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Pediatric Pathology & Molecular Medicine Volume 21, 2002 - Issue 5
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Research Article

PATHOLOGICAL CASE OF THE MONTH: SUDDEN DEATH IN A CHILD AS A RESULT OF PANCREATITIS DURING VALPROIC ACID THERAPY

Darinka Mileusnic Office of the Medical Examiner County of Cook, Chicago, Illinois
,
Edmund R. Donoghue Office of the Medical Examiner County of Cook, Chicago, IllinoisCorrespondence[email protected]
&
Barry D. Lifschultz Office of the Medical Examiner County of Cook, Chicago, Illinois
Pages 477-484 | Published online: 09 Jul 2009

  • Dreifuss FE, Santilli N, Langer DH, et al. Valproic acid hepatic fatalities: A retrospective review. Neurology 1987;37:379-385.
  • Parker PH, Helinek GL, Ghishan FK, et al. Recurrent pancreatitis induced by valproic acid. Gastroenterology 1981;80:826-828.
  • Batalden PB, Van Dyne BJ, Cloyd J. Pancreatitis associated with valproic acid therapy. Pediatrics 1979;64:520-522.
  • Camfield PR, Bagnell P, Camfield GS, et al. Pancreatitis due to valproic acid. Lancet 1979;1:1198-1199.
  • Baselt CR. Valproic acid. In Baselt CR, Disposition of Toxic Drugs and Chemicals in Man. 5th ed. Foster City, CA: Chemical Toxicology Institute, 2000,867-871.
  • Roodhooft AM, Van Dam K, Verpooten GA, et al. Acute sodium valproate intoxication: Occurrence of renal failure and treatment with haemoperfusionhaemodialysis. EurJ Pediatr 1990;149:363-364.
  • Schmidt D. Adverse effects of valproate. Epilepsia 1984; 25 (suppl 1):S44-S49.
  • Asconapé JJ, Kiffin Penry J, Dreiffus FE, et al. Valproate - associate d pancreatitis. Epilepsia 1993;34:177-183.
  • Dreifuss EF, Langer DH. Hepatic considerations in the use of antiepileptic drugs. Epilepsia 1987;28(suppl 2):S23-S29.
  • Isom JB. On the toxicity of valproic acid. AJDC 1984;138:901-903.
  • Kane RE, Kotagel S, Bacon BR, et al. Valproate use associated with persistent hyperammonemia and mitochondrial injury in a child with Down's syndrome. J Pediatr Gastroenterol Nutr 1992;14:223-227.
  • König SA, Siemes H, Bläker F, et al. Severe hepatotoxicity during valproate therapy: An update and report of eight new fatalities. Epilepsia 1994;35:1005-1015.
  • Powell - Jackson PR, Tredger JM, Williams R. Hepatotoxicity to sodium valproate: A review. Gut 1984;25:673-681.
  • Fenichel GM, Greene HL. Valproate hepatotoxicity: Two new cases, a summary of others, and recommendations. Pediatr Neurol 1985;1:109-113.
  • Pinkston R, Anderson Walker L. Multiorgan system failure caused by valproic acid toxicity. Am J Emerg Med 1997;15:504-506.
  • Kotlus Rosenberg H, Ortega W. Hemorrhagic pancreatitis in a young child following valproic acid therapy. Clin Pediatr 1987;26:98-101.
  • Banerjee AK, Patel KJ, Grainger SL. Drug - induced acute pancreatitis: A critical review. Med Toxicol Adverse Drug Exp 1989;4:186-198.
  • Steinberg W, Tenner S. Acute pancreatitis. NEJM 1994;330:1198-1210.
  • Graf WD, Oleinik OE, Glauser TA, et al. Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics 1998;29:195-201.
  • Binek J, Hany A, Heer M. Valproic - acid - induced pancreatitis: Case report and review of the literature. J Clin Gastroenterol 1991;13:690-693.
  • Sasaki M,Tonoda S, Aoki Y, et al. Pancreatitis due to valproic acid. Lancet 1980;1:1196.
  • Ford DM, Portman RJ, Lum GM. Pancreatitis in children on chronic dialysis treated with valproic acid. Pediatr Nephrol 1990;4:259-261.
  • Levin TL, Berdon WE, Seigle RR, et al. Valproic - acid - associated pancreatitis and hepatic toxicity in children with endstage renal disease. Pediatr Radiol 1997;27:192-193.
  • Moreiras Plaza M, Rguez Goyanes G, Cuifla L, et al. On the toxicity of valproic acid. Clin Nephrol 1999;51:187-189.
  • Padilla B, Pollak VE, Pesce A, et al. Pancreatitis in patients with end - stage renal disease. Medicine 1994;73:8-20.
  • King LR, Siegel MJ, Balfe DM. Acute pancreatitis in children: CT findings of intraand extrapancreatic fluid collections. Radiology 1995;195:196-200.
  • Redington K, Wells G, Petito E Erythromycin and valproate interaction. Ann Intern Med 1992;116:877-878.
  • Harden CL. Therapeutic safety monitoring: What to look for and when to look for it. Epilepsia 2000;41 (suppl 8):S37-S44.
  • Depakene, Valproic acid capsules and syrup, box warning. In Murray L, Kelly GL, Physician Desk Reference, 55th ed. Montevale, NJ: Medical Economics Company, Inc., Thomson Healthcare, 2001;422.

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