Obesity is a risk factor for early pregnancy loss after IVF or ICSI

References

• Zaadstra BM, Seidell JC, Van Noord PA, te Velde ER, Habbema JD, Vrieswijk B et al. Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 1993; 306: 484–7.
   Google Scholar
• Wass P, Waldenstrom U, Rossner S, Hellberg D. An android body fat distribution in females impairs the pregnancy rate of in-vitro fertilization-embryo transfer. Hum Reprod 1997; 12: 2057–60.
   Google Scholar
• Green BB, Weiss NS, Daling JR. Risk of ovulatory infertility in relation to body weight. Fertil Steril 1988; 50: 721–6.
   Google Scholar
• Hartz AJ, Barboriak PN, Wong A, Katayama KP, Rimm AA, Kalkhoff R et al. The association of obesity with infertility and related menstrual abnormalities in women. A study of factors associated with the ability to maintain weight loss. Int J Obes 1979; 8: 471–83.
   Google Scholar
• Dale PO, Tanbo T, Haug E, Åbyholm T. The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome. Hum Reprod 1998; 13: 567–70.
   Google Scholar
• Hamilton-Fairley D, Kiddy D, Watson H, Paterson C, Franks S. Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br J Obstet Gynaecol 1992; 99: 128–31.
   Google Scholar
• Homburg R, Armar NA, Eshel A, Adams J, Jacobs HS. Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome. BMJ 1988; 297: 1024–6.
   Google Scholar
• Homburg R, Levy T, Berkovitz D, Farchi J, Feldberg D, Ashkenazi J et al. Gonadotropin-releasing hormone agonist reduces the miscarriage rate for pregnancies achieved in women with polycystic ovarian syndrome. Fertil Steril 1993; 59: 527–31.
   Google Scholar
• Tarlatzis BC, Grimbizis G. The significance of high follicular-phase luteinizing hormone levels in the treatment of women with polycystic ovarian syndrome by in vitro fertilization. J Assist Reprod Genet 1997; 14: 1–4.
   Google Scholar
• Dale PO, Tanbo T, Vaaler S, Åbyholm T. Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations. Fertil Steril 1992; 58: 487–91.
   Google Scholar
• Smith SR. The endocrinology of obesity. Endocrinol Metab Clin North Am 1996; 25: 921–42.
   Google Scholar
• Tanbo T, Kjekshus E, Dale PO, Storeng R, Lunde O, Magnus Ø et al. Intracytoplasmatic spermieinjeksjon. [Intracytoplasmic sperm injection]. (in Norwegian with English abstract). Tidsskr Nor Laegeforen 1998; 118: 864–9.
   Google Scholar
• Åbyholm T, Tanbo T, Dale PO, Kjekshus E, Magnus Ø. The first attempt at IVF treatment. Results and requirements for a satisfactory success rate. Eur J Obstet Gynecol Reprod Biol 1991; 38: 125–32.
   Google Scholar
• Mills CL. Factors affecting embryological parameteres and embryo selection for IVF-ET. In: Brinsden PR, Rainsbury PA, eds. A textbook of in vitro fertilization and assisted reproduction. Carnforth: Parthenon, 1992; 187–204.
   Google Scholar
• Risch HA, Weiss NS, Clarke EA, Miller AB. Risk factors for spontaneous abortion and its recurrence. Am J Epidemiol 1988; 128: 420–30.
   Google Scholar
• Groll M. Endometriosis and spontaneous abortion. Fertil Steril 1984; 41: 933–5.
   Google Scholar
• Jansen RP. Spontaneous abortion incidence in the treatment of infertility. Am J Obstet Gynecol 1982; 143: 451–73.
   Google Scholar
• Fedele L, Bianchi S. Habitual abortion: endocrinological aspects. Curr Opin Obstet Gynecol 1995; 7: 351–6.
   Google Scholar
• Holte J, Bergh T, Gennarelli G, Wide L. The independent effects of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. Clin Endocrinol (Oxf) 1994; 41: 473–81.
   Google Scholar
• Zhang H, Bracken MB. Tree-based, two-stage risk factor analysis for spontaneous abortion. Am J Epidemiol 1996; 144: 989–96.
   Google Scholar
• Hollmann M, Runnebaum B, Gerhard I. Effects of weight loss on the hormonal profile in obese, infertile women. Hum Reprod 1996; 11: 1884–91.
   Google Scholar
• Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 1998; 13: 1502–5.
   Google Scholar
• Pellestor F, Girardet A, Andreo B, Arnal F, Humeau C. Relationship between morphology and chromosomal constitution in human preimplantation embryo. Mol Reprod Dev 1994; 39: 141–6.
   Google Scholar
• Richards JS. Hormonal control of gene expression in the ovary. Endocr Rev 1994; 15: 725–51.
   Google Scholar
• Poretsky L, Piper B. Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome. Obstet Gynecol 1994; 84: 61321.
   Google Scholar
• Auwerx J, Staels B. Leptin. Lancet 1998; 351: 737–42.
   Google Scholar
• Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997; 82: 4144–8.
   Google Scholar
• Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Snodgrass HR. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3: 467–72.
   Google Scholar
• Cano F, Garcia-Velasco JA, Millet A, Remohi J, Simon C, Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet 1997; 14: 254–61.
   Google Scholar
• Katagiri S, Moon YS, Yuen BH. The role for the uterine insulin-like growth factor I in early embryonic loss after superovulation in the rat. Fertil Steril 1996; 65: 426–36.
   Google Scholar
• Ertzeid G, Storeng R, Lyberg T. Treatment with gonadotropins impaired implantation and fetal development in mice. J Assist Reprod Genet 1993; 10: 286–91.
   Google Scholar
• Ertzeid G, Storeng R. Adverse effects of gonadotrophin treatment on preand postimplantation development in mice. J Reprod Fertil 1992; 96: 649–55.
   Google Scholar
• Fridström M, Sjöblom P, Pousette A, Hillensjö T. Serum FSH levels in women with polycystic ovary syndrome during ovulation induction using down-regulation and urofollitropin. Eur J Endocrinol 1997; 136: 488–92.
   Google Scholar