258
Views
42
CrossRef citations to date
0
Altmetric
(RG) Obstetrics and Gynaecology

Estrogen receptor knockout mice: phenotypes in the female reproductive tract

&
Pages 169-176 | Published online: 28 Aug 2009

References

  • Shoham Z, Schachter M. Estrogen biosynthesis — regulation, action, remote effects, and value of monitoring in ovarian stimulation cycles. Fertil Steril 1996;65:687–701
  • Richards JS. Hormonal control of gene expression in the ovary. Endocr Rev 1994;15:725–51
  • Enmark E, Pelto-Huikko M, Grandien K, et al. Human estrogen receptor beta — gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 1997;82:4258–65
  • Kuiper GG, Enmark E, Pelto-Huikko M, et al. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996; 93:5925–30
  • Green S, Walter P, Kumar V, et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986;320:134–9
  • Mosselman S, Polman J, Dijkema R. ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 1996;392:49–53
  • Tremblay GB, Tremblay A, Copeland NG, et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 1997;11:353–65
  • Kuiper GG, Carlsson B, Grandien K, et al. Com-parison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997;138:863–70
  • Lubahn DB, Moyer JS, Golding TS, et al. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 1993;90:1162–6
  • Couse JF, Korach KS. Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 1999;20:358–417
  • Krege JH, Ho dgin JB, Couse JF, et al. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA 1998;95: 15677–82
  • Couse JF, Hewitt SC, Bunch DO, et al. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 1999;286:2328–31
  • Saunders PT, Millar MR, Williams K, et al. Differential expression of estrogen receptor-alpha and -beta and androgen receptor in the ovaries of marmosets and humans. Biol Rep rod 2000;63: 1098–105
  • Sar M, Welsch F. Differential expression of estrogen receptor-beta and estrogen receptor-alpha in the rat ovary. Endocrinology 1999;140:963–71
  • Pelletier G, El-Alfy M. Immuno cyto chemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab 2000;85:4835–40
  • Schomberg DW, Couse JF, Mukhejee A, et al. Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology 1999;140:2733–44
  • Couse JF, Bunch DO, Lindzey J, et al. Prevention of the polycystic ovarian phenotype and charac-terization of ovulatory capacity in the estrogen receptor-alpha knockout mouse. Endocrinology 1999; 140:5855–65
  • Shughrue PJ, Lane MV, Merchenthaler I. Com-parative distribution of estrogen receptor-alpha and-beta mRNA in the rat central nervous system. J Comp Neurol 1997;388:507–25
  • Shughrue PJ, Lane MV, Scrim° PJ, et al. Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract. Steroids 1998;63: 498–504
  • Scully KM, Gleiberman AS, Lindzey J, et al. Role of estrogen receptor-alpha in the anterior pituitary gland. Mol Endocrinol 1997;11:674–81
  • Risma KA, Clay CM, Nett TM, et al. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci USA 1995;92: 1322–6
  • Byers M, Kuiper GG, Gustafsson JA, et al. Estrogen receptor-beta mRNA expression in rat ovary: down-regulation by go nadotropins. Mol Endocrinol 1997;11: 172–82
  • Cheng G, Weihua Z, Makinen S, et al. A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary. Biol Reprod 2002;66:77–84
  • Lydon JP, DeMayo FJ, Funk CR, et al. Mice lacking progesterone receptor exhibit pleiotropic repro-ductive abnormalities. Genes Dev 1995;9:2266–78
  • White R, Leonardsson G, Rosewell I, et al. The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility. Nature Med 2000;6: 1368–74
  • Matzuk MM, Dionne L, Guo Q. Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology 1998;139: 4008–11
  • Lim H, Paria BC, Das SK, et al. Multiple female reproductive failures in cyclo oxygenase 2-deficient mice. Cell 1997;91:197–208
  • Hizaki H, Segi E, Sugimoto Y, et al. Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP (2). Proc Natl Acad Sci USA 1999;96:10501–6
  • Wu JY, Gonzalez-Robayna IJ, Richards JS, et al. Female fertility is reduced in mice lacking Ca2±/ calmodulin-dependent protein kinase IV. Endo-crinology 2000;141:4777–83
  • Mahesh VB, Brann DW. Regulation of the preovulatory gonadotropin surge by endogenous steroids. Steroids 1998;63:616–29
