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Infectious Diseases Volume 52, 2020 - Issue 9
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Letter to the Editor

Increased CD4/CD8 ratio as a risk factor for critical illness in coronavirus disease 2019 (COVID-19): a retrospective multicentre study

Carlo PallottoInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy; ;Section of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy; Correspondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-0355-2885
ORCID Icon,
Lorenzo Roberto SuardiInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy; ORCID Iconhttp://orcid.org/0000-0001-6753-4793
ORCID Icon,
Sara EspertiInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy;
,
Roberto TarquiniInternal Medicine Unit 1, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Florence, Italy;
,
Elisa GrifoniInternal Medicine Unit 2, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Florence, Italy; ORCID Iconhttp://orcid.org/0000-0002-7889-6367
ORCID Icon,
Simone MeiniInternal Medicine Unit, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy;
,
Alice ValorianiInternal Medicine Unit 1, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Florence, Italy;
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Stefania Di MartinoInternal Medicine Unit 2, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Florence, Italy;
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Francesco CeiInternal Medicine Unit 1, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Florence, Italy;
,
Eleonora SistiInternal Medicine Unit 2, San Giuseppe Hospital, Azienda USL Toscana Centro, Empoli, Florence, Italy;
,
Fiorella PianiInternal Medicine Unit, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy;
,
Annarita BottaInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy; ;Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
,
Elena SalomoniInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy;
,
Filippo BaragliInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy;
&
Pierluigi BlancInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Bagno a Ripoli, Florence, Italy; ORCID Iconhttp://orcid.org/0000-0003-4544-9349
ORCID Icon show all
Pages 675-677 | Received 21 May 2020, Accepted 29 May 2020, Published online: 16 Jun 2020

References

  • Hou W, Zhang W, Jin R, et al. Risk factors for disease progression in hospitalized patients with COVID-19: a restrospective cohort study. Infect Dis (Lond). 2020;52(7):498–505.
  • World Health Organization Coronavirus disease (COVID-19) Situation Report 111 – 10 May 2020.
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  • Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020. DOI:10.1001/jamainternmed.2020.0994
  • Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017;39(5):529–539.
  • Qin C, Zhou L, Hu Z, Zhang S, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020;ciaa248. DOI:10.1093/cid/ciaa248
  • Liu Z, Long W, Tu M, et al. Lymphocyte subset (CD4+, CD8+) counts reflects the severity of infection and predict the clinical outcomes in patients with COVID-19. J Infect. 2020;S0163-4453(20)30182–1. DOI:10.1016/j.jinf.2020.03.054
  • Wan S, Yi Q, Fan S, et al. Relationships among lymphocyte subsets, cytokines and the pulmonary inflammation index in coronavirus (COVID-19) infected patients. Br J Haematol. 2020; 189(3):428–437.
  • Wang F, Nie J, Wang H, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis. 2020; 221(11):1762–1769.

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