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Cell Communication & Adhesion Volume 10, 2003 - Issue 4-6
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Gap Junction Gating & Permeability

The Voltage Gates of Connexin Channels are Sensitive to CO2

Camillo Peracchia Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
,
Kate C. Young Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
,
Xiao G. Wang Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
,
Joey T. Chen Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
&
Lillian L. Peracchia Department of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA
Pages 233-237 | Published online: 11 Jul 2009

REFERENCES

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  • Duffy HS, Sorgen PL, Girvin ME, O’Donnell P, Coombs W, Taffet SM, Delmar M, Spray DC (2002). pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains. J Biol Chem 277: 36706–36714.
  • Lazrak A, Peracchia C (1993). Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells. Biophys J 65: 2002–2012.
  • Peracchia C (1990). Increase in gap junction resistance with acidification in crayfish septate axons is closel related to changes in intracellular calcium but not hydrogen ion concentration. J Membr Biol 113: 75–92.
  • Peracchia C, Sotkis A, Wang XG, Peracchia LL, Persechini A (2000). Calmodulin directly gates gap junction channels. J Biol Chem 275: 26220–26224.
  • Peracchia C, Wang X, Li L, Peracchia LL (1996). Inhibition of calmodulin expression prevents low-pH-induced gap junction uncoupling in Xenopus oocytes. PflÜgers Arch 431: 379–387.
  • Peracchia C, Wang XG, Peracchia LL (1999). Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels. Am J Physiol 276: C1361–C1373.
  • Peracchia C, Wang XG, Peracchia LL (2000). Slow gating of gap junction channels and calmodulin. J Membr Biol 78: 55–70.
  • Peracchia C, Young KC, Wang XG, Peracchia LL (2003). Is the voltage gate of connexins CO2-sensitive? Cx45 channels and inhibition of calmodulin expression. J Membr Biol 195: 53–62.
  • Weingart R, FF Bukauskas FF (1998). Long-chain-alkanols and arachidonic acid interfere with the Vm-sensitive gating mechanism of gap junction channels. PflÜg Arch 435: 310–319.
  • Werner R, Levine E, Rabadan-Diehl C, Dahl G (1991). Gating properties of connexin32 cell-cell channels and their mutant expressed in Xenopus oocytes. Proc R Soc Lond 243: 5–11.
  • Young KC, PeracchiaC(2002). Carbon dioxide sensitive voltage gating of connexin32 and connexin 32/45 chimeric channels. Mol Biol Cell 13: 351a.

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