- on various factors, including clearance of the molecu
- lar structures and the amount of cartilage matrix1. Myers SL. Synovial ? uid markers in osteoarthritis. Rheum Dis Clin North Am 1999;25:433-49.
- remaining in the joint. Besides, the majority of the 2. Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne
- markers are not only produced in articular cartilage R, Rorabeck C, et al. Enhanced cleavage of type II collagen
- but to varying extents also in the synovial membrane by collagenases in osteoarthritic articular cartilage. J Clin
- and other organs. Invest 1997;99:153 4-45. 3. Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier
- Tenascin and MMP-13 might be a helpful tool in
- J. The new collagenase, collagenase-3, is expressed and synthe-Ja¨rvinen M. Tenascin-C in the pathophysiology and healing process of musculoskeletal tissue injury. Scand J Med Sci
- sized by human chondrocytes but not in synoviocytes: a role Sports 2000;10:376-2.
- in osteoarthritis. J Clin Invest 1996;97:2011-9. 22. Salter DM. Tenascin is increased in cartilage and synovium
- Johansen JS, Jensen HS, Price PA. A new biochemical marker from arthritic knees. Br J Rheumatol 1993;32:780-6.
- for joint injury. Analysis of YKL-40 in serum and synovial 23. Natali PG, Nicotra MR, Bigotti A, Bartolazze A, Motolese
- ? uid. Br J Rheumatol 1993;32:949-55. M, Coscia N, et al. Comparative analysis of the expression of
- Conrozier T, Carlier MC, Mathieu P, Colson F, Debard AL, the extra-cellular matrix protein tenascin in normal humanRichard S, et al. Serum levels of YKL-40 and C reactive fetal, adult and tumor tissues. Int J Cancer 1991;47:811-6.protein in patients with hip osteoarthritis and healthy subjects: 24. Ja¨rvinen TA, Jozsa L, Kannus P, Ja¨rvinen TLN, Kvist M,
- a cross sectional study. Ann Rheum Dis 2000;59:828-31. Hurme T, et al. Mechanical loading regulates tenascin-c expres-
- Jones FS, Jones PL. The tenascin family of ECM glycoproteins: sionintheosteotendineousjunction.JCellScistructure, function, and regulation during embryonic develop-1999;112:3157-66.ment and tissue remodeling. Dev Dyn 2000;218:23 5-59. 25. Massova I, Kotra LP, Fridman R, Mobashery S. Matrix
- Chevalier X, Groult N, Larget-Piet B, Zardi L, Hornebeck W. metalloproteinases: structures, evolution, and diversi? cation.
- Tenascin distribution in articular cartilage from normal sub-FASEB J 1998;12:1075-95.
- jects and from patients with osteoarthritis and rheumatoid 26. Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL,
- arthritis. Arthritis Rheum 1994;37:101 3-22. Yocum SA, Rosner PJ, et al. Cloning, expression, and type II
- Dahlberg L, Roos H, Saxne T, Heinegard D, Lark MW, collagenolytic activity of matrix metalloproteinase-13 fromHoerrner LA, et al. Cartilage metabolism in the injured and human osteoarthritic cartilage. J Clin Invest 1996;97:761-8.
- uninjured knee of the same patient. Ann Rheum Dis 27. Wernicke D, Seyfert C, Hinzmann B, Gromnica-Ihle E.
- 1994;53:823-7. Cloning of collagenase-3 from the synovial membrane and its
- Lohmander LS, Hoerrner LA, Dahlberg L, Roos H, Bjo¨rnsson expression in rheumatoid arthritis and osteoarthritis. J
- S, Lark MW. Stromelysin, tissue inhibitor of metallo-Rheumatol 1996;23:590-5.
- proteinases and proteoglycan fragments in human knee joint 28. Lohmander LS, Hoerrner LA, Dahlberg L, Roos H, Bjo¨ rnsson
- ? uid after injury. J Rheumatol 1993;20:1362-8. S, Lark MW. Stromelysin, tissue inhibitor of metallo-
- Outerbridge RE. The etiology of chondromalacia patellae. J proteinases and proteoglycan fragments in human knee joint
- Bone Joint Surg [Br] 1961;43-B:752-7. ? uid after injury. J Rheumatol 1993;20:136 2-8.
