Regulation of Adhesion Molecules: A New Target for the Treatment of Chronic Venous Insufficiency

References

• Belcaro G, Christopoulos D, Nicolaides AN. (1989). Skin flow and swelling in postphlebitic limbs. [aVasa] 18:136�139.
   Google Scholar
• Bouskela E, Cyrino FZGA, Lerond L. (1997). Micro-vascular reactivity after ischemia/reperfusion in the hamster cheek pouch : Beneficial effects of different oral doses of S-5682 (Daflon 500 mg). Angiology 48: 33�37.
   Google Scholar
• Bouskela E, Cyrino FZGA, Lerond L. (1999). Leu�kocyte adhesion after oxidant challenge in the ham�ster cheek pouch microcirculation. J Vasc Res 36\(suppl 1):11�14.
   Google Scholar
• Bouskela E, Donyo KA. (1997). Effects of oral ad�ministration of purified micronized flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/reperfusion in the hamster cheek pouch. Angiology 48:391�399.
   Google Scholar
• Bouskela E, Donyo KA, Verbeuren TJ. (1995). Ef�fects of Daflon 500 mg on increased microvascular permeability in normal hamsters. Int J Microcirc 15\(suppl 1):22�26.
   Google Scholar
• Bouskela E, Grampp W. (1992). Spontaneous vaso-motion in hamster cheek pouch arterioles in varying experimental conditions. Am J Physiol 262:H478� H485.
   Google Scholar
• Braide M, Amundson B, Chien S, Bagge U. (1984). Quantitative studies of leukocytes on the vascular re�sistance in a skeletal muscle preparation. Microvasc Res 27:331�352.
   Google Scholar
• Braide M, Blixt A, Bagge U. (1986). Leukocyte effects on the vascular resistance and glomerular filtration of the isolated rat kidney at normal and low flow rates. Circ Shock 20:71�80.
   Google Scholar
• Cayatte A, Rupin A, Oliver-Krasinski J, Sansilvestri-Morel P, Boussard MF, Wierzbicki M, Verbeuren TJ, Cohen RA. (2000). S 17834: A new inhibitor of cel�lular adhesion targeting endogenous superoxide anion generation. (submitted)
   Google Scholar
• Coleridge Smith P. (1999). Neutrophil activation and mediators of inflammation in chronic venous insuffi�ciency. J Vasc Res 36\(suppl 1):24�36.
   Google Scholar
• Coleridge Smith PD. (1999). Treatment of microcir�culation disorders in venous leg ulcer. In: Microcircu�lation in Chronic Venous Insufficiency. (K Messmer, Ed.) Karger. Munich. pp. 121�141.
   Google Scholar
• Dormandy JA. (1995). Microcirculation in venous disorders: The role of the white blood cells. Int J Mi-crocirc 15\(suppl 1):3�8.
   Google Scholar
• Duling BR. (1973). The preparation and use of the hamster cheek pouch for the studies of the microcir�culation. Microvasc Res 5:423�429.
   Google Scholar
• Erlansson M, Bergqvist D, Persson NH, Svensjo E. (1991). Modification of postischemic increase of leu�kocyte adhesion and vascular permeability in the hamster by iloprost. Prostaglandins 41:157�168.
   Google Scholar
• Friesenecker B, Tsai AM, Allegra C, Intaglietta M. (1994). Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: In vivo observation in the hamster skin fold. Int J Microcirc Clin Exp 15: 50�55.
   Google Scholar
• Gaehtgens P. (1987). Pathways and interactions of white cells in the microcirculation. Prog Appl Micro-circ 12:51�66.
   Google Scholar
• Korthuis RJ, Anderson DC, Granger DN. (1994). Role of neutrophil-endothelial cell adhesion in inflamma�tory disorders. J Crit Care 9:47�71.
   Google Scholar
• Korthuis RJ, Gute DC. (1999). Adhesion molecule expression in postischemic microvascular dysfunc�tion: Activity of a micronized purified flavonoid frac�tion. J Vasc Res 36\(suppl 1):15�23.
   Google Scholar
• Linas SL, Shanley PF, Whittenburg D, Berger E, Re�pine JE. (1988). Neutrophils accentuate ischemia-reperfusion injury in isolated perfused rat kidneys. Am J Physiol. 255:F728�F735.
   Google Scholar
• Moyses C, Cederholm-Williams SA, Michel CC. (1987). Haemoconcentration and accumulation of white cells in the feet during venous stasis. Int J Mi-crocirc Clin Exp 5:311�320.
   Google Scholar
• Nicolaides AN. (1994). Overview Daflon 500 mg. An-giology 45:493�494.
   Google Scholar
• Olszewski W. (2000). Clinical efficacy of micronized purified flavonoid fraction (MPFF) in edema. Angi-ology 51:25�29.
