169
Views
125
CrossRef citations to date
0
Altmetric
(RG) Obstetrics and Gynaecology

The effects of tibolone on vaginal blood flow, sexual desire and arousability in postmenopausal women

, &
Pages 28-41 | Published online: 03 Jul 2009

References

  • Oldenhave A, Jaszmann JB, Haspels AA, Everaerd WM. Impact of climacteric on well being. A survey based on 5213 women aged 39 to 60 years old. Am J Obstet Gynecol 1993;168: 772–80
  • Easley ED. Sex problems after the menopause. Gun Obstet Gynecol 1978; 21: 269–77
  • Montgomery JC, Studd JWW. Psychological and sexual aspects of the menopause. Br J Hosp Med 1991;45:300–2
  • Laan E, Everaerd W, van Berlo R, Rijs L. Mood and sexual arousal in women. Behav Res Ther 1995;33:441–3
  • Graham CA, Janssen E, Sanders SA. Graham CA, Janssen E, Sanders SA. Effects of fragrance on female sexual arousal and mood across the menstrual cycle. Psychophysiology 2000;37: 76–84
  • Laan E, van Lunsen RHW. Hormones and sexuality in postmenopausal women: a psycho-physiological study. J Psychosom Obstet Gynecol 1997;18:126–33
  • Laan E, Everaerd W. Determinants of female sexual arousal: psychophysiological theory and data. Annu Rev Sex Res 1995;6:32–76
  • Leiblum S, Bachmann G, Kemmann E, Colburn D, Schwartzman L. Vaginal atrophy in the post-menopausal woman: the importance of sexual activity and hormones. J Am Med Assoc 1983; 249:2195–8
  • Weber AM, Walters MD, Schover LR, Mitchinson A. Vaginal anatomy and sexual function. Obstet Gynecol 1995;86:946–9
  • Bachmann G, Leiblum SR, Kemmann E, Colburn DW, Schwartzman L, Shelden R. Sexual expres-sion and its determinants in the postmenopausal woman. Maturitas 1984;6:19–29
  • Davis SR, Burger HG. Use of androgens in postmenopausal women. Curr Opin Obstet Gynecol 1997;9:177–80
  • Sherwin B, Gelfand M, Brender W. Androgen enhances sexual motivation in females: a pros-pective, crossover study of sex steroid adminis-tration in the surgical menopause. Psychosom Med 1985;47:339–51
  • Bancroft J, Wu FCW. Changes in erectile responsiveness during androgen replacement therapy. Arch Sex Behav 1983;12:59–66
  • Carani C, Bancroft J, Granata A, Del Rio G, Marrama P. Testosterone and erectile function, nocturnal penile tumescence and rigidity, and erectile response to visual erotic stimuli in hyopgonadal and eugonadal men. Psych oneuro-endocrinology 1992;17:647–54
  • Moore RA. Livial: a review of clinical studies. Br J Obstet Gynaecol 1999;106(Suppl 19):1–21
  • Markiewicz L, Gurpide E. In vitro evaluation of estrogenic, estrogen antagonistic and progesta-genic effects of a steroidal drug (Org OD-14) and its metabolites on human endometrium. J Steroid Biochem 1990;35:535–41
  • Bergeron C. Microscopic evaluation of the effect of hormone replacement therapy on the endo-metrium in women who bleed. Gynecol Endo-crinol 1997;11(Suppl 2):11–16
  • Rymer J, Chapman MG, Fogelman I, Wilson POG. A study of the effect of tibolone on the vagina in postmenopausal women. Maturitas 1994;18:127–33
  • Ross LA, Alder EM. Tibolone and climacteric symptoms. Maturitas 1995;21:127–36
  • Kikovic PM, Cortes-Prieto J, Luisi M, Milojevic S, Franchi F. Placebo-controlled cross-over study of effects of Org OD 14 in menopausal women. Reproduction 1982;6:81–91
  • Nevinny-Stickel J. Double-blind cross-over study with Org OD 14 and placebo in postmenopausal patients. Arch Gynecol 1983;234:27–31
  • Volpe A, Facchinetti F, Grasso A, Petraglia F, Campanini D, Genazzani AR. Benefits and risks of different hormonal replacement therapies in postmenopausal women. Maturitas 1986;8: 327–34
  • Crona N, Samsioe G, Lindberg UB, Silfverstolpe G. Treatment of climacteric symptoms with ORG OD 14: a comparative study with oestradiol valerate and placebo. Maturitas 1988;9:303–8
