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Research Article

Pneumocystis infections: the iceberg?

Pages 23-32 | Published online: 01 Apr 2010

References

  • Center for Disease Control. Update: acquired immunodefi-ciency syndrome- Unites States. MMWR 1986; 35: 757–766.
  • Dei-Cas E, Soulw B, Palluault F, Charet P, Camus D. Pneu-mocystis carinii, un défi pour le biologiste. AIM Sci 1990; 6: 517–525.
  • Yale SH, Limper AH. Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associ-ated disorders and prior corticosteroid therapy. Mayo Clin Proc 1996; 71: 5–13.
  • Pifer LL, Hughes WT, Stagno S, Woods D. Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressekl children. Pediatrics 1978; 61: 35–41.
  • Peglow SL, Smulian AG, Linke MJ, et al. Serologic responses to Pneumocystis carinii antigens in health and disease. J Infect Dis 1990; 161: 296–306.
  • Wakefield AE, Stewart TJ, Moxon ER, Marsh K, Hopkin JM. Infection with Pneumocystis carinii is prevalent in healthy Gambian children. Trans R Soc Trop Med Hyg 1990; 84: 800–802.
  • Hughes WT. Current issues in the epidemiology, transmission, and reactivation of Pneumocystis carinii. Semin Respir Infect 1998; 13: 283–288.
  • Dumoulin A, Mazars E, Seguy N, et al. Immunocompetent Contacts of Pneumocystis carinii-infected-hosts can potentially transmit the disease to susceptible hosts. Eur J Gun Microbiol Infect Dis 2000; (in press).
  • Calderon E, Regordan C, Medrano FJ, 011ero M, Varela JM. Pneumocystis carinii infection in patients with chronic bronchial disease. Lancet 1996; 347: 977.
  • Hughes WT. Natural mode of acquisition for de novo infec-tion with Pneumocystis carinii. J Infect Dis 1982; 145: 842–848.
  • Soulez B, Palluault F, C,esbron JY, Dei-Cas E, Capron A, Camus D. Introduction of Pneumocystis carinii in a colony of SCID mice. J Protozool 1991; 3& 123–125.
  • Cushion MT. Transmission and epidemiology. In: Walzer PD, ed. Pneumocystis carinii Pneumonia, 2nd edn. New York: Marcel Dekker, Inc, 1994: 123–140.
  • The Pneumocystis Workshop. Revised nomenclature for Pneu-mocystis carinii. J Eukaryot Microbiol 1994; 41 (Suppl.): 121–122.
  • Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ. Pneumo-cystis carinii is not universally transmissible between mam-malian species. Infect Immun 1993; 61: 2886–2890.
  • Aliouat EM, Mazars E, Dei-Cas E, Cesbron JY, Camus D. Intranasal inoculation of mouse, rat or rabbit-derived Pneumocystis in SCID mice. J Protozool Res 1993; 3: 94–98.
  • Aliouat EM, Mazars E, Dei-Cas E, Delcourt P, Billaut P, Camus D. Pneumocystis cross infection experiments using SCID mice and Nude rats as recipient host, showed strong host-species specificity. J Eukaryot Microbiol 1994; 419 (Suppl.): 71.
  • Wakefield AE, Stringer JR, Tamburrini E, Dei-Cas E. Genet-ics, metabolism and host specificity of Pneumocystis carinii. Med Mycol 1998; 36 (Suppl.): 183–193.
  • Walzer PD. Experimental models of Pneumocystis carinii in-fection. In: Young LS, ed. Pneumocystis carinii Pneumonia. 1st edn. New York: Marcel Dekker, Inc., 1984: 37–43.
  • Sethi KK. Multiplication of human-derived Pneumocystis carinii in severe combined immunodeficient (SCID) mice. Ex - perientia 1992; 48: 63–66.
  • Hughes WT. Pneumocystis carinii Pneumonitis, 1st edn. Boca Raton: CRC Press, 1987.
  • Mazars E, Dei-Cas E. Epidemiological and taxonomic impact of Pneumocystis biodiversity. FEMS Immunol Med Microbiol 1998; 2/. 75–80.
  • Stringer JR Pneumocystis carinii: what is it, exactly? Clin Microbiol Rev 1996; 9: 489–498.
  • Mazars E, Guyot K, Durand I, et al. Isoenzyme diversity in Pneumocystis carinii from rats, mice and rabbits. J Infect Dis 1997; 175: 655–660.
