17
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Oral Ingestion of Ginkgo biloba Extract Reduces Thiobarbituric Acid Reacting (TBAR) Substances in Washed Platelets of Healthy Subjects

, , &
Pages 1-15 | Published online: 20 Aug 2009

References

  • Le Bars P L, Katz M M, Berman N, et al. A placebo-controlled, double-blind, randomised trial of an extract of Ginkgo biloba for dementia. JAMA 1997; 278: 1327–32
  • Oken B S, Storzbach D M, Kaye J A. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 1998; 55: 1409–15
  • Moulton P L, Boyko L N, Fitzpatrick J L., Petros T V. The effect of Ginkgo biloba on memory in healthy male volunteers. Physiol Behav 2001; 73: 659–65
  • Solomon P R, Adams F, Silver A, Zimmer J, DeVeaux R. Ginkgo for memory enhancement. A randomized controlled trial. JAMA 2002; 288: 835–40
  • Kleijnen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 1992; 34: 352–8
  • Guinot P, Caffrey E, Lambe R, Darragh A. Tanakan inhibits platelet-activat-ing-factor-induced platelet aggregation in healthy male volunteers. Haemostasis 1989; 19: 219–23
  • Tzeng S-H, Ko W-C, Ko F-N, Teng C-M. Inhibition of platelet aggregation by some flavonoids. Thom Res 1991; 64: 90–100
  • Sobol A, Watala C. The role of platelets in diabetes-related vascular complications. Diabetes Res Clin Pract Suppl 2000; 50: 1–16
  • Hishinuma T, Koseki Y, Murai Y, Yamazaki T, Suzuki K-I, Mizugaki M. Urinary thromboxane A2/prostacyclin balance reflects the pathological state of a diabetic. Prostaglandins Other Lipid Mediat 1999; 58: 263–71
  • Gryglewski R J, Korbut R, Robak J, Swies J. On the mechanism of anti-thrombotic action of flavonoids. Biochem Pharmacol 1987; 36: 317–22
  • Smith W L, Garavito R M, DeWitt D L. Prostaglandin endoperoxide H synthases (cyclo-oxygenases) -1 and -2. J Biol Chem 1996; 271: 33157–60
  • Inder T E, Darlow B A, Slius K B, Winterbourn C C, Graham P, Sanderson K J, Taylor B J. The correlation of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birth weight infant. Acta Paediatr 1996; 85: 1116–22
  • Smith L H, Boutand O, Breyer M, Morrow J D, Oates J A, Vaughan D E. Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipo-protein cholesterol in vitro. Arteriosclerosis, Thrombosis, and Vascular Biology 2002; 22: 983–8
  • Kudolo G B, Dorsey S, Blodgett J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and type 2 diabetic subjects. Throm Res 2003; 108: 151–60
  • Niehaus W G, Jr, Samuelson B. Formation of malonaldehyde from phospholipids arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968; 6: 126–30
  • Kudolo G B. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic b-cell function in response to glucose loading in healthy volunteers. J Clin Pharmacol 2000; 40: 647–54
  • Kudolo G B. The effect of 3-month ingestion of Ginkgo biloba extract (EGb 761) on pancreatic b-cell function in response to glucose loading in individuals with non-insulin dependent diabetes mellitus. J Clin Pharmacol 2001; 41: 600–11
  • Kudolo G B. Ingestion of Ginkgo biloba extract significantly inhibits collagen-induced platelet aggregation and thromboxane A2 synthesis. Alternative Therapies in Health and Medicine 2001; 7: 105
  • Kudolo G B, Blodgett J. In vitro effects of Ginkgo biloba extract on collagen-induced aggregation and thromboxane B2 synthesis in platelets from type 2 diabetic subjects. 2nd International Scientific Conference on Complementary, Alternative and Integrative Medicine Research, Boston, MA, April, 11–162002
  • Van Wauwe J, Goossens J. Effects of antioxidants on cyclooxygenase and lipoxnase activities in intact human platelets: comparison with indomethacin and ETYA. Prostaglandins 1983; 26: 725–30
  • Chi Y S, Jong H G, Son K H, Chang H W, Kang S S, Kim H P. Effects of naturally occurring prenylate flavonoids on enzymes metabolizing arachidonic acid: cyclo-oxygenases and lipoxygenases. Biochem Pharcol 2001; 62: 1185–91
  • Oyama Y, Fuchs P A, Katayama N, Noda K. Myricetin and quercetin, the flavonoid constituents of Ginkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+ loaded brain neurons. Brain Res 1994; 635: 125–9
  • Maitra I, Marcocci L, Droy-Lefaix M T, Packer L. Peroxyl radical scavenging activity of Ginkgo biloba extract EGb761. Biochem Pharmacol 1995; 49: 1649–55
  • Pasquale P, Pulcinelli F M, Celestini A, Lenti L, Ghiselli A, Gazzaniga P P, Violi F. The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. Am J Clin Nutr 2000; 72: 1150–5
  • Carvahlo A C, Colman R W, Lees R S. Platelet function in hyperlipoprotein-nemia. N Engl J Med 1974; 290: 434–48
  • Harrison J E, Saeed F A. Radical acetoacetate oxidation by myeloperoxidase, lactoperoxidase, prostaglandin synthetase, and prostacyclin synthetase: implications for atherosclerosis. Biochem Med 1983; 29: 149–63
  • Walach H. The efficacy paradox in randomized controlled trials of CAM and elsewhere: beware of the placebo trap. J Altern Complement Med 2001; 7: 213–8
  • Mori T A, Burke V, Puddey I B, Watts G F, O'Neal D N, Best J D, Beilin L. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlip-idemic men. Am J Clin Nutr 2000; 71: 1085–94

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.