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Biomarkers

PROSA—a multicenter prospective observational study to develop low-burden digital speech biomarkers in ALS and FTD

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Pages 589-598 | Received 24 Mar 2023, Accepted 15 Jul 2023, Published online: 30 Jul 2023

References

  • Goyal D, Tjandra D, Migrino RQ, Giordani B, Syed Z, Wiens J. Characterizing heterogeneity in the progression of Alzheimer’s disease using longitudinal clinical and neuroimaging biomarkers. Alzheimers Dement. 2018;10:629–37.
  • van den Berg LH, Sorenson E, Gronseth G, Macklin EA, Andrews J, Baloh RH, et al. Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials. Neurology 2019;92:e1610–23–e1623.
  • Boschi V, Catricalà E, Consonni M, Chesi C, Moro A, Cappa SF. Connected speech in neurodegenerative language disorders: a review. Front Psychol. 2017;8:269.
  • Robin J, Harrison JE, Kaufman LD, Rudzicz F, Simpson W, Yancheva M. Evaluation of speech-based digital biomarkers: review and recommendations. Digit Biomark. 2020;4:99–108.
  • Küffner R, Zach N, Norel R, Hawe J, Schoenfeld D, Wang L, et al. Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression. Nat Biotechnol. 2015;33:51–7.
  • Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Wynne B, et al. Cognitive changes predict functional decline in ALS: a population-based longitudinal study. Neurology 2013;80:1590–7.
  • Broce IJ, Castruita PA, Yokoyama JS. Moving toward patient-tailored treatment in ALS and FTD: the potential of genomic assessment as a tool for biological discovery and trial recruitment. Front Neurosci. 2021;15:639078.
  • Ash S, Menaged A, Olm C, McMillan CT, Boller A, Irwin DJ, et al. Narrative discourse deficits in amyotrophic lateral sclerosis. Neurology 2014;83:520–8.
  • Ash S, Olm C, McMillan CT, Boller A, Irwin DJ, McCluskey L, et al. Deficits in sentence expression in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:31–9.
  • Ash S, Nevler N, Phillips J, Irwin DJ, McMillan CT, Rascovsky K, et al. A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia. Brain Lang. 2019;194:46–57.
  • Blair M, Marczinski CA, Davis-Faroque N, Kertesz A. A longitudinal study of language decline in Alzheimer’s disease and frontotemporal dementia. J Int Neuropsychol Soc. 2007;13:237–45. [Internet]. Mar [cited 2023 Jan 24]Available from: http://www.journals.cambridge.org/abstract_S1355617707070269
  • Hardy CJD, Buckley AH, Downey LE, Lehmann M, Zimmerer VC, Varley RA, et al. The Language Profile of Behavioral Variant Frontotemporal Dementia. Hodges J, editor. J Alzheimers Dis. 2016;50:359–71.
  • Mulligan M, Carpenter J, Riddel J, Delaney MK, Badger G, Krusinski P, et al. Intelligibility and the Acoustic Characteristics of Speech in Amyotrophic Lateral Sclerosis (ALS). J Speech Hear Res. 1994;37:496–503.
  • Poole ML, Brodtmann A, Darby D, Vogel AP. Motor Speech Phenotypes of Frontotemporal Dementia, Primary Progressive Aphasia, and Progressive Apraxia of Speech. J Speech Lang Hear Res. 2017;60:897–911.
  • Staffaroni AM, Weintraub S, Rascovsky K, Rankin KP, Taylor J, Fields JA, et al. Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Alzheimers Dement Diagn Assess Dis Monit. 2021;13:e12148.
  • Tsermentseli S, Leigh PN, Taylor LJ, Radunovic A, Catani M, Goldstein LH. Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015;17:69–76.
  • Yunusova Y, Graham NL, Shellikeri S, Phuong K, Kulkarni M, Rochon E, et al. Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Kassubek J, editor. PLOS One. 2016;11:e0147573.