  • Mayr E. Animal Species and Evolution. Cambridge, MA: The Belknap Press of Harvard University Press, 1963.
  • Latouche S, Poirot JL, Maury E, Bertrand V, Roux P. Pneu-mocystis carinii hominis sequencing to study hypothetical per-son-to-person transmission. AIDS 1997; 11: 549.
  • Helweg-Larsen J, Tsolaki AG, Miller RF, Lundgren B, Wa-kefield AE Clusters of Pneumocystis carinii pneumonia: analy-sis of person-to person transmission by genotyping. Q J Medicine 1998; 91: 813–820.
  • Furuta T, Fujita M, Mukai R, et al. Severe pulmonary pneumocystosis in simian acquired immunodeficiency syn-drome induced by simian immunodeficiency virus: its charac-terization by polymerase-chain reaction method and failure of experimental transmission to immunodeficient animals. Para-sitol Res 1993; 79: 624–628.
  • Mortier E, Pouchot J, Bossi P, Molinie V. Maternal-fetal transmission of Pneumocystis carinii in human immunodefi-ciency virus infection. N Engl J Med 1995; 332: 825.
  • Hughes WT. Pneumocystis in infants and children. N Engl J Med 1995; 332: 320.
  • Hong ST, Park YK, Kim J, Kim DH, Yun CK. Is Pneumocys-tis carinii vertically transmitted to neonatal rats? Korean J Parasitol 1999; 37: 149–156.
  • Ito M, Tsugane T, Kobayashi K, et al. Study on placental transmission of Pneumocystis carinii in mice using im-munodeficient SCID mice as a new animal model. J Protozool 1991; 38: 218–219.
  • Soulez B, Dei-Cas E, Charet P, Mougeot G, Caillaux M, Camus D. The young rabbit: a nonimmunosuppressekl model for Pneumocystis carinii pneumonia. J Infect Dis 1989; 160: 355–356.
  • Dei-Cas E, Brun-Pascaud M, Bille-Hansen V, Allaert A, Aliouat EM. Animal models of pneumocystosis. FEMS Im-munol Med Microbiol 1998; 2/ 163–168.
  • Ceré N, Drouet-Viard F, Dei-Cas E, Chanteloup N, Coudert P. In utero Transmission of Pneumocystis carinii sp.f. orycto-lagui. Parasite 1997; 4: 325–330.
  • Aliouat EM, Dei-Cas E, Billaut P, Dujardin L, Camus D. Pneumocystis carinii organisms from in vitro culture were highly infectious to the nude rat. Parasitol Res 1995; 81: 82–85.
  • European Concerted Action on Pneumocystis carinii. In vitro systems in Pneumocystis research. Parasitol Today 1996; 1/ 245–249.
  • Wakefield AE. DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora. J Clin Microbiol 1996; 34: 1754–1759.
  • Bartlett MS, Vermund SH, Jacobs R, et al. Detection of Pneumocystis carinii DNA in air samples: likely environmental risk to susceptible persons. J Gun Microbiol 1997; 35: 2511–2513.
  • Guillot J, Berthelemy M, Polack B, et al. Impaction versus filtration for the detection of Pneumocystis carinii DNA in air. J Eukaryot Microbiol 1999; 46 (Suppl.): 94.
  • Casanova-Cardiel L, Leibowitz MJ. Presence of Pneumocystis carinii DNA in pond water. J Eukaryot Microbiol 1997; 44 (Suppl.): 28.
  • Latouche S, Rabodonirina M, Mazars E. Pneumocystis: the 'carrier state': epidemiology and transmission of human pneu-mocystosis. FEMS Immunol Med Microbiol 1998; 2/ 75–80.
  • Millard PR, Heryet AR. Observations favouring Pneumocystis carinii pneumonia as a primary infection: a monoclonal anti-body study on paraffin sections. J Pathol1988; 154: 365–370.
  • Peters S, Wakefield AE, Sinclair K, Millard PR, Hopkin JM. A search for Pneumocystis carinii in post-mortem lungs by DNA amplification. J Pathol 1992; 166: 195–198.
  • Nevez G, Raccurt C, Jounieaux V, Dei-Cas E, Mazars E. Pneumocystosis versus pulmonary Pneumocystis carinii colo-nization in HIV-negative and HIV-positive patients. AIDS 1999; 13: 535–536.
