362
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Evaluating the clinical utility of semi-quantitative luciferase immunosorbent assay using Treponema pallidum antigens in syphilis diagnosis and treatment monitoring

, , , , , , , , , , , , , , , , & ORCID Icon show all
Article: 2348525 | Received 07 Jan 2024, Accepted 23 Apr 2024, Published online: 16 May 2024

References

  • Harris E. STI epidemic worsened in 2021, syphilis cases surged. JAMA. 2023;329(19):1633.
  • Huang J, Wu H, Lin S, et al. Spatial–temporal analysis of HIV/AIDS and syphilis in mainland China from 2007 to 2017. J Med Virol. 2022;94(7):3328–3337. doi:10.1002/jmv.27725
  • Clement ME, Okeke NL, Hicks CB. Treatment of syphilis: a systematic review. JAMA. 2014;312(18):1905–1917. doi:10.1001/jama.2014.13259
  • Forrestel AK, Kovarik CL, Katz KA. Sexually acquired syphilis: laboratory diagnosis, management, and prevention. J Am Acad Dermatol. 2020;82(1):17–28. doi:10.1016/j.jaad.2019.02.074
  • Wang ZS, Liu XK, Li J. Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. J Antimicrob Chemother. 2018;73(5):1348–1351. doi:10.1093/jac/dky006
  • Zhou P, Gu X, Lu H, et al. Re-evaluation of serological criteria for early syphilis treatment efficacy: progression to neurosyphilis despite therapy. Sex Transm Infect. 2012;88(5):342–345. doi:10.1136/sextrans-2011-050247
  • Holman KM, Wolff M, Seña AC, et al. Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy. Sex Transm Dis. 2012;39(8):645–647. doi:10.1097/OLQ.0b013e3182536574
  • Janier M, Unemo M, Dupin N, et al. 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2021;35(3):574–588. doi:10.1111/jdv.16946
  • Xia D, Yuan L, Zhou Q, et al. Performance evaluation of eight treponemal antibody tests in China. Diagn Microbiol Infect Dis. 2022;104(4):115790. doi:10.1016/j.diagmicrobio.2022.115790
  • Wang H, Cai Q, Liang Y, et al. A simple and high-throughput luciferase immunosorbent assay for both qualitative and semi-quantitative detection of anti-HIV-1 antibodies. Virus Res. 2019;263:9–15. doi:10.1016/j.virusres.2018.12.017
  • Liang Y, Li L, Shui J, et al. Reduction of anti-HIV antibody responses in subjects receiving antiretroviral therapy during chronic HIV-1 infection. J Clin Virol. 2020;128:104414. doi:10.1016/j.jcv.2020.104414
  • Wang T, Zhan Y, Wu D, et al. Development and evaluation of a universal and supersensitive NS1-based luciferase immunosorbent assay to detect Zika virus-specific IgG. Virol Sin. 2020;35(1):93–102. doi:10.1007/s12250-019-00160-x
  • Shui J, Xie D, Zhao J, et al. Seroepidemiology of Chlamydia trachomatis infection in the general population of Northern China: the Jidong community cohort study. Front Microbiol. 2021;12:729016. doi:10.3389/fmicb.2021.729016
  • Liang Y, Yan H, Huang L, et al. A luciferase immunosorbent assay for quantitative detection of IgG antibodies against SARS-CoV-2 nucleoprotein. J Virol Methods. 2021;292:114141. doi:10.1016/j.jviromet.2021.114141
  • Liang Z, Zhang M, Wang Y, et al. Development and evaluation of a new luciferase immunosorbent assay to detect GII.6 norovirus-specific IgG in different domestic and wild animals. Front Microbiol. 2023;14:1213007. doi:10.3389/fmicb.2023.1213007
  • Li X, Wan X, Liu J, et al. Luciferase immunosorbent assay based on multiple E antigens for the detection of Chikungunya virus-specific IgG antibodies. Microbiol Spectr. 2022;10(2):e0149621.
  • Park IU, Tran A, Pereira L, et al. Sensitivity and specificity of treponemal-specific tests for the diagnosis of syphilis. Clin Infect Dis. 2020;71(Suppl 1):S13–S20. doi:10.1093/cid/ciaa349
  • Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021;70(4):1–187. doi:10.15585/mmwr.rr7004a1
  • Zhou W, He P, Liu H, et al. A luciferase based automated assay for rapid and sensitive detection of SARS-CoV-2 antibodies. Anal Chim Acta. 2023;1238:340633. doi:10.1016/j.aca.2022.340633
  • Liu H, He P, Meng F, et al. A semiautomated luciferase immunoprecipitation assay for rapid and easy detection of African swine fever virus antibody. J Clin Microbiol. 2021;59(10):e0099021.
  • Sambri V, Marangoni A, Eyer C, et al. Western immunoblotting with five Treponema pallidum recombinant antigens for serologic diagnosis of syphilis. Clin Diagn Lab Immunol. 2001;8(3):534–539. doi:10.1128/CDLI.8.3.534-539.2001
  • Dang Q, Feng J, Lu X, et al. Evaluation of specific antibodies for early diagnosis and management of syphilis. Int J Dermatol. 2006;45(10):1169–1171. doi:10.1111/j.1365-4632.2006.02869.x
  • Burbelo PD, Ching KH, Bren KE, et al. Searching for biomarkers: humoral response profiling with luciferase immunoprecipitation systems (LIPS). Expert Rev Proteomics. 2011;8(3):309–316. doi:10.1586/epr.11.23
  • Pastuszczak M, Kotnis-Gaska A, Jakubowicz B, et al. Treponema pallidum-specific immune responses and autoimmunity in patients who remain serofast after treatment of syphilis. Adv Dermatol Allergol. 2019;36(5):620–625. doi:10.5114/ada.2018.77497
  • Liu C, Ou Q, Chen H, et al. The diagnostic value and performance evaluation of five serological tests for the detection of Treponema pallidum. J Clin Lab Anal. 2014;28(3):204–209. doi:10.1002/jcla.21667
  • Ijsselmuiden OE, Schouls LM, Stolz E, et al. Sensitivity and specificity of an enzyme-linked immunosorbent assay using the recombinant DNA-derived Treponema pallidum protein TmpA for serodiagnosis of syphilis and the potential use of TmpA for assessing the effect of antibiotic therapy. J Clin Microbiol. 1989;27(1):152–157. doi:10.1128/jcm.27.1.152-157.1989
  • Liu W, Deng M, Zhang X, et al. Performance of novel infection phase-dependent antigens in syphilis serodiagnosis and treatment efficacy determination. Clin Chim Acta. 2019;488:13–19. doi:10.1016/j.cca.2018.10.017
  • Lin LR, Zhu XZ, Liu D, et al. Are nontreponemal tests suitable for monitoring syphilis treatment efficacy? Evidence from rabbit infection models. Clin Microbiol Infect. 2020;26(2):240–246. doi:10.1016/j.cmi.2019.06.004
  • Ghanem KG, Ram S, Rice PA. The modern epidemic of syphilis. N Engl J Med. 2020;382(9):845–854. doi:10.1056/NEJMra1901593
  • Hu YT, Wu JB, Zhuang MH, et al. A 4-fold or greater decrease in TPPA titers may indicate effective BPG treatment in primary syphilis. Int Immunopharmacol. 2024;127:111333. doi:10.1016/j.intimp.2023.111333
  • Sun R, Lai DH, Ren RX, et al. Treponema pallidum-specific antibody expression for the diagnosis of different stages of syphilis. Chin Med J (Engl). 2013;126(2):206–210. doi:10.3760/cma.j.issn.0366-6999.20122207
  • Parameswaran N, Mitjà O, Bottomley C, et al. Antibody responses to two recombinant Treponemal antigens (rp17 and TmpA) before and after azithromycin treatment for yaws in Ghana and Papua New Guinea. J Clin Microbiol. 2021;59(5):e02509-20. doi:10.1128/JCM.02509-20
  • Lukehart SA, Fohn MJ, Baker-Zander SA. Efficacy of azithromycin for therapy of active syphilis in the rabbit model. J Antimicrob Chemother. 1990;25(Suppl A):91–99. doi:10.1093/jac/25.suppl_A.91
  • Baker-Zander SA, Lukehart SA. Efficacy of cefmetazole in the treatment of active syphilis in the rabbit model. Antimicrob Agents Chemother. 1989;33(9):1465–1469. doi:10.1128/AAC.33.9.1465