Prevention of urinary tract infections with vitamin D supplementation 20,000 IU per week for five years. Results from an RCT including 511 subjects

References

• DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004;80:1689S–1696S.
   PubMed Web of Science ®Google Scholar
• Stumpf WE, Sar M, Reid FA, et al. Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science. 1979;206:1188–1190.
   PubMed Web of Science ®Google Scholar
• Bhalla AK, Amento EP, Clemens TL, et al. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab. 1983;57:1308–1310.
   PubMed Web of Science ®Google Scholar
• White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008;76:3837–3843.
   PubMed Web of Science ®Google Scholar
• Martineau AR, Wilkinson KA, Newton SM, et al. IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol. 2007;178:7190–7198.
   PubMed Web of Science ®Google Scholar
• Kearns MD, Alvarez JA, Seidel N, et al. Impact of vitamin D on infectious disease. Am J Med Sci. 2015;349:245–262.
   PubMed Web of Science ®Google Scholar
• Juzeniene A, Ma LW, Kwitniewski M, et al. The seasonality of pandemic and non-pandemic influenzas: the roles of solar radiation and vitamin D. Int J Infect Dis. 2010;14:e1099–e1105.
   PubMed Web of Science ®Google Scholar
• Hayes DP. Influenza pandemics, solar activity cycles, and vitamin D. Med Hypotheses. 2010;74:831–834.
   PubMed Web of Science ®Google Scholar
• Grant WB, Giovannucci E. The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918-1919 influenza pandemic in the United States. Dermatoendocrinol. 2009;1:215–219.
   PubMedGoogle Scholar
• Sollid ST, Hutchinson MY, Fuskevåg OM, et al. No effect of high-dose vitamin D supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes. Diabetes Care. 2014;37:2123–2131.
   PubMed Web of Science ®Google Scholar
• Jorde R, Sollid ST, Svartberg J, et al. Vitamin D 20 000 IU per week for five years does not prevent progression from prediabetes to diabetes. J Clin Endocrinol Metab. 2016;101:1647–1655.
   PubMed Web of Science ®Google Scholar
• Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011;378:169–181.
   PubMed Web of Science ®Google Scholar
• van der Starre WE, van Nieuwkoop C, Thomson U, et al. Urinary proteins, vitamin D and genetic polymorphisms as risk factors for febrile urinary tract infection and relation with bacteremia: a case control study. PLoS One. 2015;10:e0121302.
   Google Scholar
• Tekin M, Konca C, Celik V, et al. The association between vitamin d levels and urinary tract infection in children. Horm Res Paediatr. 2015;83:198–203.
   PubMed Web of Science ®Google Scholar
• Nseir W, Taha M, Nemarny H, et al. The association between serum levels of vitamin D and recurrent urinary tract infections in premenopausal women. Int J Infect Dis. 2013;17:e1121–e1124.
   PubMed Web of Science ®Google Scholar
• Vaughan CP, Johnson TM, 2nd, Goode PS, et al. Vitamin D and lower urinary tract symptoms among US men: results from the 2005-2006 National Health and Nutrition Examination Survey. Urology. 2011;78:1292–1297.
   PubMed Web of Science ®Google Scholar
• Caretta N, Vigili de Kreutzenberg S, Valente U, et al. Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes. Andrology. 2015;3:1062–1067.
   PubMed Web of Science ®Google Scholar
• Kwon YE, Kim H, Oh HJ, et al. Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants. Medicine (Baltimore). 2015;94:e594.
   Google Scholar
• Chromek M, Slamová Z, Bergman P, et al. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat Med. 2006;12:636–641.
   PubMed Web of Science ®Google Scholar
• Hertting O, Holm Å, Lüthje P, et al. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One. 2010;5:e15580.
   Google Scholar
• Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008;17:348–352.
   PubMed Web of Science ®Google Scholar
• Gallagher JC, Smith LM, Yalamanchili V. Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women. Menopause. 2014;21:1173–1180.
   PubMed Web of Science ®Google Scholar
• Badalian SS, Rosenbaum PF. Vitamin D and pelvic floor disorders in women: results from the National Health and Nutrition Examination Survey. Obstet Gynecol. 2010;115:795–803.
   PubMed Web of Science ®Google Scholar
• Adorini L, Penna G, Fibbi B, et al. Vitamin D receptor agonists target static, dynamic, and inflammatory components of benign prostatic hyperplasia. Ann N Y Acad Sci. 2010;1193:146–152.
   PubMed Web of Science ®Google Scholar
• Kristal AR, Arnold KB, Schenk JM, et al. Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. Am J Epidemiol. 2008;167:925–934.
   PubMed Web of Science ®Google Scholar
• Colli E, Rigatti P, Montorsi F, et al. BXL628, a novel vitamin D3 analog arrests prostate growth in patients with benign prostatic hyperplasia: a randomized clinical trial. Eur Urol. 2006;49:82–86.
   PubMed Web of Science ®Google Scholar
• Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53–58.
   PubMed Web of Science ®Google Scholar
• Theodoratou E, Tzoulaki I, Zgaga L, et al. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014;348:g2035.
   PubMed Web of Science ®Google Scholar