Experimental Models To Investigate Inflammatory Processes in Chronic Venous Insufficiency

References

• Baron HC, Cassaro S. (1986). The role of arteriove-nous shunts in the pathogenesis of varicose veins. J Vasc Surg 4:124–128.
   Google Scholar
• Benoit JN, Granger DN. (1988). Intestinal microvas-cular adaptation to chronic portal hypertension in the rat. Gastroenterology 94:471–476.
   Google Scholar
• Bollinger A, Leu AJ. (1991). Evidence for microvas-cular thrombosis obtained by intravital fluorescence microscopy. Vasa 20:252–255.
   Google Scholar
• Bouskela E, Donyo KA, Verbeuren TJ. (1995). Effects of Daflon 500 mg on increased microvascular permeability in normal hamsters. Int J Microcirc 14\(suppl 1):22–26.
   Google Scholar
• Bouskela E, Cyrino FZGA, Lerond L. (1999). Leukocyte adhesion after oxidant challenge in the hamster cheek pouch microcirculation. J Vasc Res 36\(suppl 1):11–14.
   Google Scholar
• Burnand KG, Clemenson G, Whimster I, Gaunt J, Browse NL. (1982). The effect of sustained venous hypertension on the skin capillaries of the canine hind limb. Br J Surg 69:41–44.
   Google Scholar
• Carosi JA, Eskin SG, McIntire LV. (1992). Cyclical strain effects on production of vasoactive materials in cultured endothelial cells. J Cell Physiol 151:29–36.
   Google Scholar
• Cheatle TR, Scott HJ, Scurr JH, Coleridge-Smith PD. (1991). White cells, skin blood flow, and venous ulcers. Br J Dermatol 125:288–290.
   Google Scholar
• Cheng JJ, Wung BS, Chao YJ, Wang DL. (1996). Cyclic strain enhances adhesion of monocytes to en-dothelial cells by increasing endothelial cell adhesion molecule-1 expression. Hypertension 28:386–391.
   PubMed Web of Science ®Google Scholar
• Coleridge Smith PD, Thomas P, Scurr JH, Dormandy JA. (1988). Causes of venous ulceration: A new hypothesis. Br Med J 296:1726–1727.
   PubMed Web of Science ®Google Scholar
• Coleridge Smith PD. (1999). Neutrophil activation and mediators of inflammation in chronic venous insufficiency. J Vasc Res 36\(suppl 1):24–36.
   Google Scholar
• Cornu-Thenard A, Boivin P, Baud JM, De Vincenzi I, Carpentier PH. (1994). Importance of familial factor in varicose disease. Clinical study of 134 families. J Dermatol Surg Oncol 20:318–326.
   PubMedGoogle Scholar
• Dalsing MC, Ricotta JJ, Wakefield T, Lynch TG, Ou-riel K. (1998). Animal models for the study of lower extremity chronic venous disease: Lessons learned and future needs. Ann Vasc Surg 12:487–494.
   PubMedGoogle Scholar
• Edwards AT, DeFriend DJ, Corson RJ, McCollum CN. (1992). Oxygen-derived free radicals and ischemia-reperfusion in venous ulceration. Br J Surg 79:369.
   Google Scholar
• Engler RL, Schmid-Scho�nbein GW, Pavelec RS. (1983). Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111:98–111.
   PubMed Web of Science ®Google Scholar
• Franzeck UK, Bollinger A, Huch R, Huch A. (1984). Transcutaneous oxygen tension, capillary morphology and density in patients with chronic venous incompetence. Circulation 70:806–811.
   Google Scholar
• Freisenecker B, Tsai AG, Intaglietta M. (1995). Cellular basis of inflammation, edema, and the activity of Daflon 500 mg. Int J Microcirc 15\(suppl 1):17–21.
   Google Scholar
• Freisnecker B, Tsai AG, Allegra C, Intaglietta M. (1994). Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: In vivo observations in the hamster skin fold. Int J Microcirc 14:50–55.
   Google Scholar
• Gowland Hopkins NF, Spinks TJ, Rhodes CG, Ranis-car ASO, Jamieson CW. (1983). Positron emission tomography in venous ulceration and liposclerosis: Study of regional tissue function. Br Med J 286:333–336.
   Google Scholar
• Gute D, Korthuis RJ. (1995). Role of leukocyte adherence in reperfusion-induced microvascular dysfunction and tissue injury. (1995). In: Physiology and Pathophysiology of Leukocyte Adhesion. (DN Granger and GW Schmid-Scho�nbein, Eds.) Oxford University Press. New York. pp. 359–380.
