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Infectious Diseases Volume 51, 2019 - Issue 8
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Letter to the Editor

Efavirenz dose reduction is associated with improved lipid profile in HIV-1 infected patients

Stefano NicolèInfectious Diseases Unit, Policlinico G.B. Rossi, University Hospital, Verona, Italy; Correspondence[email protected]
,
Massimiliano LanzafameUnit of “Diagnosis and Therapy of HIV Infection”, Infectious Diseases Unit, G.B. Rossi University Hospital, Verona, Italy;
,
Emanuela LattuadaInfectious Diseases Unit, Policlinico G.B. Rossi, University Hospital, Verona, Italy;
,
Dora LuiseInfectious Diseases Unit, Policlinico G.B. Rossi, University Hospital, Verona, Italy;
,
Marta VecchiInfectious Diseases Unit, Policlinico G.B. Rossi, University Hospital, Verona, Italy;
,
Evelina TacconelliInfectious Diseases Unit, Policlinico G.B. Rossi, University Hospital, Verona, Italy;
&
Sandro VentoFaculty of Medicine, University of Puthisastra, Phnom Penh, Cambodia
 show all
Pages 615-617 | Received 29 Mar 2019, Accepted 15 Apr 2019, Published online: 12 May 2019

References

  • Eriksen J, Albert J, Blaxhult A, et al. Antiretroviral treatment for HIV infection: Swedish recommendations 2016. Infect Dis (Lond). 2017;49:1–34.
  • World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Geneva: World Health Organization; 2016. Available from: http://www.who.int/hiv/pub/guidelines/arv2016/download/en/
  • Fontas E, van Leth F, Sabin CA, D:A:D Study Group, et al. Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles? J Infect Dis. 2004;189:1056–1074.
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  • Sinxadi PZ, McIlleron HM, Dave JA, et al. Plasma efavirenz concentrations are associated with lipid and glucose concentrations. Medicine (Baltimore). 2016;95:e2385.
  • Gallant J, Seekins D, Hicks C, et al. A phase II, double-blind, placebo-control, dose-ranging study to assess the antiretroviral activity & safety of efavirenz (EFZ, sustiva, DMP266) in combination with open-label zidovudine (ZDV) w/lamivudine (3TC) at >48 weeks. [DMP266-005]. Intersci Conf Antimicrob Agents Chemother. 1998;24–27:38–441.
  • ENCORE1 Study Group, Carey D, Puls R, Amin J, et al. Efficacy and safety of efavirenz 400 mg daily versus 600 mg daily: 96-week data from the randomised, double-blind, placebo-controlled, non-inferiority ENCORE1 study. Lancet Infect Dis. 2015;15:793–802.
  • Lanzafame M, Bonora S, Lattuada E, et al. Efavirenz dose reduction in HIV-infected patients. HIV Med. 2012;13:252–253.
  • Lanzafame M, Lattuada E, Cucchetto G, et al. Efavirenz dose reduction in HIV-infected patients: a long-term follow-up. AIDS. 2014;28:2789–2790.
  • Santos JR, Saumoy M, Curran A, et al. Randomized, crossover, double-blind, placebo-controlled trial to assess the lipid lowering effect of co-formulated TDF/FTC. J Int AIDS Soc. 2014;17(4):19550.

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