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Letter to the Editor

Do we really need to calculate a minimal important difference for ALSFRS-R?: A letter in response to ‘Clinically meaningful change: evaluation of the Rasch-built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) and the ALSFRS-R’ published in Vol. 24(3–4), pp. 311–316

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Pages 214-215 | Received 26 Jul 2023, Accepted 08 Aug 2023, Published online: 30 Aug 2023

References

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  • van Eijk RPA, de Jongh AD, Nikolakopoulos S, McDermott CJ, Eijkemans MJC, Roes KCB, et al. An old friend who has overstayed their welcome: the ALSFRS-R total score as primary endpoint for ALS clinical trials. Amyotroph Lateral Scler Frontotemporal Degener. 2021; 22;300–7. 10.1080/21678421.2021.1879865
  • Terwee CB, Peipert JD, Chapman R, Lai JS, Terluin B, Cella D, et al. Minimal important change (MIC): a conceptual clarification and systematic review of MIC estimates of PROMIS measures. Qual Life Res. 2021;30:2729–54. Available at:/pmc/articles/PMC8481206/

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