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Original Article

Treatment of Diabetes Mellitus with Ginseng?

(Director, Complementary Therapies, Education and Research, Associate Professor)
Pages 99-113 | Published online: 20 Aug 2009

References

  • Sherwin R S. Diabetes mellitus. Cecil Textbook of Medicine. 21st edition, R L Cecil, J C Bennett, L Goldman. WB Saunders Co, Philadelphia, PA 2000
  • Anon. Diabetes Facts and Figures. American Diabetes Association. 2000, http://www.diabetes.org/ada/facts.asp. Accessed Oct. 23, 2000.
  • Steil C F. Diabetes Mellitus. Pharmacotherapy: A Pathophysiologic Approach. 4th ed., J T DiPiro, R L Talbert, D C Yee, et al. Appleton & Lange, Stamford, CN 1999
  • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. American Diabetes Association Clinical Practice Recommendations. Diabetes Care 1997; 20: 1183–1197
  • Molitch M E, Steffes M W, Cleary P A, Nathan D M. Baseline analysis of renal function in the Diabetes Control and Complications Trial Research Group. Kidney Int 1993; 43(3)668–674
  • Turner R, Cull C, Holman R. United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin dependent diabetes mellitus. Ann Intern Med 1996; 124(1)136–145, Pt 2
  • Paes H P, Bakker A, Soe-Agnie C I. Impact of dosage frequency on patient compliance. Diabetes Care 1997; 20(10)1512–1517
  • Pineiro F, Gil V, Donis M, Torres M T, Orozco D, Merino J. Factors involved in noncompliance with drug treatment in non-insulin diabetes mellitus. Aten Primaria 1997; 20(8)415–420
  • Brown J B, Nichols G A, Glauber H S, Bakst A. Ten-year follow-up of antidia-betic drug use, nonadherence, and mortality in a defined population with type-2 diabetes mellitus. Clin Ther 1999; 21(6)1045–1057
  • Perez R M, Zavala M A, Perez S, Perez C. Antidiabetic effect of compounds isolated from plants. Phytomedicine 1998; 5(1)55–75
  • Gill G V, Redmon S, Garratt F, Paisey R. Diabetes and alternative medicine: cause for concern. BioMedicina 1999; 2(4)176–178
  • Gori M, Campbell R K. Natural products and diabetes treatment. The Diabetes Educator 1998; 24(2)201–208
  • Bailey C D, Day C. Traditional plant medicines as treatment for diabetes. Diabetes Care 1989; 12: 553–564
  • Brown D J, Gaby A, Reichert R B, Yarnell E. Phytotherapeutic and nutritional approaches to diabetes mellitus. Quarterly Rev Natural Medicine 1998; 329–351, (Winter)
  • Ivorra M D, Paya M, Villar A. A review of natural products and plants as potential antidiabetic drugs. J Ethnopharmacol 1989; 27: 243–275
  • Bailey C J. Biguanides and NIDDM. Diabetes Care 1992; 15: 755–772
  • Johnston B A. Prevention Magazine Assesses the Use of Dietary Supplements. HerbalGram 2000; 48: 65
  • Berman B M, Swyers J P, Kaczmarczyk J. Complementary and alternative medicine: herbal therapies for diabetes. J Assoc Acad Minor Phys. 1999; 10(1)10–14
  • Noel P H, Pugh J A, Larme A C, Marsh G. The use of traditional plant medicines for non-insulin dependent diabetes mellitus in South Texas. Phytother Res 1997; 11: 512–517
  • Perez R M, Ocegueda A, Munoz J L, Avila J G, Morrow W W. A study of the hypoglycemic effect of some Mexican plants. J Ethnopharmacol 1984; 12: 252–262
  • Winkleman M. Ethanobotanical treatments of diabetes in Baja California Norte. Med Anthropol 1989; 11: 255–268
  • Vogler B K. The efficacy of ginseng. A systematic review of randomized clinical trials. Eur J Clin Pharmacol 1999; 55(8)567–575