  • Couse, JF, Lindzey J, Grandien K, et al. Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology 1997; 138:4613–21
  • Dupont S, Krust A, Gansmuller A, et al. Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse repro-ductive phenotypes. Development 2000;127:4277–91
  • Fisher CR, Graves KH, Parlow AF, et al. Character-ization of mice deficient in aromatase (ArK0) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 1998;95:6965–70
  • Britt KL, Drummond AE, Dyson M, et al. The ovarian phenotype of the aromatase knockout (ArK0) mouse. J Steroid Biochem Mol Biol 2001;79: 181–5
  • Drummond AE, Britt KL, Dyson M, et al. Ovarian steroid receptors and their role in ovarian function. Mol Cell Endocrinol 2002;191:27–33
  • Wang H, Masironi B, Eriksson H, et al. A comparative study of estrogen receptors alpha and beta in the rat uterus. Biol Reprod 1999;61:955–64
  • Saunders PT, Maguire SM, Gaughan J, et al. Expression of oestrogen receptor beta (ER beta) in multiple rat tissues visualised by immunohisto-chemistry. J Endocrinol 1997;154:R13–16
  • Couse JF, Curtis SW, Washburn TF, et al. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol 1995;9:1441–54
  • Curtis SW, Clark J, Myers P, et al. Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus. Proc Natl Acad Sci USA 1999;96:3646–51
  • Kurita T, Lee KJ, Cooke PS, et al. Paracrine regulation of epithelial progesterone receptor by estradiol in the mouse female reproductive tract. Biol Reprod 2000;62: 821–30
  • Kurita T, Lee K, Saunders PT, et al. Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse. Biol Reprod 2001;64:272–83
  • Paria BC, Reese J, Das SK, et al. Deciphering the cross-talk of implantation: advances and challenges. Science 2000;296:2185–8
  • Paria BC, Tan J, Lubahn DB, et al. Uterine decidual response occurs in estrogen receptor-alpha-deficient mice. Endocrinology 1999;140:2704–10
  • Cooke PS, Buchanan DL, Young P, et al. Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium. Proc Natl Acad Sci USA 1997;94:6535–40
  • Buchanan DL, Setiawan T, Lubahn DB, et al. Tissue compartment-specific estrogen receptor-alpha participation in the mouse uterine epithelial secre-tory response. Endocrinology 1999;140:484–91
  • Smith CL. Cross-talk between peptide growth factor and estrogen receptor signaling pathways. Biol Reprod 1998;58:627–32
  • Curtis SW, Washburn T, Sewall C, et al. Physio-logical coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. Proc Natl Acad Sci USA 1996;93:12626–30
  • Klotz DM, Hewitt SC, Ciana P, et al. Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem 2002;277:8531–7
  • Klotz DM, Hewitt SC, Korach KS, et al. Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha. Endocrinology 2000;141:3430–9
  • Weihua Z, Saji S, Makinen S, et al. Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus. Proc Natl Acad Sci USA 2000;97:5936–41
  • Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994;331:1056–61
  • Murata Y, Robertson K, Jones M, et al. Effect of estrogen deficiency in the male: the ArK0 mouse model. Mol Cell Endocrinol 2002;193:7
  • Georgiou I, Konstantelli M, Syrrou M, et al. Oestrogen receptor gene polymorphisms and ovarian stimulation for in-vitro fertilization. Hum Reprod 1997; 12:1430–3
  • Sundarrajan C, Liao W, Roy AC, et al. Association of oestrogen receptor gene polymorphisms with out-come of ovarian stimulation in patients undergoing IVF. Mol Hum Reprod 1999;5:797–802
  • Sundarrajan C, Liao WX, Roy AC, et al. Association between estrogen receptor-beta gene polymorphisms and ovulatory dysfunctions in patients with menstrual disorders. J Clin Endocrinol Metab 2001;86:135–9
  • Rosenfeld CS, Murray AA, Simmer G, et al. Gonadotropin induction of ovulation and corpus luteum formation in young estrogen receptor-alpha knockout mice. Biol Reprod 2000;62:599–605
  • Korach KS, Couse JF, Curtis SW, et al. Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. Recent Prog Horm Res 1996;51:159–86
  • Couse JF, Dixon D, Yates M, et al. Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects o f neo natal diethylstilbestrol exposure on the female reproductive tract. Dev Biol 2001;238:224–38
  • Das SK, Taylor JA, Korach KS, et al. Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway. Proc Natl Acad Sci USA 1997;94:12786–91

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.