sclerosis. Neurol Genet. 2015;1:e3.
   PubMed Web of Science ®Google Scholar
• Fabes J, Matthews L, Filippini N, Talbot K, Jenkinson M, Turner MR. Quantitative FLAIR MRI in amyotrophic lateral sclerosis. Acad Radiol. 2017;24:1187–94.
   PubMed Web of Science ®Google Scholar
• Kolind S, Sharma R, Knight S, Johansen-Berg H, Talbot K, Turner MR. Myelin imaging in amyotrophic and primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:562–73.
   PubMed Web of Science ®Google Scholar
• Mitsumoto H, Chiuzan C, Gilmore M, Zhang Y, Simmons Z, Paganoni S, et al. Primary lateral sclerosis (PLS) functional rating scale: PLS-specific clinimetric scale. Muscle Nerve. 2020;61:163–72.
   PubMed Web of Science ®Google Scholar
• Schuster C, Elamin M, Hardiman O, Bede P. Presymptomatic and longitudinal neuroimaging in neurodegeneration-from snapshots to motion picture: a systematic review. J Neurol Neurosurg Psychiatry. 2015;86:1089–96.
   PubMed Web of Science ®Google Scholar
• Menke RAL, Abraham I, Thiel CS, Filippini N, Knight S, Talbot K, et al. Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. Arch Neurol. 2012;69:1493–9.
   PubMedGoogle Scholar
• Clark MG, Smallwood Shoukry R, Huang CJ, Danielian LE, Bageac D, Floeter MK. Loss of functional connectivity is an early imaging marker in primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2018;19:562–9.
   PubMed Web of Science ®Google Scholar
• Ferraro PM, Agosta F, Riva N, Copetti M, Spinelli EG, Falzone Y, et al. Multimodal structural MRI in the diagnosis of motor neuron diseases. Neuroimage Clin. 2017;16:240–7.
   PubMed Web of Science ®Google Scholar
• Ciccarelli O, Behrens TE, Johansen-Berg H, Talbot K, Orrell RW, Howard RS, et al. Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics. Hum Brain Mapp. 2009;30:615–24.
   PubMed Web of Science ®Google Scholar
• Machts J, Cardenas-Blanco A, Acosta-Cabronero J, Kaufmann J, Loewe K, Kasper E, et al. Prefrontal cortical thickness in motor neuron disease. Neuroimage Clin. 2018;18:648–55.
   PubMed Web of Science ®Google Scholar
• Unrath A, Müller H-P, Riecker A, Ludolph AC, Sperfeld A-D, Kassubek J. Whole brain-based analysis of regional white matter tract alterations in rare motor neuron diseases by diffusion tensor imaging. Hum Brain Mapp. 2010;31:1727–40.
   PubMed Web of Science ®Google Scholar
• Turner MR, Verstraete E. What does imaging reveal about the pathology of amyotrophic lateral sclerosis? Curr Neurol Neurosci Rep. 2015;15:45.
   PubMed Web of Science ®Google Scholar
• Quartuccio N, Van Weehaeghe D, Cistaro A, Jonsson C, Van Laere K, Pagani M. Positron emission tomography neuroimaging in amyotrophic lateral sclerosis: what is new? Q J Nucl Med Mol Imaging. 2014;58:344–54.
   PubMed Web of Science ®Google Scholar
• Cistaro A, Cuccurullo V, Quartuccio N, Pagani M, Valentini MC, Mansi L. Role of PET and SPECT in the study of amyotrophic lateral sclerosis. Biomed Res Int. 2014;2014:237437.
   PubMed Web of Science ®Google Scholar
• Chew S, Atassi N. Positron emission tomography molecular imaging biomarkers for amyotrophic lateral sclerosis. Front Neurol. 2019;10:135.
   PubMed Web of Science ®Google Scholar
• Arruda WO, Coelho Neto M. Primary lateral sclerosis. A case report with SPECT study. Arq Neuropsiquiatr. 1998;56:465–71.
   PubMed Web of Science ®Google Scholar
• Garnett E, Chirakal R, Firnau G, Nahmias C, Hudson A. Recent developments in PET scanning related to amyotrophic lateral sclerosis and primary lateral sclerosis. In: Amyotrophic lateral sclerosis: concepts in pathogenesis and etiology. Toronto, Canada: University of Toronto Press; 1990:358–70.