  • Palacios S, Menendez C, Jurado AR, Castano R. Changes in sex behaviour after menopause: effects of tibolone. Maturitas 1995;22:155–61
  • Ginsburg J, Prelevic G, Butler D, Okolo S. Clinical experience with tibolone (Livial) over 8 years. Maturitas 1995;21:71–6
  • Nathorst-Böös J, Hammar M. Effect on sexual life — a comparison between tibolone and a continuous estradiol—norethisterone acetate regimen. Maturitas 1997;26:15–20
  • Laan E, Everaerd W, Evers A. Assessment of female sexual arousal: response specificity and construct validity. Psychophysiology 1995;32: 476–85
  • Laan E, Everaerd W, van Bellen G, Hanewald G. Women's sexual and emotional responses to male- and female-produced erotica. Arch Sex Behav 1994;23:153–70
  • Greene JG. Guide to the Greene Climacteric Scale. Glasgow: University of Glasgow, 1991
  • Greene JG. A factor analytic study of climacteric symptoms. J Psychosom Res 1976;20:425–30
  • BMDP statistical software, inc. BMDP statistical software manual. Los Angeles, 1990
  • Bancroft J, Janssen E. The dual control model of male sexual response: a theoretical approach to centrally mediated erectile dysfunction. Neurosci Biobehav Rev 2000;24:571–9
  • Carani C, Granata ARM, Bancroft J, Marrama P. The effects of testosterone replacement on nocturnal penile tumescence and rigidity and erectile response to visual erotic stimuli in hypogonadal men. Psych oneuroendocrinology 1995;20:743–53
  • Ledoux JE. The Emotional Brain. New York: Simon and Schuster, 1996
  • Milner M, Sinnott M, Gasparo D, Kelly A, Carole B-K, Harrison R. Climacteric symptoms, gona-dotropins, sex steroids, and binding proteins with conjugated equine estrogen—progestin and tibo-lone over two years. Menopause 1996;3:208–13
  • Abdalla HI, MacKay Hart D, Lindsay R, Beastall GH. Organon OD 14 (tibolone) and menopausal dynamic hormone profiles. Maturitas 1986; 8:81–5
  • Labrie F, Belanger A, Simard J, Luu-The V, Labrie C. DHEA and peripheral androgen and estrogen formation: intracrinology. Ann NY Acad Sci 1995;774:16–28
  • Tax L, Goorissen EM, Kicovic PM. Clinical profile of Org OD 14. Maturitas 1987;Suppl 1: 3–13
  • Egarter C, Huber J, Leikermoser R, et al. Tibo-lone versus conjugated estrogens and sequential progestagen in the treatment of climacteric com-plaints. Maturitas 1996;23:55–62
  • Genazzani AR, Petraglia F, Facchinetti F, Genazzani AD, Bergamaschi M, Grasso A, et al. Effects of Org OD 14 on pituitary and peripheral 0-endorphin in castrated rats and post-menopausal women. Maturitas 1987;Suppl 1: 35–48
  • Genazzani AR, Facchinetti F, Ricci-Danero MG, Parrini D, Petraglia F, La Rosa R, et al. Beta-lipoprotin and beta-endorphin in physio-logical and surgical menopause. J Endocrinol Invest 1981;4:375–8
  • Catania JA, Gibson DR, Chitwood DD, Coates TJ. Methodological problems in AIDS behavioral research: influences on measurement error and participation bias in studies of sexual behavior. Psychol Bull 1990;108:339–62
  • Morokoff PJ. Volunteer bias in the psycho-physiological study of female sexuality. J Sex Res 1986;22:35–51
  • Statistics Netherlands. Statistical Yearbook 2000. Voorburg, The Netherlands, 2000
  • Oldenhave A, Jaszmann LJB. The climacteric: absence or presence of hot flushes and their relation to other complaints. In Schonbaum E, ed. The Climacteric Hot Flush. Prog Basic Clin Pharmacol. Basel: Karger, 1991;6:103–15
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington DC, 1994
  • Simons J, Carey MP. Prevalence of sexual dysfunctions: results from a decade of research. Arch Sex Behav 2001; in press

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.