Differences in breast tumor response to neoadjuvant chemotherapy by race – Is obesity the key?

References

• Alkabban FM, Ferguson T. Breast cancer. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2022.
   Google Scholar
• Centers for Disease Control and Prevention. Breast Cancer Statistics. Breast cancer statistics | CDC. [accessed 2022 December 18].
   Google Scholar
• DeSantis CE, Ma J, Gaudet MM, et al. Breast cancer statistics, 2019. CA Cancer J Clin. 2019;69(6):438–451. doi:10.3322/caac.21583
   PubMed Web of Science ®Google Scholar
• Yedjou CG, Sims JN, Miele L, et al. Health and racial disparity in breast cancer. Adv Exp Med Biol. 2019;1152:31–49. doi:10.1007/978-3-030-20301-6_3
   PubMed Web of Science ®Google Scholar
• Masood S. Neoadjuvant chemotherapy in breast cancers. Womens Health (Lond). 2016;12(5):480–491. doi:10.1177/1745505716677139
   PubMedGoogle Scholar
• Spring LM, Fell G, Arfe A, et al. Pathologic complete response after neoadjuvant chemotherapy and impact on breast cancer recurrence and survival: a comprehensive meta-analysis. Clin Cancer Res. 2020;26(12):2838–2848. doi:10.1158/1078-0432.CCR-19-3492
   PubMed Web of Science ®Google Scholar
• Liu SV, Melstrom L, Yao K, et al. Neoadjuvant therapy for breast cancer. J Surg Oncol. 2010;101(4):283–291. doi:10.1002/jso.21446
   PubMed Web of Science ®Google Scholar
• Karatas F, Erdem GU, Sahin S, et al. Obesity is an independent prognostic factor of decreased pathological complete response to neoadjuvant chemotherapy in breast cancer patients. Breast. 2017;32:237–244. doi:10.1016/j.breast.2016.05.013. Epub 2016 Jun 16. PMID: 27318645.
   PubMed Web of Science ®Google Scholar
• Killelea BK, Yang VQ, Wang SY, et al. Racial differences in the use and outcome of neoadjuvant chemotherapy for breast cancer: results from the national cancer data base. J Clin Oncol. 2015;33(36):4267–4276. doi:10.1200/JCO.2015.63.7801
   PubMed Web of Science ®Google Scholar
• Al-Saleh K, Abd El-Aziz N, Ali A, et al. A multicenter study of the impact of body mass index (BMI) on the incidence of pathologic complete response (pCR) among Saudi patients with locally advanced breast cancer (LABC) post neoadjuvant chemotherapy (NAC). Gulf J Oncolog. 2019;1(30):33–42.
   PubMedGoogle Scholar
• Ma SJ, Serra LM, Yu B, et al. Racial/ethnic differences and trends in pathologic complete response following neoadjuvant chemotherapy for breast cancer. Cancers (Basel). 2022;14(3):534. doi:10.3390/cancers14030534
   PubMed Web of Science ®Google Scholar
• Calip GS, Hoskins KF, Ko NY. Abstract PO-102: racial disparities in outcomes following neoadjuvant chemotherapy by breast cancer subtype: analyses from the National Cancer Database, 2010–2016. Cancer Epidemiol Biomark Prev. 2020;29(12_Supplement):PO-102. doi:10.1158/1538-7755.DISP20-PO-102
   Google Scholar
• Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. doi:10.1016/j.jbi.2008.08.010
   PubMed Web of Science ®Google Scholar
• Shubeck S, Zhao F, Howard FM, et al. Response to treatment, racial and ethnic disparity, and survival in patients with breast cancer undergoing neoadjuvant chemotherapy in the US. JAMA Netw Open. 2023;6(3):e235834. doi:10.1001/jamanetworkopen.2023.5834. PMID: 36995711; PMCID: PMC10064248.
   PubMed Web of Science ®Google Scholar
• Tichy JR, Deal AM, Anders CK, et al. Race, response to chemotherapy, and outcome within clinical breast cancer subtypes. Breast Cancer Res Treat. 2015;150(3):667–674. doi:10.1007/s10549-015-3350-2
   PubMed Web of Science ®Google Scholar
• Lee K, Kruper L, Dieli-Conwright CM, et al. The impact of obesity on breast cancer diagnosis and treatment. Curr Oncol Rep. 2019;21(5):41–47. doi:10.1007/s11912-019-0787-1
   PubMed Web of Science ®Google Scholar
• Ligibel JA, Strickler HD. Obesity and its impact on breast cancer: tumor incidence, recurrence, survival, and possible interventions. Am Soc Clin Oncol Educ Book. 2013;33:52–59. doi:10.14694/EdBook_AM.2013.33.52
   Google Scholar
• Litton JK, Gonzalez-Angulo AM, Warneke CL, et al. Relationship between obesity and pathologic response to neoadjuvant chemotherapy among women with operable breast cancer. J Clin Oncol. 2008;26(25):4072–4077. doi:10.1200/JCO.2007.14.4527
   PubMed Web of Science ®Google Scholar
• Copson ER, Maishman TC, Tapper WJ, et al. Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study. Lancet Oncol. 2018;19(2):169–180. doi:10.1016/S1470-2045(17)30891-4
   PubMed Web of Science ®Google Scholar
• Engin A. Obesity-associated breast cancer: analysis of risk factors. Obes Lipotoxicity. 2017;960:571–606. doi:10.1007/978-3-319-48382-5_25
   Web of Science ®Google Scholar
• Wang H, Zhang S, Yee D, et al. Impact of body mass index on pathological complete response following neoadjuvant chemotherapy in operable breast cancer: a meta-analysis. Breast Cancer. 2021;28(3):618–629. doi:10.1007/s12282-020-01194-w. Epub 2021 Jan 2. PMID: 33387284.
   PubMed Web of Science ®Google Scholar
• Ho Y, Harris A, Wesolowski M, et al. Impact of race and health insurance status on response to neoadjuvant chemotherapy for breast cancer patients. Cureus. 2021;13(7):e16127. doi:10.7759/cureus.16127. PMID: 34367759; PMCID: PMC8330506.
   PubMed Web of Science ®Google Scholar
• Ayanian JZ, Kohler BA, Abe T, et al. The relation between health insurance coverage and clinical outcomes among women with breast cancer. N Engl J Med. 1993;329(5):326–331. doi:10.1056/NEJM199307293290507. PMID: 8321261.
   PubMed Web of Science ®Google Scholar
• Ibrahim EM, Al-Homaidh A. Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies. Med Oncol. 2011;28(3):753–765. doi:10.1007/s12032-010-9536-x. Epub 2010 Apr 22. PMID: 20411366.
   PubMed Web of Science ®Google Scholar
• Bradley CJ, Given CW, Roberts C. Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst. 2002;94(7):490–496. doi:10.1093/jnci/94.7.490. PMID: 11929949.
   PubMed Web of Science ®Google Scholar