  • Armbruster C, Hassl A, Kriwanek S. Pneumocystis carinii colonization in the absence of immunosuppression. Scand J Infect Dis 1997; 29: 591–593.
  • Contini C, Villa MP, Romani R, Merolla R, Delia S, Ronchetti R. Detection of Pneumocystis carinii among chil-dren with chronic respiratory disorders in the absence of HIV infection and immunodeficiency. J Med Microbiol 1998; 47: 329–333.
  • Sing A, Roggenkamp A, Autenrieth IB, Heesemann J. Pneu-mocystis carinii carriage in immunocompetent patients with primary pulmonary disorders as detected by single or nested PCR. J Gun Microbiol 1999; 37: 3409–3410.
  • Nevez G, Raccurt C, Vincent P, Jounieaux V, Dei-Cas E. Pulmonary colonization with Pneumocystis carinii in human immunodeficiency virus-negative patients: assessing risk with blood CD4 + T cell counts. Clin Infect Dis 1999; 29: 1331–1332.
  • Vargas SL, Hughes WT, Wakefield AE, Oz HS. Limited persistence in and subsequent elimination of Pneumocystis carinii from the lungs after P. carinii pneuonia. J Infect Dis 1995; 172: 506–510.
  • Chen W, Gigliotti F, Harmsen AG. Latency is not an in-evitable outcome of infection with Pneumocystis carinii. Infect Immun 1993; 61: 5406–5409.
  • Leigh TR, Millett MJ, Jameson B, Collins JV. Serum titres of Pneumocystis carinii antibody in health care workers caring for patients with AIDS. Thorax 1993; 48: 619–621.
  • Sepkowitz K, Schluger N, Goldwin T, Armstrong D, Cerami A, Bucala R. DNA amplification in experimental pneumocys-tosis: characterization of serum Pneumocystis carinii DNA and potential Pneumocystis carinii carrier states. J Infect Dis 1993; 168: 421–426.
  • Helweg-Larsen J, Benfield TL, Eugen-Olsen J, Lundgren JD, Lundgren B. Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associ-ated P. carinii pneumonia. Lancet 1999; 354: 1347–1351.
  • Meshnick SR. Drug-resistant Pneumocystis carinii. Lancet 1999; 354: 1318–1319.
  • Vargas SL, Ponce CA, Hughes WT, et al. Association of primary Pneumocystis carinii infection and sudden infant death syndrome. Clin Infect Dis 1999; 29: 1489–1493.
  • Stagno S, Pifer LL, Hughes WT, Brasfield DM, Tiller RE. Pneumocystis carinii pneumonitis in young immunocompetent infants. Pediatr 1980; 66: 56–62.
  • Blasi F, Cosentini R. Noninvasive methods for the diagnosis of pneumonia. In: Torres A, Woodhead M, eds. Pneumonia. Sheffield: European Respiratory Society Journals Ltd., 1997: 157–174.
  • Wakefield AE, Miller RF, Guiver LA, Hopkin JM. Oropha-ryngeal samples for detection of Pneumocystis carinii by DNA amplification. Q J Med 1993; 86: 401–406.
  • Tamburrini E, Mencarini P, Visconti E, et al. Potential impact of Pneumocystis genetic diversity on the molecular detection of the parasite in human host. FEMS Immunol Med Microbiol 1998; 21 123–128.
  • Tsolaki AG, Miller RF, Wakefield AE. Oropharyngeal sam-ples for genotyping and monitoring response to treatment in AIDS patients with Pneumocystis carinii pneumonia. J Med Microbiol 1999; 48: 897–905.
  • Hughes WT. Clinical manifestations in children. In: Walzer PD, ed. Pneumocystis carinii Pneumonia, 2nd edn. New York: Marcel Dekker, Inc, 1994: 319–329.
  • Frenkel JK. Pneumocystis pneumonia, an immunodeficiency-dependent disease: a critical historical overview. J Eukaryot Microbiol 1999; 46 (Suppl.): 89–92.
  • Roux P, Ha MC, Brucker G, Costagliola D. Pneumocystis and pneumocystosis in Europe at the end of the 20th century. FEMS Immunol Med Microbiol 1998; 22: 87–91.
  • Dohn MN, Frame PT. Clinical Manifestations in Adults. In: Walzer PD, ed. Pneumocystis carinii Pneumonia. 2nd edn. New York: Marcel Dekker, Inc., 1994: 331–359.
  • Raviglione MC. Extrapulmonary pneumocystosis: the first 50 cases. Rev Infect Dis 1990; 12: 1127–1138.
