References
- Ehrrnann DA. Insulin-lowering therapeutic modali-ties for polycystic ovary syndrome. Endocrinol Metab Clin North Am 1999;28:423–38
- Nestler JE, Jakubowicz DJ, Evans WS. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Eng1J Med 1998;338: 1876–80
- Vandermolen DT, Ratts VS, Evans WS. Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril 2001;75:310–5
- De Leo V, la Marca A, Ditto A. Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome. Fertil Steril 1999;72:282–5
- Kim LH, Taylor AE, Barbieri RL. Insulin sensitizers and polycystic ovary syndrome: can a diabetes medi-cation treat infertility? Fertil Steril 2000;73:1097–8
- Barbieri RL. Induction of ovulation in infertile women with hyperandrogenism and insulin resist-ance. Am J Obstet Gynecol 2000;183:1412–18
- Diamanti-Kandarakis E, Zapanti E. Insulin sensitizers and antiandrogens in the treatment o fp olycystic ovary syndrome. Ann N Y Acad Sci, 2000;900:203–12
- Duleba AJ, Pawelczyk LA, Yuen BH. Insulin actions on ovarian steroidogenesis are not modulated by metformin. Hum Reprod 1993;8:1194–8
- Arlt W, Auchus RJ, Miller WL. Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta-hydroxysteroid dehydrogenase. J Biol Chem 2001;276: 16767–71
- Attia GR, Rainey WE, Carr BR. Metformin directly inhibits androgen production in human thecal cells. Fertil Steril 2001;76:517–24
- Fedorcsik P, Dale PO, Storeng R. The impact of obesity and insulin resistance on the outcome of IVF or ICSI in women with polycystic ovarian syndrome. Hum Reprod 2001;16:1086–91
- Stadtmauer LA, Toma SK, Riehl RM. Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors. Fertil Steril 2001;75:505–9
- Adams J, Franks S, Polson DW. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet 1985;2:1375–9
- HoskerJP, Matthews DR, Rudenski AS. Continuous infusion of glucose with model assessment: measure-ments of insulin resistance and beta-cell function in man. Diabetologia 1985;28:401–11
- Dale PO, Tanbo T, Haug E. The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome. Hum Rep rod 1998;13:567–70
- Berry DA. Statistics: A Bayesian Perspective. Belmont, CA: Duxbury Press, 1996
- Spiegelhalter DJ, Freedman LS, Parmar MKB. Bayesian approaches to randomized trials. In Stangl DK, Berry DA, eds. Bayesian Biostatistics. New York: Marcel Dekker, 1996:67–108
- Pocock SJ. Clinical Trials: A Practical Approach. Chichester: Wiley, 1983
- Yuan W, Giudice LC. Insulin-like growth factor-II mediates the steroidogenic and growth promoting actions of follicle stimulating hormone on human ovarian pre-antral follicles cultured in vitro. J Clin Endocrinol Metab 1999;84:1479–82
- Franks S, Gilling-Smith C, Watson H. Insulin action in the normal and polycystic ovary. Endocrinol Metab Clin North Am 1999;28:361–78
- Khan KS, Daya S, Collins JA. Empirical evidence of bias in infertility research: overestimation of treat-ment effect in crossover trials using pregnancy as the outcome measure. Fertil Steril 1996;65:939–45
- Cohlen BJ, te Velde ER, Looman CW. Crossover or parallel design in infertility trials? The discussion continues. Fertil Steril 1998;70:40–5
- Lilford RJ, Thomton JG, Braunholtz D. Clinical trials and rare diseases: a way out of a conundrum. Br MedJ 1995;311:1621–5