   Google Scholar
• Claassen DO, Josephs KA, Peller PJ. The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography. Arch Neurol. 2010;67:122–5.
   PubMedGoogle Scholar
• Cosgrove J, Jamieson S, Chowdhury FU. Teaching neuro images: hypometabolism of the primary motor cortex in primary lateral sclerosis. Neurology 2015;84:e206.
   PubMed Web of Science ®Google Scholar
• Van Laere K, Vanhee A, Verschueren J, De Coster L, Driesen A, Dupont P, et al. Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study. JAMA Neurol. 2014;71:553–61.
   PubMed Web of Science ®Google Scholar
• Van Weehaeghe D, Ceccarini J, Delva A, Robberecht W, Van Damme P, Van Laere K. Prospective validation of 18F-FDG brain PET discriminant analysis methods in the diagnosis of amyotrophic lateral sclerosis. J Nucl Med. 2016;57:1238–43.
   PubMed Web of Science ®Google Scholar
• Van Weehaeghe D, Devrome M, Schramm G, De Vocht J, Deckers W, Baete K, et al. Combined brain and spinal FDG PET allows differentiation between ALS and ALS mimics. Eur J Nucl Med Mol Imaging. 2020;47:2681–90.
   PubMed Web of Science ®Google Scholar
• Mills CK. A case of unilateral progressive ascending paralysis, probably representing a new form of degenerative disease. J Nervous Mental Dis 1900;27:195–200.
   Google Scholar
• Barohn RJ, Fink JK, Heiman-Patterson T, Huey ED, Murphy J, Statland JM, et al. The clinical spectrum of primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 2020, In Press.
   PubMed Web of Science ®Google Scholar
• Scialò C, Morbelli S, Girtler N, Mandich P, Mancardi GL, Caponnetto C, et al. Bilateral motor and premotor cortex hypometabolism in a case of Mills syndrome. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:414–7.
   PubMed Web of Science ®Google Scholar
• Turner MR, Gerhard A, Al-Chalabi A, Shaw CE, Hughes RAC, Banati RB, et al. Mills’ and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET. J Neurol Neurosurg Psychiatry. 2005;76:871–4.
   PubMed Web of Science ®Google Scholar
• Le Forestier N, Maisonobe T, Piquard A, Rivaud S, Crevier-Buchman L, Salachas F, et al. Does primary lateral sclerosis exist? A study of 20 patients and a review of the literature. Brain. 2001;124:1989–99.
   PubMed Web of Science ®Google Scholar
• Turner MR, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, et al. Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET. J Neurol. 2007;254:1033–6.
   PubMed Web of Science ®Google Scholar
• Wicks P, Turner MR, Abrahams S, Hammers A, Brooks DJ, Leigh PN, et al. Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study. Amyotroph Lateral Scler. 2008;9:43–9.
   PubMed Web of Science ®Google Scholar
• Banati R, Newcombe J, Gunn R, Cagnin A, Turkheimer F, Heppner F, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000;123:2321–37.
   PubMed Web of Science ®Google Scholar
• Turner MR, Cagnin A, Turkheimer FE, Miller CCJ, Shaw CE, Brooks DJ, et al. Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol Dis. 2004;15:601–9.
   PubMed Web of Science ®Google Scholar
• Kreisl WC, Fujita M, Fujimura Y, Kimura N, Jenko KJ, Kannan P, et al. Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission tomographic imaging of this inflammation biomarker. Neuroimage. 2010;49:2924–32.
   PubMed Web of Science ®Google Scholar
• Owen DR, Yeo AJ, Gunn RN, Song K, Wadsworth G, Lewis A, et al. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab. 2012;32:1–5.
   PubMed Web of Science ®Google Scholar
• Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O, et al. Integrated magnetic resonance imaging and [11 C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis. Ann Neurol. 2018;83:1186–97.
   PubMed Web of Science ®Google Scholar
• Paganoni S, Alshikho MJ, Zürcher NR, Cernasov P, Babu S, Loggia ML, et al. Imaging of glia activation in people with primary lateral sclerosis. Neuroimage Clin. 2018;17:347–53.
   PubMed Web of Science ®Google Scholar