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Research Article

Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus

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Pages 133-139 | Published online: 12 Jul 2009

References

  • Gripenberg M, Helve T. Outcome of systemic lupus eryth-ematosus. A study of 66 patients over 7 years with special reference to the predictive value of anti-DNA antibody deter-minations. Scand J Rheumatol 1991;20:10 4–9.
  • Manoussakis MN, Kistis CG, Aidinis V, Guialis A, Piha L, Sekeris CE, et al. Detection of human-specific anti-La(SSB) antibodies in patients with rheumatoid arthritis. J Autoimmun 1995;8:959–69.
  • Reichlin M. Systemic lupus erythematosus. Immunol Ser 1991;54:163–99.
  • Slobbe RL, Pruijn GT, Damen WG, van der Kemp JW, van Venrooij WJ. Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these pro-teins. Clin Exp Immunol 1991;86: 99–105.
  • Pourmand N, Blomberg S, Rönnblom L, Karlsson-Parra A, Pettersson I, Wahren-Herlenius M. Ro 52kD autoantibodies are detected in a subset of ANA-negative sera. Scand J Rheumatol 2000;29:11 6–23.
  • Halse AK, Marthinussen MC, Wahren-Herlenius M, Jonsson R. Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and saliva of patients with Sjogren's syndrome. Scand J Rheumatol 2000;29:1 3–9.
  • Deutscher SL, Harley JB, Keene JD. Molecular analysis of the 60-kDa human Ro ribonucleoprotein. Proc Natl Acad Sci U S A 1988;85: 9479–83.
  • Chan EK, Hamel JC, Buyon JP, Tan EM. Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. J Clin Invest 1991;87:68–76.
  • Rinke J, Steitz JA. Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La lupus antibodies. Cell 1982;29:149–59.
  • O'Brien CA, Wolin SL. A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors. Genes Dev 1994;8:289 1–903.
  • Gottlieb E, Steitz JA. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. Embo J 1989;8:85 1–61.
  • Yoo CJ, Wolin SL. The yeast La protein is required for the 3, endonucleolytic cleavage that matures tRNA precursors. Cell 1997;89:393–402.
  • Sontheimer RD, Maddison PJ, Reichlin M, Jordon RE, Stastny P, Gilliam JN. Serologic and HLA associations in subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus. Ann Intern Med 1982;97:664–71.
  • Purcell SM, Lieu TS, Davis BM, Sontheimer RD. Relationship between circulating anti-Ro/SS-A antibody levels and skin disease activity in subacute cutaneous lupus erythematosus. Br J Dermatol 1987;117:277–87.
  • Buyon JP. Congenital complete heart block. Lupus 1993;2:291–5.
  • Wahren M, Tengner P, Gunnarsson I, Lundberg I, Hedfors E, Ringertz NR, et al. Ro/SS-A and La/SS-B antibody level variation in patients with Sjogren's syndrome and systemic lupus erythematosus. J Autoimmun 1998;11:29–38.
  • Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classifica-tion of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271–7.
  • Hay EM, Bacon PA, Gordon C, Isenberg DA, Maddison P, Snaith ML, et al. The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus. Q J Med 1993;86:447–58.
  • Tengner P, Halse AK, Haga HJ, Jonsson R, Wahren-Herlenius M. Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjogren's syndrome. Arthritis Rheum 1998;41:223 8–48.
  • Elagib KE, Tengner P, Levi M, Jonsson R, Thompson KM, Natvig JB, et al. Immunoglobulin variable genes and epitope recognition of human monoclonal anti-Ro 52-kd in primary Sjogren's syndrome. Arthritis Rheum 1999;42:247 1–81.
  • Scofield RH, Henry WE, Kurien BT, James JA, Harley JB. Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro auto-antigen results in anti-Ro ribonucleoprotein autoimmunity. J Immunol 1996;156: 4059–66.
  • Topfer F, Gordon T, McCluskey J. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc Natl Acad Sci U S A 1995;92:875–9.
  • Tseng CE, Chan EK, Miranda E, Gross M, Di Donato F, Buyon JP. The 52-kd protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex. Arthritis Rheum 1997;40:93 6–44.
  • Meilof JF, Veldhoven CH, Swaak AJ, Smeenk RJ. Production of anti-Ro/SS-A and anti-La/SS-B autoantibodies is closely coordinated in systemic lupus erythematosus and independent of anti-dsDNA production. J Autoimmun 1997;10:67–75.
  • St Clair EW, Burch JA, Jr., Ward MM, Keene JD, Pisetsky DS. Temporal correlation of antibody responses to different epitopes of the human La autoantigen. J Clin Invest 1990;85:515–21.
  • Ho A, Magder LS, Barr SG, Petri M. Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:2342–9.
  • Swaak AJ, Huysen V, Nossent JC, Smeenk RJ. Antinuclear antibody profiles in relation to specific disease manifestations of systemic lupus erythematosus. Clin Rheumatol 1990;9: 82–94.
  • Wasicek CA, Reichlin M. Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La. J Clin Invest 1982;69:835–43.
  • Liang MH, Socher SA, Larson MG, Schur PH. Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum 1989;32:1107–18.
  • Nossent H, Rekvig OP. Antinuclear antibody screening in this new millennium: farewell to the microscope? Scand J Rheumatol 2001;30:12 3–6.

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