Cyclooxygenase-2 (COX-2) polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population

References

• Warner TD, Mitchell JA. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J. 2004;18:790–804.
   PubMed Web of Science ®Google Scholar
• Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol. 1998;38:97–120.
   PubMed Web of Science ®Google Scholar
• Tay A, Squire JA, Goldberg H, et al. Assignment of the human prostaglandin-endoperoxide synthase 2 (PTGS2) gene to 1q25 by fluorescence in situ hybridization. Genomics. 1994;23:718–719.
   PubMed Web of Science ®Google Scholar
• Papafili A, Hill MR, Brull DJ, et al. Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol. 2002;22:1631–1636.
   PubMed Web of Science ®Google Scholar
• Prakash G, Umar M, Ajay S, et al. COX-2 gene polymorphisms and risk of chronic periodontitis: a case-control study and meta-analysis. Oral Dis. 2015;21:38–45.
   PubMed Web of Science ®Google Scholar
• Xie CJ, Xiao LM, Fan WH, et al. Common single nucleotide polymorphisms in cyclooxygenase-2 and risk of severe chronic periodontitis in a Chinese population. J Clin Periodontol. 2009;36:198–203.
   PubMed Web of Science ®Google Scholar
• Andersen V, Nimmo E, Krarup HB, et al. Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. Inflamm Bowel Dis. 2011;17:937–946.
   PubMed Web of Science ®Google Scholar
• de Vries HS, te Morsche RH, van Oijen MG, et al. The functional −765G–>C polymorphism of the COX-2 gene may reduce the risk of developing Crohn's disease. Plos One. 2010;11:e15011.
   Web of Science ®Google Scholar
• Rudock ME, Liu Y, Ziegler JT, et al. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. Atherosclerosis. 2009;203:459–465.
   PubMed Web of Science ®Google Scholar
• Wu GL, Cai HY, Cai HB, et al. Influence of the cyclooxygenase-2 Gene −765G/C and −1195G/A polymorphisms on development of ischemic stroke. J Stroke Cerebrovasc Dis. 2016;25:2126–2135.
   PubMed Web of Science ®Google Scholar
• Panteli M, Giannoudis PV. Chronic osteomyelitis: what the surgeon needs to know. Efort Open Rev. 2016;1:128–135.
   PubMedGoogle Scholar
• Kremers HM, Nwojo ME, Ransom JE, et al. Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009. J Bone Joint Surg Am. 2015;97:837–845.
   PubMed Web of Science ®Google Scholar
• Zhou J, Li Y, Wang QK, et al. Status of road safety and injury burden: China. J Orthop Trauma. 2014;28:S41–S42.
   PubMed Web of Science ®Google Scholar
• Hogan A, Heppert VG, Suda AJ. Osteomyelitis. Arch Orthop Trauma Surg. 2013;133:1183–1196.
   PubMed Web of Science ®Google Scholar
• Osman AE, Mubasher M, ElSheikh NE, et al. Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis. Genet Mol Res. 2015;14:16981–16986.
   PubMed Web of Science ®Google Scholar
• Valle-Garay E, Montes AH, Corte JR, et al. tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis. J Infect Dis. 2013;208:218–223.
   PubMed Web of Science ®Google Scholar
• Tsezou A, Poultsides L, Kostopoulou F, et al. Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis. Clin Vaccine Immunol. 2008;15:1888–1890.
   PubMed Web of Science ®Google Scholar
• Metsemakers WJ, Kuehl R, Moriarty TF, et al. Infection after fracture fixation: current surgical and microbiological concepts. Injury. 2016. doi: 10.1016/j.injury.2016.09.019
   Google Scholar
• Zimmerli W. Clinical presentation and treatment of orthopaedic implant-associated infection. J Intern Med. 2014;276:111–119.
   PubMed Web of Science ®Google Scholar
• Jiang N, Zhao XQ, Qin CH, et al. Association of vitamin D receptor gene TaqI, BsmI, FokI and ApaI polymorphisms and susceptibility to extremity chronic osteomyelitis in Chinese population. Injury. 2016;47:1655–1660.
   PubMed Web of Science ®Google Scholar
• Thakore RV, Greenberg SE, Shi H, et al. Surgical site infection in orthopedic trauma: a case-control study evaluating risk factors and cost. J Clin Orthop Trauma. 2015;6:220–226.
   PubMedGoogle Scholar
• Tseng CH, Huang WS, Muo CH, et al. Increased depression risk among patients with chronic osteomyelitis. J Psychosom Res. 2014;77:535–540.
   PubMed Web of Science ®Google Scholar
• Ho MW, Tseng CH, Chen JH, et al. Chronic osteomyelitis as a risk factor for development of rheumatoid arthritis: a nationwide, population-based, cohort study. Clin Rheumatol. 2015;9:1521–1527.
   Web of Science ®Google Scholar
• Tseng CH, Chen JH, Muo CH, et al. Increased risk of ischaemic stroke amongst patients with chronic osteomyelitis: a population-based cohort study in Taiwan. Eur J Neurol. 2015;22:633–639.
   PubMed Web of Science ®Google Scholar
• Lin SY, Lin CL, Tseng CH, et al. The association between chronic osteomyelitis and increased risk of diabetes mellitus: a population-based cohort study. Eur J Clin Microbiol Infect Dis. 2014;33:1647–1652.
   PubMed Web of Science ®Google Scholar
• Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury. 2006;37:S59–S66.
   PubMed Web of Science ®Google Scholar
• Li H, Guo Q, Zhou B, et al. Cyclooxygenase-2 gene polymorphisms and the risk of colorectal cancer: a population-based study. Oncol Lett. 2015;10:1863–1869.
   PubMed Web of Science ®Google Scholar
• Dai ZJ, Shao YP, Ma XB, et al. Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer: an updated meta-analysis involving 34,590 subjects. Dis Markers. 2014;2014:484729.
   PubMed Web of Science ®Google Scholar
• Zheng J, Chen S, Jiang L, et al. Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. Eur J Haematol. 2011;87:486–493.
   PubMed Web of Science ®Google Scholar
• Jiang N, Ma YF, Jiang Y, et al. Clinical characteristics and treatment of extremity chronic osteomyelitis in Southern China: a retrospective analysis of 394 consecutive patients. Medicine (Baltimore). 2015;94:e1874.
   PubMed Web of Science ®Google Scholar