   Google Scholar
• Pane�s J, Granger DN. (1998). Leukocyte-endothelial cell interactions: Molecular mechanisms and implica�tions in gastro-intestinal disease. Gastroenterology 114:1066�1090.
   Google Scholar
• Pane�s J, Perry M, Granger DN. (1999). Leukocyte-endothelial cell adhesion: Avenues for therapeutic in�tervention. Brit J Pharmacol 126:537�550.
   Google Scholar
• Ramelet AA. (2000). Pharmacologic aspects of a phlebotropic drug in CVI-associated edema. Angiol-ogy 51:19�23.
   Google Scholar
• Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR. (1983). Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 67:1016�1023.
   Google Scholar
• Rupin A, Cokelaer P, Vallez M-O, Wierzbicki M, Bouskela E, Verbeuren TJ. (1998). The new synthetic flavonoid S 17834 inhibits leukocyte adhesion in vitro and in vivo. In: Proceedings of the 20th European Conference on Microcirculation. (PH Carpentier, E Vicaut, and J-L Guilmot, Eds.) Monduzzi Editore. Bologna. pp. 289�292.
   Google Scholar
• Schmid-Scho�nbein GW, Lee J. (1995). Leukocytes in capillary flow. Int J Microcirc 15:255�264.
   Google Scholar
• Scott HJ, McGullin GM, Coleridge Smith PD, Scurr JH. (1990). A histological study into white blood cells and their association with lipodermatosclerosis and ulceration. Br J Surg 78:210�211.
   Google Scholar
• Struckmann JR. (1999). Clinical efficacy of micron-ized purified flavonoid fraction: An overview. J Vasc Res 36\(suppl 1):37�41.
   Google Scholar
• Stucker O, Bonhomme E, Lenaers A, Teisseire B. (1989). Daflon 500 mg depresses bradykinin-ischemia-induced microvascular leakage of FITC dextran in rat cremaster muscle. Angiology 8\(suppl 4):39�43.
   Google Scholar
• Takase S, Delano FA, Lerond L, Bergan JJ, Schmid-Scho�nbein GW. (1999). Inflammation in chronic ve�nous insufficiency: Is the problem insurmountable? J Vasc Res 36\(suppl 1):3�10.
   Google Scholar
• Vallez MO, Cyrino FZGA, Bouskela E, Boussard MF, Wierzbicki M, Verbeuren TJ. (1996). A novel flavo-noid, S 19207, inhibits the macromolecular perme�ability increase in the hamster cheek pouch microcir�culation. In: 6th World Congress for Microcirculation. (K Messmer and WM Ku�bler, Eds.) Monduzzi Edi�tore. Bologna. pp. 663�667.
   Google Scholar
• Vallez M-O, Cyrino FZGA, Bouskela E, Boussard M-F, Wierzbicki M, Verbeuren TJ. (1998). The novel flavonoid, S 17834, inhibits permeability in the ham�ster cheek pouch. In: Proceedings of the 20th Euro�pean Conference on Microcirculation.(PH Carpentier, E Vicaut, and J-L Guilmot, Eds.) Monduzzi Editore. Bologna. pp. 293�296.
   Google Scholar
• Vanhoutte PM, Corcaud S, de Montrion C. (1997). Venous disease: From pathophysiology to quality of life. Angiology 48:559�567.
   Google Scholar
• Verbeuren TJ, Vallez M-O, Wierzbicki M, Boussard M-F, Cyrino FZGA, Bouskela E. (1996). Inhibition of macromolecular permeability by structurally related flavonoids in the hamster cheek pouch microcircula�tion. In: Proceedings of the 6th Congress for Micro�circulation. (K Messmer and WM Ku�ller, Eds.) Mon-duzzi Editore. Bologna. pp. 669�673.
   Google Scholar
• Verbeuren TJ, Vallez MO, Rupin A, Wierzbicki M, Cayatte A, Cohen RA, Bouskela E. (1999). New syn�thetic diosmetin derivatives: Effects on different ex�perimental models of the microcirculation. In: Micro�circulation in Chronic Venous Insufficiency. (F Mess-mer, Ed.) Karger. Munich. pp. 104�113.
   Google Scholar
• Wilson JW. (1972). Leukocyte sequestration and morphologic augmentation in the pulmonary network following haemorrhagic shock and related forms of stress. Adv Microcirc 4:197�232.
   Google Scholar
• Yamakawa T, Suguyama I, Niimi H. (1984). Behav�iour of white blood cells in microcirculation of the cat brain cortex during hemorrhagic shock. Intravital mi�croscopic study. Int J Microcirc Clin Exp 3:554.
   Google Scholar