Crushing riluzole tablets: evaluation of loss of powder and active principle in a home-simulation experiment

References

• Dyer AM, Smith A. Riluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosis. Dddt. 2017;11:59–64.
   PubMed Web of Science ®Google Scholar
• Stegemann S, Gosch M, Breitkreutz J. Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy. Int J Pharm. 2012;430:197–206.
   PubMed Web of Science ®Google Scholar
• Fang T, Al Khleifat AA, Meurgey JH, Jones A, Leigh PN, Bensimon G, Al-Chalabi A. Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study. Lancet Neurol. 2018; 17:416–22.
   PubMed Web of Science ®Google Scholar
• Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet 1996;347:1425–31.
   PubMed Web of Science ®Google Scholar
• Miller RG, Mitchell JD, Moore DH. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev. 2012;2012:CD001447.
   PubMedGoogle Scholar
• Andrews JA, Jackson CE, Heiman-Patterson TD, Bettica P, Rix Brooks B, Pioro EP. Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis. Amyotroph Lateral Scler Front Degener. 2020; 0:1–10.
   Google Scholar
• Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, Van Damme F, et al. EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force. European J Neurol.2012; 19:360–75.
   PubMed Web of Science ®Google Scholar
• Povedano Panades M, Couratier P, Sidle K, Sorarù G, Tsivgoulis G, Ludolph AC. Administration of riluzole oral suspension during the different stages of amyotrophic lateral sclerosis. Front Neurol. 2021; 12:633854.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan C, Forough AS, Cichero JAY, Smyth HE, Raidhan A, Nissen LA, et al. A difficult pill to swallow: an investigation of the factors associated with medication swallowing difficulties. Ppa. 2021; 15:29–40.
   Google Scholar
• Onesti E, Schettino I, Gori MC, Frasca V, Ceccanti M, Cambieri C, et al. Dysphagia in amyotrophic lateral sclerosis: impact on patient behavior, diet adaptation, and riluzole management. Front Neurol. 2017;8:94.
   PubMed Web of Science ®Google Scholar
• Fodil M, Nghiem D, Colas M, Bourry S, Poisson-Salomon AS, Rezigue H, et al. Assessment of clinical practices for crushing medication in geriatric units. J Nutr Health Aging. 2017;21:904–8.
   PubMed Web of Science ®Google Scholar
• Mercovich N, Kyle GJ, Naunton M. Safe to crush? A pilot study into solid dosage form modification in aged care. Australas J Ageing.2014; 33:180–4.
   PubMed Web of Science ®Google Scholar
• Paradiso LM, Roughead EE, Gilbert AL, Cosh D, Nation RL, Barnes L, et al. Crushing or altering medications: what’s happening in residential aged-care facilities? Australas J Ageing.2002; 21: 123–7.
   Web of Science ®Google Scholar
• Stubbs J, Haw C, Dickens G. Dose form modification: a common but potentially hazardous practice. A literature review and study of medication administration to older psychiatric inpatients. Int Psychogeriatr 2008; 20:616–27.
   PubMed Web of Science ®Google Scholar
• Brooks BR, Bettica P, Cazzaniga S. Riluzole oral suspension: bioavailability following percutaneous gastrostomy tube-modeled administration versus direct oral administration. Clin Ther. 2019;41:2490–9.
   PubMed Web of Science ®Google Scholar
• Kelly J, Wright D, Wood J. Medicine administration errors in patients with dysphagia in secondary care: a multi-centre observational study. J Adv Nurs. 2011; 67:2615–27.
   PubMed Web of Science ®Google Scholar
• Gill D, Spain M, Edlund BJ. Crushing or splitting medications unrecognized hazards. J Gerontol Nurs. 2012;38:8–12.
   PubMed Web of Science ®Google Scholar
• Palese A, Bello A, Magee J. Triturating drugs for administration in patients with difficulties in swallowing: evaluation of the drug lost. J Clin Nurs. 2011;20:587–90.
   PubMed Web of Science ®Google Scholar
• FDA Guidance for Industry - Tablet Scoring: Nomenclature, Labeling, and Data for Evaluation 2013_Available from: https://www.fda.gov/drugs/guidance-compliance-regulatory-information/guidances-drugs
   Google Scholar
• Jacques ER, Alexandridis P. Tablet scoring: current practice, fundamentals, and knowledge gaps. Appl Sci. 2019; 9:3066.
   Google Scholar
• Casiraghi A, Musazzi UM, Franceschini I, Berti IO, Paragò V, Cardosi L, et al. Is propranolol compounding from tablet safe for pediatric use? Results from an experimental tests. Minerva Pediatr 2014; 66:355–62.
   PubMed Web of Science ®Google Scholar
• Thong MY, Manrique YJ, Steadman KJ. Drug loss while crushing tablets: Comparison of 24 tablet crushing devices. PLoS One. 2018; 13:e0193683.
   PubMed Web of Science ®Google Scholar
• Woerdenbag HJ, Visser JC, Leferink op Reinink MPAM, van Orsoy RR, Eissen AC, Hagerdoorn P, et al. Performance of tablet splitters, crushers, and grinders in relation to personalized medication with tablets. Pharmaceutics 2022; 14:320.
   PubMed Web of Science ®Google Scholar
• Papiez A, Odehnalova K, Sramek V, Suk P. Comparison of active substance losses and total weight losses of tablets administered via feeding tube. Pharmacology 2019;103:246–9.
   PubMed Web of Science ®Google Scholar
• Mandrioli J, Malerba SA, Beghi E, Fini N, Fasano A, Zucchi E, et al. Riluzole and other prognostic factors in ALS: a population‑based registry study in Italy. J Neurol. 2018;265:817–27.
   PubMed Web of Science ®Google Scholar
• Qureshi I, Lovegren M, Wirtz V, Larouche R, Tanguay M, Anderson MS, et al. A pharmacokinetic bioequivalence study comparing sublingual riluzole (BHV-0223) and oral tablet formulation of riluzole in healthy volunteers. Clin Pharmacol Drug Dev. 2020; 9:476–85.
   PubMed Web of Science ®Google Scholar
• Manrique-Torres YJ, Lee DJ, Islam F, Nissen LM, Cichero JAY, Stokes JR, et al. Crushed tablets: does the administration of food vehicles and thickened fluids to aid medication swallowing alter drug release? J Pharm Pharm Sci. 2014; 17:207–19.
   PubMed Web of Science ®Google Scholar
• Emilyf (R) Summary of Product Characteristics_Revised on October 2022.
   Google Scholar
• Rahnemai-Azar AA, Rahnemaiazar AA, Naghshizadian R, Kurtz A, Farkas DT. Percutaneous endoscopic gastrostomy: indications, technique, complications and management. Wjg. 2014; 20:7739–51.
   PubMed Web of Science ®Google Scholar
• Malhi H, Thompson R. PEG tubes: dealing with complications. Nursing Times 2014; 110:18–21.
   PubMedGoogle Scholar
• Introna A, D'Errico E, Modugno B, Scarafino A, Fraddosio A, Distaso E, et al. Adherence to riluzole in patients with amyotrophic lateral sclerosis: an observational study. Ndt. 2018; 14:193–203.
   Google Scholar