  • Nevler N, Ash S, McMillan C, Elman L, McCluskey L, Irwin DJ, et al. Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders. Neurology 2020;95:e1629–39–e1639.
  • Vieira H, Costa N, Sousa T, Reis S, Coelho L. Voice-based classification of amyotrophic lateral sclerosis: where are we and where are we going? a systematic review. Neurodegener Dis. 2019;19:163–70.
  • Chiaramonte R, Bonfiglio M. Acoustic analysis of voice in bulbar amyotrophic lateral sclerosis: a systematic review and meta-analysis of studies. Logoped Phoniatr Vocol. 2020;45:151–63.
  • Stegmann GM, Hahn S, Liss J, Shefner J, Rutkove S, Shelton K, et al. Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis. NPJ Digit Med. 2020;3:132.
  • Roberts-South A, Findlater K, Strong M, Orange JB. Longitudinal Changes in Discourse Prouction in Amyotrophic Lateral Sclerosis. Semin Speech Lang. 2012;33:79–94.
  • Miyagawa T, Brushaber D, Syrjanen J, Kremers W, Fields J, Forsberg LK, et al. Utility of the global CDR ® plus NACC FTLD rating and development of scoring rules: data from the ARTFL/LEFFTDS Consortium. Alzheimers Dement. 2020;16:106–17.
  • Cho S, Nevler N, Shellikeri S, Ash S, Liberman M, Grossman M. Automatic classification of primary progressive aphasia patients using lexical and acoustic features. 2020.
  • Cho S, Nevler N, Ash S, Shellikeri S, Irwin DJ, Massimo L, et al. Automated analysis of lexical features in frontotemporal degeneration. Cortex. 2021;137:215–31.
  • Nevler N, Ash S, Irwin DJ, Liberman M, Grossman M. Validated automatic speech biomarkers in primary progressive aphasia. Ann Clin Transl Neurol. 2019;6:4–14.
  • Nevler N, Ash S, Jester C, Irwin DJ, Liberman M, Grossman M. Automatic measurement of prosody in behavioral variant FTD. Neurology 2017;89:650–6.
  • Kiernan MC, Vucic S, Talbot K, McDermott CJ, Hardiman O, Shefner JM, et al. Improving clinical trial outcomes in amyotrophic lateral sclerosis. Nat Rev Neurol. 2021;17:104–18.
  • Rutkove SB, Narayanaswami P, Berisha V, Liss J, Hahn S, Shelton K, et al. Improved ALS clinical trials through frequent at‐home self‐assessment: a proof of concept study. Ann Clin Transl Neurol. 2020;7:1148–57.
  • Seelaar H, Rohrer JD, Pijnenburg YAL, Fox NC, van Swieten JC. Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review. J Neurol Neurosurg Psychiatry. 2011;82:476–86.
  • Robin J, Xu M, Kaufman LD, Simpson W. Using digital speech assessments to detect early signs of cognitive impairment. Front Digit Health. 2021;3:749758.
  • Yeung A, Iaboni A, Rochon E, Lavoie M, Santiago C, Yancheva M, et al. Correlating natural language processing and automated speech analysis with clinician assessment to quantify speech-language changes in mild cognitive impairment and Alzheimer’s dementia. Alzheimers Res Ther 2021;13:109.
  • Tröger J, Baykara E, Zhao J, Huurne D, ter Possemis N, Mallick E, et al. Validation of the remote automated ki:e speech biomarker for cognition in mild cognitive impairment: verification and validation following DiME V3 framework. Digit Biomark. 2022;6:107–16.
  • Schäfer S, Mallick E, Schwed L, König A, Zhao J, Linz N, et al. Screening for mild cognitive impairment using a machine learning classifier and the remote speech biomarker for cognition: evidence from two clinically relevant cohorts. J Alzheimers Dis. 2023;91:1165–71.
  • Borroni B, Agosti C, Premi E, Cerini C, Cosseddu M, Paghera B, et al. The FTLD-modified Clinical Dementia Rating scale is a reliable tool for defining disease severity in Frontotemporal Lobar Degeneration: evidence from a brain SPECT study: usefulness of FTLD-modified CDR. Eur J Neurol. 2010;17:703–7.
