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The Journal of Maternal-Fetal & Neonatal Medicine Volume 13, 2003 - Issue 4
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(RG) Obstetrics and Gynaecology

Effect of vaginal pH on efficacy of the controlled-release dinoprostone vaginal insert for cervical ripening/labor induction

P. S. Ramsey Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Pharmacy, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
,
P. L. Ogburn Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
,
D. Y. Harris Mayo Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, USA
,
R. H. Heise Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
,
C. S. DiMarco Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
&
K. D. Ramin Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pages 250-253 | Published online: 07 Jul 2009

References

  • Hayashi RH. Spontaneous and induced cervical ripening: natural dilation and effacement process and current cervical ripening techniques. J Reprod Med 1993;38:66–72
  • Trofatter KF. Cervical ripening. Clin Obstet Gynecol 1992; 35:476–86
  • Keirse MJNC. Prostaglandins in preinduction cervical ripening: meta-analysis of worldwide clinical experience. J Reprod Med 1993;38:89–100
  • Uldbjerg N, Ulmsten U, Ekman G. The ripening of the human uterine cervix in terms of connective tissue bio-chemistry. Clin Obstet Gynecol 1983;26:14
  • Theobald PW, Rath W, Kuhnle H, et at. Histological and electron-microscopicexaminations of collagenous connective tissue of the non-pregnant cervix, the pregnant cervix, and the pregnant prostaglandin-treat ai cervix. Arch Gynecol 1982; 231:241–5
  • Uldbjerg N, Ekman O, Malmström A, et at. Biochemical changes in human cervical connective tissue after local appli-cation of prostaglandin E2. Gynecol Obstet Invest 1983; 15:291–9
  • Rayburn WF, Wapner RJ, Barass VA, et at. An intravaginal controlled-release prostaglandin E2 pessary for cervical ripening and initiation of labor at term. Obstet Gynecol 1992;79:374–9
  • Witter FR, Rocco LE, Johnson TR. A randomized trial of prostaglandin E2 in a controlled-release vaginal pessary for cervical ripening at term. Am J Obstet Gynecol 1992; 146:830–4
  • Hughes EG, Kelly AJ, Kavanagh J. Dinoprostone vaginal insert for cervical ripening and labor induction: a meta-analysis. Obstet Gynecol 2001;97:847–55
  • American College of Obstetricians and Gynecologists. Induction of Labor. ACOG Practice Bulletin - Number 10. Washington, DC: ACOG, 1999
  • Ramsey PS, Ramin KD, Ramin SM. Labor induction. Curr Op in Obstet Gynecol 2000;12:463–73
  • Stehle RG. Physical chemistry, stability, and handling of prostaglandin E2, F2, D2, 12: a critical summary. Methods Enzymol 1982;86:436–58
  • Johnson TA, Greer IA, Kelly RW, et at. The effect of pH on release of POE2 from vaginal and endocervical preparations for induction of labour: an in-vitro study. Br J Obstet Gynaeco11992;99:877–80
  • MacDonald IA, Weir RF. The effect of pH on release of POE2 from vaginal and endocervical preparations for induc-tion of labour. Br J Obstet Gynaecol 1993;100:1066–7
  • Lyrenas S, Clason I, Ulmsten U. In vivo controlled release of POE2 from a vaginal insert (0.8 mm, 10 mg) during induction of labour. Br J Obstet Gynaecol 2001;108: 169–78
  • Ramsey PS, Ogburn PL, Harris DY, et at. Effect of vaginal pH on efficacy of the dinoprostone gel (Prepidil®) for cervical ripening/labor induction. Am J Obstet Gynecol; in press
  • Physicians Desk Reference, 56th edn. Montevale, NJ: Medical Economics Company, 2002
  • Ramsey PS, Harris DY, Ogburn PL, et at. Comparative efficacy and cost of prostaglandin analogues dinoprostone and misoprostol as labor preinduction agents. Am J Obstet Gynecol in press
  • Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964;24:266–8

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