  • Cohen OJ, Stoeckle MY. Extrapulmonary Pneumocystis carinii infections in the acquired immunodeficiency syndrome. Arch Intern Med 1991; 151: 1205–1214.
  • Telzak EF, Armstrong D. Extrapulmonary infection and other unusual manifestations of Pneumocystis carinii. In: Walzer PD, ed. Pneumocystis carinii Pneumonia 2nd edn. New York: Marcel Dekker, Inc., 1994: 361–378.
  • Dei-Cas E, Vemes A. Parasitic adaptation of pathogenic fungi to mammalian hosts. CRC Grit Rev Microbiol 1986; 13: 173–218.
  • Denis CM, Cailliez JC, Aliouat EM, et al. Does Pneumocystis carinii remain infectious in the bloodstream?J Eukaryot Mi-crobiol 1994; 41 (Suppl.): 86.
  • Oz HS, Hughes WT, Vargas SL. Search for extrapulmonary Pneumocystis carinii in an animal model. J Parasito11996; 357–359.
  • Pottratz ST, Martin WJ. Role of fibronectin in Pneumocystis carinii attachment to cultured lung cells. J Clin Invest 1990; 85: 351–356.
  • Aliouat A, Dei-Cas E, Ouaissi MA, Palluault F, Soulez B, Camus D. In vitro attachment of Pneumocystis carinii from mouse and rat origin. Biol Cell 1993; 77: 209–217.
  • Narasimhan S, Armstrong MY, Rhee K, Edman JC, Richards FF, Spicer E. Gene for an extracellular matrix receptor protein from Pneumocystis carinii. Proc Natl Acad Sci USA 1994; 91: 7440–7444.
  • Lugli EB, Bampton ETW, Ferguson DJ, Wakefield AE. Cell surface protease PRT1 identfied in the fungal pathogen Pneu-mocystis carinii. Mol Microbiol 1999; 31: 1723-1733.
  • Settnes OP, Nielsen MJ. Host-parasite relationships in Pneu-mocystis carinii infection: activation of the plasmalemmal vesicular system in type I alveolar epithelial cells. J Protozool 1991; 38 (Suppl.): 174–176.
  • Dei-Cas E, Jackson H, Palluault F, et al. Ultrastructural observations on the attachment of Pneumocystis carinii in vitro. J Protozool 1991; 38 (Suppl.): 205–207.
  • Limper AH, Thomas CF, Anders RA, Leof EB. Interactions of parasite and host epithelial cell cycle regulation during Pneumocystis carinii pneumonia. J Lab Clin Med 1997; 130: 132–138.
  • Beck J, Preston AM, Wagner JG, et al. Interaction of rat Pneumocystis carinii and rat alveolar epithelial cells in vitro. Am J Physiol 1998; 275: L118–L125.
  • Walzer PD. Pathogenic mechanisms. In: Walzer PD, ed. Pneu-mocystis carinii Pneumonia, 2nd edn. New York: Marcel Dekker, Inc, 1994: 251–265. @ 2000 ISHAM, Medicd Mycology, 38, Suppl. I, 23–32
  • Benfield TL, Prento P, Junge J, Vestbo J, Lundgren JD. Alveolar damage in AIDS-related Pneumocystis carinii pneu-monia. Chest 1997; 111: 1993–1999.
  • Rajagopalan-Levasseur P, Allaert A, Diidba M, et al. Re-sponse to Pneumocystis infection in an immunocompetent host. FEMS Immunol Med Microbiol 1998; 22: 107–121.
  • Durand-Joly I, Wakefield AE, Palmer RJ, et al. Ultrastruc-tural and molecular characterization of Pneumocystis carinii isolated from a rhesus monkey (Macaca mulatta). Med Mycol 2000; 38: 61–72.
  • Tamburrini E, Ortona E, Visconti E, et al. Pneumocystis carinii infection in young non-immunosuppressekl rabbits. Ki-netics of infection and of primary specific immune response. Med Microbiol Immunol (Berl) 1999; 188: 1–7.
  • Pesanti EL. Pneumocystis carinii: oxygen uptake, antioxidant enzymes, and susceptibility to oxygen-mediated damage. Infect Immun 1984; 44: 7–11.
  • Denis CM, Cidberg-Ferragut C, Guyot K, Dei-Cas E, Camus D, Dive D. Manganese-cofactored Superoxide Dismutase ac-tivity in rat-derived Pneumocystis carinii. J Eukaryot Microbiol 1996; 43 (Suppl.): 26.