- Noyes FR, Stabler CL. A system for grading articular cartilage 29. Naito K, Takahashi M, Kushida K, Suzuki M, Ohishi T,
- lesions at arthroscopy. Am J Sports Med 1989;17:505-13. Miura M, et al. Measurement of matrix metalloproteinases
- Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1)
- K, et al. Development of criteria for the classi? cation and in patients with knee osteoarthritis: comparison with general-
- reporting of osteoarthritis of the knee. Arthritis Rheum ized osteoarthritis. Rheumatology 1999;38:510-5.
- 1986;29:1039-49. 30. Ishiguro N, Ito T, Ito H, Iwata H, Jugessur H, Ionescu M,
- Lequesne M, Mery C, Samson M, Gerard P. Indices of severity et al. Relationship of matrix metalloproteinases and their
- for osteoarthritis of the hip and the knee. Validation - value inhibitor to cartilage proteoglycan and collagen turnover.
- in comparison with other assessment tests. Scand J Rheumatol Arthritis Rheum 1999;42:129-36.
- 1987;16 Suppl 65:85-9. 31. Neidhart M, Hauser N, Paulsson M, DiCesare PE, Michel
- Bellamy N, Buchanan WW, Goldsmith CH, Campbell, Stitt BA, Hauselmann HJ. Small fragments of oligomeric matrix
- LW. Validation of WOMAC: a health status instrument for protein in synovial ? uid and serum as markers for cartilage
- measuring clinically important patient relevant outcomes to degradation. Br J Rheumatol 1997;36:1151-60.
- antirheumatic drug therapy in patients with osteoarthritis of 32. Lohmander LS, Saxne T, Heinegard D, Release of cartilage
- the hip or the knee. J Rheumatol 1988;15:183 3-40. oligomeric matrix protein (COMP) into joint ? uid after knee
- RoosEM,Kla¨ssboM,LohmanderLS.WOMAC injury and in osteoarthritis. Ann Rheum Dis 1992;53:8-13.
- osteoarthritis index. Reliability, validity, and responsiveness in 33. Sharif M, Saxne T, Shepstone L, Kirwan JR, Elson CJ, Dieppe
- patients with arthroscopically assessed osteoarthritis. Scand J PA. Relationship between serum cartilage oligomeric matrix
- Rheumatol 1999;28:210-5. protein levels and disease progression in osteoarthritis of the
- Kellgren JH, Lawrence JS. Radiological assessment of knee joint. Br J Rheumatol 1995;34:306-10.
- osteoarthritis. Ann Rheum Dis 1957;16:494-501. 34. Clark AG, Jordan JM, Vilim V, Renner JB, Dragomir AD,
- Ayral X, Altman R. Arthroscopic evaluation of knee articular Luta G, et al. Serum cartilage oligomeric matrix protein re? ects
- cartilage. In: Brandt KD, Doherty M, Lohmander LS (1998). osteoarthritispresenceandseverity.ArthritisRheum
- Osteoarthritis. Oxford University Press, Oxford, UK. 1999;42:2356-64.
- Lohmander LS, Dahlberg L, Ryd L, Heinegard D. Increased35. Volck B, Ostergaard K, Johansen JS, Garbarsch C, Price PA.
- levels of proteoglycan fragments in knee joint ? uid after injury.The distribution of YKL-40 in osteoarthritic and normal
- Arthritis Rheum 1989;32:1434-42.human articular cartilage. Scand J Rheumatol 1999;28:171-9.
- Va¨a¨ta¨inen U, Lohmander LS, Thonar EJ, Hongisto T, Agren36. Johansen JS, Hvolris J, Hansen M, Backer V, Lorenzen I,
- U, Ro¨ nkko¨ S, et al. Markers of cartilage and synovial metabol-Price PA. Serum YKL-40 levels in healthy children and adults.
- ism in joint ? uid and serum of patients with chondromalaciaComparison with serum and synovial ? uid levels of YKL-40
- of the patella. Osteoarthritis Cartilage 1998;6:115-24.in patients with osteoarthritis or trauma of the knee joint. Br
- Mackie EJ, ThesleV I, Chiquet-Erishmann R. Tenascin isJ Rheumatol 1996;35:553-9.
- associated with chondrogenic and osteogenic diVerentiation in37. Harvey S, Whaley J, Eberhardt K. The relationship between
- vivio and promotes chondrogenesis in vitro. J Cell Biolserum levels of YKL-40 and disease progression in patients
- 1987;105:2569-79.withearlyrheumatoidarthritis.ScandJRheumatol 2000;29:391-3.
- Ja¨rvinen TAH, Kannus P, Ja¨rvinen TLN, Jozsa L, Kalimo H,
New potential markers for cartilage degradation of the knee joint
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.