  • Schulz V, Hansel R, Tyler V E. Rational Phytotherapy: A Physicians' Guide to Herbal Medicine. 34rd ed. Springer, New York, NY 1998
  • Chong S K, Oberholzer V G. Ginseng-is there a use in clinical medicine?. Postgrad Med J. 1988; 64(757)841–846
  • Li T SC, Harries D. Medicinal values of ginseng. Herb Spice Medicinal Plant Digest 1996; 17(3)1–5
  • Reynolds L B. Effects of drying on chemical and physical characteristics of American ginseng (Panax quinquefolius L.). J Herbs Spices Medicinal Plants 1998; 6(2)9–21
  • Brown D J, Foster S. Phytotherapy. Herbal medicine meets clinical science. Amer Pharm June, 1997; 31–46
  • Schulz Bahrke M S, Morgan W P. Evaluation of the ergogenic properties of ginseng. Sports Med 1994; 18(4)229–248
  • Bahrke M S, Morgan W P. Evaluation of the ergogenic properties of ginseng. Sports Med 1994; 18(4)229–248
  • Anonymous. Ginseng. Lawrence Review of Natural Products. Facts and Comparisons, St. Louis, MO Sept, 1990
  • Anonymous. Ginsana: Tonic or dud?. Consumer Reports on Heath. 1998; 10(7)2
  • Tomoda M, Shimada K, Konno C, Sugiyama K, Hikino H. Partial structure of panaxan A, a hypoglycaemic glycan of Panax ginseng roots. Planta Med 1984; 50(5)436–438
  • Kono C, Murakami M, Oshima Y, Hikino H. Isolation and hypoglycemic activity of panaxans Q, R, S, T and U, glycans of Panax ginseng roots. J Ethnopharma-col 1985; 14(1)69–74
  • Oshima Y, Konno C, Hikino H. Isolation and hypoglycemic activity of panax-ans I, J, K and L, glycans of Panax ginseng roots. J Ethnopharmacol 1985; 14(2–3)255–259
  • Oshima Y, Sato K, Hikino H. Isolation and hypoglycemic activity of quinque-folans A, B, and C, glycans of Panax quinquefolium roots. J Nat Prod 1987; 50(2)188–190
  • Yokozawa T. Molecular biological analysis of the effects of ginsenoside Rb2 on albumin mRNA in streptozotocin-induced diabetic rats. J Phar. Pharmacol 1996; 48(7)763–767
  • Suzuki Y, Hikino H. Mechanisms of hypoglycemic activity of panaxans A and B, glycans of panax ginseng roots: effects of plasma level, secretion, sensitivity, and binding of insulin in mice. Phytother Res 1989; 3: 20–24
  • Suzuki Y, Hikino H. Mechanisms of hypoglycemic activity of panaxans A and B, glycans of Panax ginseng roots: effects on key enzymes of glucose metabolism in the liver of mice. Phytother Res 1989; 3: 15–19
  • Sekiya K, Okuda H, Hotta Y, et al. Enhancement of adipose differentiation of mouse 3T3-L1 fibroblasts by ginsenosides. Phytother Res 1987; 1: 58
  • Waki I, Kyo H, Yasuda M, Kimura M. Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J Pharmaco-giodyn 1982; 5(8)547–554
  • Kim Y R, Lee S Y, Shin B A, Kim K M. Panax ginseng blocks morphine-induced thymic apoptosis by lowering plasma corticosterone level. Gen Pharmacol 1999; 32(6)647–652
  • Lin J H, Wu L S, Tsai K T, Leu S P, Jeang Y F, Hsieh M T. Effects of ginseng on the blood chemistry profile of dexamethasone-treated male rats. Am J Chin Med 1995; 23(2)167–172
  • Takaku T, Kameda K, Matsuura Y, et al. Studies of insulin-like substances in Korean red ginseng. Planta Med 1990; 56: 27–30
  • Onomura M, Tsukada H, Fukuda K, Hosokawa M, Nakamura H, Kodama M, Ohya M, Seino Y. Effects of ginseng radix on sugar absorption in the small intestine. Am J Chin Med 1999; 27(3–4)347–354
  • Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem Phar. Bull (Tokyo) 1985; 33(2)869–872
  • Kimura I. The antihyperglycemic blend effect of traditional Chinese medicine byakko-ka-ninjin-to on alloxan and diabetic KK-CA(y) mice. Phytother Res 1999; 13(6)484–488