  • Denis CM, Guyot K, Wakefield AE, et al. Molecular cloning and characterization of a superoxide dismutase (sod) gene in Pneumocystis carinii. J Eukaryot Microbiol 1998; 45: 475–483.
  • Roths FB, Sidman CL. Both immunity and hyperresponsive-ness to Pneumocystis carinii result from transfer of CD4 but not CD8 T cells in severe combined immunodeficient mice. J Clin Invest 1992; 90: 673–678.
  • Beck JM, Liggit HD, Brunette EN, Fuchs HJ, Shellito JE, Debs RJ. Reduction in intensity of Pneumocystis carinii pneu-monia in mice by aerosol administration of gamma interferon. Infect Immun 1991; 59: 3859–3862.
  • Masur H, Jones TC. The interaction Pneumocystis carinii with macrophages and L-cells. J Exp Med 1978; 147: 157–170.
  • Koziel H, O'Riordan D, Warner A, Rose RM. Alveolar macrophage interaction with Pneumocystis carinii. Immunol Series 1994; 160: 417–436.
  • Ezekowitz RAB, Williams DJ, Koziel H, et al. Uptake of Pneumocystis carinii mediated by macrophage mannose recep-tor. Nature 1991; 351: 155–158.
  • Hidalgo HA, Helmke RJ, German VF, Mangos JA. Pneumo-cystis carinii induces an oxidative burst in alveolar macro-phages. Infect Immun 1992; 60: 1–7.
  • Shellito JE, Kolls JK, Olariu R, Beck JM. Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. J Infect Dis 1996; 173: 432–439.
  • Jensen T, Aliouat EM, Lundgren B, et al. Cultured rat and purified human Pneumocystis carinii stimulate intra- but not extracellular free radical production in human neutrophils. J Eukaryot Microbiol 1998; 45: 544–547.
  • Giglioti F, Hughes WT. Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonia in animal models. J Clin Invest 1988; 81: 1666–1668.
  • Harmsen AG, Stankiewicz MT. T cells are not sufficient for resistance to Pneumocystis carinii pneumonia in mice. J Proto-zol 1991; 38 (Suppl.): 44–45.
  • Prevost MC, Escamilla R, Aliouat EM, Ceré N, Coudert P, Dei-Cas E. Pneumocystosis pathophysiology. FEMS Immunol Med Microbiol 1998; 22: 123–128.
  • Escamilla R, Prevost MC, Hermant C, Caratero A, Cariven C, Krempf M. Surfactant analysis during Pneumocystis carinii pneumonia in HIV-infected patients. Chest 1992; 101: 1558–1562.
  • Hoffman AGD, Marion G, Lawrence MS, et al. Reduction of pulmonary surfactant in patients with human immunodefi-ciency virus infection and Pneumocystis carinii pneumonia. Chest 1992; 102: 1730–1736.
  • Escamilla R, Prevost MC, Cariven C, Hermant C, Krempf M, Chap H. Bronchoalveolar lavage phospholipid abnormalities in HIV-infected patients. Eur Resp J 1993; 6: 1301–1307.
  • Rose RM, Catalano PJ, Koziel H, Furlong ST. Abnormal lipid composition of bronchoalveolar lavage fluid obtained from individuals with AIDS-related lung disease. Am J Respir Crit Care Med 1994; 149: 332–338.
  • Phelps DS, Rose RM. Increased recovery of surfactant protein A in AIDS-related pneumonia. Am Rev Respir Dis 1991; 143: 1072–1075.
  • Limper AH, Crouch EC, O'Riordan DM, et al. Surfactant protein-D modulates interaction of Pneumocystis carinii with alveolar macrophages. J Lab Clin Med 1995; 126: 416–422.
  • Beers MF, Atochina EN, Preston AM, Beck JM. Inhibition of lung surfactant protein B expression during Pneumocystis carinii pneumonia in mice. J Lab Clin Med 1999; 133: 423–433.
  • Atochina EN, Beers MF, Scanlon ST, Preston AM, Beck JM. P. carinii induces selective alterations in component expression and biophysical activity of lung surfactant. Am J Physiol Lung Cell Mol Physiol 2000; 278: L599–L609.