   Google Scholar
• Gute DC, Korthuis RJ. (1999). Daflon 500 mg reduces postischemic leukocyte-endothelial cell interactions and microvascular barrier dysfunction. Prog Appl Microcirc 23:91–100.
   Google Scholar
• Hahn TL, Unthank JL, Lalka SG. (1999). Increased hindlimb leukocyte concentration in a chronic rodent model of venous hypertension. J Surg Res 81:38–41.
   Google Scholar
• Hahn, TL, Whitfield R, Salter J, Granger DN, Un-thank JL, Lalka SG. (2000). Evaluation of the role of intercellular adhesion molecule 1 in a rodent model of chronic venous hypertension. J Surg Res 88:150–154.
   Google Scholar
• Haselbach P, Vollenweider U, Moneta G, Bollinger A. (1986). Microangiopathy in severe chronic venous in-sufficiency evaluated by fluorescence video-microscopy. Phlebology 1:159–169.
   Google Scholar
• Homans J. (1917). The aetiology and treatment of varicose ulcer of the leg. Surg Gynecol Obstet 24: 300–311.
   Google Scholar
• Howard AB, Alexander RW, Nerem RM, Griendling KK, Taylor WR. (1997). Cyclic strain induces an oxi-dative stress in endothelial cells. Am J Physiol 272:C421–C427.
   Google Scholar
• Jerome SN, Akimitsu T, Korthuis RJ. (1994). Leukocyte adhesion, edema and postischemic capillary no-reflow. Am J Physiol 267:H1329–H1336.
   Google Scholar
• Korthuis RJ, Gute DC. (1999). Adhesion molecule expression in postischemic microvascular dysfunction: Activity of a micronized purified flavonoid fraction. J Vasc Res 36\(suppl 1):15–23.
   Google Scholar
• Korthuis RJ, Gute DC. (1997). Postischemic leuko-cyte/endothelial cell interactions and microvascular barrier dysfunction in skeletal muscle: Cellular mechanisms and the effect of Daflon 500 mg. Int J Microcirc 17\(suppl 1):11–17.
   Google Scholar
• Lalka SG, Unthank JL, Nixon JC. (1998). Elevated cutaneous leukocyte concentration in a rodent model of acute venous hypertension. J Surg Res 74:59–63.
   Google Scholar
• Lerond L. (1994). Action of Daflon 500 mg on the principal inflammatory mediators. Phlebology 9\(suppl 1):34–39.
   Google Scholar
• Mani R, Gorman FW, White JE. (1986). Transcuta-neous measurements of oxygen tension at edges of leg ulcers: Preliminary communication. J R Soc Med 79: 650–655.
   Google Scholar
• Massberg S, Enders G, Eisenmenger S, Leiderer R, Vestweber D, Krombach F, Messmer K. (1999). Platelet-endothelial cell interactions in the postisch-emic microvasculature. Prog Appl Microcirc 23:66–81.
   Google Scholar
• Michiels C, Arnould T, Thibaut-Vercruyssen R, Bouaziz N, Janssens D, Remacle J. (1997). Perfused human saphenous veins for the study of the origin of varicose veins: Role of endothelium and hypoxia. Int Angiol 16:134–141.
   PubMedGoogle Scholar
• Moyses C, Cederholm-Williams SA, Michel CC. (1987). Haemoconcentration and accumulation of white cells in the feet during venous stasis. Int J Mi-crocirc 5:311–320.
   Google Scholar
• Nagel T, Resnick N, Atkinson WJ, Dewey CF Jr, Gim-brone MA Jr. (1994). Shear stress selectively upregu-lates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest 94:885–891.
   PubMed Web of Science ®Google Scholar
• Nolte D, Pickelman S, Schutze E, Mollman M, Mess-mer K. (1997). Effects of Daflon 500 mg on postisch-emic macromolecular leak syndrome in striated skin muscle of the hamster. Int J Microcirc Clin Exp 17\(suppl 1):6–10.
   Google Scholar
• Pearson JD. (1999). Pathophysiologic mechanisms involving leukocytes in chronic venous insufficiency. Prog Appl Microcirc 23:82–90.