  • Kimura M, Waki I, Chujo R, Kikuchi T, Hiyama C, Yamazaki K, Tanaka O. Effects of hypoglycemic components in ginseng radix on blood insulin level in allox-an diabetic mice and on insulin release from perfused rat pancreas. J Pharmacobio-dyn 1981; 4(6)410–417
  • Ng T B, Yeung H W. Hypoglycemic constituents of Panax ginseng. Gen Pharmacol 1985; 16(6)549–552
  • Sotaniemi E A, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995; 18(10)1373–1375
  • Vladimir V, Sievenpiper J L, Koo V YY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E. American ginseng (Panax quinquefolius L) reduces postprandial glyce-mia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000; 160(7)1009–1013
  • Vuksan V. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000; 160(7)1009–1013
  • Thomas S C, Harries D. Medicinal values of ginseng. The Herb Spice Medicinal Plant Digest 1996; 17(3)1–5
  • Greenspan E M. Ginseng and vaginal bleeding. JAMA 1983; 249(12)2018
  • Hopkins M P, Androff L, Benninghoff A S. Ginseng face cream and unexplained vaginal bleeding. Amer J Obst Gyn 1988; 159: 1121–1122
  • Palmer B V, Montgomery A CV, Monteiro J CMP. Ginseng and mastalgia. (Letter). Br Med J 1978; 1: 1284
  • Punnonen R, Lukola. Oestrogen-like effect of ginseng. (Letter). BMJ 1980; 281: 1110
  • Ryu S, Chien Y. Ginseng-associated cerebral arteritis. Neurology 1995; 45: 829–830
  • Blumenthal M. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. American Botanical Council, Austin, Texas 1998
  • Siegel R K. Ginseng abuse syndrome. Problems with the panacea. JAMA 1979; 241(15)1614–1615
  • Blumenthal M. Debunking the ginseng abuse syndrome. Whole Foods March, 1991; 89–82
  • Shader R I, Greenblatt D J. Phenelzine and the dream machine-ramblings and reflections. (Letter). J Clin Psychopharmacol 1985; 5(2)65
  • Jones B D, Runikis A M. Interaction of ginseng with phenelzine (letter). J Clin Psychopharmacol 1987; 7(3)201–202
  • Janetzky K, Morreale A P. Probable interaction between warfarin and ginseng. Am J Health-Syst Pharm 1997; 44: 692–693
  • Hikino H, Takahashi M, Otake K. Konno Isolation oand hypoglycaemic activity of eleutherans A, B, C, D, E, F and G: Glycans of Eleutherococcus senticosus roots. J Nat Prod 1986; 49(2)293–297
  • Medon P J, Ferguson P W, Watson C F. Effects of Eleutherococcus senticosus extract on hexobarbital metabolism in vivo and in vitro. J Ethnopharmacol 1984; 10(2)235–241
  • McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. Can Med Assoc J 1996; 155(3)293–295
  • Muller J, Clauson K. Top herbal products encountered in drug information requests (part 1). Drug Benefit Trends 1998; 10: 43–50
  • Anonymous. Product review. Asian & American ginseng, ConsmerLab.com. http:/www.consumerlab.com/results/ginseng/html. Accessed July 18, 2000
  • Chuang W-C, Wu H-K, Sheu S-J, Chiou S-H, Chang H-C, Chen Y-P. A comparative study on commercial samples of Ginseng Radix. Planta Med 1995; 61: 459–465
  • Cui J F, Garle M, Bjorkhem I, Eneroth P. Determination of aglycones of ginse-nosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng. Scand J Clin Lab Invest. 1996; 56(2)151–60
  • Koren G, et al. Maternal use of ginseng and neonatal androgenization [letter] has been questioned. JAMA 1990; 264: 2866
  • Awang D V. Siberian ginseng toxicity may be a case of mistaken identity (letter). CMAJ 1996; 155: 1237

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