  • Kembaum S, Masliah J, Alcindor L, Bouton C, Christol D. Phospholipase activities of bronchoalveolar lavage fluid in rat Pneumocystis carinii pneumonia. Brit J Exp Pathol 1983; 6: 75–80.
  • Sheehan PM, Stokes DC, Yeh Y, Hughes WT. Surfactant phospholipids and lavage phospholipase A2 in experimental Pneumocystis carinii pneumonia. Am Rev Respir Dis 1986; 134: 526–531.
  • Phelps DS, Umstead TM, Rose RM, Fishman JA. Surfactant protein-A levels increase during Pneumocystis carinii pneumo-nia in the rat. Eur Respir J 1996; 9: 565–570.
  • Deterding RR, Shimizu H, Fisher JH, Shannon JM. Regula-tion of surfactant protein D expression by glucocorticoids in vitro and in vivo. Am J Respir Cell Mol Biol 1994; 10: 30–37.
  • Guo Z, Kaneshiro ES. Phospholipid composition of Pneumo-cystis carinii and effects of methylprednisolone immunosup-pression on rat lung lipids. Infect Immun 1995; 63: 1286–1290.
  • Aliouat EM, Escamilla R, Cariven C, etal. Surfactant changes during experimental pneumocystosis are related to the Pneu-mocystis development. Eur Respir J 1998; 11: 542–547.
  • Rice WR, Singleton FM, Linke MJ, Waltzer PD. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. J Clin Invest 1993; 92: 2778–2782.
  • Zimmermann PE, Voelker DR, McCormack FX, Paulsrud JR, Martin WJ. 120kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A. J Clin Invest 1992; 89: 143–149.
  • O'Riordan DM, Standing JE, Kwon KY, Chang D, Crouch EC, Limper AH. Surfactant protein D interacts with Pneumo-cystis carinii and mediates organisms adherence to alveolar macrophages. J Clin Invest 1995; 95: 2699–2710.
  • Williams MD, Wright JR, March KL, Martin WJ. Human surfactant protein A enhances attachment of Pneumocystis carinii to rat alveolar macrophages. Am J Respir Cell Mol Biol 1996; 14: 232–238.
  • Eijking EP, van Daal GJ, Tenbrinck R, et al. Effect of surfactant replacement on Pneumocystis carinii pneumonia in rats. Intensive Care Med 1991; 17: 475–478.
  • Fishman JA. Treatment of infection due to Pneumo-cystis carinii. Antimicrob Agents Chemother 1998; 42: 1309–1314.
  • Kaneshiro ES, Ellis JE, Thou LH, et al. Isoprenoid metabolism in Pneumocystis carinii. J Eukaryot Microbiol 1994; 41 (Suppl.): 93.
  • Schmatz D, Romancheck M, Pittarelli L, et al. Treatment of Pneumocystis carinii with 1,3-glucan synthesis inhibitors. Proc Natl Acad Sci USA 1990; 87: 5950–5954.
  • Schmatz D, Powles MA, McFadden D, et al. New semisyn-thetic pneumocandins with improved efficacies against Pneu-mocystis carinii in the rat. Antimicrob Agents Chemother 1995; 39: 1320–1323.
  • Herreros E, Martinez CM, Almela MJ, et al. Sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, Pneumocystis carinii, and filamentous fungi. Antimicrob Agents Chemother 1998; 42: 2863–2869.
  • Aviles P, Aliouat EM, Dei-Cas E, Herreros E, Dujardin L, Gargallo-Viola D. In vitro pharmacodynamic parameters of sordarin derivatives in comparison with atovaquone, pen-tamidine and trimethoprim/sulfamethoxazol against rat-derived Pneumocystis carinii. Antimicrob Agents Chem.other 2000; 44: 1284–1290.
  • Diop Santos L, Lacube P, Latouche S, et al. Contribution of dihydropteroate synthase gene typing for Pneumocystis carinii f.sp. hominis epidemiology. J Eukaryot Microbiol 1999; 46 (Suppl.): 133–134.
  • Aliouat EM, Dujardin L, Martinez A, Duriez T, Dei-Cas E. Pneumocystis carinii growth kinetics in culture systems and in hosts: involvement of each life cycle parasite stage. J Eukaryot Microbiol 1999; 46 (Suppl.): 116–117.
  • Merali S, Frevert U, Williams JH, Chin K, Bryan R, Clarkson AB. Continuous axenic cultivation of Pneumocystis carinii. Proc Natl Acad Sci USA 1999; 96: 2402–2407.

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