Impact of obesity and leptin levels on the secretion of estradiol, inhibin A and inhibin B during ovarian stimulation with gonadotropins

References

• Azziz R. Reproductive endocrinologic alterations in female asymptomatic obesity. Fertil Steril 1989; 52:703–25
   PubMed Web of Science ®Google Scholar
• Wass P, Waldenstrom U, Rossner S, et al. An android body fat distribution in females impairs the pregnancy rate of in-vitro fertilization—embryo transfer. Hum Reprod 1997;12:2057–60
   PubMed Web of Science ®Google Scholar
• Hamilton-Fairley D, Kiddy D, Watson H, et al. Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonado-trophin. Br J Obstet Gynaecol 1992;99:128–31
   Google Scholar
• Fedorcsik P, Storeng R, Dale PO, etal. Obesity is associated with early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000;79:43–8
   PubMedGoogle Scholar
• Holte J. Disturbances in insulin secretion and sensitivity in women with the polycystic ovary syndrome. Baillieres Clin Endocrinol Metab 1996; 10:221–47
   PubMed Web of Science ®Google Scholar
• Karlsson C, Lindell K, Svensson E, etal. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997;82:4144–8
   PubMed Web of Science ®Google Scholar
• Cioffi JA, Van Blerkom J, Antczak M, et al. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3:467–72
   PubMed Web of Science ®Google Scholar
• Agarwal SK, Vogel K, Weitsman SR, et al. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 1999;84:1072–6
   PubMed Web of Science ®Google Scholar
• Brannian JD, Zhao Y, McElroy M. Leptin inhibits gonadotrophin-stimulated granulosa cell proges-terone production by antagonizing insulin action. Hum Reprod 1999;14:1445–8
   Google Scholar
• Halvorson LM, DeCherney AH. Inhibin, activin, and follistatin in reproductive medicine. Fertil Steril 1996;65:459–69
   PubMedGoogle Scholar
• Lockwood GM, Muttukrishna S, Ledger WL. Inhibins and activins in human ovulation, conception and pregnancy. Hum Reprod Update 1998;4:284–95
   PubMed Web of Science ®Google Scholar
• Magoffin DA, Jakimiuk AJ. Inhibin A, inhibin B and activin A in the follicular fluid of regularly cycling women. Hum Reprod 1997;12:1714–19
   PubMedGoogle Scholar
• Welt CK, Adams JM, Sluss PM, etal. Inhibin A and inhibin B responses to gonadotropin withdrawal depends on stage of follicle development. J Clin Endocrinol Metab 1999;84:2163–9
   PubMedGoogle Scholar
• Eldar-Geva T, Robertson DM, Cahir N, et al. Relationship between serum inhibin A and B and ovarian follicle development after a daily fixed dose administration of recombinant follicle-stimulating hormone. J Clin Endocrinol Metab 2000;85:607–13
   Google Scholar
• Hall JE, Welt CK, Cramer DW. Inhibin A and inhibin B reflect ovarian function in assisted repro-duction but are less useful at predicting outcome. Hum Reprod 1999;14:409–15
   Google Scholar
• Lockwood GM, Muttukrishna S, Groome NP, et al. Circulating inhibins and activin A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in-vitro fertilization—embryo transfer. Clin Endocrinol (Oxj) 1996;45:741–8
   PubMed Web of Science ®Google Scholar
• Groome NP, Illingworth PJ, O'Brien M, et al. Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay. Clin Endocrinol (Oxj) 1994;40: 717–23
   Google Scholar
• Zachow RJ, Magoffin DA. Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradio1-17 beta production by rat ovarian granulosa cells. Endo-crinology 1997;138:847–50
   PubMed Web of Science ®Google Scholar
• Duggal PS, Van Der Hoek KH, Milner CR, et al. The in vivo and in vitro effects of exogenous leptin on ovulation in the rat. Endocrinology 2000;141: 1971–6
   PubMed Web of Science ®Google Scholar
• Fedorcsik P, Storeng R, Dale PO, etal. Leptin and leptin binding activity in the preovulatory follicle of polycystic ovary syndrome patients. ScandJ Clin Lab Invest 2000;60:649–55
   PubMedGoogle Scholar
• Barroso G, Barrionuevo M, Rao P, et al. Vascular endothelial growth factor, nitric oxide, and leptin follicular fluid levels correlate negatively with embryo quality in IVF patients. Fertil Steril 1999;72: 1024–6
   PubMed Web of Science ®Google Scholar
• Mantzoros CS, Cramer DW, Liberman RF, et al. Predictive value of serum and follicular fluid leptin concentrations during assisted reproductive cycles in normal women and in women with the polycystic ovarian syndrome. Hum Reprod 2000; 15:539–44
   PubMed Web of Science ®Google Scholar
• Antczak M, Van Blerkom J. O ocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells ofthe preimplantation stage embryo. Mol Hum Reprod 1997;3:1067–86
   PubMed Web of Science ®Google Scholar
• Alfer J, Muller-Schottle F, Classen-Linke I, et al. The endometrium as a novel target for leptin: differences in fertility and subfertility. Mol Hum Reprod 2000;6:595–601
   PubMedGoogle Scholar
• Kitawaki J, Koshiba H, Ishihara H, etal. Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle. J Clin Endocrinol Metab 2000;85:1946–50
   PubMed Web of Science ®Google Scholar