  • Silverman JM, Raiford K, Edland S, Fillenbaum G, Morris JC, Clark CM, et al. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD): part VI. Family history assessment: a multicenter study of first‐degree relatives of Alzheimer’s disease probands and nondemented spouse controls. Neurology 1994;44:1253–9.
  • Wear HJ, Wedderburn CJ, Mioshi E, Williams-Gray CH, Mason SL, Barker RA, et al. The Cambridge Behavioural Inventory revised. Dement Neuropsychol. 2008;2:102–7.
  • Lulé D, Burkhardt C, Abdulla S, Böhm S, Kollewe K, Uttner I, et al. The edinburgh cognitive and behavioural amyotrophic lateral sclerosis screen: a cross-sectional comparison of established screening tools in a German-Swiss population. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:16–23.
  • Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci. 1999;169:13–21.
  • Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results: MDS-UPDRS: clinimetric Assessment. Mov Disord. 2008;23:2129–70.
  • Golbe LI, Ohman-Strickland PA. A clinical rating scale for progressive supranuclear palsy. Brain. 2007;130:1552–65.
  • Ludolph A, Drory V, Hardiman O, Nakano I, Ravits J, Robberecht W, et al. A revision of the El Escorial criteria - 2015. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:291–2.
  • Mesulam MM. Primary progressive aphasia. Ann Neurol. 2001;49:425–32.
  • Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011;134:2456–77.
  • Strong MJ, Abrahams S, Goldstein LH, Woolley S, Mclaughlin P, Snowden J, et al. Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): revised diagnostic criteria. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18:153–74.
  • Salmon K, Genge A. Clinical Trials in ALS – Current Challenges and Strategies for Future Directions. In: Shaw CA, Morrice JR, editors. Spectrums of amyotrophic lateral sclerosis. 1st ed. Oxford: Wiley; 2021. p. 161–80.
  • Eshghi M, Yunusova Y, Connaghan KP, Perry BJ, Maffei MF, Berry JD, et al. Rate of speech decline in individuals with amyotrophic lateral sclerosis. Sci Rep. 2022;12:15713.
  • Rong P. Automated acoustic analysis of oral diadochokinesis to assess bulbar motor involvement in amyotrophic lateral sclerosis. J Speech Lang Hear Res. 2020;63:59–73.
  • Stegmann GM, Hahn S, Duncan CJ, Rutkove SB, Liss J, Shefner JM, et al. Estimation of forced vital capacity using speech acoustics in patients with ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2021;22:14–21.
  • Korpás J, Sadlonová J, Vrabec M. Analysis of the cough sound: an overview. Pulm Pharmacol. 1996;9:261–8.
  • Rey A. Memorisation d’une serie de 15 mots en 5 repetitions. L’examen Clin En Psycologie 1958.
  • Fraser KC, Meltzer JA, Graham NL, Leonard C, Hirst G, Black SE, et al. Automated classification of primary progressive aphasia subtypes from narrative speech transcripts. Cortex. 2014;55:43–60.
  • MacWhinney B, Fromm D, Forbes M, Holland A. AphasiaBank: methods for studying discourse. Aphasiology 2011;25:1286–307.
  • Wagner S, Maurer J, Pape V, Mitschke T, Helmreich I, Tadić A. Entwicklung von drei parallelversionen des kategorienwechsels des regensburger wortflüssigkeitstests. Z Für Neuropsychol 2015;26:27–34.
  • Ryan JJ, Lopez SJ. Wechsler adult intelligence scale-III. In: Dorfman WI, Hersen M, editors. Understanding psychological assessment. Boston, MA: Springer US; 2001. p. 19–42.

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