   Google Scholar
• Peschen M, Lahaye T, Hennig B, Weyl A, Simon JC, Vanscheidt W. (1999). Expression of the adhesion molecules ICAM-1, VCAM-1, LFA-1 and VLA-4 in the skin is modulated in progressing stages of chronic venous insufficiency. Acta Derm Venereol (Stockh) 79:27–32.
   PubMed Web of Science ®Google Scholar
• Powell CC, Rohrer MF, Barnard MR, Peyton BD, Fur-man MI, Michelson AD. (1999). Chronic venous insufficiency is associated with increased platelet and monocyte activation and aggregation. J Vasc Surg 30: 844–853.
   PubMed Web of Science ®Google Scholar
• Rubin BB, Romaschin A, Walker PM, Gute DC, Korthuis RJ. (1996). Mechanisms of postischemic skeletal muscle dysfunction: Intervention strategies. J Appl Physiol 80:369–387.
   PubMed Web of Science ®Google Scholar
• Saharay M, Shields DA, Porter JB, Scurr JH, Coleridge Smith PD. (1997). Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease. J Vasc Surg 26:265–273.
   PubMed Web of Science ®Google Scholar
• Scott HJ, Coleridge Smith PD, Scurr JH. (1991). His-tological study of white blood cells and their association with lipodermatosclerosis and venous ulceration. Br J Surg 78:210–211.
   PubMedGoogle Scholar
• Shields DA, Andaz SK, Abeysinghe RD, Porter JB, Scurr JH. (1995). Markers of neutrophil degranula-tion in patients with venous disease. Phlebology 10\(suppl 1):110–112.
   Google Scholar
• Shields DA, Andaz SK, Abeysinghe RD, Scurr JH, Porter JB. (1994). Lactoferrin release in experimental venous hypertension. Phlebology 9\(suppl 1):34–39.
   Google Scholar
• Stible ECL, Cheatle TR, Coleridge Smith PD, Scurr PD, Scurr JH. (1990). Liposclerotic skin: A diffusion block or a perfusion problem? Phlebology 5:231–236.
   Google Scholar
• Takase S, Schmid-Scho�nbein GW, Bergan JJ. (1999). Leukocyte activation in patients with venous insufficiency. J Vasc Surg 30:148–156.
   Google Scholar
• Takase S, Delano FA, Lerond L, Bergan JJ, Schmid-Scho�nbein GW. (1999). Inflammation in chronic venous insufficiency: Is the problem insurmountable? J Vasc Res 36\(suppl 1):3–10.
   Google Scholar
• Takase S, Lerond L, Bergan JJ, Schmid-Scho�nbein GW. (2000). The inflammatory reaction during venous hypertension in the rat. Microcirculation 7:41–52.
   PubMed Web of Science ®Google Scholar
• Thomas PRS, Nash GB, Dormandy JA. (1988). White cell accumulation in dependent legs of patients with venous hypertension: A possible mechanism for trophic changes in the skin. Br Med J 296:1693–1695.
   Web of Science ®Google Scholar
• van Bemmelen SP, Hoynck van Papendrecht AA, Hodde KC, Klopper PJ. (1986). A study of valve incompetence that developed in an experimental model of venous hypertension. Arch Surg 121:1048–1052.
   Google Scholar
• Wang DL, Wung BS, Shyy YJ, Lin CF, Chao YJ, Usami S, Chien S. (1995). Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells. Effects of mechanical strain on monocyte adhesion to endothelial cells. Circ Res 77: 294–302.
   Google Scholar
• Weyl A, Vanscheidt W, Weiss JM, Peschen M, Schopf E, Simon J. (1996). Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers. J Am Acad Dermatol 34:418–423.
   PubMed Web of Science ®Google Scholar
• Whiston RJ, Hallett MB, Davies EV, Harding KG, Lane IF. (1994). Inappropriate neutrophil activation in venous disease. Br J Surg 81:695–698.
   Google Scholar
• Whiston RJ, Hallett MB, Lane IF, Harding KG. (1993). Lower limb neutrophil oxygen radical production is increased in venous hypertension. Phlebol-ogy 8:151–154.
   Google Scholar
• Yuan Y, Chilian WM, Granger HJ, Zaweija DC. (1993). Permeability to albumin in isolated coronary venules. Am J Physiol 265:H543–H552.
   Google Scholar
• Yuan Y, Mier RA, Chilian WM, Zawieja DC, Granger HJ. (1995). Interaction of neutrophils and endothe-lium in isolated coronary venules and arterioles. Am J Physiol 268:H490–H498.
   Google Scholar